Differential Radiodiagnosis of Pseudogynecomastia, Gynecomastia and Breast Cancer in Men

Author(s):  
Н. Воротынцева ◽  
N. Vorotynceva ◽  
И. Мошуров ◽  
I. Moshurov ◽  
М. Ганзя ◽  
...  

Background: With the growth in the equipment clinics with modern diagnostic equipment is increasing the detectability of male breast pathology. In this connection there is a need to determine X-ray characteristics of some forms of the male breast pathology especially breast cancer, because in Russia it stills a problem of detecting male breast cancer at early stages. Purpose: To determine the diagnostic capabilities of chest CT to detect various pathologies of the male breast and to identify the statistically significant radiological symptoms for the differential diagnosis of pseudogynecomastia, gynecomastia and breast cancer. Material and methods: 150 chest CT of men who were screened and treated for the various diseases in the Voronezh Regional Clinical Diagnostic Center and Kursk Regional Clinical Hospital in 2013–2015. X-ray examinations (13 chest CT, 4 PET-CT and 16 mammography) of 31 male patients with breast cancer who were surgically treated at the Voronezh Regional Oncology Hospital in 2010–2016 are presented. Results: The obtained data on the prevalence of pseudogynecomastia and gynecomastia in men who have no presenting complaints about changes in breast. Determined the forms of gynecomastia in this group of patients. Identified radiographic signs that allow a differential diagnosis between gynecomastia and breast cancer. Conclusions: 1. Gynecomastia is a common pathology of the male breast diagnosed by chest CT, and was diagnosed in 68.7 % of patients, who have no presenting complaints about changes in breast. In 96.1 % of cases, gynecomastia had a dendritic form. Diffuse glandular and nodular were rare forms of the disease and were respectively 2.9 % and 1 % of all cases of this disease. 2. Statistically significant signs of malignant character of breast masses in men were: a) the connection of the tumor with skin, areola or nipple in the form of «track» to them, thickening of the skin, «pulling» of the skin or nipple to neoplasm or their immediate invasion by tumor; b) tumor invasion into the pectoralis major muscle; c) presence of microcalcifications in neoplasm; d) presence of pathologically altered axillary lymph nodes. The determination of these radiological symptoms require immediate consultation of an oncologist. 3. Statistically significant signs of the benign character of breast masses in men were: a) bilateral lesion and the symmetry of the changes in the breasts; b) adipose tissue inclusions in breast masses. When detection gynecomastia it needs the consultation of urologist, endocrinologist, oncologist. 4. Awareness of physicians and radiologists on the possibility of developing breast cancer in men and the knowledge of the symptoms of this disease is crucial to detect male breast cancer at early stages and, as a consequence, more successful treatment and a favorable prognosis.

2017 ◽  
Author(s):  
Kimberly S. Stone ◽  
Irene L Wapnir

This is a contemporary review of risk factors and genetic predisposition associated with breast cancer in men. The workup and evaluation of breast masses and surgical management of cancer in this population are detailed. In addition, systemic therapies for the treatment of breast cancer in men are reviewed and compared with the therapeutic approaches used for women.    This reviews contains 5 figures, 2 tables and 50 references.  Key words: breast-conserving surgery, chemotherapy, endocrine therapy, genetic predisposition testing, genomic profiling, lymphadenectomy, male breast cancer, mastectomy, radiotherapy, sentinel lymph node biopsy


2017 ◽  
Author(s):  
Kimberly S. Stone ◽  
Irene L Wapnir

This is a contemporary review of risk factors and genetic predisposition associated with breast cancer in men. The workup and evaluation of breast masses and surgical management of cancer in this population are detailed. In addition, systemic therapies for the treatment of breast cancer in men are reviewed and compared with the therapeutic approaches used for women.    This reviews contains 5 figures, 2 tables and 50 references.  Key words: breast-conserving surgery, chemotherapy, endocrine therapy, genetic predisposition testing, genomic profiling, lymphadenectomy, male breast cancer, mastectomy, radiotherapy, sentinel lymph node biopsy


2020 ◽  
pp. 030089162097698
Author(s):  
Emma Zattarin ◽  
Francesca Ligorio ◽  
Federico Nichetti ◽  
Giulia Bianchi ◽  
Giuseppe Capri ◽  
...  

