scholarly journals Clinical Presentation of Nonhaemolytic Transfusion Reactions

1980 ◽  
Vol 8 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Bryan Rush ◽  
Newton L. Y. Lee

Due to the sophistication of red cell compatibility testing, the majority of transfusion reactions are non-haemolytic in origin. This paper reviews the clinical presentation of these reactions, emphasising that blood transfusion reaction must always be considered in the differential diagnosis when a patient develops unexpected complications during his hospital stay. Fever, allergic reactions, respiratory distress, hypotension and jaundice may all be manifestations of a transfusion reaction.

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Neila Sulung

<p>Transfusion reaction is the reaction of the recipient's body to blood donors, blood transfusion reactions can be mild to severe, and could be either fast, medium and slow. Hospital Dr. Achmad Darwis District Lima Puluh Kota every month UTDRS blood for transfusion are 45 to 55 bags. Survey of 30 patients who received a blood transfusion, there are 10 people have reactions such as fever of 4 people, as many as 4 people dizzy, urtikariat (itching) as much as one person and as many as three people shivering. The aim of research to find out the difference Reaction Giving Whoole Blood Transfusion Blood (WB) and Packed Red Cell (PRC) in Patients Sectio Caesare (SC). Type pre-experimental study, the design of Static Group Comparison. The population was patients post SC who receive blood transfusion, with sampling purposive sampling of 20 people. The data collection was done by direct observation, then processed and analyzed using independent t-test. Results that the average transfusion reactions in patients receiving blood transfusions WB is 1.30 and the patients who receive blood transfusion PRC is 0.40. The results of the bivariate no difference Whoole blood transfusion reaction Blood (WB) and Packed Red Cell (PRC) in Patients with Post Sectio Caesarea (SC) (p = 0.009). It was concluded that there is a difference of transfusion reactions in blood transfusions WB and blood transfusions PRC. Expected to medicine and nurse to be more selective in giving blood transfusions to patients and intensive control of blood transfusion process , so that a transfusion reaction can be immediately known. .</p><p> </p><p>Keywords: transfusion reactions, Whoole Blood (WB), Packed Red Cell (PRC)</p><p> </p><p> </p><p>Reaksi Transfusi adalah reaksi tubuh resipien terhadap darah donor, reaksi transfusi darah dapat ringan sampai berat, dan dapat berupa reaksi cepat, sedang, dan lambat. RSUD Dr. Achmad Darwis Kabupaten Lima Puluh Kota setiap bulannya UTDRS mengeluarkan darah untuk transfusi berjumlah 45 sampai 55 kantong. Survey terhadap 30 orang pasien yang mendapatkan transfusi darah, terdapat 10 orang mengalami reaksi berupa demam sebanyak 4 orang, pusing sebanyak 4 orang, menggigil sebanyak 3 orang dan urtikariat (gatal-gatal) sebanyak 1 orang. Tujuan penelitian untuk mengetahui Perbedaan Reaksi Pemberian Transfusi Darah <em>Whoole Blood </em>(WB) dan <em>Packed Red Cell </em>(PRC) pada Pasien Sectio Caesare (SC). Jenis penelitian pra eksperimen, dengan rancangan <em>Statis Group Comparison. </em>Populasi adalah pasien post SC yang mendapatkan transfusi darah, dengan pengambilan sampel secara <em>pu</em><em>rposive sampling </em>sebanyak 20 orang. Pengumpulan data dilakukan dengan cara observasi langsung, kemudian diolah dan dianalisa menggunakan <em>t-test independent</em>. Didapatkan hasil rata- rata  reaksi  transfusi  pada  pasien  yang  mendapatkan  transfusi  darah  WB  adalah  1,30  dan  pasien  yang mendapatkan transfusi darah PRC adalah 0,40. Terdapat perbedaan reaksi pemberian transfusi darah <em>Whoole Blood </em>(WB) dan <em>Packed Red Cell </em>(PRC) pada Pasien Post <em>Sectio Caesarea (SC) (p = </em>0,009). Disimpulkan bahwa ada perbedaan reaksi transfusi pada transfusi darah WB dan transfusi darah PRC. Diharapkan dokter dan perawat agar lebih selektif dalam memberikan darah transfusi pada pasien dan intensif dalam mengontrol proses transfusi darah, sehingga adanya reaksi transfusi dapat segera diketahui.</p><p> </p><p>Kata Kunci : Reaksi Transfusi, <em>Whoole Blood </em>(WB), <em>Packed Red Cell </em>(PRC)</p>


BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e045081
Author(s):  
Patou Masika Musumari ◽  
Samclide Mutindu Mbikayi ◽  
Kriengkrai Srithanaviboonchai ◽  
Teeranee Techasrivichien ◽  
Arunrat Tangmunkongvorakul ◽  
...  

