scholarly journals Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study

2020 ◽  
Vol 5 ◽  
pp. 52 ◽  
Author(s):  
Robert W. Aldridge ◽  
Dan Lewer ◽  
Sarah Beale ◽  
Anne M. Johnson ◽  
Maria Zambon ◽  
...  
Keyword(s):  
Cohort Study ◽  
Influenza Pandemic ◽  
Respiratory Illness ◽  
H1n1 Influenza ◽  
The Novel ◽  
Government Response ◽  
Four Seasons ◽  
2009 H1n1 ◽  
Novel Coronavirus ◽  
The Uk

Background: There is currently a pandemic caused by the novel coronavirus SARS-CoV-2. The intensity and duration of this first and second waves in the UK may be dependent on whether SARS-CoV-2 transmits more effectively in the winter than the summer and the UK Government response is partially built upon the assumption that those infected will develop immunity to reinfection in the short term. In this paper we examine evidence for seasonality and immunity to laboratory-confirmed seasonal coronavirus (HCoV) from a prospective cohort study in England. Methods: In this analysis of the Flu Watch cohort, we examine seasonal trends for PCR-confirmed coronavirus infections (HCoV-NL63, HCoV-OC43, and HCoV-229E) in all participants during winter seasons (2006-2007, 2007-2008, 2008-2009) and during the first wave of the 2009 H1N1 influenza pandemic (May-Sep 2009). We also included data from the pandemic and ‘post-pandemic’ winter seasons (2009-2010 and 2010-2011) to identify individuals with two confirmed HCoV infections and examine evidence for immunity against homologous reinfection. Results: We tested 1,104 swabs taken during respiratory illness and detected HCoV in 199 during the first four seasons. The rate of confirmed HCoV infection across all seasons was 390 (95% CI 338-448) per 100,000 person-weeks; highest in the Nov-Mar 2008/9 season at 674 (95%CI 537-835) per 100,000 person-weeks. The highest rate was in February at 759 (95% CI 580-975) per 100,000 person-weeks. Data collected during May-Sep 2009 showed there was small amounts of ongoing transmission, with four cases detected during this period. Eight participants had two confirmed infections, of which none had the same strain twice. Conclusion: Our results provide evidence that HCoV infection in England is most intense in winter, but that there is a small amount of ongoing transmission during summer periods. We found some evidence of immunity against homologous reinfection.

scholarly journals Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study

2020 ◽  
Vol 5 ◽  
pp. 52 ◽  
Author(s):  
Robert W. Aldridge ◽  
Dan Lewer ◽  
Sarah Beale ◽  
Anne M. Johnson ◽  
Maria Zambon ◽  
...  
Keyword(s):  
Cohort Study ◽  
Influenza Pandemic ◽  
Respiratory Illness ◽  
H1n1 Influenza ◽  
The Novel ◽  
Government Response ◽  
Four Seasons ◽  
2009 H1n1 ◽  
Novel Coronavirus ◽  
The Uk

Background: There is currently a pandemic caused by the novel coronavirus SARS-CoV-2. The intensity and duration of this first wave in the UK may be dependent on whether SARS-CoV-2 transmits more effectively in the winter than the summer and the UK Government response is partially built upon the assumption that those infected will develop immunity to reinfection in the short term. In this paper we examine evidence for seasonality and immunity to laboratory-confirmed seasonal coronavirus (HCoV) from a prospective cohort study in England. Methods: In this analysis of the Flu Watch cohort, we examine seasonal trends for PCR-confirmed coronavirus infections (HCoV-NL63, HCoV-OC43, and HCoV-229E) in all participants during winter seasons (2006-2007, 2007-2008, 2008-2009) and during the first wave of the 2009 H1N1 influenza pandemic (May-Sep 2009). We also included data from the pandemic and ‘post-pandemic’ winter seasons (2009-2010 and 2010-2011) to identify individuals with two confirmed HCoV infections and examine evidence for immunity against homologous reinfection. Results: We tested 1,104 swabs taken during respiratory illness and detected HCoV in 199 during the first four seasons. The rate of confirmed HCoV infection across all seasons was 390 (95% CI 338-448) per 100,000 person-weeks; highest in the Nov-Mar 2008/9 season at 674 (95%CI 537-835). The highest rate was in February at 759 (95% CI 580-975). Data collected during May-Sep 2009 showed there was small amounts of ongoing transmission, with four cases detected during this period. Eight participants had two confirmed infections, of which none had the same strain twice. Conclusion: Our results provide evidence that HCoV infection in England is most intense in winter, but that there is a small amount of ongoing transmission during summer periods. We found some evidence of immunity against homologous reinfection.

