Unusual Recurrence of Antituberculosis Drug-Induced Hepatotoxicity in Children: A Case Series

Drug induced encephalopathy is an established side effect of many drugs when used in a higher dose. Though we do not encounter this side effect frequently in our day to day practice, yet with renal impairment this is not uncommon. Even with a reduced dose many of these can precipitate encephalopathy in this special group of patients. We are presenting here a series of seven such cases of drug induced encephalopathy in patients with renal impairment.Birdem Med J 2018; 8(2): 172-176

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Drug-induced subacute cutaneous lupus erythematosus in previously diagnosed systemic lupus erythematosus patients - a case series

JAAD Case Reports ◽

10.1016/j.jdcr.2021.03.048 ◽

2021 ◽

Author(s):

Emily Keyes ◽

Madison Grinnell ◽

Thomas Vazquez ◽

DeAnna Diaz ◽

Preethi Thomas ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Cutaneous Lupus Erythematosus ◽

Case Series ◽

Subacute Cutaneous Lupus Erythematosus ◽

Systemic Lupus ◽

Drug Induced ◽

Cutaneous Lupus

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CYP2E1, GSTM1, and GSTT1 genetic polymorphisms and their associations with susceptibility to antituberculosis drug-induced liver injury in Thai tuberculosis patients

Heliyon ◽

10.1016/j.heliyon.2021.e06852 ◽

2021 ◽

Vol 7 (4) ◽

pp. e06852

Author(s):

Noppadol Chanhom ◽

Sukanya Wattanapokayakit ◽

Nusara Satproedprai ◽

Supharat Suvichapanich ◽

Surakameth Mahasirimongkol ◽

...

Keyword(s):

Liver Injury ◽

Genetic Polymorphisms ◽

Antituberculosis Drug ◽

Drug Induced ◽

Tuberculosis Patients ◽

Drug Induced Liver Injury

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Drug-Induced Restless Legs Syndrome

Annals of Pharmacotherapy ◽

10.1177/1060028018760296 ◽

2018 ◽

Vol 52 (7) ◽

pp. 662-672 ◽

Cited By ~ 9

Author(s):

Edna Patatanian ◽

Melanie K. Claborn

Keyword(s):

Restless Legs Syndrome ◽

English Language ◽

Case Reports ◽

Data Extraction ◽

Case Series ◽

Predisposing Factors ◽

Drug Induced ◽

Restless Legs ◽

Drug Classes ◽

Study Selection

Objective: To review the literature on drug-induced restless legs syndrome (DI-RLS). Data Sources: The review included a search for English-language literature from 1966 to December 2017 in the MEDLINE, PubMed, and Ovid databases using the following search terms: restless legs syndrome (RLS), periodic limb movement, adverse effects, and drug-induced. In addition, background articles on the pathophysiology, etiology, and epidemiology of RLS were retrieved. Bibliographies of relevant articles were reviewed for additional citations. Study Selection and Data Extraction: All case reports, case series, and review articles of DI-RLS were identified and analyzed. There were only a small number of controlled clinical trials, and most data were from case reports and case series. Results: Several drugs and drug classes have been implicated in DI-RLS, with antidepressants, antipsychotics, and antiepileptics having the most evidence. In addition, RLS may be linked with a number of disorders or underlying predisposing factors as well. Conclusions: The prevalence of RLS is variable and ranges from 3% to 19% in the general population. There are many predisposing factors to RLS, but an emerging body of evidence suggests that there is an association between numerous drugs and RLS.

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Association of N-acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India

Journal of Gastroenterology and Hepatology ◽

10.1111/jgh.12194 ◽

2013 ◽

Vol 28 (8) ◽

pp. 1368-1374 ◽

Cited By ~ 30

Author(s):

Vinod H Gupta ◽

Deepak N Amarapurkar ◽

Meenakshi Singh ◽

Preetha Sasi ◽

Jyotsna M Joshi ◽

...

