MINERAL BALANCE IN HEALTHY AND ILL PEOPLE OF BLAGOVESHCHENSK CITY

The mineral status of healthy and ill citizens of Blagoveshchensk was studied with the help of atomic absorption spectroscopy. It was found out that in the whole blood of healthy people from Blagoveshchensk in comparison with some average standard rates given in literature, there was a bigger (p<0.001) concentration of Co (3.5 and more times), of Cs (15 times more), of Li (4.5 times more), of Mn (34.3 times more), of Ni (4 times more), and there was significantly less of Cu, Fe, Hg, K, Na, Mg, Rb, Zn. At focal tuberculosis the deficit of Ca and Mg and the excess of Cd, Cr, Cs, Hg, K, Li and Pb were registered. And the other way round, under fibrous-cavernous type in the blood there was a low level of Ca, Mg, Mn and Ni (p<0.001), approximately normal contents of Cu, Fe and Zn, and a high (p<0.001) concentration of Cd, Cr, Cs, Hg, K, Li, Mn, Na, Ni, Pb, Rb. Moreover, in the blood of people with lung tuberculosis the contents of Hg were 3-5 times more than in healthy people. Under the peptic ulcer disease the mineral imbalance was revealed through the decrease in the blood of Ca and Mg level (p<0.001) and the increase of (p<0.001) Cd, Cr, Cs, K, Li, Mn, Na, Ni and Pb concentration.

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INFILTRATIVE LUNG TUBERCULOSIS, PEPTIC ULCER DISEASE AND HIV INFECTION (COMORBIDITY AND MULTIMORBIDITY OF DISEASES)

Science and Innovations in Medicine ◽

10.35693/2500-1388-2016-0-1-19-24 ◽

2016 ◽

Vol 1 (1) ◽

pp. 19-24

Author(s):

IL L Davydkin ◽

AM M Osadchuk ◽

EA A Borodulina ◽

TA A Gritsenko

Keyword(s):

Weight Loss ◽

Peptic Ulcer ◽

Pulmonary Tuberculosis ◽

Hiv Infection ◽

Peptic Ulcer Disease ◽

Aetiological Factor ◽

Hiv Positive ◽

Ulcer Disease ◽

Lung Tuberculosis ◽

Multiple Categories

Aim - to explore the features of comorbidity and multimorbidity of infiltrative pulmonary tuberculosis (IPT), peptic ulcer (PU), HIV infection in modern conditions. Materials and methods. The study involved 392 patients with IPT aged 20-44 years, HIV-positive with CD4 200500/pl, suffering from uncomplicated ulcer. Results. Peptic ulcer disease was diagnosed in 20.5% of patients with IPT and 19.5% patients with HIV infection in stage C2 and IPT, complaining of dyspepsia. The multimorbid combination of IPT, HIV infection and PU is characterized by: oligosymptomatic onset of tuberculosis; the clinical picture shows the dominance of asthenic syndrome, manifestations of gastric and intestinal dyspepsia, weight loss (2-4 times more frequently than in patients without HIV infection), less prominent destructive process in the lung tissue (2 times less than in patients without HIV infection). H.pylori is the aetiological factor of PU in 62.5% of patients with IPT and 58.7% patients with HIV infection in stage C2 and IPT. The combination of H.pylori-negative PU and IPT has significantly more unfavorable prognosis compared to comorbidity of H.pylori-positive peptic ulcer and IPT. Conclusion. Diagnosis of PU, HIV infection and H.pylori-status allows defining multiple categories of comorbidity (patients with IPT and dyspeptic syndrome, patients with IPT and H.pylori-associated peptic ulcer, patients with IPT and H.pylori-negative ulcer) and multimorbidity (HIV-infected patients with IPT and H.pylori-associated ulcer, HIV-infected patients with IPT and H.pylori-negative ulcer).

