scholarly journals Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Yuanda Zhang ◽  
Binbin Bi ◽  
Xu Guo ◽  
Shaohui Zhang
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Interleukin 1Β ◽  
Control Group ◽  
Creative Commons ◽  
Paediatric Patients ◽  
One Year ◽  
Recurrence Group ◽  
Open Access Article

Objective: To study whether the levels of 25-hydroxyvitamin D3 (25-(OH)D3) and Interleukin-1β (IL-1β) are correlated to the eradication and recurrence of helicobacter pylori (Hp) in paediatric patients with Hp infection-related gastritis. Methods: A total of 142 paediatric patients with Hp infection-related gastritis from November 2017 to March 2018 in Baoding Children’s Hospital were selected as study subjectswere selected as study subjects and were followed up for one year. Paediatric patients were grouped and analyzed according to the effect of follow-up treatment and recurrence. Results: The levels of 25-(OH) D3 in the non-eradication group were lower than those in the eradication group and the control group (F=27.087, P<0.05); the levels of IL-1β were higher than those in the eradication group and the control group (F=16.610, P<0.05). Recurrence during follow-up visits: The levels of 25-(OH) D3 in the recurrence group were lower than those in the non-recurrence group and the control group (F=33.837, P<0.05); the levels of IL-1β in the recurrence group were higher than those in the non-recurrence group and the control group (F=7.896, P<0.05). Correlation analysis showed the levels of 25-(OH) D3 and IL-1β in the eradication group and the non-eradication group were negatively correlated (r=-0.232, P<0.05); the levels of 25-(OH) D3 and IL-1β in the recurrence group and the non-recurrence group were negatively correlated (r=-0.225, P<0.05). Conclusion: Relatively high levels of IL-1β may be correlated to the difficulty in eradicating the Hp infection in paediatric patients. Relatively low levels of 25-(OH) D3 may be correlated to the difficulty in eradicating the Hp infection and recurrence in paediatric patients. doi: https://doi.org/10.12669/pjms.36.6.2292 How to cite this:Zhang Y, Bi B, Guo X, Zhang S. Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis. Pak J Med Sci. 2020;36(6):---------.   doi: https://doi.org/10.12669/pjms.36.6.2292 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Efficacy of Platelet Rich Fibrin in Myringoplasty

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Nida Riaz ◽  
Ajmal Muhammad ◽  
Muhammad sheharyar Khan
Keyword(s):  
Controlled Trial ◽  
Control Group ◽  
Infection Rates ◽  
Hearing Improvement ◽  
Platelet Rich Fibrin ◽  
Creative Commons ◽  
Randomized Controlled ◽  
Autologous Platelet ◽  
Open Access Article

Objective: To determine the efficacy of usage of topical autologous platelet rich fibrin (PRF) in improving outcomes of myringoplasty regarding graft uptake and hearing improvement. Methods: This study was conducted in the ENT department of Holy Family Hospital, Rawalpindi, over a period of six months from August 2019 to January 2020. It was designed as a prospective single blinded randomized controlled trial. The study involved a total of 50 participants in whom myringoplasty was done through post auricular approach using underlay technique. In 25 patients topical drops of PRF were used. Outcomes were compared after three months with the control group (n=25), who underwent myringoplasty without PRF. Results: After three months follow-up, graft uptake was reported 78% and 52% in cases and controls, respectively (P=0.070). Mean hearing improvement was 18 dB and 6 dB in cases and controls, respectively (P=0.014). Postoperative infection occurred in 8% of the cases, and in 32% controls (P=0.037). Conclusion: Topical use of Platelet-Rich Fibrin during myringoplasty results in improved graft uptake. Hence, resulting in much improved hearing, significant reduction in infection rates and decrease in perforation sizes. doi: https://doi.org/10.12669/pjms.37.1.3059 How to cite this:Riaz N, Ajmal M, Khan MS. Efficacy of Platelet Rich Fibrin in Myringoplasty. Pak J Med Sci. 2021;37(1):212-216. doi: https://doi.org/10.12669/pjms.37.1.3059 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Outcome of modified interlaminar decompression: A conservative decompressive surgery for lumbar spine stenosis

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Farooq Azam ◽  
Seema Sharafat ◽  
Zahid Khan ◽  
Mumtaz Ali
Keyword(s):  
Lumbar Spine ◽  
Decompressive Surgery ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Creative Commons ◽  
One Year ◽  
Complication Of Surgery ◽  
Lumbar Spinal ◽  
Open Access Article ◽  
Structured Questionnaire

