scholarly journals City-based action to reduce harmful alcohol use: review of reviews

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 120 ◽  
Author(s):  
Peter Anderson ◽  
Eva Jané-Llopis ◽  
Omer Syed Muhammad Hasan ◽  
Jürgen Rehm
Keyword(s):  
Controlled Trial ◽  
Review Literature ◽  
Convincing Evidence ◽  
Global Strategy ◽  
World Health ◽  
Community Based Interventions ◽  
Review Of Reviews ◽  
Harmful Use ◽  
The Impact ◽  
Harmful Use Of Alcohol

Background: The World Health Organization global strategy on alcohol called for municipal policies to reduce the harmful use of alcohol. Yet, there is limited evidence that documents the impact of city-level alcohol policies. Methods: Review of reviews for all years to July 2017. Searches on OVID Medline, Healthstar, Embase, PsycINFO, AMED, Social Work Abstracts, CAB Abstracts, Mental Measurements Yearbook, Health and Psychosocial Instruments, International Pharmaceutical Abstracts, International Political Science Abstracts, NASW Clinical Register, and Epub Ahead of Print databases. All reviews that address adults, without language or date restrictions resulting from combining the terms (“review” or “literature review” or “review literature” or “data pooling” or “comparative study” or “systematic review” or “meta-analysis” or “pooled analysis”), and “alcohol”, and “intervention” and (“municipal” or “city” or “community”). Results: Five relevant reviews were identified. Studies in the reviews were all from high income countries and focussed on the acute consequences of drinking, usually with one target intervention, commonly bars, media, or drink-driving. No studies in the reviews reported the impact of comprehensive city-based action. One community cluster randomized controlled trial in Australia, published after the reviews, failed to find convincing evidence of an impact of community-based interventions in reducing adult harmful use of alcohol.     Conclusions: To date, with one exception, the impact of adult-oriented comprehensive community and municipal action to reduce the harmful use of alcohol has not been studied. The one exception failed to find a convincing effect. We conclude with recommendations for closing this evidence gap.

scholarly journals City-based action to reduce harmful alcohol use: review of reviews

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 120 ◽  
Author(s):  
Peter Anderson ◽  
Eva Jané-Llopis ◽  
Omer Syed Muhammad Hasan ◽  
Jürgen Rehm
Keyword(s):  
Controlled Trial ◽  
Review Literature ◽  
Convincing Evidence ◽  
Global Strategy ◽  
World Health ◽  
Community Based Interventions ◽  
Review Of Reviews ◽  
Harmful Use ◽  
The Impact ◽  
Harmful Use Of Alcohol

Background: The World Health Organization global strategy on alcohol called for municipal policies to reduce the harmful use of alcohol. Yet, there is limited evidence that documents the impact of city-level alcohol policies. Methods: Review of reviews for all years to July 2017. Searches on OVID Medline, Healthstar, Embase, PsycINFO, AMED, Social Work Abstracts, CAB Abstracts, Mental Measurements Yearbook, Health and Psychosocial Instruments, International Pharmaceutical Abstracts, International Political Science Abstracts, NASW Clinical Register, and Epub Ahead of Print databases. All reviews that address adults, without language or date restrictions resulting from combining the terms (“review” or “literature review” or “review literature” or “data pooling” or “comparative study” or “systematic review” or “meta-analysis” or “pooled analysis”), and “alcohol”, and “intervention” and (“municipal” or “city” or “community”). Results: Five relevant reviews were identified. Studies in the reviews were all from high income countries and focussed on the acute consequences of drinking, usually with one target intervention, commonly bars, media, or drink-driving. No studies in the reviews reported the impact of comprehensive city-based action. One community cluster randomized controlled trial in Australia, published after the reviews, failed to find convincing evidence of an impact of community-based interventions in reducing adult harmful use of alcohol.     Conclusions: To date, with one exception, the impact of adult-oriented comprehensive community and municipal action to reduce the harmful use of alcohol has not been studied. The one exception failed to find a convincing effect. We conclude with recommendations for closing this evidence gap.

