scholarly journals The impact of social variables in preclinical models of cocaine abuse

2021 ◽  
Vol 10 ◽  
Author(s):  
Michael A Nader
Keyword(s):  
Cocaine Abuse ◽  
Social Variables ◽  
Preclinical Models ◽  
The Impact

The role of information structure in the instantiation of objects: Evidence from Amazonian Spanish

2020 ◽  
Vol 13 (1) ◽  
pp. 219-245
Author(s):  
Rosa Vallejos ◽  
Evelyn Fernández-Lizárraga ◽  
Haley Patterson
Keyword(s):  
Regression Analysis ◽  
Information Structure ◽  
Mixed Model ◽  
Linguistic Variables ◽  
Social Variables ◽  
Null Objects ◽  
The Impact ◽  
Role Of Information ◽  
Activation Status

AbstractThis study analyzes the instantiation of objects in Peruvian Amazonian Spanish (PAS) discourse in two communities with distinct linguistic contexts. We examine the impact of two social variables (gender and place) and nine linguistic variables (transitivity, animacy, definiteness, anaphora function, anaphora expression, cataphora function, cataphora expression, activation, topic persistence) on the speech of eight participants. Our findings indicate that null instantiation in PAS is pervasive, occurring with a range of verb lexemes. While neither gender nor place are significant predictors of null objects, various linguistic variables contribute to the instantiation of objects. The five significant variables as determined by a mixed model regression analysis include the following: animacy, definiteness, anaphora expression, cataphora expression, and activation status. Several findings are consistent with previous research (e. g. human and definite referents disfavor null objects), while other results differ (e. g. PAS propositions disfavor null objects). Activation status and anaphora expression are the most significant predictors of null objects in PAS. In particular, highly accessible referents in discourse and anaphoric null objects favored null objects in subsequent clauses. Thus, the results in the present study demonstrate the pivotal role of information structure in object instantiation, furthering the discussion on syntax-discourse interplay phenomena.

scholarly journals Clinical and social factors associated with attention-deficit hyperactivity disorder medication use: population-based longitudinal study

2014 ◽  
Vol 205 (4) ◽  
pp. 291-297 ◽  
Author(s):  
Cédric Galéra ◽  
Jean-Baptiste Pingault ◽  
Grégory Michel ◽  
Manuel-Pierre Bouvard ◽  
Maria Melchior ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Psychiatric Comorbidity ◽  
Medication Use ◽  
Population Based ◽  
Social Characteristics ◽  
Adhd Medication ◽  
Social Variables ◽  
Hyperactivity Disorder ◽  
The Impact

BackgroundThe impact of longitudinal psychiatric comorbidity, parenting and social characteristics on attention-deficit hyperactivity disorder (ADHD) medication use is still poorly understood.AimsTo assess the baseline and longitudinal influences of behavioural and environmental factors on ADHD medication use.MethodSurvival regressions with time-dependent covariates were used to model data from a population-based longitudinal birth cohort. The sample (n = 1920) was assessed from age 5 months to 10 years. Measures of children's psychiatric symptoms, parenting practices and social characteristics available at baseline and during follow-up were used to identify individual and family-level features associated with subsequent use of ADHD medication.ResultsUse of ADHD medication ranged from 0.2 to 8.6% between ages 3.5 to 10 years. Hyperactivity–inattention was the strongest predictor of medication use (hazard ratio (HR) = 2.75, 95% CI 2.35–3.22). Among all social variables examined, low maternal education increased the likelihood of medication use (HR = 2.09, 95% CI 1.38–3.18) whereas immigrant status lowered this likelihood (HR = 0.40, 95% CI 0.17–0.92).ConclusionsBeyond ADHD symptoms, the likelihood of receiving ADHD medication is predicted by social variables and not by psychiatric comorbidity or by parenting. This emphasises the need to improve global interventions by offering the same therapeutic opportunities (including medication) as those received by the rest of the population to some subgroups (i.e. immigrants) and by diminishing possible unnecessary prescriptions.