Objective: To evaluate the outcomes of modified interlaminar decompression in patients with degenerative lumbar spinal stenosis (LSS). Methods: This descriptive observational study was conducted at the Department of Neurosurgery, Lady Reading Hospital Peshawar from July 2014 to June 2018. All patients with degenerative LSS who underwent modified interlaminar decompression during the study period were included in the study. The patients were followed up to one year after surgery. The data was entered into a structured questionnaire designed according to the study which was then analyzed using SPSS version 21. Results: A total of 182 LSS cases were included in the study and 236 levels were operated during the study period. According to the records increased prevalence of LSS was found among males i.e. 58.8%. The common level with degenerative stenosis involved was L4-5. Good to excellent outcomes were observed in 93.9% patients in the 1st follow-up visit. The most common complication of surgery was dural tear followed by wound infection. Conclusion: Modified interlaminar decompression is a conservative surgical technique, proved to be a potential approach with acceptable complications, satisfactory outcomes and it is easy to learn. doi: https://doi.org/10.12669/pjms.36.4.1170 How to cite this:Azam F, Sharafat S, Khan Z, Ali M. Outcome of modified interlaminar decompression: A conservative decompressive surgery for lumbar spine stenosis. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1170 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Frequency of autoimmune thyroiditis in children with Celiac disease and effect of gluten free diet

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Javaria Rasheed ◽  
Rushan Hassan ◽  
Muhammad Khalid ◽  
Fauzia Zafar
Keyword(s):  
Celiac Disease ◽  
Autoimmune Thyroiditis ◽  
Prospective Observational Study ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Creative Commons ◽  
Euthyroid Status ◽  
One Year ◽  
Open Access Article

Objective: To determine the frequency of autoimmune thyroiditis in children with Celiac disease and the effect of gluten free diet on autoimmune thyroiditis. Methods: We enrolled 100 patients, age 1-12 years of either gender diagnosed as Celiac disease (CD) in this prospective observational study in the Department of Pediatric Medicine, from 1st January 2018 to 30th June 2019. Diagnosis of autoimmune thyroiditis was made if anti–thyroperoxidase >35 iu/ml or anti–thyroglobulin >20 iu/ml at diagnosis of CD and then at one year on gluten free diet (GFD) in all cases. Children with repeat anti-tTG levels > 10 times upper limit normal at 6-months after enrollment were labelled as non-compliant to GFD. Descriptive statistics were used to analyze the data. Results: Mean age of the participants was 5.94±3.16 years and 53% were females. Fourteen cases of autoimmune thyroiditis were detected at enrollment and six (7%, n/N = 6/86) were later diagnosed on follow-up who were initially negative. Seven hypothyroid cases among the autoimmune thyroiditis were treated with thyroxine and became euthyroid on follow-up testing. Compliance to GFD was 52%. Autoimmune thyroiditis improved on gluten free diet in four cases (28.6%). Of the six euthyroid cases at diagnosis three cases became hypothyroid and all were non-compliant. Conclusion: Frequency of autoimmune thyroiditis was 20% over a follow-up period of one year. Good compliance with the GFD has some effect on improving autoimmune thyroiditis and maintaining euthyroid status of CD patients. doi: https://doi.org/10.12669/pjms.36.6.2226 How to cite this:Rasheed J, Hassan R, Khalid M, Zafar F. Frequency of autoimmune thyroiditis in children with Celiac disease and effect of gluten free diet . Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2226 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals The Effectiveness Sustainability of Supervised Balance Training in Chronic Ankle Instability With Grade Iii Ligament Injury: A One-year Prospective Study

2021 ◽  
Author(s):  
Zongchen Hou ◽  
Hongshi Huang ◽  
Yingfang Ao ◽  
Yuelin Hu ◽  
Chen Jiao ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Ankle Instability ◽  
Balance Training ◽  
The Self ◽  
Ligament Injury ◽  
Control Group ◽  
One Year ◽  
Recurrence Group ◽  
Grade Iii

Abstract Background: To determine the effectiveness sustainability of the supervised balance training in the chronic ankle instability (CAI) cases with grade III ligament injury. Methods: Twenty young adults (12 males and 8 females) diagnosed as CAI with grade III ligament injury underwent a 3-months supervised balance training. The self-reported functional questionnaire, plantar pressure, and isokinetic ankle strength were consecutively evaluated at pre-training, 3 months, 6 months and one year. Paired T test was used to explore the changes of muscle strength and foot pressure to evaluate the effectiveness sustainability of balance training. According to whether the patient has sprain recurrence, the patients were divided into sprain recurrence group and control group. The risk factors of sprain recurrence were explored with univariate analysis and multivariable logistic regression.Results: The self-reported functional scores, the plantar pressure distribution and the muscle strength showed significant immediate improvements after 3-month supervised balance training. At post-training 6 months, peak force under 2nd metatarsal, time to peak force under the medial hindfoot, time to boundary measurements and dorsiflexion, and eversion strength were partly declined to the pre-training level. 16 patients (80%) resumed the daily life and sports without sprain recurrence during the follow-up. Four patients (20%) reported ankle sprain during the follow-up, and the sprain recurrence group showed significantly higher Beighton scores (p=0.012) and weaker initial inversion strength (p=0.022) than the control group.Conclusions: Three months’ supervised balance training could effectively improve postural control and muscle strength of the CAI cases with grade III ankle ligament, although these improvements would be partial deceased over time. Additional strength exercises for dorsiflexion and eversion should be supplemented from 6 months. Higher Beighton score and initial inversion muscle strength weakness might increase the risk of sprain recurrence.Clinical registration: ChiCTR1900023999, June 21th, 2019