Die Globale Strategie zur Reduktion schädlichen Alkoholkonsums:

2011 ◽  
Vol 57 (2) ◽  
pp. 81-83 ◽  
Author(s):  
Jürgen Rehm
Keyword(s):  
Global Strategy ◽  
World Health ◽  
Capita Consumption ◽  
Member States ◽  
Harmful Use ◽  
Per Capita ◽  
Alcohol Related Harm ◽  
Harmful Use Of Alcohol ◽  
Per Capita Consumption ◽  
Related Harm

Global Strategy to Reduce the Harmful Use of Alcohol: First Step towards an Alcohol Framework Convention? English Summary: At the 61st World Health Assembly, the 193 member states discussed and ratified the global strategy to reduce the harmful use of alcohol. Firstly, 10 target areas have been identified within the strategy and alcohol policy should be structured according to these areas. The contribution of Anderson (2011) discusses these target areas with respect to supporting empirical evidence and policy implications. The final target area is Monitoring and Surveillance, and the other two contributions fall under this topic. Shield, Rehm, Patra & Rehm (2011) provide an overview of worldwide adult per capita consumption. Per capita consumption is associated indirectly to alcohol-related harm: as higher consumption generally leads to more harm, but the level of association varies according to economic indicators. Countries with lower GDP PPP experience more harm as they have more risks associated to alcohol such as infectious diseases like tuberculosis and/or a less developed health care system. The last contribution to this topic focuses solely on Germany and includes both health as well as social consequences ( Kraus, Piontek, Pabst & Bühringer, 2011 ). It needs to be recognized that the global strategy contains merely suggestions that are not binding to any of the member states. It is not yet shown whether this strategy is enough to combat the rising global alcohol-related harm and there have been suggestions to adopt a more binding form of international arrangement such as the Framework Convention for Tobacco Control.

scholarly journals Тhe impact of alcohol abuse on the development of non-communicable diseases (analytical review)

Public Health ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 48-61
Author(s):  
T. V. Kaigorodova ◽  
I. A. Kryukova
Keyword(s):  
Alcohol Abuse ◽  
World Health Organization ◽  
World Health ◽  
Scientific Publications ◽  
Non Communicable Diseases ◽  
The World ◽  
Harmful Use ◽  
Health Organization ◽  
The Impact ◽  
Harmful Use Of Alcohol

The harmful use of alcohol is a risk factor for the development of non-communicable diseases (NCDs), such as cancer, cardiovascular disease, gastrointestinal diseases, diabetes and others. In addition to morbidity, alcohol abuse increases mortality, especially at young ages. An important characteristic is the frequency and amount of alcohol consumed by a person. The more often and more a person abuses alcohol, the higher the risk of developing NCDs and the mortality rate. Purpose of the study: analysis of publications of the World Health Organization and scientific publications of foreign researchers on the influence of alcohol on the development of non-communicable diseases.Materials and research methods. Content analysis of documents of the World Health Organization and foreign studies on the assessment of the impact of alcohol In total, 48 documents of international organizations were analyzed, including the World Health Organization (WHO), the United Nations (UN), the International Agency for Research on Cancer (IARC-IARC) and the World Bank, as well as 211 scientific publications. Of these, 19 documents were selected, which included materials from WHO, UN, IARC and the World Bank on the impact of alcohol abuse on health, and 63 scientific publications on this topic. Selection criterion: the content in the documents of materials that adequately describe the impact of alcohol abuse on health as a risk factor for the development of various diseases.Results. An analysis of the documents and publications presented revealed a large massif of evidence that the harmful use of alcohol is a causal factor in the development of a number of noncommunicable diseases, an increase in mortality and disability at earlier stages of life, and the development of a link between harmful use of alcohol and a number of mental and behavioral disorders.