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The Association ofHelicobacter pyloriInfection and Nonsteroidal Anti-Inflammatory Drugs in Peptic Ulcer Disease

Canadian Journal of Gastroenterology ◽

10.1155/2006/175217 ◽

2006 ◽

Vol 20 (4) ◽

pp. 277-280 ◽

Cited By ~ 37

Author(s):

Juan Carlos Zapata-Colindres ◽

Sergio Zepeda-Gómez ◽

Aldo Montaño-Loza ◽

Edgar Vázquez-Ballesteros ◽

José de Jesús Villalobos ◽

...

Keyword(s):

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Bleeding Peptic Ulcer ◽

The Other ◽

Ulcer Disease ◽

Group 3 ◽

Anti Inflammatory ◽

Group 2 ◽

H Pylori ◽

Group 1

BACKGROUND AND AIM: Peptic ulcer disease (PUD) affects 10% of the world population.Helicobacter pyloriinfection and the use of a nonsteroidal anti-inflammatory drug (NSAID) are the principal factors associated with PUD. The aim of the present study was to evaluate a cohort of patients with PUD and determine the association betweenH pyloriinfection and NSAID use.PATIENTS AND METHODS: The medical charts of patients with endoscopic diagnosis of PUD were retrospectively reviewed from September 2002 to August 2003. Patients were divided into three groups according to ulcer etiology:H pyloriinfection (group 1); NSAID use (group 2); and combinedH pyloriinfection and NSAID use (group 3).RESULTS: One hundred two patients were evaluated: 36 men (35.3%) and 66 women (64.7%). Forty patients hadH pyloriinfection, 43 had used NSAIDs and 15 had combinedH pyloriinfection and NSAID use; four patients with ulcers secondary to malignancy were excluded. The frequency of women was significantly higher in group 2 (P=0.01). The mean age of patients in group 1 was significantly lower than in the other two groups (P=0.003). PUD developed earlier in group 3 than in group 2 (5.0±4.7 months versus 1.4±2.1 months, respectively, P=0.018). Thirty-two patients (32.7%) had bleeding peptic ulcer. Group 2 had a higher risk of bleeding peptic ulcer than the other two groups (P=0.001).CONCLUSIONS: The development of PUD was observed earlier in the combinedH pyloriand NSAID group than in patients with only NSAID use. This suggests a synergic effect between the two risks factors in the development of PUD.

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Morphological changes of Helicobacter pylori caused in vitro by cytoprotective anti-ulcer drug, Sofalcone

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100160650 ◽

1990 ◽

Vol 48 (3) ◽

pp. 620-621

Author(s):

Isamu Kondo ◽

Masashl Yamaguchi

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

Bactericidal Activity ◽

Morphological Changes ◽

Bacterial Activity ◽

The Other ◽

H2 Receptor Antagonists ◽

Ulcer Disease ◽

H Pylori

Since Helicobacter pylori has recently been regarded as a possible causative agent of a chronic gastritis and a peptic ulcer disease, the susceptibilities of this organism to anti-ulcer agents or antibiotics have attracted much interest of not only clinical docters but also medicobiologists.We have reported that Sofalcone, a cytoprotective anti-ulcer drug, has anti-bacterial and bactericidal activity as well as TDS (tripotassium dicitrats bithmuthate) and Clarithromycin (a derivative of erythromycin), but the other anti-ulcer drugs Including anti-acid or H2 receptor antagonists such as cimetidine could not show such bacterial activity as those shown by the sofalcone (SFC), TDB, and clarithromycin (CLM). It was also found that therewere distinct differences between the morphological damage of H. pylori caused by SFC and those caused by TDB and CLM.

