A case of pulmonary tuberculosis with multiple nodules mimicking lung metastases

Tuberculosis (TB) may present as multiple pulmonary nodules mimicking lung metastases. Many asymptomatic cases of TB are detected incidentally on chest radiography, and patients are often negative for acid-fast bacilli staining and culture in spite of having active TB. It is important to know the imaging findings characteristic of pulmonary TB and its variant forms. Multiple pulmonary nodules were detected in an 80-year-old female during a medical checkup. TB was not suspected until her imaging findings worsened; however, in retrospect, centrilobular micronodules were observed amongst multiple well-circumscribed nodules on the initial images and worsened during conservative management. Although bilateral multiple well-circumscribed pulmonary nodules are suggestive of metastases, when a nodule surrounded by centrilobular or satellite micronodules is found, even in the absence of characteristic findings such as cavitation or the tree-in-bud sign, pulmonary TB should be considered in the differential diagnosis to prevent delays in treatment.

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Inflammatory Myofibroblastic Tumor of Lung – Computed Tomographic Features in 20 Patients

Nepalese Journal of Radiology ◽

10.3126/njr.v2i1.6974 ◽

2012 ◽

Vol 2 (1) ◽

pp. 18-24 ◽

Cited By ~ 1

Author(s):

P Ghimire ◽

L Zhu ◽

G Wu

Keyword(s):

Differential Diagnosis ◽

Inflammatory Myofibroblastic Tumor ◽

Pulmonary Nodules ◽

Location Pattern ◽

Multiple Pulmonary Nodules ◽

Computed Tomographic ◽

Pleural Surface ◽

Salient Characteristic ◽

Marked Enhancement ◽

Edge Pattern

Aim: To study the salient characteristic computed tomographic findings of inflammatory myofibroblastic tumor of lung. Materials and methods: We retrospectively reviewed the CT examinations of twenty histopathologically confirmed cases of inflammatory myofibroblastic tumor of lung and analyzed the involvement, predominant location, pattern of presentation, shape, edge, pattern and degree of enhancement and any atypical findings in those cases. Results: Fourteen cases presented as pulmonary nodules among which twelve as solitary while two cases as multiple pulmonary nodules. Six cases presented as masses. The location was in the parenchyma of the lung among all cases except two masses that were predominantly mediastinal and endobronchial respectively. All nodules demonstrated mild enhancement except one nodule showed moderate and another one marked enhancement. Four masses demonstrated mild enhancement whearas one showed moderate and another marked enhancement. Pleural surface abutting was noticed in one nodule and two masses. Stippled calcification was present in one mass while necrosis was noticed in two other cases that presented as mass. Mass were associated with consolidation in one and as cavity in another case. Conclusion: Although diagnosis of inflammatory myofibroblastic tumor of lung cannot be confirmed radiologically, certain features as presence of nodules or masses that enhance mildly in a patient with equivocal clinical and radiological presentation warrants its inclusion in the differential diagnosis. NJR I VOL 2 I ISSUE 1 18-24 Jan-June, 2012 DOI: http://dx.doi.org/10.3126/njr.v2i1.6974

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Hyperdense Endobronchial Mass - A Rare Manifestation of Metastatic Melanoma

Journal of Clinical Imaging Science ◽

10.4103/2156-7514.127833 ◽

2014 ◽

Vol 4 ◽

pp. 7 ◽

Cited By ~ 1

Author(s):

Chul Y Chung ◽

Gauruv S Likhari ◽

Neda Zarrin-Khameh ◽

Arun C Nachiappan

Keyword(s):

Differential Diagnosis ◽

Malignant Melanoma ◽

Metastatic Melanoma ◽

Lung Metastases ◽

Melanoma Metastasis ◽

Imaging Findings ◽

Rare Manifestation ◽

Parenchymal Lung

Parenchymal lung metastases are common in malignant melanoma. However, endobronchial metastatic melanoma is uncommon. In this report, we describe a patient with a hyperdense endobronchial mass diagnosed as a melanoma metastasis. We review the imaging findings of pulmonary metastatic melanoma and discuss the differential diagnosis of an endobronchial mass in adults.

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Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis

Communications Biology ◽

10.1038/s42003-020-01318-0 ◽

2020 ◽

Vol 3 (1) ◽

Author(s):

Qiyao Chai ◽

Zhe Lu ◽

Zhidong Liu ◽

Yanzhao Zhong ◽

Fuzhen Zhang ◽

...

Keyword(s):

Gene Expression ◽

Differential Diagnosis ◽

Molecular Markers ◽

Pulmonary Tuberculosis ◽

Lung Diseases ◽

Expression Patterns ◽

Migration And Invasion ◽

Molecular Signatures ◽

Tumor Cell Proliferation ◽

Pulmonary Tb

Abstract Previous reports have suggested a link between pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), and the development of lung adenocarcinoma (LUAD) and sarcoidosis. Furthermore, these lung diseases share certain clinical similarities that can challenge differential diagnosis in some cases. Here, through comparison of lung transcriptome-derived molecular signatures of TB, LUAD and sarcoidosis patients, we identify certain shared disease-related expression patterns. We also demonstrate that MKI67, an over-expressed gene shared by TB and LUAD, is a key mediator in Mtb-promoted tumor cell proliferation, migration, and invasion. Moreover, we reveal a distinct ossification-related TB lung signature, which may be associated with the activation of the BMP/SMAD/RUNX2 pathway in Mtb-infected macrophages that can restrain mycobacterial survival and promote osteogenic differentiation of mesenchymal stem cells. Taken together, these findings provide novel pathogenic links and potential molecular markers for better understanding and differential diagnosis of pulmonary TB, LUAD and sarcoidosis.