Global and Country Specific Adult per capita Consumption of Alcohol, 2008

2011 ◽  
Vol 57 (2) ◽  
pp. 99-117 ◽  
Author(s):  
Kevin D. Shield ◽  
Maximillien Rehm ◽  
Jaydeep Patra ◽  
Bundit Sornpaisarn ◽  
Jürgen Rehm
Keyword(s):  
Alcohol Consumption ◽  
Burden Of Disease ◽  
Eastern Mediterranean Region ◽  
Global Strategy ◽  
World Health ◽  
Capita Consumption ◽  
Harmful Use ◽  
Per Capita ◽  
Harmful Use Of Alcohol ◽  
Per Capita Consumption

Aims: Alcohol is a substantial risk factor for mortality and the burden of disease globally. In accordance with the World Health Organization’s (WHO) global strategy to reduce the harmful use of alcohol, we estimated recorded, unrecorded, tourist, and total adult per capita consumption by country and WHO sub-region for 2008, and characterized the association between per capita consumption of alcohol and gross domestic product (GDP-PPP) per capita. Methods: Using data from the Global Information System on Alcohol and Health database ( World Health Organization, 2010 a) and the 2005 Global Burden of Disease study ( Institute for Health Metrics and Evaluation, 2010 ) on adult per capita consumption of alcohol, we estimated recorded adult per capita consumption for 2008 through time series analyses for 189 countries within WHO sub-regions, and then from these estimates calculated recorded adult per capita consumption estimates for each of the WHO sub-regions. Estimates for populations were obtained for 2008 from the United Nations Populations Division. 2008 GDP-PPP data by country (N = 178) were obtained from the International Monetary Fund. Results: Adult per capita consumption of alcohol in 2008 is estimated to have been 6.04 litres (95 % CI: 4.43 to 7.65). This can be broken down into 4.39 l (95 % CI: 3.72 to 4.86) of recorded per capita consumption of alcohol, 1.75 l (95 %CI: 0.25 to 3.25) of unrecorded per capita consumption of alcohol, and 0.00 l (95 %CI: 0.00 to 0.129) per capita consumption of alcohol consumed by tourists. Adult per capita consumption was highest for the European regions and lowest for the Eastern Mediterranean region. Total adult per capita consumption of alcohol showed an increase as GDP-PPP increased until approximately 15,000 international dollars of GDP-PPP per capita. Recorded consumption showed a general increase with GDP-PPP. Unrecorded consumption showed a U-shaped association with GDP-PPP per capita, with countries with the lowest and highest GDP-PPPs per capita having the lowest unrecorded adult per capita consumption of alcohol. Conclusions: In accordance with the WHO’s global strategy to reduce the harmful use of alcohol, we present estimates of the recorded, unrecorded, tourist, and total adult per capita alcohol consumption for 189 countries and the 14 WHO sub-regions. Accurate and up-to-date estimates of alcohol consumption are imperative for monitoring and developing effective strategies to control the large and increasing global alcohol-attributable burden of disease and injury.

Missing in Action: The Global Strategy to Reduce the Harmful Use of Alcohol and the WTO

2020 ◽  
pp. 1-22 ◽  
Author(s):  
Paula O’BRIEN
Keyword(s):  
Legal Status ◽  
Global Strategy ◽  
World Health ◽  
The World ◽  
Different Types ◽  
Regulatory Instruments ◽  
Harmful Use ◽  
Missing In Action ◽  
Health Organization ◽  
Harmful Use Of Alcohol

This article addresses the question of how the World Health Organization (WHO) Global Strategy to Reduce the Harmful Use of Alcohol (Global Strategy) and its Framework Convention on Tobacco Control (FCTC) have been used in the context of discussions about alcohol and tobacco measures, respectively, in the World Trade Organization (WTO) Committee on Technical Barriers to Trade. The article finds considerable differences not only in the extent to which the FCTC is used compared to the Global Strategy , but also in the ways in which the two global health instruments have been used in the WTO context. The article proffers three key reasons for these differences: the legal status of the instrument; the content of the instrument in terms of whether it contains guidance as to the use of detailed, evidence-based measures; and the role and legitimacy that the instrument accords to the relevant industry interests. The article considers how the insights from the research can inform the developments in global governance of alcohol that are underway in WHO policy. It also positions its findings in terms of the wider international law debates about hard law versus soft law, and whether different types of international regulatory instruments and the legal status of these instruments impact their effectiveness in supporting domestic public health measures.

