Έκφραση πρωτεϊνών θερμικού σοκ και νεοαγγειογένεση στα νεοπλάσματα των σιελογόνων αδένων

2013 ◽  
Author(s):  
Βασίλειος Παπανικολάου
Keyword(s):  
Salivary Gland ◽  
Angiogenesis Inhibitor ◽  
Salivary Gland Neoplasms ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Benign Neoplasms ◽  
Related Molecule ◽  
Collagen Xviii ◽  
Pleomorphic Adenomas ◽  
Endothelial Marker

IntroductionSalivary gland neoplasms comprise a wide group of tumors with diverse histology and broad biologic behavior, often presenting difficulties in their definitive diagnosis and treatment. In the last decades, the prominent role of angiogenesis in the neoplastic process has been recognized, and alterations of its promoters and inhibitors have been investigated in most human tumors. However, angiogenesis in salivary gland neoplasms has not been thoroughly studied.Material and MethodsWe evaluated the immunohistochemical expression of various angiogenesis-related molecules and the vascularity of 61 malignant (16 adenoid cystic carcinomas, 12 mucoepidermoid carcinomas, 11 polymorphous low grade adenocarcinomas, 9 adenocarcinomas NOS, 6 salivary duct carcinomas, 3 carcinomas ex-pleomorphic adenomas, 2 lymphoepithelial carcinomas, 1 myoepithelial carninoma, 1 clear cell carinoma NOS) and 18 benign salivary gland neoplasms (13 pleomorphic adenomas, 5 Warthin tumours).The evaluated molecules were: angiogenesis-promoter vascular endothelial growth factor (VEGF). angiogenesis-inhibitor Endostatin. angiogenesis related molecule collagen angiogenesis related molecule HSP47. endothelial marker FVIIIR:Ag. Vascularity was assessed by calculation of MicroVessel Density (MVD) and by FVIIIR:Ag immunostaining intensity.ResultsVEGF was expressed in 83.6% of malignant and 94.44% of benign neoplasms. Endostatin was expressed in 91.8% and 100% of malignant and benign cases respectively. Collagen XVIII was expressed in 100% of both benign and malignant neoplasms. HSP47 was expressed in 78.68% of malignant and 100% of benign neoplasms.All markers predominantly showed a diffuse pattern of immunostaining (more than 50% positive cells). VEGF immunostaining intensity varied widely among cases, ranging from weak to strong for both malignant and benign cases. Endostatin, Collagen XVIII and HSP47 presented varying immunointensity for malignant cases, whereas benign cases mainly presented strong immunostaining.Statistical analysis correlated VEGF expression in malignant neoplasms with TNM stage and extraparenchymal infiltration (p=0,0005 and 0,00063 respectively). The total score of immunoreactivity for Endostatin, Collagen XVIII and HSP47 was significantly higher in benign compared to malignant cases (p=0.01, p=0.02, and p=0,00996 respectively). Furthermore, HSP47 positivity and intensity was statistically higher in benign neoplasms, compared to malignant (p=0,0067 and p=0.0249 respectively). Additionally Endostatin immunoexpression correlated with Collagen XVIII expression in benign cases (p<0.001). No association was found regarding tumor MVD. However, immunostaining intensity of the endothelial marker FVIIIR:Ag was higher in malignant tumours (p=0,013).ConclusionsOur results show that benign compared to malignant salivary gland neoplasms express higher levels of Endostatin, Collagen XVIII and HSP47. Ιn malignant neoplasms an increase in the ratio of angiogenic to angiostatic elements is observed. It suggested that enhanced angiogenesis may contribute to salivary gland carcinogenesis.

scholarly journals Comprehensive study of salivary gland neoplasms: single department study in a tertiary care centre

2019 ◽  
Vol 5 (3) ◽  
pp. 581
Author(s):  
S. Muthuchitra ◽  
V. Saravanaselvan ◽  
R. Malarvizhi
Keyword(s):  
Salivary Gland ◽  
Facial Nerve ◽  
Salivary Glands ◽  
Malignant Tumors ◽  
Tertiary Care ◽  
Female Gender ◽  
Salivary Gland Neoplasms ◽  
Malignant Neoplasms ◽  
Tertiary Care Centre ◽  
General Surgeons

