scholarly journals The potential role of microbiota for controlling the spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in neonatal population

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1217 ◽  
Author(s):  
Thibaud Delerue ◽  
Loic de Pontual ◽  
Etienne Carbonnelle ◽  
Jean-Ralph Zahar
Keyword(s):  
Hand Hygiene Compliance ◽  
Potential Role ◽  
Antibiotic Consumption ◽  
Scientific Data ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum ◽  
Hygiene Compliance ◽  
Neonatal Population

The spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in the hospital and also the community is worrisome. Neonates particularly are exposed to the risk of ESBL-PE acquisition and, owing to the immaturity of their immune system, to a higher secondary risk of ESBL-PE-related infection. Reducing the risk of acquisition in the hospital is usually based on a bundle of measures, including screening policies at admission, improving hand hygiene compliance, and decreasing antibiotic consumption. However, recent scientific data suggest new prevention opportunities based on microbiota modifications.

scholarly journals Extended-spectrum beta-lactamase (ESBL)-positive Escherichia coli presence in urban aquatic environments in Kanpur, India

2020 ◽  
Vol 18 (5) ◽  
pp. 849-854
Author(s):  
Ann Johnson ◽  
Olivia Ginn ◽  
Aaron Bivins ◽  
Lucas Rocha-Melogno ◽  
Sachchida Nand Tripathi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Aquatic Environment ◽  
Significant Risk ◽  
Uttar Pradesh ◽  
Environmental Water ◽  
Antibiotic Consumption ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
E Coli ◽  
Extended Spectrum

Abstract In India, high rates of antibiotic consumption and poor sanitation infrastructure combine to pose a significant risk to the public through the environmental transmission of antimicrobial resistance (AMR). The WHO has declared extended-spectrum beta-lactamase (ESBL)-positive Escherichia coli a key indicator for the surveillance of AMR worldwide. In the current study, we measured the prevalence of AMR bacteria in an urban aquatic environment in India by detecting metabolically active ESBL-positive E. coli. Water samples were collected in duplicate from 16 representative environmental water sources including open canals, drains, and rivers around Kanpur, Uttar Pradesh. We detected culturable E. coli in environmental water at 11 (69%) of the sites. Out of the 11 sites that were positive for culturable E. coli, ESBL-producing E. coli was observed at 7 (64%). The prevalence of ESBL-producing E. coli detected in the urban aquatic environment suggests a threat of AMR bacteria to this region.

scholarly journals Bloodstream infection with extended-spectrum beta-lactamase–producing Escherichia coli: The role of virulence genes

2019 ◽  
Vol 52 (6) ◽  
pp. 947-955 ◽  
Author(s):  
Wan-Ting Hung ◽  
Ming-Fang Cheng ◽  
Fan-Chen Tseng ◽  
Yao-Shen Chen ◽  
Susan Shin-Jung Lee ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Bloodstream Infection ◽  
Virulence Genes ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum

scholarly journals High Carrying Rate of Extended-Spectrum Beta-Lactamase (ESBL) Producing Enterobacteriaceae by Slaughterhouse Workers in Lomé, Togo in 2019

2020 ◽  
pp. 30-41
Author(s):  
Amivi Mawussi Godonou ◽  
Fifonsi Adjidossi Gbeasor-Komlanvi ◽  
Novissi Tsogbale ◽  
Fiali Lack ◽  
Sika Dossim ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Health Concern ◽  
Diffusion Method ◽  
Food Chains ◽  
Beta Lactamase ◽  
Bacterial Strains ◽  
Carriage Rate ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum

Introduction: Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL) represent a real public health concern because of their spread. The role of agri-food chains in transmitting of digestive ESBL-producing bacterial strains in the community, was demonstrated but little work was done in our settings (Togo, west Africa). The aim of this study was to estimate the rate of digestive carrying ESBL producing enterobacteriacae in slaughterhouse workers in Lomé, Togo. Material and Methods: This was a cross-sectional study carried out in three slaughterhouses in Lomé. Fresh stools of 60 slaughterhouse workers and socio-demographic data were collected during the period of September to October 2019 after obtaining the consent of each participant. The bacterial strains of interest were isolated on the selective medium Purple Bromocresol + Ceftazidime at 6µg/l. UriselectÒ and API 20E media were used for identification. Antibiotic susceptibility test was performed in Mueller-Hinton agar plate diffusion method (Kirby Bauer technic) and according to CASFM-EUCAST recommendations. Results: The digestive carriage rate of ESBL producing enterobacteriacae among professionals of three slaughterhouses of Lomé was 80% (n=48/60). Escherichia coli was the main bacteria 78.2% (n = 43/55) followed by Klebsiella pneumoniae 16.4% (n = 9/55) and Enterobacter cloacae 5.4% (n = 3/55). The antibiotic profile of ESBL producing enterobacteriacae showed resistance to Amoxycillin + Clavulanic Acid (26%), Ticarcillin + Clavulanic Acid (86%), Piperacillin + Tazobactam (14%), Cefoxitin (7%) Ciprofloxacin (63%), Levofloxacin (49%), Nalidixic Acid (42%), Chloramphenicol (33%), Gentamicin (21%), Sulfamethoxazole-Trimetoprim (93%). These bacteria were 100% sensitive to Imipenem, Ertapenem, Amikacin and Fosfomycin. Conclusion: This study revealed a very high carriage rate of ESBL producing Enterobacteriacae among Slaughterhouse Workers in Lomé. It confirmed the major potential role of the agri-food chains in the spread of ESBL producing bacteria in the Community.

Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae and trends in antibiotic consumption in a county of Sweden

2010 ◽  
Vol 42 (11-12) ◽  
pp. 831-838 ◽  
Author(s):  
Åse Östholm-Balkhed ◽  
Maria Tärnberg ◽  
Maud Nilsson ◽  
Anita V. Johansson ◽  
Håkan Hanberger ◽  
...  
Keyword(s):  
Antibiotic Consumption ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum
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