scholarly journals A Framing Analysis of Consultation Submissions on the WHO Global Strategy to Reduce the Harmful Use of Alcohol: Values and Interests

2021 ◽  
Author(s):  
Chiara Rinaldi ◽  
May CI van Schalkwyk ◽  
Matt Egan ◽  
Mark Petticrew
Keyword(s):  
Global Strategy ◽  
Individual Responsibility ◽  
World Health ◽  
Value Systems ◽  
Framing Analysis ◽  
Consultation Process ◽  
Member States ◽  
Harmful Use ◽  
Harmful Use Of Alcohol ◽  
Policy Solutions

Background: In response to the magnitude of harms caused by alcohol, the World Health Organization (WHO) Global Strategy to Reduce the Harmful Use of Alcohol (GAS) was endorsed in 2010. We analysed submissions to the 2019 WHO consultation on the implementation of the GAS to identify how different stakeholders frame alcohol use and control; and to assess how stakeholders engage with the consultation process, with possibly harmful consequences for public health policy. Methods: All submissions from WHO Member States, international organisations, non-governmental organisations (NGOs), academic institutions and private sector entities were identified and used as data for an inductive framing analysis. This involved close reading and data familiarisation, thematic coding and identifying emergent framings. Through the analysis of texts, framing analysis can give insights into the values and interests of stakeholders. Because framing influences how issues are conceptualised and addressed, framing analysis is a useful tool to study policy-making processes. Results: We identified 161 unique submissions and seven attachments. Emerging frames were grouped according to their function: defining the problem, assigning causation, proposing solutions, or justifying and persuading. Submissions varied in terms of the framing they deployed and how this was presented, eg, how the problem was defined. Proposed policy solutions also varied. Targeted solutions emphasising individual responsibility tended to be supported by industry and some Member States. Calls for universal regulation and global mobilisation often came from NGOs and academia. Stakeholders drew on evidence and specific value systems to support the adoption of certain problem and solution ideas and to oppose competing framing. Conclusion: Alcohol control is a contested policy field in which different stakeholders use framing to set the agenda and influence what policy solutions are considered legitimate. WHO should consider which interests are served by these different framings and how to weigh different stakeholders in the consultation process.

scholarly journals The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 451
Author(s):  
José María Gutiérrez ◽  
Laura-Oana Albulescu ◽  
Rachel H. Clare ◽  
Nicholas R. Casewell ◽  
Tarek Mohamed Abd Abd El-Aziz ◽  
...  
Keyword(s):  
Snake Venom ◽  
Serine Proteinase ◽  
Global Strategy ◽  
World Health ◽  
Wide Range ◽  
Variable Chemical ◽  
Snake Venom Metalloproteinase ◽  
Health Organization ◽  
The Impact ◽  
Natural And Synthetic

A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments. The mainstay in the therapy of snakebite envenoming is the administration of animal-derived antivenoms. In addition, new therapeutic options are being explored, including recombinant antibodies and natural and synthetic toxin inhibitors. In this review, snake venom toxins are classified in terms of their abundance and toxicity, and priority actions are being proposed in the search for snake venom metalloproteinase (SVMP), phospholipase A2 (PLA2), three-finger toxin (3FTx), and serine proteinase (SVSP) inhibitors. Natural inhibitors include compounds isolated from plants, animal sera, and mast cells, whereas synthetic inhibitors comprise a wide range of molecules of a variable chemical nature. Some of the most promising inhibitors, especially SVMP and PLA2 inhibitors, have been developed for other diseases and are being repurposed for snakebite envenoming. In addition, the search for drugs aimed at controlling endogenous processes generated in the course of envenoming is being pursued. The present review summarizes some of the most promising developments in this field and discusses issues that need to be considered for the effective translation of this knowledge to improve therapies for tackling snakebite envenoming.

