scholarly journals Intraoperative Diagnosis and Management of Acute Hypotensive Blood Transfusion Reaction (AHTR): A Report of Two Cases

2018 ◽  
Vol 19 ◽  
pp. 1283-1287 ◽  
Author(s):  
Uzung Yoon ◽  
Madeel Abdullah ◽  
Elia Elia ◽  
Jay Herman
2007 ◽  
Vol 84 (2) ◽  
pp. 648-650 ◽  
Author(s):  
Minh-Tri Jean-Pierre Nguyen ◽  
Sébastien Trop ◽  
Constantine Soulellis ◽  
Peter Szego ◽  
Lorenzo E. Ferri

2011 ◽  
Vol 29 (29) ◽  
pp. e751-e753 ◽  
Author(s):  
Yuebo Gan ◽  
Michi M. Shinohara ◽  
Misha Rosenbach ◽  
David Elder ◽  
Noelle Frey ◽  
...  

Cureus ◽  
2020 ◽  
Author(s):  
Purva Sharma ◽  
Sukesh Manthri ◽  
Emily Patterson ◽  
Bahaaeldin Youssef ◽  
Kanishka Chakraborty

1980 ◽  
Vol 8 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Bryan Rush ◽  
Newton L. Y. Lee

Due to the sophistication of red cell compatibility testing, the majority of transfusion reactions are non-haemolytic in origin. This paper reviews the clinical presentation of these reactions, emphasising that blood transfusion reaction must always be considered in the differential diagnosis when a patient develops unexpected complications during his hospital stay. Fever, allergic reactions, respiratory distress, hypotension and jaundice may all be manifestations of a transfusion reaction.


Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4021-4021 ◽  
Author(s):  
Shelonitda S. Rose ◽  
Simi George ◽  
Serena Wong ◽  
Grace Tenorino ◽  
Mercy Kuriyan

Abstract Acute hemolytic transfusion reaction (AHTR) is a potentially serious complication associated with the transfusion of ABO incompatible blood. It results in disseminated intravascular coagulation (DIC), shock, renal failure and death. Patient misidentification, sample mislabeling are some of the causes of an AHTR. To-date there is no data available on the use of RBCET in the management of an AHTR. We report the clinical course and successful management of an AHTR following massive ABO incompatible blood transfusion. The patient is a 68-year-old female with known coronary artery disease and type O Rh negative blood, who presented to the emergency room with unstable angina. She was taken emergently to the operating room for a quadruple coronary artery bypass graft. Due to sample mislabeling, she received 7 units of incompatible type A Rh negative packed red blood cells (PRBC) intra-operatively. During the immediate post-operative period, she was noted to have increased drainage from the surgical site, decreased urine output, hematuria and a precipitous drop in hemoglobin to 6.5 g/dL. She underwent re-exploration and received an additional 2 units of incompatible type A Rh negative PRBC and other blood products including fresh frozen plasma (FFP), platelets and cryoprecipitate that were ABO incompatible. In the recovery room, family members confirmed her blood type as type O Rh negative. Immediate re-typing utilizing pre-transfusion blood samples collected for CBC and chemistry, and obtaining blood bank records from her previous admission from another hospital a diagnosis of ABO incompatible AHTR was established. Further work-up revealed a strong positive DAT (3+ IgG) with a positive eluate (patient’s anti-A antibodies coating the transfused type A RBC’s). Hemolysis parameters showed elevated LDH 753 IU, bilirubin 2.1 mg/dL, and decreased haptoglobin 29.4 mg/dL. Her urine output continued to decrease with increase in serum creatinine to 2.4mg/dL. A continuous veno-venous hemodialysis (CVVHD) was started along with fluid resuscitation and urine alkalinization. A RBCET was performed within 11 hours after the transfusion of the last incompatible unit, which was followed by a second RBCET 24 hours later. Each RBCET consisted of 8 units of type O Rh negative blood. Following the two RBCET her blood type became type O Rh negative. Hemolysis parameters improved over the next several days and became normal. Serum creatinine progressively improved with increasing urine output. Dialysis was discontinued on day 13. Patient continued to do well and was discharged home in good condition with a normal renal function three weeks after her initial admission. The severity and course of an AHTR is dictated by the load of incompatible blood cells in the circulation. The high mortality rate associated with an AHTR warrants an aggressive approach in addition to supportive care. RBCET is used in the management of severe hemolytic disease of the new born, complications of sickle cell disease, and to lower the parasite load in malaria and babesiosis. The role of RBCET in AHTR is not established. There are two case reports in the Japanese literature where a RBCET was performed in the management of an AHTR with successful outcome. The course of this patient suggests that aggressive management including supportive care, timely RBCET, and renal replacement treatment may prevent DIC, organ damage and alter the grave prognosis associated with AHTR following incompatible blood transfusion.


