Male Breast Cancer

2017 ◽  
Author(s):  
Kimberly S. Stone ◽  
Irene L Wapnir
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Genetic Predisposition ◽  
Breast Conserving Surgery ◽  
Lymph Node Biopsy ◽  
Male Breast ◽  
Therapeutic Approaches ◽  
Breast Masses ◽  
Key Words Breast ◽  
Breast Cancer In Men

This is a contemporary review of risk factors and genetic predisposition associated with breast cancer in men. The workup and evaluation of breast masses and surgical management of cancer in this population are detailed. In addition, systemic therapies for the treatment of breast cancer in men are reviewed and compared with the therapeutic approaches used for women.    This reviews contains 5 figures, 2 tables and 50 references.  Key words: breast-conserving surgery, chemotherapy, endocrine therapy, genetic predisposition testing, genomic profiling, lymphadenectomy, male breast cancer, mastectomy, radiotherapy, sentinel lymph node biopsy

Male Breast Cancer

2017 ◽  
Author(s):  
Kimberly S. Stone ◽  
Irene L Wapnir
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Genetic Predisposition ◽  
Breast Conserving Surgery ◽  
Lymph Node Biopsy ◽  
Male Breast ◽  
Therapeutic Approaches ◽  
Breast Masses ◽  
Key Words Breast ◽  
Breast Cancer In Men

This is a contemporary review of risk factors and genetic predisposition associated with breast cancer in men. The workup and evaluation of breast masses and surgical management of cancer in this population are detailed. In addition, systemic therapies for the treatment of breast cancer in men are reviewed and compared with the therapeutic approaches used for women.    This reviews contains 5 figures, 2 tables and 50 references.  Key words: breast-conserving surgery, chemotherapy, endocrine therapy, genetic predisposition testing, genomic profiling, lymphadenectomy, male breast cancer, mastectomy, radiotherapy, sentinel lymph node biopsy

Differential Radiodiagnosis of Pseudogynecomastia, Gynecomastia and Breast Cancer in Men

2018 ◽  
pp. 40-49 ◽  
Author(s):  
Н. Воротынцева ◽  
N. Vorotynceva ◽  
И. Мошуров ◽  
I. Moshurov ◽  
М. Ганзя ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Differential Diagnosis ◽  
Male Breast Cancer ◽  
Chest Ct ◽  
Male Breast ◽  
Breast Pathology ◽  
Breast Masses ◽  
X Ray ◽  
Early Stages ◽  
Breast Cancer In Men

Background: With the growth in the equipment clinics with modern diagnostic equipment is increasing the detectability of male breast pathology. In this connection there is a need to determine X-ray characteristics of some forms of the male breast pathology especially breast cancer, because in Russia it stills a problem of detecting male breast cancer at early stages. Purpose: To determine the diagnostic capabilities of chest CT to detect various pathologies of the male breast and to identify the statistically significant radiological symptoms for the differential diagnosis of pseudogynecomastia, gynecomastia and breast cancer. Material and methods: 150 chest CT of men who were screened and treated for the various diseases in the Voronezh Regional Clinical Diagnostic Center and Kursk Regional Clinical Hospital in 2013–2015. X-ray examinations (13 chest CT, 4 PET-CT and 16 mammography) of 31 male patients with breast cancer who were surgically treated at the Voronezh Regional Oncology Hospital in 2010–2016 are presented. Results: The obtained data on the prevalence of pseudogynecomastia and gynecomastia in men who have no presenting complaints about changes in breast. Determined the forms of gynecomastia in this group of patients. Identified radiographic signs that allow a differential diagnosis between gynecomastia and breast cancer. Conclusions: 1. Gynecomastia is a common pathology of the male breast diagnosed by chest CT, and was diagnosed in 68.7 % of patients, who have no presenting complaints about changes in breast. In 96.1 % of cases, gynecomastia had a dendritic form. Diffuse glandular and nodular were rare forms of the disease and were respectively 2.9 % and 1 % of all cases of this disease. 2. Statistically significant signs of malignant character of breast masses in men were: a) the connection of the tumor with skin, areola or nipple in the form of «track» to them, thickening of the skin, «pulling» of the skin or nipple to neoplasm or their immediate invasion by tumor; b) tumor invasion into the pectoralis major muscle; c) presence of microcalcifications in neoplasm; d) presence of pathologically altered axillary lymph nodes. The determination of these radiological symptoms require immediate consultation of an oncologist. 3. Statistically significant signs of the benign character of breast masses in men were: a) bilateral lesion and the symmetry of the changes in the breasts; b) adipose tissue inclusions in breast masses. When detection gynecomastia it needs the consultation of urologist, endocrinologist, oncologist. 4. Awareness of physicians and radiologists on the possibility of developing breast cancer in men and the knowledge of the symptoms of this disease is crucial to detect male breast cancer at early stages and, as a consequence, more successful treatment and a favorable prognosis.