ObjectivesBlood transfusion is a life-saving procedure and is also associated with a range of risks including the occurrence of symptoms of acute transfusion reactions (ATRs). Very few studies in sub-Saharan Africa have reported on ATRs. The present study addresses this gap in the literature by documenting the prevalence of and factors associated with ATRs in the Democratic Republic of Congo (DRC).DesignThis is a cross-sectional descriptive and analytical study using blood bank data from a general referral hospital.SettingCentre Hospitalier Mère-Enfant (CHME) Monkole, a general referral hospital in Kinshasa, DRC.ParticipantsGeneral population who have received blood transfusion in CHME Monkole between 2014 and 2019.ResultsThe data set included a total of 7166 patients; 3153 (44%) men and 4013 (56%) women. The overall prevalence of symptoms of ATRs was 2.6%; the lowest prevalence was in 2017 (2.34%) and highest in 2018 (2.95%) and 2019 (2.94%). The documented symptoms included 74 (39.6%) cases of dyspnoea/respiratory distress, 60 (32.1%) cases of fever, 36 (19.2%) cases of pruritus/urticaria and 17 (9.1%) cases of vomiting. None of the studied factors was associated with symptoms of ATRs.ConclusionSymptoms of ATRs were not uncommon in the studied population. Dyspnoea and respiratory distress, fever and pruritus/urticaria were the most common symptoms of ATRs. This study highlights the need for a clinical and biological surveillance to detect, prevent and manage ATRs in the context of the DRC.


2020 ◽  
Vol 10 (31) ◽  
pp. 65-73
Author(s):  
Amanda Azevedo Bastos da Silva Santos ◽  
Josilene Da Costa Teixeira ◽  
Luana Do Carmo da Silva Pereira ◽  
Amanda Lorena de Araújo Silva

Descrever por meio de uma revisão integrativa da literatura o conhecimento dos enfermeiros sobre reações transfusionais. Trata-se de uma pesquisa descritiva, qualitativa cujo levantamento bibliográfico ocorreu em outubro de 2019. As bases de dados utilizadas foram PubMed, SciELO, BDEnf e LILACS. Foram identificadas 459 publicações, das quais 56 disponíveis no formato completo, excluíram-se produções duplicadas, que não atendem aos critérios de inclusão e artigos de outras bases de dados que não as supracitadas, restando 08 artigos, como amostra final. Os dados foram organizados em um quadro, com a identificação do artigo com base em sua referência e a sumarização de seus resultados. Conclui-se que há fragilidade no conhecimento dos profissionais de enfermagem e falta de estudos voltados para a temática, e com isso, incorrendo em negligência e, por conseguinte, riscos à saúde do paciente, prejudicando a qualidade da assistência à saúde.Descritores: Reação transfusional, Enfermagem, Transfusão de Sangue. Knowledge of nurses about transfusion reactions: integrative reviewAbstract: Describe, through an integrative literature review, the knowledge of nurses about transfusion reactions. This is a descriptive, qualitative research, which bibliographic survey took place in October 2019. The databases used were PubMed, SciELO, BDEnf and LILACS. Were identified 459 publications, of which 56 were available in full format, were excluded duplicate productions that don’t attend the inclusion criteria and articles from other databases than those mentioned above, leaving 8 articles as final sample. The data were organized in a table, with the identification of the article based on its reference and a summary of its results. In conclusion, there is a fragility in the knowledge of nursing professionals and a lack of studies focused on the theme, and therefore, incurring negligence and, consequently, risks for the patient's health, impairing the quality of health care.Descriptors: Transfusion Reaction, Nursing, Blood Transfusion. Conocimiento de enfermeras sobre reacciones de transfusión: revisión integrativaResumen: Describir, a través de una revisión integradora, el conocimiento de enfermeros sobre las reacciones transfusionales. Esta es una investigación descriptiva, cualitativa cuya encuesta bibliográfica se realizó en octubre de 2019. Las bases de datos utilizadas fueron PubMed, SciELO, BDEnf y LILACS. Se identificaron 459 publicaciones, de los cuales 56 disponibles en formato completo, se excluyeron las producciones duplicadas, que no cumplen con los criterios de inclusión y los artículos de bases de datos distintas a las mencionadas anteriormente, dejando 8 artículos como muestra final. Los datos se organizaron en un quadro, con la identificación del artículo en función de su referencia y resumen de sus resultados. Se concluye que existe fragilidad en el conocimiento de los profesionales de enfermería y falta de estudios centrados en el tema, y con esto, incurrir en negligencia y, por lo tanto, riesgos para la salud del paciente, perjudicando la calidad de la atención al salud.Descriptores: Reacción a la Transfusión, Enfermería, Transfusión Sanguínea.


Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 1262-1262
Author(s):  
Robert IS Cohen ◽  
Ana Lima ◽  
Alioska Escorcia ◽  
Farzana Tasmin ◽  
Yulia Lin ◽  
...  

Abstract Introduction: Serologic testing of post-transfusion reaction specimens aims to ascertain potentially accountable immune hemolytic incompatibility. With the exception of low-risk fevers or uncomplicated allergic reactions (ie- reactions with a likelihood of incompatibility that is deemed too low to justify testing), all transfusion reactions undergo serologic investigation as a matter of local institutional policy. However, compliance with guidelines, and the yields of testing according to reaction types, remain unknown. These measures may indicate the quality of applied practice, and provide evidence for maintaining (or changing) investigation algorithms. Study Design and Methods: Interrogation of two hemovigilance databases identified all possible-to-definite transfusion reactions over a 4-year period (2013-2016) at four academic hospitals (with 1493 adult-care beds). The performance and outcome of reaction-oriented serology were assessed by site, year, reaction type, implicated product, and patient location. Serologic testing of transfusion reaction samples entailed the performance (and pre-transfusion comparison) of grouping (ABO, RHD type) and red cell antibody screening (indirect antiglobulin testing [IAT]), with a post-transfusion Coomb's/direct antiglobulin test [DAT]. Appropriate reflex tests (elutions, panel investigations, or IAT re-crossmatching) proceeded from pertinent positives. Allergic reactions were "complicated" if significant vital sign changes occurred, while fevers were "high-risk" (HRF) if symptomatic or if the Tmax rose to ≥39⁰C. Cardiorespiratory reactions (CRR) involved symptomatic and/or objective disturbances in heart/lung function, while unclassifiable presentations (changes in sensorium or non-precordial pain) were placed in an atypical/"other" category for analysis. Results: Sites received 338-367 reaction referrals per year. By referral proportions (and with overlaps), fevers accounted for 47% of events, allergic disturbances for 40%, and CRR events for 37%, with unclassifiable reactions in 7% (Table). Serologic examination occurred in 773 (55%) of 1412 referrals (of which 1346 were deemed to be transfusion-attributable disturbances, among 1119 unique recipients). The majority of cases (1153 or 82%) were compliant with guidelines. Similar proportions deviated to over-testing (85/550 [15%]) as to under-testing (174/862 [20%]). Overall, 34 (4.4%) of 773 cases yielded a new finding, with 6 (0.8%) reflecting (new or recrudescent) host-derived anti-erythrocyte antibodies, for a number-needed-to-test (NNT) of 129. Serologic yields occurred in all categories where testing was mandated, with most yields (62% or 26/42) owing to HRF and CRR events. Whereas these were often non-ABO (minor antigen-targeting) antibodies (76% or 25/33) and followed reactions to red blood cell transfusions (RBC), the yields from complicated allergic reactions and "other" reactions were entirely due to passively acquired isoagglutinins (11/11). The former non-ABO antibodies were revealed by IAT (with no additional gains from elution studies), while ABO isoagglutinins were revealed by DAT alone (and type-specific eluates), and followed plasma (antibody-) containing products. IVIG-associated reactions exhibited the highest serologic yields (in 48% of cases, or in 70% of non-O type recipients), with 60% experiencing some degree of hemolysis. Conclusion: A fifth of reactions were either over-tested or under-tested. Analysis of the performance and contextual yields of serologic tests revealed that certain products and presentations merit greater attention while others merit less. The IAT is a greater priority than the DAT in HRF and CRR following RBC, while the DAT alone is informative in isoagglutinin-risk cases, irrespective of presentation type, and with predictable eluate specificities. A re-evaluation of traditional serologic testing reflexes may reduce costs and allow re-investment in other more informative reaction-specific assays. Table Table. Disclosures No relevant conflicts of interest to declare.