scholarly journals Internet-based surveillance of Influenza-like-illness in the UK during the 2009 H1N1 influenza pandemic

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Natasha L Tilston ◽  
Ken TD Eames ◽  
Daniela Paolotti ◽  
Toby Ealden ◽  
W John Edmunds
Keyword(s):  
Influenza Pandemic ◽  
H1n1 Influenza ◽  
Influenza Like Illness ◽  
2009 H1n1 ◽  
The Uk ◽  
H1n1 Influenza Pandemic

scholarly journals COVID-19 pandemic spread across geographical and social borders: Can we face it?

Geografie ◽  
2020 ◽  
Vol 125 (1) ◽  
pp. 1-20
Author(s):  
Dagmar Dzúrová ◽  
Jan Jarolímek
Keyword(s):  
Global Health ◽  
Future Development ◽  
Influenza Pandemic ◽  
H1n1 Influenza ◽  
Protective Equipment ◽  
The Novel ◽  
Medical Facilities ◽  
Health Complications ◽  
Novel Coronavirus ◽  
H1n1 Influenza Pandemic

The global health threat of the novel coronavirus virus SARS-CoV-2 has been the most severe virus since the (A) H1N1 influenza pandemic of 1918–1920. The aim of this paper is to document the spread of the COVID-19 epidemic, on the basis of daily WHO and Chinese CDC data, from the time of the first recorded outbreak of the epidemic. Furthermore, the aim of the paper, based on knowledge of the epidemic cycle in the province of Hubei, is to attempt to simulate the future development of the epidemic in the Czech population. According to the optimistic prediction model, it is expected that the epidemic peak could occur in Czechia in mid-April with a daily number of 700–750 new cases. The total number of people with confirmed disease could reach roughly 20,000 (20% of people may experience serious health complications). The conclusion of the article points to the need for Czechia to build its own infrastructure to cover the needs of the state – especially in the areas of preparedness of medical facilities, medical staff, and the availability of protective equipment and medicines.

scholarly journals How I treat influenza in patients with hematologic malignancies

Blood ◽  
2010 ◽  
Vol 115 (7) ◽  
pp. 1331-1342 ◽  
Author(s):  
Corey Casper ◽  
Janet Englund ◽  
Michael Boeckh
Keyword(s):  
Hematopoietic Cell Transplantation ◽  
Influenza Pandemic ◽  
Antiviral Treatment ◽  
Clinical Manifestations ◽  
Influenza Virus Infection ◽  
Hematologic Malignancies ◽  
H1n1 Influenza ◽  
The Novel ◽  
H1n1 Strain ◽  
2009 H1n1

Abstract The 2009 H1N1 influenza pandemic has heightened the interest of clinicians for options in the prevention and management of influenza virus infection in immunocompromised patients. Even before the emergence of the novel 2009 H1N1 strain, influenza disease was a serious complication in patients with hematologic malignancies receiving chemotherapy or undergoing hematopoietic cell transplantation. Here we review the clinical manifestations of seasonal and 2009 H1N1 influenza and discuss current diagnosis, antiviral treatment, and prophylaxis options. We also summarize infection control and vaccination strategies for patients, family members, and caregivers.

scholarly journals Sequential Seasonal H1N1 Influenza Virus Infections Protect Ferrets against Novel 2009 H1N1 Influenza Virus

2012 ◽  
Vol 87 (3) ◽  
pp. 1400-1410 ◽  
Author(s):  
Donald M. Carter ◽  
Chalise E. Bloom ◽  
Eduardo J. M. Nascimento ◽  
Ernesto T. A. Marques ◽  
Jodi K. Craigo ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
Cross Reactivity ◽  
Influenza Viruses ◽  
The Novel ◽  
Virus Infections ◽  
H1n1 Influenza Virus ◽  
Virus Shedding ◽  
2009 H1n1 ◽  
Novel H1n1 Influenza