Histological changes in refractory Helicobacter pylori infection and its relationship with increased levels of resistance to antibiotics and therapeutic regimens: one‐year follow‐up

Apmis ◽  
2019 ◽  
Vol 128 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Saeed Bayati ◽  
Masoud Alebouyeh ◽  
Nour Amirmozafari ◽  
Nasser Ebrahimi Daryani ◽  
Maliheh Talebi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Histological Changes ◽  
Resistance To Antibiotics ◽  
One Year

scholarly journals Frequency of success and complications of primary endoscopic third ventriculostomy in infants with obstructive hydrocephalous

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Seema Sharafat ◽  
Zahid Khan ◽  
Farooq Azam ◽  
Mumtaz Ali
Keyword(s):  
Success Rate ◽  
Endoscopic Third Ventriculostomy ◽  
Case Series ◽  
Csf Leak ◽  
Third Ventriculostomy ◽  
Creative Commons ◽  
Male Patients ◽  
One Year ◽  
Open Access Article

Objectives: To determine the success rate and complications of primary endoscopic third ventri-culostomy (ETV) in infants with obstructive hydrocephalous. Methods: This case series was conducted at the Department of Neurosurgery, Medical and Teaching Institute, Lady Reading Hospital Peshawar from July 2016 to June 2018. All consecutive patients with age less than one year who underwent ETV for primary obstructive hydrocephalous, of both gender, were included in the study. The patients were followed up to six months after surgery. The data was entered in a specially designed Performa. Patients’ data was analyzed using SPSS version 21.0. Results: We had total 21 patients with age less than one year during the study period. Male patients were 11 (52.4%). Success rate of ETV at six months of follow up was 12 (57.1%). Post-op complications observed were in 9.52% (2/21) cases. One patient had cerebrospinal fluid CSF) leak and the other had significant bleed. Conclusion: ETV is successful in 57.1% of infants with obstructive type of hydrocephalous. The post op complications in case of ETV are lower than Ventriculo-peritoneal shunts. Therefore, ETV can be offered to infants having obstructive hydrocephalous. doi: https://doi.org/10.12669/pjms.38.1.4097 How to cite this:Sharafat S, Khan Z, Azam F, Ali M. Frequency of success and complications of primary endoscopic third ventriculostomy in infants with obstructive hydrocephalous. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4097 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Natural history of helicobacter pylori infection from infancy to adulthood: A 21-year follow-up cohort study

2001 ◽  
Vol 120 (5) ◽  
pp. A128-A128 ◽  
Author(s):  
H MALATY ◽  
D GRAHAM ◽  
A ELKASABANY ◽  
S REDDY ◽  
S SRINIVASAN ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Cohort Study ◽  
Natural History ◽  
Helicobacter Pylori Infection ◽  
History Of

RELATED FACTORS TO RELAPSE IN DEPRESSED PATIENTS AFTER COGNITIVE BEHAVIOURAL THERAPY DURING ONE YEAR PROSPECTIVE FOLLOW-UP

2011 ◽  
pp. 13-19
Author(s):  
Nhu Minh Hang Tran ◽  
Huu Cat Nguyen ◽  
Dang Doanh Nguyen ◽  
Van Luong Ngo ◽  
Vu Hoang Nguyen ◽  
...  
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Relapse Rate ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Related Factors ◽  
Depressed Patients ◽  
One Year

Objectives: To determine factors impact on the relapse in depressed patients treated with Cognitive Behavioral Therapy (CBT) during one year follow-up. Materials and Methods: 80 depressed patients divided into two groups, group 1: included 40 patients treated with CBT; group 2: 40 patients on amitriptyline. Non-randomized controlled clinical trial, opened, longiditual and prospective research. Results and Conclusions: relapse rate after CBT during 1 year follow-up is 10% (compared to 25% in control group), related factors to relapse rate in depression after CBT are age and education. Shared predictors between 2 groups are severity and recurrence of depression. Key words: Depression, relapse, Cognitive Behavioral Therapy (CBT)

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