Author(s):  
Xiuping Zhang ◽  
Yanli Zhang ◽  
Yanli Zhang ◽  
Cao Qi ◽  
Chunling Ma

Background: We aimed to explore the influencing factors of clinical adverse blood transfusion reactions, to provide theoretical basis and support for clinical safe blood transfusion, and to minimize the occurrence of adverse blood transfusion reactions. Methods: The method was to retrospectively analyze the report of adverse blood transfusion reports from 6 hospitals in Linyi area, Shandong, China to the blood station in Linyi City center from 2013 to 2020. We aimed to classify factors, analyze the occurrence of adverse transfusion reactions, and discuss the correlation between the occurrence of adverse transfusion reactions and the above factors. Results: Overall, 248 patients (77.98%) had a history of blood transfusion. The difference between this group and the group with no history was statistically significant (P<0.05). The incidence of adverse transfusion reactions in middle-aged and elderly patients was relatively high, especially for those over 50 yr old, with an adverse reaction of 135, for example, the proportion reached 42.45%. In addition, a retrospective analysis found that the occurrence of adverse transfusion reactions was mostly concentrated from Mar to Sep, a total of 228 cases, accounting for 71.69% of all adverse reactions, which was the highest incidence of adverse transfusion reactions. Conclusion: The main adverse reactions of transfusion were allergic reactions, followed by non-hemolytic febrile reactions, mainly caused by transfusion of suspended red blood cells.


Author(s):  
Drew Provan ◽  
Trevor Baglin ◽  
Inderjeet Dokal ◽  
Johannes de Vos ◽  
Hassan Al-Sader

Septic shock/neutropenic fever - Acute transfusion reactions - Delayed transfusion reaction - Post-transfusion purpura - Hypercalcaemia - Hyperviscosity - Disseminated intravascular coagulation - Overdosage of thrombolytic therapy - Heparin overdosage - Heparin-induced thrombocytopenia - Warfarin overdosage - Massive blood transfusion - Paraparesis/spinal collapse - Leucostasis - Thrombotic thrombocytopenic purpura - Sickle crisis


Author(s):  
Rejla Rahim ◽  
Sheela Varghese ◽  
Renu Thambi ◽  
M. S. Suma

Background: Blood transfusion is a routine life- saving medical intervention which is generally regarded as safe when done appropriately. Without blood transfusion, many medical and surgical conditions like anemia, road traffic accidents, obstetric hemorrhage, cardiothoracic surgeries are nearly impossible to manage. However, this life-saving procedure is often associated with adverse effects ranging from minor chills and rigors to life-threatening anaphylaxis. Incidence of transfusion reactions is estimated at 0.001% -10%. The knowledge about the adverse transfusion reaction (ATRs) will help in early identification, management, and prevention of adverse transfusion reactions.Methods: Descriptive cross-sectional study done in 1047 patients, admitted and received at least one unit of whole blood and blood components in the surgery department, Government Medical College, Kottayam during the study period. Information regarding the issue of blood component collected from the transfusion medicine department and the details of the reactions were collected from the patients, and the transfusion reaction workups were done in the transfusion medicine department. The collected data was analysed using Microsoft Excel sheets.Results: The frequency of acute transfusion reaction in this study is 1%. The majority of the reactions were seen with a packed PRBC transfusion. Febrile non-hemolytic transfusion accounted for 54.64% followed by allergic reactions (36.36%) and Transfusion associated cardiac overload (9%).Conclusions: The frequency of ATR in our study was 1%. Febrile non-hemolytic transfusion (FNHTR) and allergic reactions were common patterns followed by transfusion associated cardiac overload (TACO) seen.


10.3823/2526 ◽  
2017 ◽  
Vol 10 ◽  
Author(s):  
João Paulo dos Santos ◽  
Angela Alzamora ◽  
Mariana Dutra Teles ◽  
Veruska Lucena ◽  
Tatiana Almeida Omura de Paula ◽  
...  

Transfusion of blood components is considered safer, but it took years to reach this level. One of the most effective ways to make blood transfusion a safer practice is hemovigilance, which provides important data, including the history of feared transfusion reactions. In recent years in Brazil, there has been an improvement in the reporting of transfusion reactions, however due to the great diversity of hematology services, there are still transfusion reactions. The aims of this study were described the main types of transfusion reactions, as well as to evaluate the underreporting importance of transfusion occurrences of hemotherapy services in Brazil.