Keyword(s):

Cytochrome P450 ◽

Gene Polymorphisms ◽

Western India ◽

Antituberculosis Drug ◽

Cytochrome P450 2E1 ◽

Drug Induced

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Outcomes of TB/HIV co-infected patients presenting with antituberculosis drug-induced liver injury

South African Medical Journal ◽

10.7196/samj.8217 ◽

2015 ◽

Vol 105 (5) ◽

pp. 393 ◽

Cited By ~ 6

Author(s):

S Naidoo ◽

D Evans ◽

E Jong ◽

K Mellet ◽

R Berhanu

Keyword(s):

Liver Injury ◽

Antituberculosis Drug ◽

Drug Induced ◽

Drug Induced Liver Injury

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Ultrasound-guided epidural anesthesia and sedation foropen abdominal surgery in 20 consecutive children:a prospective case series and proof-of-concept study

10.21203/rs.3.rs-120514/v1 ◽

2020 ◽

Author(s):

Werner Schmid ◽

Philipp Opfermann ◽

Markus Zadrazil ◽

Ursula Tonnhofer ◽

Martin Metzelder ◽

...

Keyword(s):

Abdominal Surgery ◽

Airway Management ◽

Epidural Anesthesia ◽

Recovery Room ◽

Case Series ◽

Skin Incision ◽

Study Endpoint ◽

Primary Study ◽

Ultrasound Guided ◽

Drug Induced

Abstract General anesthesia (GA) in children is associated with respiratory events and a potential for drug-induced neurotoxicity. Aiming to reduce airway manipulation and the use of GA drugs, we designed a study of abdominal surgery under epidural anesthesia in sedated, spontaneously breathing children. We enrolled 20 children (3 − 83 months, 6.3 − 25.0 kg) scheduled for open abdominal surgery with Pfannenstiel incision. Sedation was followed by ultrasound-guided epidural anesthesia. Increases in heart rate by > 15% and or patient movements upon skin incision were rated as block deficiencies. Intubation equipment for advanced airway management was kept on standby. The primary study endpoint was successful blockade, meaning that no sequential airway management was required during surgery. Secondary endpoints included any use of fentanyl/propofol intraoperatively and of postoperative analgesics in the recovery room. All 20 blocks were successful, with no block deficiencies upon skin incision, no need for sequential airway management, and stable SpO2 levels (97–100%). Surgery took a median of 120.5 minutes (IQR: 89.3–136.5) and included one bolus of fentanyl 120 minutes into a protracted operation. No more systemic analgesia had to be provided in the recovery room. Sedation and epidural anesthesia emerged as a useful alternative to GA from our consecutive case series.

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Case series and review of Ayurvedic medication induced liver injury

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-021-03251-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Christopher M. Karousatos ◽

Justin K. Lee ◽

David R. Braxton ◽

Tse-Ling Fong

Keyword(s):

Liver Injury ◽

Plant Extracts ◽

Significant Proportion ◽

Case Series ◽

The United States ◽

Tinospora Cordifolia ◽

Individual Plant ◽

Medicine Use ◽

Drug Induced ◽

Drug Induced Liver Injury

Abstract Background Complementary and alternative medicine use among Americans is prevalent. Originating in India, Ayurvedic medicine use in the United States has grown 57% since 2002. CAM accounts for a significant proportion of drug induced liver injury in India and China, but there have been only three reports of drug induced liver injury from Ayurvedic medications in the U.S. We report three cases of suspected Ayurvedic medication associated liver injury seen at a Southern California community hospital and review literature of Ayurvedic medication induced liver injury. Case presentations Three patients presented with acute hepatocellular injury and jaundice after taking Ayurvedic supplements for 90–120 days. First patient took Giloy Kwath consisting solely of Tinospora cordifolia. Second patient took Manjishthadi Kwatham and Aragwadhi Kwatham, which contained 52 and 10 individual plant extracts, respectively. Third patient took Kanchnar Guggulu, containing 10 individual plant extracts. Aminotransferase activities decreased 50% in < 30 days and all 3 patients made a full recovery. Roussel Uclaf Causality Assessment Method (RUCAM) scores were 7–8, indicating probable causality. These products all contained ingredients in other Ayurvedic and traditional Chinese medicines with previously reported associations with drug induced liver injury. Conclusions These patients highlight the risk of drug induced liver injury from Ayurvedic medications and the complexity of determining causality. There is a need for a platform like LiverTox.gov to catalog Ayurvedic ingredients causing liver damage.

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