Male Breast Cancer: 13-Year Single Institution Experience

2020 ◽  
Vol 86 (10) ◽  
pp. 1345-1350
Author(s):  
Marissa K. Srour ◽  
Farin Amersi ◽  
James Mirocha ◽  
Armando E. Giuliano ◽  
Alice Chung
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Ductal Carcinoma ◽  
Disease Free Survival ◽  
Recurrence Score ◽  
Breast Conserving Surgery ◽  
Male Breast ◽  
Brca Mutations ◽  
Estrogen Receptor Positive ◽  
Stage 1

Due to the low incidence of male breast cancer (BC), there are few studies evaluating outcomes. We evaluated the clinicopathologic features and outcomes of male BC. Male patients with BC from January 2006 to December 2018 were identified. Of 49 patients, mean age was 64 (range 33-94) years. Of the 27 (55.1%) patients who had genetic testing, 9 (33.3%) had a Breast Cancer gene (BRCA) 1 or 2 mutation. The majority of patients had a mastectomy (n = 43/49, 87.8%) and had invasive ductal carcinoma (n = 47/49, 95.9%). 20 patients (n = 20/43, 46.5%) had positive lymph nodes. 41 (n = 41/47, 87.2%) patients had estrogen receptor positive disease. The majority of patients were pathologic stage 2 (n = 21/46, 45.7%), followed by stage 1 (n = 15/46, 32.6%), stage 3 (n = 6/46, 13.0%), and stage 4 (n = 4/46, 8.7%). Eight patients had the 21-gene recurrence score performed. Of patients with stage 1-3 BC, 10 (n = 10/43, 23.3%) patients had recurrence. With median follow-up of 4.1 (range .6-10.6) years, 5-year overall survival was 82.9% and 5-year disease-free survival was 65.9%. In conclusion, our cohort of patients with male BC had a high incidence of BRCA mutations and most commonly had high-grade estrogen positive stage 2 tumors. Breast conserving surgery was utilized in 4% of patients and genomic testing utilized in 55% of patients.

Prolonged benefit from palbociclib plus letrozole in heavily pretreated advanced male breast cancer: case report and literature overview

2020 ◽  
pp. 030089162097698
Author(s):  
Emma Zattarin ◽  
Francesca Ligorio ◽  
Federico Nichetti ◽  
Giulia Bianchi ◽  
Giuseppe Capri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Case Report ◽  
Male Breast Cancer ◽  
Clinical Case ◽  
Previous Treatment ◽  
Male Breast ◽  
Cancer Case ◽  
Heavily Pretreated ◽  
Breast Cancer In Men

Introduction: Breast cancer in men is less common than in women and treatment recommendations are often derived from clinical trials exclusively involving women. Data on efficacy of CDK 4/6 inhibitors, which are the mainstay of treatment for hormone receptor–positive/HER2-negative advanced breast cancer, are lacking in male patients. Case report: We present a clinical case of prolonged benefit from palbociclib in combination with letrozole and LHRH analogue in a man who had previously been treated with six lines of endocrine therapies and chemotherapy regimens but was still in excellent clinical condition. Conclusions: This clinical case demonstrates that male breast cancer stands out as an endocrine-sensitive disease, which could potentially benefit from CDK 4/6 inhibitors in combination with endocrine agents even in very heavily pretreated settings of disease, underscoring both the importance of an accurate selection of patients for later treatment lines, taking into account disease history and previous treatment responses, and the peculiarity of breast cancer in men, which deserves dedicated clinical trials to tailor future recommendations.

Male Breast Cancer in the Public Imagination

2019 ◽  
pp. 220-237
Author(s):  
Piper Sledge
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Public Discourse ◽  
Male Breast ◽  
The Public ◽  
Normative Expectations ◽  
Narrative Framework ◽  
Public Imagination ◽  
Breast Cancer In Men

Breast cancer in American culture is intrinsically tied to normative ideologies of femininity. Within the highly visible public discourse about breast cancer, men with the disease (both transgender and cisgender) remain nearly invisible. The very presence of breast cancer in men is unthinkable precisely because its presence challenges the association of femininity with breasts. In this chapter I explore the ways that male breast cancer emerges in public discourse in order to explore the ways in normative expectations of masculinity emerge as a narrative framework for bringing trans and cis men into the breast cancer conversation as well as the ways that masculinity is deployed differentially in representing breast cancer in these two groups of men.

270. Sentinel Lymph Node Biopsy in Male Breast Cancer Patients

2012 ◽  
Vol 38 (9) ◽  
pp. 819
Author(s):  
F. Aydogan ◽  
O. Simsek ◽  
A. Belli ◽  
A. Karatas ◽  
F. Selcukbiricik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cancer Patients ◽  
Male Breast Cancer ◽  
Lymph Node Biopsy ◽  
Male Breast ◽  
Breast Cancer Patients ◽  
Node Biopsy

scholarly journals Efficacy of sentinel lymph node biopsy in male breast cancer

2004 ◽  
Vol 86 (2) ◽  
pp. 74-77 ◽  
Author(s):  
Vincent M. Cimmino ◽  
Amy C. Degnim ◽  
Michael S. Sabel ◽  
Kathleen M. Diehl ◽  
Lisa A. Newman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Male Breast Cancer ◽  
Lymph Node Biopsy ◽  
Male Breast ◽  
Node Biopsy
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