scholarly journals Fibrosing Mediastinitis

2017 ◽  
Vol 5 (21) ◽  
pp. 4
Author(s):  
Tatiana Denega ◽  
Hawa Edriss ◽  
David Sotello ◽  
Kenneth Nugent
Keyword(s):  
Pulmonary Function Tests ◽  
Fibrous Tissue ◽  
Pulmonary Tissue ◽  
Fibrosing Mediastinitis ◽  
Vascular Bypass ◽  
Sputum Production ◽  
Large Airways ◽  
Intravascular Stents ◽  
Vascular Bypass Grafts ◽  
Radiographic Presentation

Fibrosing mediastinitis is an uncommon thoracic disorder characterized by the extensiveproliferation of fibrous tissue in the mediastinum. This disorder frequently develops followingHistoplasma capsulatum infection with involvement of mediastinal lymph nodes. The fibroustissue can invade and compress mediastinal structures, including vessels, large airways, andthe esophagus. These patients may present with cough, sputum production, and dyspneadepending on location and extent of fibrosis. The radiographic presentation depends on thetype and extent of obstruction. Diagnosis requires computed tomography with angiography,ventilation-perfusion scans, and pulmonary function tests. Management depends on thestructures involved and the extent of infiltration and/or compression. Possible approachesinclude the use of endobronchial stents, intravascular stents, vascular bypass grafts, andthe resection of nonfunctional pulmonary tissue. Extensive surgical procedures are usuallynot warranted. These patients usually do not respond to antifungal or anti-inflammatorymedications. Several patients have responded to rituximab, and this drug is a possibleconsideration in patients with ongoing inflammation in the mediastinum.

scholarly journals New vessels: Vascular tissue engineering

2007 ◽  
Vol 29 (1) ◽  
pp. 12-15
Author(s):  
Ruben Y. Kannan ◽  
Sandip Sarkar ◽  
Jalaledin Mirzay-Razaz ◽  
Alexander M. Seifalian
Keyword(s):  
Vascular Tissue ◽  
Vascular Bypass ◽  
Synthetic Materials ◽  
Poly Ethylene Terephthalate ◽  
Tissue Engineered Blood Vessels ◽  
High Prevalence ◽  
Vascular Bypass Grafts ◽  
Poly Ethylene ◽  
The Uk ◽  
The Ideal

The use of vascular bypass grafts in patients is not new. The high prevalence of atherosclerosis has seen them being used in the treatment of some of the 800 000 cases of myocardial infarction in the UK. So, is there a need for tissue-engineered blood vessels if there is a functional prosthetic alternative? While this may hold true for vessels with high-blood-flow rates1, the patency rates of poly(ethylene terephthalate) (Dacron®) and expanded polytetrafluoroethylene (ePTFE) grafts are less satisfactory at lower flow rates. Given the limitations with synthetic materials alone, a biological or bio-hybrid vascular prosthesis could provide us with the ideal blood-vessel substitute.

Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial

The Lancet ◽  
1999 ◽  
Vol 354 (9189) ◽  
pp. 1493-1498 ◽  
Author(s):  
Michael J Mann ◽  
Anthony D Whittemore ◽  
Magruder C Donaldson ◽  
Michael Belkin ◽  
Michael S Conte ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Randomised Controlled Trial ◽  
Ex Vivo ◽  
Controlled Trial ◽  
Bypass Grafts ◽  
Single Centre ◽  
Vascular Bypass ◽  
Ex Vivo Gene Therapy ◽  
Vascular Bypass Grafts ◽  
Randomised Controlled

Arterial Tissue Regeneration for Pediatric Applications: Inspiration From Up-to-Date Tissue-Engineered Vascular Bypass Grafts

2013 ◽  
Vol 37 (5) ◽  
pp. 423-434 ◽  
Author(s):  
Giorgio Cittadella ◽  
Achala de Mel ◽  
Ryan Dee ◽  
Paolo De Coppi ◽  
Alexander M. Seifalian
Keyword(s):  
Tissue Regeneration ◽  
Bypass Grafts ◽  
Vascular Bypass ◽  
Arterial Tissue ◽  
Vascular Bypass Grafts

scholarly journals Stem cells for tissue engineered vascular bypass grafts

2016 ◽  
Vol 45 (5) ◽  
pp. 999-1010 ◽  
Author(s):  
Forough Askari ◽  
Atefeh Solouk ◽  
Mehdi Shafieian ◽  
Alexander M. Seifalian
Keyword(s):  
Stem Cells ◽  
Bypass Grafts ◽  
Vascular Bypass ◽  
Vascular Bypass Grafts

scholarly journals Recurrent Pneumonia due to Fibrosing Mediastinitis in a Teenage Girl: A Case Report with Long-Term Follow-Up