scholarly journals Impact of Spirulina corn soy blend on Iron deficient children aged 6–23 months in Ndhiwa Sub-County Kenya: a randomized controlled trial

BMC Nutrition ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Dorothy Apondi Othoo ◽  
Sophie Ochola ◽  
Elizabeth Kuria ◽  
Judith Kimiywe
Keyword(s):  
Controlled Trial ◽  
Study Groups ◽  
World Health ◽  
Deficiency Anemia ◽  
Group Assignment ◽  
Large Numbers ◽  
Blood Drawing ◽  
Iron Deficient ◽  
Risk Magnitude ◽  
The Impact

Abstract Background Iron deficiency anemia (IDA) remains high in Kenya despite interventions. Twenty-seven percent of children aged 6 months-14 years are anemic, with low iron intake (7%) among children aged 6–23 months. Standard food interventions involve a corn soy blend (CSB), which is limited in micronutrients, and fortifiers are not accessible locally. Moreover, the use of spirulina as a strategy for mitigating IDA has not been adequately documented. This study compared the impact of a spirulina corn soy blend (SCSB) on IDA among children aged 6–23 months. Methods A total of 240 children with IDA were randomly assigned to study groups at a ratio of 1:1:1 through lotteries, and caregivers and research assistants were blinded to group assignment. Dry-take-home SCSB, CSB and placebo flour (1.7 kg) was given to caregivers to prepare porridges using a flour water ratio of 1:4, producing 600 ml–700 ml of porridge to feed children 200 ml of porridge three times a day for 6 months. Impact was assessed as plasma hematocrit at baseline and after the study. Blood drawing, preparation and analysis were performed in accordance with approved procedures by the EthicsResearchCommittee. Monthly follow-up and data collection on dietary intake, anthropometry, morbidity and infant feeding practices were performed using questionnaires. Relative risk, magnitude of change and log-rank tests were used to compare the impact of the intervention, and significant differences were determined at P < 0.05. Results The survival probabilities for children consuming SCSB were significantly higher than those consuming CSB (log-rank-X2 = 0.978; CI: 0.954–1.033, P = 0.001) and the placebo (log-rankX2 = 0.971; CI: 0.943–0.984, P = 0.0001). Children consuming SCSB had a mean recovery time of 8 days (CI: 7–12 days) compared to those consuming CSB (19 days; CI: 20–23 days) and placebo (33 days; CI: 3 1–35 days). The recovery rate was 15.4 per 100 persons per day for children who consumed SCSB as opposed to 4.6 and 1.8 per 100 persons per day for those who consumed CSB and the placebo, respectively. Conclusion Management of IDA with SCSB compared to CSB and the placebo led to faster reversal and large numbers of recoveries from IDA. The recovery rates were above the World Health Organizations (WHO) minimums standards for food interventions. Efforts to realize high and faster recoveries from IDA should be heightened by fortifying CSB with spirulina powder.

scholarly journals Meeting the Global NCD Target of at Least 10% Relative Reduction in the Harmful Use of Alcohol: Is the WHO European Region on Track?

