Cancer Registry of Population in the City Ozyorsk:  Structure of Malignant Neoplasms First Diagnosed in Period From 1948 to 2016

Purpose: The analysis of the structure of malignant neoplasms (MN) incidence among the population in the city Ozyorsk, located near Mayak Production Association, based on the information from the territorial cancer registry. Materials and methods: There were 14681 first diagnosed cases of malignant neoplasms at the period from 1948 to 2016 in the territorial cancer registry of Ozyorsk. The diagnoses were verified by all available medical documents. The structure of MN incidence, vital status of diseased people, age in a year of diagnostics, rank distribution of the basic localizations were studied. Results: For 70 years period of follow-up there were 7676 cases from 14681 of MN incidence cases during the last 17 years (from 2000 to 2017) – as much as for the previous 51 years of follow-up from 1948 to 1999 (7005 cases). In the MN structure solid cancer constitutes 94.5 %, hemoblastoses – 5.5 %. As at December 31, 2016 23.3 % of the diseased people were alive, 75.2 % died from all causes, 1.5 % lost to follow-up. The cause of 80,6 % deaths was MN. Age in the year of diagnostics constitutes 61,7 years. 75.8 % diagnoses have morphological confirmation. During the entire period of follow-up first three places belong to lung cancer, gastric cancer and prostate cancer for males; breast cancer, gastric cancer and colon cancer for females in the MN structure. Conclusions: During the period from 1948 to 2016 the growth of the first diagnosed MN cases among the population of Ozyorsk was a result of the population doubling and a fourfold increase of the citizens over the age of 50. Developed and supported cancer registry allows to analyze and partially control oncological situation in the closed cities of Rosatom.

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Subsequent Malignant Neoplasms After Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning and Outpatient Conduction

Blood ◽

10.1182/blood.v122.21.5502.5502 ◽

2013 ◽

Vol 122 (21) ◽

pp. 5502-5502

Author(s):

Gabriela Zamora-Ortiz ◽

Sara Velazquez-Sanchez-de-Cima ◽

Sergio Ponce-de-Leon ◽

César H. Gutiérrez-Aguirre ◽

Guillermo J. Ruiz-Delgado ◽

...

Keyword(s):

General Population ◽

Cumulative Probability ◽

Malignant Neoplasms ◽

Outpatient Basis ◽

Reduced Intensity Conditioning ◽

Hematopoietic Stem ◽

Preparative Regimen ◽

Lost To Follow Up ◽

Reduced Intensity

Abstract Abstract 5502 Patients given allogeneic hematopoietic transplants (HSCT) may develop subsequent malignant neoplasms (SMN). Several variables have been identified but there are no data about the incidence of this complication in individuals given HSCT using reduced-intensity conditioning (RIC) methods. The objective of this study is to define the incidence of SMN in patients given HSCT using a RIC preparative regimen conducted on an outpatient basis. Patients given HSCT in two institutions between October 1998 and 2012 were analyzed. Overall survival was analyzed with the Kaplan-Meier procedure. Patients alive at the closure of the study or those lost to follow up were censored. To appraise the SMN appearance, those patients dead were also regarded as censored at that moment, as well as those lost to follow up and those alive at the closing of the study. 95% confidence intervals for the survival or failure estimate were calculated with the Greenwood’s method. All the survival analyses were processed with the StataCorp 2005. Stata Statistical Software: Release 9. College Station, TX: StataCorp LP. A total of 416 allografted patients with a Karnofsky performance index of 100% were included in the study. All patients received PBSC allografts using reduce-intensity conditioning. Engraftment occurred in 350 patients (84%). The conditioning regimen was delivered as an outpatient procedure in all individuals. No patient was given radiotherapy nor antithymocyte globulin during the conditioning. Three hundred and sixty five patients (88%) were never admitted to the hospital, whereas 12% were admitted because of grade III-IV aGVHD, fever or mucositis. Median survival time was 15.7 months. Survival at 6 months (95% CI): 66.4% (61.5- 70.8%), at 12 months: 53.3% (48.1 -58.1%), at 60 months: 30.6% (30.5-41.5%). Eight patients with a SMN were identified in the group of 416 allografted patients, the cumulative probability of SMN being 6.8 at 10 years. Since the number of expected cases in the general population is 0.62, the ratio of observed to expected cases is 3.2 (p < 0.001). This figure means that the risk of developing a malignant neoplasm in allografted individuals using our method is 3.2 times higher than that in the general population. There were three non-Hodgkin´s lymphomas (NHL), two M2 acute myelogenous leukemias (AML), one hairy cell leukemia, one tongue epidermoid carcinoma and one breast carcinoma. In conclusion, we have found a diminished incidence of SMN in this group of Mexican patients allografted with the Mexican reduced-intensity conditioning method. Possible explanations for this difference are discussed, focusing on the RIC preparative regimen. Disclosures: No relevant conflicts of interest to declare.