Nithsdale Schizophrenia Surveys 17

1998 ◽  
Vol 172 (6) ◽  
pp. 513-517 ◽  
Author(s):  
Ciara Kelly ◽  
Robin McCreadie ◽  
Tom MacEwan ◽  
Stephen Carey
Keyword(s):  
Mental Health ◽  
Mortality Rate ◽  
Tardive Dyskinesia ◽  
Rural Area ◽  
Atypical Antipsychotic ◽  
Social Adjustment ◽  
Antipsychotic Drugs ◽  
Community Care ◽  
Social Variables ◽  
The Impact

BackgroundIn recent years there has been a shift to ‘community care’ and the introduction of several ‘atypical’ antipsychotic drugs. We report the impact of these changes.MethodIn Nithsdale, Dumfries and Galloway, Scotland, the population of patients with schizophrenia was identified in 1996. This census replicated a study carried out in 1981. The population with schizophrenia were compared on clinical and social variables. The whereabouts in 1996 of the 1981 population was determined.ResultsIn comparison with the 1981 population, more patients in 1996 had positive, negative and non-schizophrenic symptoms. More showed tardive dyskinesia. Social adjustment had not changed. They had spent less time in hospital; fewer (13%) were living with their parents; and fewer (8%) were employed. By 1996, 35% of the 1981 cohort had died (standardised mortality rate male – 154, female – 162).ConclusionsThe mental health of a community of people with schizophrenia living in a rural area in 1996 was poorer than in 1981.

scholarly journals ANALISIS PANEL ATAS PENGARUH EKONOMI DAN SOSIAL MASYARAKAT TERHADAP KEMANDIRIAN FISKAL PEMERINTAH KABUPATEN/KOTA DI SULAWESI UTARA

2014 ◽  
Vol 9 (4) ◽  
Author(s):  
Herman Karamoy ◽  
Agus Tony Poputra
Keyword(s):  
Secondary Data ◽  
Economic Factor ◽  
Primary Data ◽  
Social Variables ◽  
Small Cities ◽  
Tax Base ◽  
Human Resource Capacity ◽  
North Sulawesi ◽  
The Impact ◽  
Positive Effect

This paper analyzes the impact of economic and social variables on fiscal independence of district government in Province of North Sulawesi.  Scope of research includes all districts in  2009-2012. To analyze secondary data, we utilize the Pooled EGLS (Cross-section random effects) method. This research not only use secondary data, but also primary data. The primary data are used to get deep picture about factors that lower fiscal dependence of districts in North Sulawesi. Those data are collected by interview to parties related to generate own resource revenues and by focus discussion group with academicians. This research finds that economic development and population in districts of North Sulawesi do not affect on fiscal independence. Otherwise, only variable human development index has significantly positive effect on fiscal independence. These findings are supported by primary data which show that: (1) most activities of dominant economic factor of those districts, except Manado and Bitung, namely agriculture, are not tax or surcharge objects; (2) types of local government tax have small tax base for districts and varies between dictricts that have big cities and small cities; (3) low of human resource capacity and creativity to generate own source revenues effectively and efficiently; and (4) low of taxpayers compliance.

scholarly journals Preclinical Models for Studying the Impact of Macrophages on Cancer Cachexia

2020 ◽  
Vol 91 (1) ◽  
Author(s):  
Spas Dimitrov Markov ◽  
Daisy Gonzalez ◽  
Kamiya Mehla
Keyword(s):  
Cancer Cachexia ◽  
Preclinical Models ◽  
The Impact

2011 Review of Conditionality - Outcomes of Fund-Supported Programs

Policy Papers ◽  
2012 ◽  
Vol 2012 (44) ◽  
Author(s):  
Keyword(s):  
Economic Crisis ◽  
Government Spending ◽  
Global Financial Crisis ◽  
Program Review ◽  
Social Variables ◽  
Social Outcome ◽  
Outcome Indicators ◽  
Macroeconomic Variables ◽  
The Global Financial Crisis ◽  
The Impact