2020 ◽  
Vol 17 (10) ◽  
pp. 3423 ◽  
Author(s):  
Charlotte Probst ◽  
Jakob Manthey ◽  
Maria Neufeld ◽  
Jürgen Rehm ◽  
João Breda ◽  
...  
Keyword(s):  
Action Plan ◽  
Alcohol Exposure ◽  
Heavy Episodic Drinking ◽  
World Health ◽  
European Region ◽  
Noncommunicable Diseases ◽  
Relative Reduction ◽  
Harmful Use ◽  
Health Organization ◽  
Harmful Use Of Alcohol

Background: The Global Action Plan for the Prevention and Control of Noncommunicable Diseases set the target of an “at least 10% relative reduction in the harmful use of alcohol, as appropriate, within the national context”. This study investigated progress in the World Health Organization (WHO) European Region towards this target based on two indicators: (a) alcohol per capita consumption (APC) and (b) the age-standardized prevalence of heavy episodic drinking (HED). Methods: Alcohol exposure data for the years 2010–2017 were based on country-validated data and statistical models. Results: Between 2010 and 2017, the reduction target for APC has been met with a decline by −12.4% (95% confidence interval (CI) −17.2, −7.0%) in the region. This progress differed greatly across the region with no decline for the EU-28 grouping (−2.4%; 95% CI −12.0, 7.8%) but large declines for the Eastern WHO EUR grouping (−26.2%; 95% CI −42.2, −8.1%). Little to no progress was made concerning HED, with an overall change of −1.7% (−13.7% to 10.2%) in the WHO European Region. Conclusions: The findings indicate a divergence in alcohol consumption reduction in Europe, with substantial progress in the Eastern part of the region and very modest or no progress in EU countries.

scholarly journals Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Kobié H. Toé ◽  
Frank Mechan ◽  
Julie-Anne A. Tangena ◽  
Marion Morris ◽  
Joanna Solino ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Burkina Faso ◽  
Pyrethroid Resistance ◽  
Controlled Trial ◽  
Sub Saharan Africa ◽  
World Health ◽  
Target Range ◽  
Bed Nets ◽  
Randomized Controlled ◽  
The Impact

Abstract Background Long-lasting insecticidal nets (LLINs) treated with pyrethroids are the foundation of malaria control in sub-Saharan Africa. Rising pyrethroid resistance in vectors, however, has driven the development of alternative net formulations. Here the durability of polyethylene nets with a novel combination of a pyrethroid, permethrin, and the insect juvenile hormone mimic, pyriproxyfen (PPF), compared to a standard permethrin LLIN, was assessed in rural Burkina Faso. Methods A compound-randomized controlled trial was completed in two villages. In one village 326 of the PPF-permethrin nets (Olyset Duo) and 327 standard LLINs (Olyset) were distributed to assess bioefficacy. In a second village, 170 PPF-permethrin nets and 376 LLINs were distributed to assess survivorship. Nets were followed at 6-monthly intervals for 3 years. Bioefficacy was assessed by exposing permethrin-susceptible and resistant Anopheles gambiae sensu lato mosquito strains to standard World Health Organization (WHO) cone and tunnel tests with impacts on fertility measured in the resistant strain. Insecticide content was measured using high-performance liquid chromatography. LLIN survivorship was recorded with a questionnaire and assessed by comparing the physical integrity using the proportionate hole index (pHI). Results The PPF-permethrin net met WHO bioefficacy criteria (≥ 80% mortality or ≥ 95% knockdown) for the first 18 months, compared to 6 months for the standard LLIN. Mean mosquito mortality for PPF-permethrin nets, across all time points, was 8.6% (CI 2.6–14.6%) higher than the standard LLIN. Fertility rates were reduced after PPF-permethrin net exposure at 1-month post distribution, but not later. Permethrin content of both types of nets remained within the target range of 20 g/kg ± 25% for 242/248 nets tested. The pyriproxyfen content of PPF-permethrin nets declined by 54%, from 10.4 g/kg (CI 10.2–10.6) to 4.7 g/kg (CI 3.5–6.0, p < 0.001) over 36 months. Net survivorship was poor, with only 13% of PPF-permethrin nets and 12% of LLINs still present in the original household after 36 months. There was no difference in the fabric integrity or survivorship between the two net types. Conclusion The PPF-permethrin net, Olyset Duo, met or exceeded the performance of the WHO-recommended standard LLIN (Olyset) in the current study but both net types failed the 3-year WHO bioefficacy criteria.

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