ABSTRACTIndividuals <60 years of age had the lowest incidence of infection, with ∼25% of these people having preexisting, cross-reactive antibodies to novel 2009 H1N1 influenza. Many people >60 years old also had preexisting antibodies to novel H1N1. These observations are puzzling because the seasonal H1N1 viruses circulating during the last 60 years were not antigenically similar to novel H1N1. We therefore hypothesized that a sequence of exposures to antigenically different seasonal H1N1 viruses can elicit an antibody response that protects against novel 2009 H1N1. Ferrets were preinfected with seasonal H1N1 viruses and assessed for cross-reactive antibodies to novel H1N1. Serum from infected ferrets was assayed for cross-reactivity to both seasonal and novel 2009 H1N1 strains. These results were compared to those of ferrets that were sequentially infected with H1N1 viruses isolated prior to 1957 or more-recently isolated viruses. Following seroconversion, ferrets were challenged with novel H1N1 influenza virus and assessed for viral titers in the nasal wash, morbidity, and mortality. There was no hemagglutination inhibition (HAI) cross-reactivity in ferrets infected with any single seasonal H1N1 influenza viruses, with limited protection to challenge. However, sequential H1N1 influenza infections reduced the incidence of disease and elicited cross-reactive antibodies to novel H1N1 isolates. The amount and duration of virus shedding and the frequency of transmission following novel H1N1 challenge were reduced. Exposure to multiple seasonal H1N1 influenza viruses, and not to any single H1N1 influenza virus, elicits a breadth of antibodies that neutralize novel H1N1 even though the host was never exposed to the novel H1N1 influenza viruses.

Antisemitic or Bordering on Antisemitic? Grey Areas in Romanian Fake News Discourses in the Wake of the Covid-19 Pandemic

Transilvania ◽  
2021 ◽  
pp. 121-127
Author(s):  
Anca-Simina Martin
Keyword(s):  
Influenza Pandemic ◽  
The Novel ◽  
Fake News ◽  
Jewish Communities ◽  
Elie Wiesel ◽  
Working Definition ◽  
The Holocaust ◽  
The Us ◽  
Definition Of ◽  
Novel Coronavirus

Jews as a collective have long served as scapegoats for epidemics and pandemics, such as the Bubonic Plague and, according to some scholars, the 1918–1920 influenza pandemic. This practice reemerged in the early days of the Covid-19 pandemic, when more and more fake news outlets in the US and Europe started publishing articles on a perceived linkage between Jewish communities and the novel coronavirus. What this article aims to achieve is to facilitate a dialogue between the observations on the phenomenon made by the Elie Wiesel National Institute for the Study of the Holocaust in Romania and the latest related EU reports, with a view to charting its beginnings in Romania in relation to other European countries and in an attempt to see whether Romania, like France and Germany, has witnessed the emergence of “grey area” discourses which are not fully covered by International Holocaust Remembrance Alliance working definition of antisemitism.

scholarly journals Covid-19 and food security: Jeopardy management and posterity deliberations

2021 ◽  
Vol 10 (2) ◽  
pp. 01-05
Author(s):  
Augustine Owusu-Addo ◽  
Atianashie Miracle A ◽  
Chukwuma Chinaza Adaobi ◽  
Larissa Agbemelo-Tsomafo
Keyword(s):  
Food Processing ◽  
Respiratory Illness ◽  
The United States ◽  
The Novel ◽  
Food Handling ◽  
Global Pandemic ◽  
Food Borne ◽  
Novel Coronavirus ◽  
Food Borne Infections ◽  
Safety Guidelines

COVID-19, also known as the ‘novel coronavirus disease 2019’, is a respiratory illness and the causative pathogen is officially named as ‘SARS-CoV-2’. Infections with SARS-CoV-2 have now been amplified to a global pandemic – as of April 3, 2020, nearly 1,018,000 cases have been confirmed in more than 195 countries, including more than 300,000 cases within the United States. Public safety guidelines are followed worldwide to stop the spread of COVID-19 and stay healthy. Despite COVID-19 is a respiratory illness with mode of invasion through the respiratory tract, not the gastrointestinal tract, an average food consumer is anxious and concerned about the food safety. Could an individual catch the deadly contagious COVID-19 from groceries brought home from the supermarket – or from the next restaurant takeout order? This brief review elucidates the epidemiology and pathobiological mechanism(s) of SARS-CoV-2 and its implications in food-borne infections, transmission via food surfaces, food processing and food handling.

scholarly journals Clinical and economic analysis of the 2009 H1N1 influenza pandemic among pregnant Korean women

2019 ◽  
Vol 34 (5) ◽  
pp. 1136-1144
Author(s):  
Won Suk Choi ◽  
Min Joo Choi ◽  
Ji Yoon Noh ◽  
Joon Young Song ◽  
Woo Joo Kim ◽  
...  
Keyword(s):  
Economic Analysis ◽  
Influenza Pandemic ◽  
H1n1 Influenza ◽  
Korean Women ◽  
2009 H1n1 ◽  
H1n1 Influenza Pandemic
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