1975 ◽  
Vol 21 (4) ◽  
pp. 485-489 ◽  
Author(s):  
Hugh B. Stamper Jr. ◽  
Frank W. Chorpenning

A previously undescribed Bacillus species has been characterized. The organism was isolated from a blood transfusion bottle implicated in a fatal bacteriogenic transfusion reaction and has been examined from a number of different aspects to characterize it as completely as necessary to provide identification. It was placed into group 3 of the genus Bacillus on the basis of its cellular morphology, the morphology of the sporangium, and the location of the spore within the cell. There are only three other species described in this group. Since the organism differed markedly from each of these, it appears to represent a new species.


2020 ◽  
Vol 10 (31) ◽  
pp. 65-73
Author(s):  
Amanda Azevedo Bastos da Silva Santos ◽  
Josilene Da Costa Teixeira ◽  
Luana Do Carmo da Silva Pereira ◽  
Amanda Lorena de Araújo Silva

Descrever por meio de uma revisão integrativa da literatura o conhecimento dos enfermeiros sobre reações transfusionais. Trata-se de uma pesquisa descritiva, qualitativa cujo levantamento bibliográfico ocorreu em outubro de 2019. As bases de dados utilizadas foram PubMed, SciELO, BDEnf e LILACS. Foram identificadas 459 publicações, das quais 56 disponíveis no formato completo, excluíram-se produções duplicadas, que não atendem aos critérios de inclusão e artigos de outras bases de dados que não as supracitadas, restando 08 artigos, como amostra final. Os dados foram organizados em um quadro, com a identificação do artigo com base em sua referência e a sumarização de seus resultados. Conclui-se que há fragilidade no conhecimento dos profissionais de enfermagem e falta de estudos voltados para a temática, e com isso, incorrendo em negligência e, por conseguinte, riscos à saúde do paciente, prejudicando a qualidade da assistência à saúde.Descritores: Reação transfusional, Enfermagem, Transfusão de Sangue. Knowledge of nurses about transfusion reactions: integrative reviewAbstract: Describe, through an integrative literature review, the knowledge of nurses about transfusion reactions. This is a descriptive, qualitative research, which bibliographic survey took place in October 2019. The databases used were PubMed, SciELO, BDEnf and LILACS. Were identified 459 publications, of which 56 were available in full format, were excluded duplicate productions that don’t attend the inclusion criteria and articles from other databases than those mentioned above, leaving 8 articles as final sample. The data were organized in a table, with the identification of the article based on its reference and a summary of its results. In conclusion, there is a fragility in the knowledge of nursing professionals and a lack of studies focused on the theme, and therefore, incurring negligence and, consequently, risks for the patient's health, impairing the quality of health care.Descriptors: Transfusion Reaction, Nursing, Blood Transfusion. Conocimiento de enfermeras sobre reacciones de transfusión: revisión integrativaResumen: Describir, a través de una revisión integradora, el conocimiento de enfermeros sobre las reacciones transfusionales. Esta es una investigación descriptiva, cualitativa cuya encuesta bibliográfica se realizó en octubre de 2019. Las bases de datos utilizadas fueron PubMed, SciELO, BDEnf y LILACS. Se identificaron 459 publicaciones, de los cuales 56 disponibles en formato completo, se excluyeron las producciones duplicadas, que no cumplen con los criterios de inclusión y los artículos de bases de datos distintas a las mencionadas anteriormente, dejando 8 artículos como muestra final. Los datos se organizaron en un quadro, con la identificación del artículo en función de su referencia y resumen de sus resultados. Se concluye que existe fragilidad en el conocimiento de los profesionales de enfermería y falta de estudios centrados en el tema, y con esto, incurrir en negligencia y, por lo tanto, riesgos para la salud del paciente, perjudicando la calidad de la atención al salud.Descriptores: Reacción a la Transfusión, Enfermería, Transfusión Sanguínea.


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