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Kualitas Hidup Pasien Tuberkulosis Paru yang Mengalami Stigma Diri (Quality of Life Pulmonary Tuberculosis Patients With Self Stigma))

Jurnal Kesehatan Holistic ◽

10.33377/jkh.v3i2.50 ◽

2019 ◽

Vol 3 (2) ◽

pp. 17-27

Author(s):

Yunita Sari

Keyword(s):

Quality Of Life ◽

Pulmonary Tuberculosis ◽

Descriptive Study ◽

Negative Influence ◽

Questionnaire Data ◽

Average Quality ◽

Tuberculosis Patients ◽

Pulmonary Tb ◽

Life Score

Pulmonary tuberculosis (TB) is a chronic disease that can bring about the sufferer's self-stigma and also affect his quality of life. A number of studies report that living with TB has a negative influence on the quality of life of sufferers even with or without self-stigma. The purpose of this study was to identify the quality of life of TB patients who experienced self-stigma. This research is a descriptive study, sample were 31 pulmonary TB patients. Data was collected using a questionnaire. Data analyzed by using frequency distribution and percentage. The researcher first screened TB patients who experienced self-stigma. The results showed that 25 people (80.64%) respondents experienced mild self-stigma. A total of 9 respondents (36%) had a quality of life score in the good category and as many as 16 respondents (64%) had enough category with an average quality of life score is 56.57. While respondents who had moderate self-stigma were 6 people (19.36%) with a good quality of life score was 1 person (16.67%) and enough category quality of life score were 5 people (83.33%) with an average quality of life score is 49.92.

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MR Imaging Findings of Pineal Germinoma: Focus on Differential Diagnosis from Other Germ Cell Tumors

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1998.39.4.639 ◽

1998 ◽

Vol 39 (4) ◽

pp. 639

Author(s):

Hyun Jin Kim ◽

Ho Kyu Lee ◽

Jae Kyun Kim ◽

Ji Hoon Shin ◽

Choong Gon Choi ◽

...

Keyword(s):

Differential Diagnosis ◽

Mr Imaging ◽

Germ Cell ◽

Germ Cell Tumors ◽

Imaging Findings ◽

Pineal Germinoma

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Primary breast tuberculosis: imaging findings of a rare disease

Insights into Imaging ◽

10.1186/s13244-021-00961-3 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Ali H. Baykan ◽

Hakan S. Sayiner ◽

Ibrahim Inan ◽

Elcin Aydin ◽

Sukru M. Erturk

Keyword(s):

Differential Diagnosis ◽

Rare Disease ◽

Extrapulmonary Tuberculosis ◽

Reproductive Age ◽

Malignant Diseases ◽

Imaging Findings ◽

Granulomatous Mastitis ◽

Rare Form ◽

Breast Tuberculosis

AbstractBreast tuberculosis is a rare form of extrapulmonary tuberculosis which tends to affect females of reproductive age, and is much rarer in males, postmenopausal women, and pre-pubescent girls. It is difficult to diagnose because it can mimic benign conditions such as a fibroadenoma, as well as malignant diseases like a carcinoma. It is also particularly difficult to distinguish breast tuberculosis from granulomatous mastitis, so other possible diagnoses should be ruled out first. The diagnosis of breast tuberculosis has three essential pillars: clinical examination, radiological evaluations, and histopathological sampling. Radiological evaluations are not only critical in diagnosis but are also important in the planning of the treatment and during the follow-up. This paper aims to review the imaging findings and the differential diagnosis of breast tuberculosis.

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Pulmonary nodular amyloidosis. A rare cause of multiple pulmonary nodules

Archivos de Bronconeumología (English Edition) ◽

10.1016/j.arbr.2019.11.027 ◽

2021 ◽

Author(s):

Inés Ruiz-Álvarez ◽

Ana M. Gutiérrez Palacios ◽

Beatriz Rodríguez Díaz

Keyword(s):

Pulmonary Nodules ◽

Multiple Pulmonary Nodules

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Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population

Innate Immunity ◽

10.1177/17534259211029996 ◽

2021 ◽

pp. 175342592110299

Author(s):

Alexander Varzari ◽

Igor V. Deyneko ◽

Elena Tudor ◽

Harald Grallert ◽

Thomas Illig

Keyword(s):

Pulmonary Tuberculosis ◽

Interaction Analysis ◽

P Value ◽

Fisher Exact Test ◽

Snp Analysis ◽

Nucleotide Polymorphism ◽

Single Nucleotide ◽

Exact Test ◽

Pulmonary Tb ◽

The Republic

Polymorphisms in genes that control immune function and regulation may influence susceptibility to pulmonary tuberculosis (TB). In this study, 14 polymorphisms in 12 key genes involved in the immune response ( VDR, MR1, TLR1, TLR2, TLR10, SLC11A1, IL1B, IL10, IFNG, TNF, IRAK1, and FOXP3) were tested for their association with pulmonary TB in 271 patients with TB and 251 community-matched controls from the Republic of Moldova. In addition, gene–gene interactions involved in TB susceptibility were analyzed for a total of 43 genetic loci. Single nucleotide polymorphism (SNP) analysis revealed a nominal association between TNF rs1800629 and pulmonary TB (Fisher exact test P = 0.01843). In the pairwise interaction analysis, the combination of the genotypes TLR6 rs5743810 GA and TLR10 rs11096957 GT was significantly associated with an increased genetic risk of pulmonary TB (OR = 2.48, 95% CI = 1.62–3.85; Fisher exact test P value = 1.5 × 10−5, significant after Bonferroni correction). In conclusion, the TLR6 rs5743810 and TLR10 rs11096957 two-locus interaction confers a significantly higher risk for pulmonary TB; due to its high frequency in the population, this SNP combination may serve as a novel biomarker for predicting TB susceptibility.

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