scholarly journals Effect of continuous-infusion antibiotic therapy on pulmonary function of patients with cystic fibrosis: A cross-sectional study

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1766
Author(s):  
Somaya Albhaisi ◽  
Fei-Pi Lin ◽  
Nauman Chaudary
Keyword(s):  
Cystic Fibrosis ◽  
Antibiotic Therapy ◽  
Pulmonary Function ◽  
Continuous Infusion ◽  
Intermittent Infusion ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Pulmonary Exacerbations ◽  
Infusion Protocol

Background: Cystic fibrosis (CF) is associated with frequent pulmonary exacerbations which increase the mortality risk. Therefore, most CF patients are chronically colonized with respiratory pathogens, the most common being Pseudomonas aeruginosa. Multidrug-resistant organisms are a major problem in CF patients. It’s been hypothesized that continuous-infusion antipseudomonal beta-lactam therapy in CF maintains serum concentrations above the minimum inhibitory concentration of susceptible strains and is more likely than intermittent infusion to achieve optimal pharmacodynamic targets for some intermediate and resistant strains of P. aeruginosa. The most extensively studied antibiotic for continuous-infusion protocol in CF is ceftazidime, which has been shown to improve lung function (forced expiratory volume in 1 second and forced vital capacity) and to increase pulmonary exacerbation free time. There have been no studies to evaluate the cost effectiveness or impact on quality of life of continuous infusion versus intermittent infusion antibiotic therapy in patients with CF. Our study aims to investigate the effect of continuous-infusion antibiotic therapy on pulmonary function. Methods: Cross sectional study of CF patients who were admitted to our hospital with acute pulmonary exacerbations between 1/1/2010 and 12/31/2016 and received parenteral antibiotics. We investigated the effect of use of continuous versus intermittent infusion of intravenous antibiotics on the pulmonary function (FEV1% predicted). Results: Intermittent infusion protocol was found to have a very small advantage over continuous infusion protocol on pulmonary function; however this difference is not statistically significant (p=0.0049). The longer the duration of antibiotics, the slightly better the pulmonary function at the end of the treatment, but the difference was not significant (p=0.2543). Conclusions: Even though we could not draw meaningful conclusions from our data, we would like bring attention to this subject because it carries an important therapeutic value for CF patients.

scholarly journals Analysis of quality of life among asthmatic individuals with obesity and its relationship with pulmonary function: cross-sectional study

2017 ◽  
Vol 135 (4) ◽  
pp. 332-338 ◽  
Author(s):  
Letícia Baltieri ◽  
Luiz Claudio Martins ◽  
Everton Cazzo ◽  
Débora Aparecida Oliveira Modena ◽  
Renata Cristina Gobato ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pulmonary Function ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Morbidly Obese ◽  
Life Questionnaire ◽  
Sectional Study ◽  
Anthropometric Data ◽  
Cross Sectional

ABSTRACT CONTEXT AND OBJECTIVE: The combined effect of obesity and asthma may lead to significant impairment of quality of life (QOL). The aim here was to evaluate the prevalence of asthma among obese individuals, characterize the severity of impairment of quality of life and measure its relationship with pulmonary function. DESIGN AND SETTING: Observational cross-sectional study in public university hospital. METHODS: Morbidly obese individuals (body mass index > 40 kg/m2) seen in a bariatric surgery outpatient clinic and diagnosed with asthma, were included. Anthropometric data were collected, the Standardized Asthma Quality of Life Questionnaire (AQLQ(S)) was applied and spirometry was performed. The subjects were divided into two groups based on the median of the score in the questionnaire (worse < 4 and better > 4) and were compared regarding anthropometric data and pulmonary function. RESULTS: Among the 4791 individuals evaluated, 219 were asthmatic; the prevalence of asthma was 4.57%. Of these, 91 individuals were called to start multidisciplinary follow-up during the study period, of whom 82 answered the questionnaire. The median score in the AQLQ(S) was 3.96 points and, thus, the individuals were classified as having moderate impairment of their overall QOL. When divided according to better or worse QOL, there was a statistically difference in forced expiratory flow (FEF) 25-75%, with higher values in the better QOL group. CONCLUSION: The prevalence of asthma was 4.57% and QOL was impaired among the asthmatic obese individuals. The worst QOL domain related to environmental stimuli and the best QOL domain to limitations of the activities. Worse QOL was correlated with poorer values for FEF 25-75%.