Author(s):  
Andrew Almeida de Lima ◽  
Gilberto Pinheiro da Silva ◽  
Sueli Menezes da Rocha ◽  
Eric Lima Barbosa

Contextualizar a atuação do enfermeiro, suas capacidades técnicas e científicas frente à assistência de enfermagem na reação transfusional aguda, de acordo com a literatura científica. Trata-se de um estudo descritivo, do qual foram selecionados artigos nas seguintes bases de dados: SciELO.Org e LILACS. Para busca dos artigos, foram utilizados os seguintes descritores: Enfermagem, Reação e Transfusão Sanguínea. Para fins de análise, foram elaboradas 02 tabelas sendo: caracterização dos estudos e descrição dos resultados. A partir deste estudo identificou-se a efetividade da atuação do enfermeiro em hemoterapia. A enfermagem colabora de forma significativa com seus conhecimentos científicos aos pacientes transfundidos que apresentam reação transfusional aguda nas clínicas de UTI, pediatria oncológica e pacientes de pós-operatório cardíaco, visando sempre uma assistência de qualidade e livre de danos.Descritores: Enfermagem, Reação, Transfusão Sanguínea. The importance of nurses during acute transfusion reaction: literature review Abstract: To contextualize the work of nurses, their technical and scientific capacity across the nursing care in acute transfusion reaction, according to scientific literature. This is a descriptive study, in which articles were selected in the following databases: LILACS and SciELO.Org. To search for articles, the following descriptors were used: Nursing, Reaction and Blood Transfusion. For analysis purposes, we prepared 02 tables being: characterization studies and description of the results. From this study, we identified the effectiveness of the work of nurses in hemotherapy. Nursing contributes significantly with their scientific knowledge to transfused patients with acute transfusion reactions in ICU clinics, pediatric oncology and cardiac postoperative patients, always seeking harmless and quality care.Descriptors: Nursing, Reaction, Blood Transfusion. La importancia del enfermero durante la reacción transfusional aguda: revisión de la literatura Resumen: Contextualizar el desarrollo del enfermero, sus capacidades técnicas y científicas a través de la atención de enfermería en la reacción transfusional aguda, según la literatura científica. Tratase de un estudio descriptivo, en el que fueron selecionados los artículos en las siguientes bases de datos: SciELO.Org y LILACS. Para la busca de artículos, se utilizaron los siguientes descriptores: Enfermería, Reacción y Transfusión de Sangre. Para fines de análisis, fueron hechas 2 tablas, es decir, estudios de caracterización y descripción de los resultados. A partir de este estudio se identificó la eficacia del trabajo de las enfermeras en hemoterapia. Los enfermeros contribuyen de manera significativa con sus conocimientos científicos a los pacientes transfundidos y que presentan reacciones transfusionales en la UCI, clínicas de oncología pediátrica y pacientes postoperatorios cardíacos, buscando siempre uma asistência de cualidade y libre de daños.Descriptores: Enfermería, Reacción, Transfusión de Sangre.


2020 ◽  
Vol 7 (12) ◽  
pp. A576-581
Author(s):  
Suzaan Shajil ◽  
Deepa Sowkur Anandarama Adiga ◽  
Debarshi Saha ◽  
Shrijeet Chakraborty ◽  
Ranjitha Rao

Background: Adequate and safe transfusion facility of blood and its components is necessary as blood transfusions are a part of life saving measures in medical and surgical emergencies. However, transfusion practice could result in non-fatal to fatal adverse transfusion reactions (ATR). Therefore, it is important to identify various adverse reactions so that steps can be taken to minimize such reactions and ensure safer transfusion being carried out. Methods: All ATRs reported to the blood bank from January 2013 to December 2016 were reviewed and analysed. The frequency of ATRs and its association with various component types were assessed. Result: During the study period, a total of 199106 units of blood were issued from the blood bank out of which there was an incidence of 77 (0.12%) transfusion reactions. Chills/rigors was the most common symptom (27.3%) of the symptomatic cases followed by pruritis (23.4%) Majority of the transfusion reaction were non haemolytic, 76 (98.7%) cases. One case was of haemolytic transfusion reaction. Among the non-haemolytic transfusion reactions, febrile non haemolytic transfusion reaction (FNHTR) constituted 28 (36.4%) and allergic reactions constituted 41(53.2%). Other transfusion reactions including hypotensive transfusion reaction (HTR), 1 (1.3%) case and transfusion associated dyspnoea (TAD), 6 (7.8%) cases were also seen. The frequency of ATRs was highest with packed red cells (PC) being 75.3% and least with platelet concentrate (PLTC) being 11.7%. Conclusion: The frequency of ATRs in our blood bank was found to be on a lower scale when compared to that of most of the similar studies. Allergic reactions and FNHTR were the most common ATRs seen, introduction of leukoreduction filters would help reduce FNHTRs.


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