Introduction: Breast cancer in men is less common than in women and treatment recommendations are often derived from clinical trials exclusively involving women. Data on efficacy of CDK 4/6 inhibitors, which are the mainstay of treatment for hormone receptor–positive/HER2-negative advanced breast cancer, are lacking in male patients. Case report: We present a clinical case of prolonged benefit from palbociclib in combination with letrozole and LHRH analogue in a man who had previously been treated with six lines of endocrine therapies and chemotherapy regimens but was still in excellent clinical condition. Conclusions: This clinical case demonstrates that male breast cancer stands out as an endocrine-sensitive disease, which could potentially benefit from CDK 4/6 inhibitors in combination with endocrine agents even in very heavily pretreated settings of disease, underscoring both the importance of an accurate selection of patients for later treatment lines, taking into account disease history and previous treatment responses, and the peculiarity of breast cancer in men, which deserves dedicated clinical trials to tailor future recommendations.


Author(s):  
Piper Sledge

Breast cancer in American culture is intrinsically tied to normative ideologies of femininity. Within the highly visible public discourse about breast cancer, men with the disease (both transgender and cisgender) remain nearly invisible. The very presence of breast cancer in men is unthinkable precisely because its presence challenges the association of femininity with breasts. In this chapter I explore the ways that male breast cancer emerges in public discourse in order to explore the ways in normative expectations of masculinity emerge as a narrative framework for bringing trans and cis men into the breast cancer conversation as well as the ways that masculinity is deployed differentially in representing breast cancer in these two groups of men.


2005 ◽  
Vol 17 (4) ◽  
pp. 207-212 ◽  
Author(s):  
Miki KUSHIMA ◽  
Takahiko TONOIKE ◽  
Yoshiko TSUDA ◽  
Atsumi SUWA ◽  
Emi TAKABA ◽  
...  

2014 ◽  
pp. 97-123
Author(s):  
Alexander N. Sencha ◽  
Elena V. Evseeva ◽  
Irina A. Ozerskaya ◽  
Elena P. Fisenko ◽  
Yury N. Patrunov ◽  
...  

2021 ◽  
Vol 11 ◽  
pp. 21
Author(s):  
Shaza AlSharif ◽  
Khalid Misfer Alshamrani ◽  
Anabel Scaranelo ◽  
Nuha Khoumais ◽  
Ahmad Subahi ◽  
...  

Most of male breast masses are benign with gynecomastia being the most common entity encountered. Primary male breast cancer accounts for less than 1% of the total number of breast cancer. Male breast can be affected by a variety of conditions affecting the female breast with less frequency due to the lack of hormonal influence and consequent glandular sub-development. Imaging features of male breast masses are quite similar to the female breast. Therefore, using the knowledge of the female breast and applying it may help in the diagnosis and management of male breast abnormalities. In this article, we aim to review a variety of unusual male breast masses. We discuss the demographics of male breast tumors, describe the diagnostic algorithm for evaluating male breast masses, and review the imaging features of rare breast masses and mimickers of male breast cancer.


2011 ◽  
Vol 96 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Harold E. Carlson

Gynecomastia is a common and sometimes distressing condition that may occur in males of all ages. Although most cases have benign causes and many are self-limited, male breast enlargement may also be a sign of underlying systemic disease or drug toxicity. Although rare, male breast cancer must also be considered in the differential diagnosis. A careful diagnostic evaluation should be pursued, tailored to the individual patient’s circumstances. Treatment may include reassurance, medication, or surgery.


The Breast ◽  
2005 ◽  
Vol 14 ◽  
pp. S33
Author(s):  
Y. Hotko ◽  
O. Litvinenko ◽  
N. Hotko

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