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Avigdor Hevroni ◽  
Chaim Springer ◽  
Oren Wasser ◽  
Avraham Avital ◽  
Benjamin Z. Koplewitz
Keyword(s):  
Fibrous Tissue ◽  
Rare Condition ◽  
High Morbidity ◽  
Healthy Children ◽  
Teenage Girl ◽  
Positive Serology ◽  
Recurrent Pneumonia ◽  
Fibrosing Mediastinitis ◽  
The Right

A teenage girl was evaluated for recurrent right pneumonia. The evaluation revealed a calcified mediastinal mass that compressed the right intermediate and middle lobar bronchi, as well as the right pulmonary artery and veins. The clinical picture together with imaging studies and borderline positive serology testing suggested a diagnosis of fibrosing mediastinitis associated with histoplasmosis. This rare condition is characterized by the local proliferation of invasive fibrous tissue within the mediastinum due to a hyperimmune reaction to Histoplasma capsulatum. Antifungal and anti-inflammatory therapies are usually ineffective, and surgical intervention contains a high morbidity risk. Palliative surgery and stenting of the compressed airway have been suggested. In the past, the prognosis was thought to be poor, but recent studies demonstrate a more positive outcome. Our patient had been radiologically and functionally stable under follow-up for over thirteen years and has married and delivered two healthy children, both following an uneventful pregnancy.

Improvements in Respiratory and Psychosocial Functioning following Total Laryngectomy by the Use of a Heat and Moisture Exchanger

1993 ◽  
Vol 102 (11) ◽  
pp. 878-883 ◽  
Author(s):  
Annemieke H. Ackerstaff ◽  
Frans J. M. Hilgers ◽  
Alfons J. M. Balm ◽  
Neil K. Aaronson ◽  
Nico van Zandwuk
Keyword(s):  
Pulmonary Function ◽  
Psychosocial Functioning ◽  
Total Laryngectomy ◽  
Sleep Problems ◽  
Pulmonary Function Tests ◽  
Prospective Clinical Study ◽  
Heat And Moisture Exchanger ◽  
Moisture Exchanger ◽  
Sputum Production ◽  
Heat And Moisture

A prospective clinical study in 61 patients was undertaken to investigate the subjective and objective influence of a heat and moisture exchanger (HME) on the respiratory and psychosocial problems following total laryngectomy. Although statistical comparisons failed to detect significant differences between the experimental and the control groups, there was a clear trend toward improvements in respiratory and psychosocial functioning in the experimental group. Analyses of differences over time within the HME user group showed significant reductions in the incidence of coughing, the mean daily frequency of sputum production, forced expectoration, and stoma cleaning. Significant improvements were also found in shortness of breath, fatigue and malaise, sleep problems, levels of anxiety and depression, and perceived voice quality. Pulmonary function tests showed significant improvements in inspiratory flow and volume values following use of the HME. This objective improvement in inspiratory pulmonary function reflects the decrease in sputum production reported by the patients.

scholarly journals Fibrosing mediastinitis mimicking as chronic pulmonary thromboembolism

2020 ◽  
Vol 6 (1) ◽  
pp. 20190049
Author(s):  
Dimpi Sinha ◽  
Nischal G Kundaragi ◽  
Sudhir Kumar Kale ◽  
Sukrity Sharma
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Vein ◽  
Clinical Presentation ◽  
Pulmonary Thromboembolism ◽  
Fibrous Tissue ◽  
Young Male ◽  
Fibrosing Mediastinitis ◽  
Vascular Structures ◽  
Progressive Disorder ◽  
Variable Clinical Presentation

Fibrosing mediastinitis is an uncommon, benign, progressive disorder caused by proliferation of fibrous tissue within mediastinum resulting in encasement of vital mediastinal broncho-vascular structures. Due to its rarity and variable clinical presentation, it is often misdiagnosed. We are presenting a case of fibrosing mediastinitis in an Ethiopian origin young male presenting with pulmonary hypertension due to simultaneous occlusion of pulmonary vein and arteries, clinically misdiagnosed as chronic pulmonary thromboembolism.

Obstetrical management of patients with extra-anatomic vascular bypass grafts due to Takayasu arteritis

2016 ◽  
Vol 42 (12) ◽  
pp. 1864-1869 ◽  
Author(s):  
Naoyuki Miyasaka ◽  
Makiko Egawa ◽  
Mitsuaki Isobe ◽  
Yoshinori Inoue ◽  
Toshiro Kubota
Keyword(s):  
Takayasu Arteritis ◽  
Bypass Grafts ◽  
Vascular Bypass ◽  
Vascular Bypass Grafts ◽  
Obstetrical Management
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