<p class="abstract"><strong>Background:</strong> Pathologies of salivary glands are common in the general population. Of them few are neoplasms-benign or malignant. The presentation of salivary gland pathologies are both to general surgeons and otorhinolaryngologists of the same hospital. The presentation to concerned treating surgeon is based on the symptoms during presentation. This study aims at the various types of salivary gland pathologies requiring surgical intervention and the rate of recurrence following surgery in a single department.</p><p class="abstract"><strong>Methods:</strong> Retrospective study was conducted. Study period was from May 2017 to February 2019. All salivary gland neoplasms were studied for presentation and recurrence following surgery.  </p><p class="abstract"><strong>Results:</strong> Intraoperative difficulties and post-operative complications more common in malignant tumors. Female gender is more commonly affected by benign neoplasms. There is no gender predilection in malignant neoplasms. Facial nerve is most common nerve to get affected in pre-operative and during surgery as well.</p><p class="abstract"><strong>Conclusions:</strong> Neoplasms of salivary glands are common in females though it has equal incidence in malignancy. Facial nerve is most commonly affected as complication in malignant neoplasms.</p>

scholarly journals TP53 mutations in salivary gland neoplasms

2005 ◽  
Vol 16 (2) ◽  
pp. 162-166 ◽  
Author(s):  
Luciana Fasanella Matizonkas-Antonio ◽  
Ricardo Alves de Mesquita ◽  
Suzana C. Orsini Machado de Souza ◽  
Fabio Daumas Nunes
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Tp53 Gene ◽  
Salivary Gland Neoplasms ◽  
Low Grade ◽  
Chain Reaction ◽  
Adenoid Cystic ◽  
Single Stranded Conformational Polymorphism ◽  
Mutation Profile ◽  
Polymerase Chain

Many studies have demonstrated that loss of TP53 gene function has an important role in the genesis of many neoplasms, including salivary gland neoplasms. The purpose of this study was to examine the mutation profile of the TP53 gene in salivary gland neoplasms. Genomic DNA was extracted from paraffin-embedded tissues of pleomorphic adenoma, carcinoma in pleomorphic adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. Exons 5 to 8 of the TP53 gene were amplified by polymerase chain reaction (PCR) to perform single-stranded conformational polymorphism (SSCP) analysis. Band shifting was observed in exons 5, 6 and 8 in 9 out of 18 neoplasms. The results of this study suggest that mutations in TP53 gene are related to salivary gland neoplasms pathogenesis and that exons 5 and 8 are most frequently involved.

scholarly journals Critical Update on Malignant Salivary Gland Neoplasms

2017 ◽  
Vol 8 (2) ◽  
pp. 71-75
Author(s):  
Natalya Chernichenko
Keyword(s):  
Salivary Gland ◽  
Recent Literature ◽  
Locally Advanced ◽  
Salivary Gland Neoplasms ◽  
Adjuvant Radiation ◽  
Low Grade ◽  
Wide Range ◽  
Locally Advanced Tumors ◽  
Head Neck

ABSTRACT Salivary gland neoplasms are relatively rare tumors with a wide range of biologic behavior. Early low-grade malignancies could be adequately treated with surgery alone, while larger locally advanced tumors will require adjuvant radiation therapy. The role of chemotherapy remains palliative. The goal of this article is to provide a critical review of recent literature on diagnosis and management of salivary neoplasms. How to cite this article Chernichenko N. Critical Update on Malignant Salivary Gland Neoplasms. Int J Head Neck Surg 2017;8(2):71-75.

Cytology of low-grade cribriform cystadenocarcinoma in salivary glands: Cytological and immunohistochemical distinctions from other salivary gland neoplasms

2015 ◽  
Vol 44 (3) ◽  
pp. 241-245 ◽  
Author(s):  
Yoshiki Ohta ◽  
Yuko Hirota ◽  
Yohko Kohno ◽  
Koji Kishimoto ◽  
Tomoko Norose ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Salivary Gland Neoplasms ◽  
Low Grade

The Role of Ancillary Techniques in Salivary Gland Cytopathology Specimens

2019 ◽  
Vol 64 (1-2) ◽  
pp. 92-102 ◽  
Author(s):  
Kimberly Point du Jour ◽  
Christopher C. Griffith
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Molecular Characteristics ◽  
Malignant Neoplasms ◽  
Benign Neoplasms ◽  
Gland Tumor ◽  
Aspiration Cytology ◽  
Preoperative Test ◽  
Neoplastic Lesions

Salivary gland tumor aspiration cytology is a useful preoperative test to guide the most appropriate clinical and surgical management for these patients. Although salivary gland cytology is often useful to distinguish between non-neoplastic lesions, benign neoplasms and malignant neoplasms, there remain many challenges in this area. Specifically, these tumors are uncommon and may have considerable morphologic overlap, especially in the setting of a malignant tumor. This article reviews some of the immunohistochemical and molecular characteristics of more common salivary gland neoplasms that pathologists and cytotechnologists may encounter. When used in combination with morphologic features, such ancillary testing can be useful to further refine the differential diagnosis, more strongly favor a particular entity, or in some instances confidently provide a specific diagnosis.