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Diagnostic Validity of High-Density Barium Sulfate in Gastric Cancer Screening: Follow-up of Screenees by Record Linkage with the Osaka Cancer Registry

Journal of Epidemiology ◽

10.2188/jea.je20090116 ◽

2010 ◽

Vol 20 (4) ◽

pp. 287-294 ◽

Cited By ~ 7

Author(s):

Kenyu Yamamoto ◽

Hideo Yamazaki ◽

Chikazumi Kuroda ◽

Tsugio Kubo ◽

Akira Oshima ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Screening ◽

Cancer Registry ◽

Record Linkage ◽

Barium Sulfate ◽

High Density ◽

Diagnostic Validity ◽

Gastric Cancer Screening

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Changing patterns of prognosticators during long-term follow-up of gastric cancer after D2–3 resection and adjuvant chemotherapy: 15-year follow-up at one Korean institution

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.4050 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 4050-4050

Author(s):

H. C. Jeung ◽

Y. W. Moon ◽

S. Y. Rha ◽

S. H. Noh ◽

G. E. Kim ◽

...

Keyword(s):

Gastric Cancer ◽

Adjuvant Chemotherapy ◽

Survival Rates ◽

Clear Cut ◽

Stage Ib ◽

Long Term Follow Up ◽

Recurrence Patterns ◽

Lost To Follow Up

4050 Background: Clinical outcome of long-term follow-up after 5 years of gastrectomy, such as recurrence or survival rate, recurrence patterns, and prognosticators, have not been studied well. We evaluated long-term natural history of gastric cancer with a median follow up duration of 15 years after D2–3 resection and adjuvant chemotherapy at a single institution. Especially in survived patients after 5 years of surgery, we analyzed risk factors for recurrence or survival. Methods: A total of 525 patients with stage IB to IVM0 (AJCC 2002) were accrued between 1984 and 1996. As a standard surgery, radical gastrectomy with D2–3 lymphadenectomy was performed. All the patients had adjuvant 5-FU plus adriamycin chemotherapy and 160 of them had also immunotherapy with poly A:U. Results: The median follow-up duration was 191 months. 15 patients (2.9%) were lost to follow-up with median follow-up of 45 months. 15-year disease-free and overall survival rates were 49.5% and 42.9%, respectively. In survivors after 5 years, recurrence rate was 16.0% (11.3% between 5 and 10 years; 4.7% after 10 years). The dominant recurrence patterns were distant metastasis (29.0%) between 5 and 10 years and secondary cancer (53.9%) after 10 years of surgery. Stage (IB vs II vs IIIA vs IIIB vs IVM0) was a clear-cut prognosticator during 5 years of gastrectomy, but its significance was lost between 5 to 10 years. At this time, only stage IVM0 was a significant poor prognosticator for gastric cancer-specific recurrence (HR = 6.61; P = 0.000) and cancer-specific death (HR = 7.04, P = 0.000). However, stage did not represent any significance after 10 years of surgery. Conclusions: In gastric carcinoma with D2–3 resection and adjuvant treatment, late recurrences after 5 years of surgery were not rare. Prognosticators were different in survivors after 5-years, 5–10 years and more than 10 years of surgery. No significant financial relationships to disclose.

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Second Malignant Neoplasms After Childhood Cancer in Germany – Results from the Long-term Follow-up of the German Childhood Cancer Registry

Strahlentherapie und Onkologie ◽

10.1007/s00066-009-1005-0 ◽

2009 ◽

Vol 185 (S2) ◽

pp. 8-10 ◽

Cited By ~ 19

Author(s):

Peter Kaatsch ◽

Desiree Debling ◽

Maria Blettner ◽

Claudia Spix

Keyword(s):

Childhood Cancer ◽

Cancer Registry ◽

Malignant Neoplasms ◽

Long Term Follow Up ◽

Second Malignant Neoplasms ◽

German Childhood Cancer Registry

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764. Correlates of Lost to Follow-up Among Newly Diagnosed Older People with HIV in Ukraine

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.954 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S427-S428

Author(s):

Amy J Allen ◽

Oleksandr Zeziulin ◽

Oleksandr Postnov ◽

Julia Rozanova ◽

Taylor Litz ◽

...

