Evaluation of rectus extraocular muscles using dynamic contrast-enhanced MR imaging in patients with Graves' ophthalmopathy for assessment of disease activity

2012 ◽  
Vol 53 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Hong Jiang ◽  
Zhenchang Wang ◽  
Junfang Xian ◽  
Jing Li ◽  
Qinghua Chen ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Disease Activity ◽  
Extraocular Muscles ◽  
Active Group ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Graves Ophthalmopathy ◽  
Contrast Enhanced ◽  
Inactive Group ◽  
Assessment Of Disease Activity

Background It is important to assess the activity of Graves' ophthalmopathy (GO) for planning optimal treatment strategy. Dynamic contrast-enhanced MR imaging (DCE-MRI) is a technique for assessment of microcirculation status. The correlation between disease activity and the microcirculation characteristics of extraocular muscles (EOMs) has been demonstrated in GO. Purpose To investigate the changes of rectus EOMs in patients with active vs. inactive GO using DCE-MRI, and to evaluate the value of DCE-MRI in assessing the activity of GO. Material and Methods Rectus EOMs of 20 healthy controls, 18 patients with active GO, and 16 patients with inactive GO were studied. The signal intensity (SI) of rectus EOMs on T2W images was evaluated. Regions of interest were placed on each rectus on DCE-MRI images. The DCE-MRI parameters including time to peak enhancement (Tpeak), enhancement ratio (ER), and wash-out ratio (WR) were calculated. Results There were significant differences in SI and Tpeak, ER and WR values among the three groups ( P = 0.000). However, there was no significant difference in SI between the active and inactive groups ( P = 0.07). Tpeak values of each rectus were significantly increased in inactive group compared with the active group ( P < 0.05). ER and WR values of the inferior rectus and WR values of the superior rectus in inactive group were significantly lower than those in active group ( P < 0.05). There was significant correlation between clinical activity score (CAS) and minimum Tpeak (minTpeak), maximum ER (maxER) and maximum WR (maxWR) ( P < 0.001). The cut-off values of minTpeak, maxER and maxWR were 156.98s, 1.31 and 13.50% respectively, giving positive predictive values of 68.00%, 88.90%, and 94.44% for the assessment of disease activity. Conclusion DCE-MRI could demonstrate the microcirculatory changes of rectus EOMs in both active and inactive GO, and this MRI method is a useful tool in differentiating active from inactive GO.

Use-fullness of dynamic contrast-enhanced MR imaging and diffusion weighted MR imaging for differentiation of benign and malignant parotid tumors

2018 ◽  
pp. 1-6
Keyword(s):  
Mr Imaging ◽  
Malignant Tumors ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Parotid Tumors ◽  
Contrast Enhanced ◽  
Type C ◽  
Sensitivity Specificity ◽  
And Diffusion ◽  
Malignant Parotid Tumors

Objectives: To evaluate the usefullness of dynamic contrast-enhanced MR Imaging (DCE-MRI) and diffusion weighted imaging (DWI) for differentiating benign from malignant parotid tumors. Methods: Prospectively,DCE-MRI and DWI were performed in 112 patients, with 148 confirmed parotid masses. The differential optimal thresholds were determined. Results: WConsidering tumors with time-intensity curve (TIC) Type C as malignant, sensitivity, specificity, accuracy were 95%, 76%, 79%, respectively. Considering ADC threshold values 0.709×10-3mm2 /s<ADC<0.948×10-3mm2 /s as malignant, sensitivity, specificity, accuracy were 75%, 78%, 78%, respectively. Considering TIC Type C and ADC values 0.709×10-3mm2 /s<ADC<0.948×10-3mm2 /s as malignant, sensitivity, specificity, accuracy were 75%, 91%, 89%, respectively. With threshold Kep<1.118 min-1 and Ve >0.315 between Warthin and malignant tumors, threshold Kep>0.555 min-1 and Ve <0.605 between pleomorphic adenomas and malignant tumors, sensitivity, specificity, accuracy for malignancy were 70% vs 90%, 96% vs 74%, 92% vs 80%, respectively. Conclusion: DCE-MRI and DWI provide more information in differentiating benign from malignant parotid tumors.

scholarly journals Assessment of Correlation between Intravoxel Incoherent Motion Diffusion Weighted MR Imaging and Dynamic Contrast-Enhanced MR Imaging of Sacroiliitis with Ankylosing Spondylitis

