scholarly journals Abo blood group frequency in Ischemic heart disease patients in Pakistani population

1969 ◽  
Vol 30 (3) ◽  
Author(s):  
Naureen Anwar
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Blood Group ◽  
Ischemic Heart ◽  
Abo Blood Group ◽  
Pakistani Population ◽  
Group Frequency

Cytochrome 2C19 and paraoxonase-1 polymorphisms and clopidogrel resistance in ischemic heart disease patients

2019 ◽  
Vol 16 (5) ◽  
pp. 379-386
Author(s):  
Nabila Akram ◽  
Ghulam Mustafa ◽  
Anum A Hanif ◽  
Shahzad Tawwab ◽  
Shabbir Hussain ◽  
...  
Keyword(s):  
Heart Disease ◽  
Platelet Aggregation ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Paraoxonase 1 ◽  
Loss Of Function ◽  
Pakistani Population ◽  
Clopidogrel Resistance ◽  
Pcr Rflp ◽  
Clopidogrel Therapy

Aim: Polymorphisms in cytochrome P450 (CYP) 2C19 and paraoxonase-1 (PON-1) genes are thought to be involved in clopidogrel high on treatment reactivity in ischemic heart disease (IHD) patients. Methods: A total of 240 patients with IHD were screened for CYP2C19 loss-of-function alleles (LOF; *2, *3) and PON-1 Q192R. Patients were classified as responders and nonresponders to clopidogrel based upon platelet aggregation studies. Genotyping of the CYP2C19 and PON-1 allele was carried out by PCR-RFLP. Results: Results showed that 14.3% of the patients were nonresponders, whereas 85.7% were responders to the clopidogrel therapy. CYP2C19*3 allele showed significant association with clopidogrel high on treatment reactivity in IHD patients. Conclusion: Result of our study demonstrate that IHD patients with CYP2C19*3 allele can face the problem of clopidogrel high on treatment reactivity in Punjabi Pakistani population.

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