Keyword(s):

Older People ◽

Retrospective Chart Review ◽

Hiv Care ◽

People Living With Hiv ◽

Newly Diagnosed ◽

Loss To Follow Up ◽

Increased Risk ◽

Lost To Follow Up ◽

The City

Abstract Background Ukraine has the second largest HIV epidemic in Eastern Europe and Central Asia. Older People with HIV (OPWH) are at increased risk of poor outcomes compared to younger patients. We examined the prevalence and correlates of loss to follow-up (LTFU) among newly diagnosed patients in Ukraine. Methods Retrospective chart review was conducted of 400 patients newly diagnosed with HIV July 1, 2017 - Dec 1, 2018. Data was collected from clinics in the city of Odessa and surrounding regions. OPWH were ≥50 years old at diagnosis and LTFU was defined as no contact with the HIV clinic for 90 days. Demographic, clinical characteristics, and follow-up outcomes were examined, and multivariate logistic regression was used to estimate the adjusted odds ratios at 95% confidence intervals. Results Of the 400 people living with HIV, median age was 50 (IQR35-55), 196 (49%) were women, and 177 (44%) had CD4< 200cell/mm3 at diagnosis. Overall, 65 (16.5%) were LTFU from diagnosis and 54/65 (83%) were lost after their first appointment at the HIV clinic. Among those lost to follow-up, 49 (75%) were ≥50 at the time of diagnosis. Multivariate analysis showed LTFU was associated with age >50years (aOR 3.6, CI 1.8-7.3, p=0.001), lack of ART prescription (aOR 16.4, CI 8.5-31.8, p= 0.001), and living outside the city of Odessa (aOR 2.9, CI 1.5-5.7, p=0.002). Figure 1 shows the breakdown of lost to follow-up for OPWH. Figure 1. Retainment in HIV Care for OPWH compared to those <50 years old. Conclusion LTFU among OPWH is significantly greater than younger people with HIV, and associated with lack of ART and living in nonurban settings. OPWH may benefit from differentiated HIV service delivery to reduce loss to follow up and interventions tailored to improving HIV outcomes for OPWH in resource-limited settings are urgently needed. Disclosures All Authors: No reported disclosures

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Second malignant neoplasms in a nationwide population-based cohort of childhood cancer survivors in Taiwan.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.10569 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 10569-10569

Author(s):

Chu-Ling Yu ◽

Emily S. Tonorezos ◽

Chiung-Yu Huang ◽

Brian C-H Chiu ◽

Chun-Ju Chiang ◽

...

Keyword(s):

Cancer Survivors ◽

Childhood Cancer ◽

Cancer Registry ◽

Cumulative Incidence ◽

Childhood Cancer Survivors ◽

Malignant Neoplasms ◽

Gastrointestinal Cancers ◽

Second Malignant Neoplasms ◽

Survivors Of Childhood Cancer

10569 Background: Childhood cancer survivors have excess risk of second malignant neoplasms, but data are limited in Asian populations. We established a nationwide retrospective cohort of childhood cancer survivors in Taiwan to study the risk of second malignant neoplasms in the population. Methods: Children and adolescents diagnosed with cancer before age 21 years between 1990 and 2011 were identified from the Taiwan Cancer Registry, the national cancer registry in Taiwan. One-year survivors of childhood cancer were ascertained through data linkage with the national death registry. Survivors were followed up through December 2012. Standardized incidence ratios (SIRs), absolute excess risks (AERs), and cumulative incidence of second malignant neoplasms were calculated. Results: A total of 186 second malignant neoplasms occurred among 15,263 1-year survivors of childhood cancer after a mean follow-up time of 8.0 years (SIR = 5.4, 95% confidence interval [CI] = 4.6-6.2; AER = 12.4 per 10,000 person-years). The most common types of second malignant neoplasms were gastrointestinal cancers (n = 37), leukemia (n = 28), endocrine cancers (n = 18), and brain cancer (n = 17). Cancers in the liver (n = 11, including 9 hepatocellular carcinoma) and colorectum (n = 16) accounted for 73% of second gastrointestinal malignant neoplasms in this population. The cumulative incidence of second malignant neoplasms at 10 and 20 years from follow-up was 1.0% (95% CI = 0.8-1.2%) and 3.0% (95% CI = 2.3-3.6%), respectively. Conclusions: Childhood cancer survivors in Taiwan experience excess risk of second malignant neoplasms, in particular gastrointestinal cancers, compared with the general population.

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