2017 ◽  
Vol 2017 ◽  
pp. 1-9
Author(s):  
Yinghua Zhao ◽  
Qun Zhang ◽  
Wei Li ◽  
Yanqiu Feng ◽  
Yihao Guo ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Mr Imaging ◽  
Molecular Diffusion ◽  
Critical Role ◽  
Intravoxel Incoherent Motion ◽  
Maximum Enhancement ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Diffusion Weighted ◽  
Contrast Enhanced

The relationships between IVIM and DCE-MRI parameters in AS are not clear. We explore the correlation between intravoxel incoherent motion (IVIM) diffusion weighted imaging (DWI) and dynamic contrast-enhanced (DCE) parameters obtained on MR images in patients with ankylosing spondylitis (AS). Forty-four patients with AS were prospectively examined using a 1.5-T MR system. IVIM DWI was performed with 11 b values (range, 0–800 s/mm2) for all patients. The correlation coefficients between IVIM and DCE-MRI parameters were analyzed using Spearman’s method. Our results showed that intra- and interobserver reproducibility were excellent to relatively good (ICC = 0.804–0.981; narrow width of 95% limits of agreement). Moderate positive correlations were observed between pure molecular diffusion (Ds) and maximum enhancement (ME) and relative enhancement (RE) (r = 0.700, P<0.001; r=0.607, P < 0.001, resp.). Perfusion-related diffusion (Df) showed negative moderate correlation with ME (r = -0.608, P < 0.001). However, no correlation was observed between perfusion fraction (f) and any parameters of ME, RE, TTP, and BE (r = −0.093–0.213; P > 0.165). In conclusion, the IVIM parameters, especially f, might play a critical role in detecting the progression of AS, because it can provide more perfusion information compared with DCE-MRI; besides the IVIM MRI is a noninvasive method.

scholarly journals Characterization of Pure Ductal Carcinoma In Situ on Dynamic Contrast-Enhanced MR Imaging: Do Nonhigh Grade and High Grade Show Different Imaging Features?

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Siwa Chan ◽  
Jeon-Hor Chen ◽  
Garima Agrawal ◽  
Muqing Lin ◽  
Rita S. Mehta ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Kinetic Curve ◽  
Imaging Features ◽  
High Grade ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Significant Difference ◽  
Mass Lesions ◽  
Grade Iii

To characterize imaging features of pure DCIS on dynamic contrast-enhanced MR imaging (DCE-MRI), 31 consecutive patients (37-81 years old, mean 56), including 2 Grade I, 16 Grade II, and 13 Grade III, were studied. MR images were reviewed retrospectively and the morphological appearances and kinetic features of breast lesions were categorized according to the ACR BI-RADS breast MRI lexicon. DCE-MRI was a sensitive imaging modality in detecting pure DCIS. MR imaging showed enhancing lesions in 29/31 (94%) cases. Pure DCIS appeared as mass type or non-mass lesions on MRI with nearly equal frequency. The 29 MR detected lesions include 15 mass lesions (52%), and 14 lesions showing non-mass-like lesions (48%). For the mass lesions, the most frequent presentations were irregular shape (50%), irregular margin (50%) and heterogeneous enhancement (67%). For the non-mass-like lesions, the clumped internal enhancement pattern was the dominate feature, seen in 9/14 cases (64%). Regarding enhancement kinetic curve, 21/29 (78%) lesions showed suspicious malignant type kinetics. No significant difference was found in morphology (), tumor size (P= 0.21), and kinetic characteristics () between non-high grade (I+II) and high-grade (III) pure DCIS.

Dynamic Contrast-Enhanced MRI of the Bowel Wall for Assessment of Disease Activity in Crohn's Disease

2006 ◽  
Vol 186 (5) ◽  
pp. 1384-1392 ◽  
Author(s):  
Jasper Florie ◽  
Martin N. J. M. Wasser ◽  
Kasia Arts-Cieslik ◽  
Erik M. Akkerman ◽  
Peter D. Siersema ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Bowel Wall ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Assessment Of Disease Activity ◽  
Contrast Enhanced Mri

ENHANCEMENT PATTERN OF NORMAL EXTRAOCULAR MUSCLES IN DYNAMIC CONTRAST-ENHANCED MR IMAGING WITH FAT SUPPRESSION

2000 ◽  
Vol 41 (3) ◽  
pp. 211-216
Author(s):  
T. Taoka ◽  
S. Iwasaki ◽  
H. Uchida ◽  
A. Fukusumi ◽  
K. Kichikawa ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Extraocular Muscles ◽  
Fat Suppression ◽  
Enhancement Pattern ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced
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