scholarly journals Pulmonary Function Tests in Hypertensive Patients Attending Zewditu Memorial Hospital, Addis Ababa, Ethiopia

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Mekuriaw Mesfin Birhan ◽  
Yekoye Abebe
Keyword(s):  
Pulmonary Function ◽  
Addis Ababa ◽  
Pulmonary Function Tests ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Memorial Hospital ◽  
Systematic Sampling ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hypertensive Patients

Background. Hypertension imposes stresses on many organs like heart and kidney. However, studies that show the effect of hypertension on the lungs are limited. Objective. To assess pulmonary function status of hypertensive patients aged 30-64 years at Zewditu Memorial Hospital, 2017. Methods. Hospital based comparative cross-sectional study was conducted on 61 hypertensive patients (cases) and 61 nonhypertensive clients (controls) aged 30-64 years. Computerized spirometry was done in all cases and controls which were selected by systematic sampling technique. The study was conducted from January 20, 2017, to May 25, 2017. Result. The values of FVC, FEV1, and FEF25-75% were 3.52±1.02 liters, 2.97±0.89 liters, and 3.34±1.3 liters/second in hypertensive patients and 4.31±0.82 liters, 3.54±0.7 liters, and 3.94±1.09 liters/second in controls, respectively. These values were significantly lower (p<0.05) in hypertensive patients compared to controls. Restrictive pulmonary defect was dominant in hypertensive patients. FEV1% which was 85%±7% in hypertensive patients and 82%±5% in controls was significantly higher (p<0.05) in hypertensive patients compared to controls. Conclusion. Hypertensive patients exhibit lower pulmonary function values. Routine check-up of the pulmonary function status of such patients should be done to prevent undesired outcomes.

scholarly journals Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Lung ◽  
2017 ◽  
Vol 195 (4) ◽  
pp. 445-453 ◽  
Author(s):  
Jan K. Nowak ◽  
Irena Wojsyk-Banaszak ◽  
Edyta Mądry ◽  
Andrzej Wykrętowicz ◽  
Patrycja Krzyżanowska ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei

Thorax ◽  
2018 ◽  
Vol 74 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Michelle E Wood ◽  
Rebecca E Stockwell ◽  
Graham R Johnson ◽  
Kay A Ramsay ◽  
Laura J Sherrard ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Cross Sectional Study ◽  
Gram Negative Bacteria ◽  
Sectional Study ◽  
Bacterial Strains ◽  
Cross Sectional ◽  
Gram Negative ◽  
Droplet Nuclei

The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.

Exercise capacity and ventilation inhomogeneity in cystic fibrosis: A cross‐sectional study

2020 ◽  
Vol 55 (2) ◽  
pp. 394-400 ◽  
Author(s):  
Simone Gambazza ◽  
Riccardo Guarise ◽  
Federica Carta ◽  
Federico Ambrogi ◽  
Marina Mirabella ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Capacity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ventilation Inhomogeneity

scholarly journals Tissue oxygenation in peripheral muscles and functional capacity in cystic fibrosis: a cross‐sectional study

2020 ◽  
Vol 105 (9) ◽  
pp. 1571-1578
Author(s):  
Cristiane Cenachi Coelho ◽  
Evanirso da Silva Aquino ◽  
Ana Luiza Reis Diniz ◽  
Mariana da Silva Santos ◽  
Lídia Cunha de Oliveira ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Functional Capacity ◽  
Tissue Oxygenation ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional
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