Human Kallikrein 3 (prostate-specific antigen) and Human Kallikrein 5 Expression in Salivary Gland Tumors

2006 ◽  
Vol 21 (4) ◽  
pp. 201-205 ◽  
Author(s):  
M.R. Darling ◽  
S. Tsai ◽  
L. Jackson-Boeters ◽  
T.D. Daley ◽  
E.P. Diamandis
Keyword(s):  
Salivary Gland ◽  
Prostate Specific Antigen ◽  
Prostate Gland ◽  
Specific Antigen ◽  
Salivary Gland Tumors ◽  
Low Grade ◽  
Normal Tissues ◽  
Potential Biomarker ◽  
Pleomorphic Adenomas ◽  
Adenocarcinoma Of The Prostate

The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus. It has also been shown to be a potential biomarker for breast, ovarian and testicular cancer. Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland. The aim of this study was to determine whether hK3 and hK5 are expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues. Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas and adenocarcinomas not otherwise specified of both minor and major salivary glands were examined. The results of this study indicate that most salivary gland tumors do not show high levels of expression of hK5. Staining was most prominent in keratinizing epithelia in pleomorphic adenomas. hK3 is not expressed in salivary gland tumors.

Salivary gland tumours as second neoplasms: two cases and literature review

2009 ◽  
Vol 124 (5) ◽  
pp. 577-580 ◽  
Author(s):  
N Zidar ◽  
N Gale ◽  
A Župevc ◽  
M Žargi
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Case Reports ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Malignant Tumours ◽  
Second Neoplasms ◽  
Increased Risk

AbstractObjectives:Patients who survive malignant tumours have an increased risk of second neoplasms, including those of the salivary glands. Mucoepidermoid carcinoma of the parotid gland is by far the most common type of second salivary gland tumour; other types have rarely been reported. We describe here two patients with a second tumour of the salivary glands.Case reports:The first patient was a 22-year-old woman with a low grade mucoepidermoid carcinoma of the parotid gland, which developed 21 years after completion of chemoradiotherapy for acute lymphoblastic leukaemia. The second patient was a 40-year-old woman with an epithelial-myoepithelial carcinoma of the buccal mucosa, which arose 11 years after treatment for two malignant neoplasms – retroperitoneal liposarcoma and squamous cell carcinoma of the uterine cervix.Conclusions:It is mandatory that survivors of cancer should be monitored carefully, so that the complications related to their previous disease and therapy are detected early and managed properly.

scholarly journals Quality of life in patients submitted to surgical treatment for minor salivary gland neoplasms

2007 ◽  
Vol 21 (4) ◽  
pp. 375-379 ◽  
Author(s):  
Sílvio Kenji Hirota ◽  
Sibele Sarti Penha ◽  
Carlos Neutzling Lehn ◽  
Norberto Nobuo Sugaya ◽  
Dante Antônio Migliari
Keyword(s):  
Quality Of Life ◽  
Salivary Gland ◽  
Surgical Treatment ◽  
Family Relationships ◽  
Minor Salivary Gland ◽  
Well Being ◽  
Salivary Gland Neoplasms ◽  
Low Grade ◽  
Emotional Status

This study was aimed at assessing the quality of life in patients submitted to surgical treatment for minor salivary gland neoplasms (MSGN). Twelve patients (10 women and 2 men, mean age: 49.4 years) with histopathologic diagnosis of pleomorphic adenoma (PA, 3 cases), polymorphous low-grade adenocarcinoma (PLGA, 2 cases), cystic adenoid carcinoma (CAC, 4 cases), and muco-epidermoid carcinoma (MEC, 3 cases) were evaluated. All of them were treated by surgical excision; patients with CAC received radiotherapy as well. The patients’ quality of life was evaluated through a self-administered questionnaire concerning their physical well-being, emotional status, normal daily activities, and family relationships. The results showed that patients with MEC - the youngest among all patients - reported a significantly greater worsening of their physical well-being and emotional status after treatment as compared with patients treated for PA (P < 0.05), and also of their functional activities as compared with those treated for PA and PLGA (P < 0.05). In conclusion, age of development of the neoplasm and type of disease produce more impact on patients’ quality of life than does the therapy’s degree of aggression.

Sign in / Sign up

Export Citation Format

Share Document