This paper examines the effects of Fund-supported programs initiated during 2002-11, with special emphasis on programs started after the onset of the recent global economic crisis. The paper investigates the effects of Fund-supported programs on key macroeconomic variables and, data restrictions permitting, on social variables (social government spending, unemployment and social outcome indicators). Further, it analyzes the contribution of fiscal and external accommodation in helping program countries get through the recent global crisis. The assessment of the impact of Fund-supported programs is necessarily incomplete to the extent that the global financial crisis is ongoing and the most recent crisis programs such as the March 2012 program for Greece are not included. The Crisis Program Review provides detailed analysis of recent GRA-supported programs.

ONC201 in previously irradiated pediatric H3 K27M-mutant glioma or newly diagnosed DIPG.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 3619-3619
Author(s):  
Sharon L. Gardner ◽  
Carl Johannes Koschmann ◽  
Rohinton Tarapore ◽  
Jeffrey C. Allen ◽  
Wafik Tharwat Zaky ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Body Weight ◽  
Single Agent ◽  
High Grade Glioma ◽  
Biologically Active ◽  
High Grade ◽  
Newly Diagnosed ◽  
Preclinical Models ◽  
Open Label ◽  
The Impact

3619 Background: ONC201 is a first-in-class DRD2 antagonist and ClpP agonist that has demonstrated promising activity in high-grade glioma preclinical models and radiographic regressions with single agent ONC201 in recurrent H3 K27M-mutant glioma patients . The recommended phase 2 dose (RP2D) of 625mg ONC201 orally once a week has been established in adult patients as well tolerated and biologically active. ONC201 efficacy has been shown in high-grade glioma preclinical models and radiographic regressions with single agent ONC201 have been reported in adult recurrent H3 K27M-mutant glioma patients. We report results from the first Phase I pediatric clinical trial of ONC201. Methods: This open-label, multi-center trial for pediatric H3 K27M-mutant glioma or non-biopsied DIPG employed a 3+3 dose-escalation and dose-expansion design with 6 arms. Arms A and E, which have completed accrual, determined the RP2D of ONC201 using oral capsule and liquid formulations in post-radiation pediatric H3 K27M-mutant glioma patients ONC201, respectively. Arm B aims to determine the RP2D for ONC201 in combination with radiotherapy in patients with newly diagnosed DIPG. Arms C and D aim to measure intratumoral ONC201 concentrations in midline glioma patients and the impact of ONC201 on H3 K27M DNA levels in CSF, respectively. Arm F was recently opened to study ONC201 as a single agent in patients with progressive H3 K27M-mutant tumors (excluding DIPG and spinal cord tumors) following radiotherapy. After determining the RP2D, a dose-expansion cohort will evaluate the safety, radiographic response, and activity of ONC201. Results: An RP2D of weekly 625mg ONC201 scaled by body weight as a capsule or in liquid formulation was established in the primary endpoints of arms A, B and E alone or in combination with radiation, without incidence of dose-limiting toxicity (DLT). Pharmacokinetic profiles were similar to those observed in adults (T1/2: 8.4h; Tmax: 2.1h; Cmax: 2.3ug/mL; AUC0-tlast: 16.4ug/mL), with similar exposure across body weights. Conclusions: ONC201 was well tolerated without DLTs at the same adult RP2D scaled by body weight as monotherapy or in combination with radiotherapy in pediatric H3 K27M-mutant glioma patients. Further investigation of ONC201 to treat H3 K27M-mutant glioma and DIPG is warranted. Clinical trial information: NCT03416530 .

Creativity and Music Education: The Impact of Social Variables

2000 ◽  
Vol os-36 (1) ◽  
pp. 58-68 ◽  
Author(s):  
Raymond A.R. Macdonald ◽  
Dorothy Miell
Keyword(s):  
Music Education ◽  
Social Variables ◽  
The Impact
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