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PATIENT, PHYSICIAN, AND PAYER PERCEPTIONS AND MISPERCEPTIONS OF WILLINGNESS TO PAY FOR DIAGNOSTIC CERTAINTY

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462300016147 ◽

2000 ◽

Vol 16 (1) ◽

pp. 35-49 ◽

Cited By ~ 12

Author(s):

Richard A. Hirth ◽

Bernard S. Bloom ◽

Michael E. Chernew ◽

A. Mark Fendrick

Keyword(s):

Peptic Ulcer ◽

Gastroesophageal Reflux Disease ◽

Managed Care ◽

Gastroesophageal Reflux ◽

Willingness To Pay ◽

Practice Guidelines ◽

The Other ◽

Access To Services ◽

Ulcer Disease ◽

Diagnostic Certainty

Little is known about the value patients, physicians, and payers place on intangible attributes of care. Differences in valuations among these groups and misperceptions of value of intangible attributes to other groups can contribute to conflicts about treatment recommendations or coverage decisions. We surveyed patients, physicians, and managed care executives to assess their willingness to pay (WTP) for diagnostic certainty for peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). To determine if patients, physicians, and payers accurately perceive each other's valuations of diagnostic certainty, participants were also asked to estimate the WTP of each of the other types of respondents. Patients were most likely, and executives least likely, to value diagnostic certainty. For PUD, 84% of patients, 61% of physicians, and 43% of executives expressed a positive WTP. Median WTP was low for all three groups ($1–9 for patients and physicians; $0 for payers). Physicians and executives both correctly predicted patient WTP. For GERD, 87% of patients, 52% of physicians, and 29% of executives expressed a positive WTP. Executives underestimated patient WTP. For both diseases, physicians' WTP was overestimated by patients and underestimated by executives. The inconsistency in the value that patients, physicians, and managed care executives place on diagnostic certainty indicates the potential for conflict over practice guidelines or access to services. WTP surveys can provide information to aid in anticipating and addressing areas of disagreement.

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A comparative study between benign and malignant conditions of upper gastrointestinal tract of helicobacter pylori using upper gastrointestinal scopy in a tertiary care hospital, Kanchipuram, Tamil Nadu, India

International Surgery Journal ◽

10.18203/2349-2902.isj20170866 ◽

2017 ◽

Vol 4 (3) ◽

pp. 1082

Author(s):

Dhinesh Babu K. ◽

M. Bhaskar

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

The Other ◽

Rapid Urease Test ◽

Gi Tract ◽

Duodenal Ulcers ◽

Ulcer Disease ◽

Upper Gi ◽

Urease Test ◽

Upper Gastrointestinal

Background: Acid peptic disease comprises of a wide spectrum of diseases, which cause considerable morbidity. The objective of this study was to study the prevalence of Helicobacter pylori in patients with dyspepsia and symptomatic patients undergoing upper gastrointestinal endoscopy (UGIE) in Karpaga Vinayaga Medical College and Hospital, Kanchipuram, Tamilnadu, India and to study the association of Helicobacter pylori with acid peptic diseases and malignant conditions of upper Gastro intestinal tract.Methods: 389 cases of dyspepsia, studied clinically, were subjected to UGIE, during which 4 biopsies, two each from the antrum and the pathological areas were taken. One of the antral area and the other of the pathological finding were immediately subjected to Rapid urease test. Positive test for Helicobacter pylori was indicated by change in colour of the medium from yellow to pink or red. The other two biopsy specimens were sent for routine histopathology and special staining with Giemsa stain. The case was taken as Helicobacter pylori positive when the rapid urease test and/or histopathological examination was positive.Results: Out of 468 patients, with mean age of 41.8 years, 171 patients were diagnosed to have been infected with Helicobacter pylori (44.21%). Out of 49 patients with gastric and duodenal ulcers, 37 patients were infected with Helicobacter pylori (75.51%). In which 22 out of 25 patients (88%) with duodenal ulcers and 10 out of 14 patients (71.4%) with gastric ulcers were positive for H. pylori while only 8 out of 10 patients (80%) with gastric cancer were positive for H. pylori.Conclusions: In this study, we found that Helicobacter pylori were consistently associated with peptic ulcer disease and malignant conditions of upper GI tract, which is in broad agreement with the studies done earlier. Thus, we conclude that, Helicobacter pylori infection may have a major role in the etiopathogenesis of peptic ulcer disease and malignant conditions of upper GI tract appear to be no significant association between Helicobacter pylori infection and unexplained dyspepsia.

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