scholarly journals Clinical and prognostic value of TAMX index of interlobar arteries of the middle segment in patients after allograph kidney transplantation in the late postoperative period

2020 ◽  
Vol 10 (11) ◽  
pp. 171
Author(s):  
V. V. Yakimenko
Author(s):  
A. P. Faenko ◽  
A. B. Zulkarnayev ◽  
Ju. Ju. Chuksina ◽  
V. A. Fedulkina ◽  
R. O. Kantaria ◽  
...  

Aim– to perform a comparative study of the long-term results of the combined use of extracorporeal photochemotherapy (photopheresis) and drug immunosuppression and standard immunosuppressive therapy in patients after kidney transplantation.Materials and methods. An open cohort randomized study was conducted, including 60 patients with chronic kidney disease stage 5D. All patients underwent single-group cadaveric kidney transplantation. Patients were randomly divided into two groups. All transplants were paired, the fi rst kidney transplant was received by the patient of the main group, the second – by comparison group. 30 patients of the main group received standard protocol of immunosuppression and 10–15 sessions of photopheresis during the fi rst six months after transplantation. All patients of the comparison group received standard immunosuppressive therapy only. End points: primary – graft loss, surrogate – the number of acute rejection episodes and infectious complications, the dynamics of creatinine blood concentration, the glomerular fi ltration rate and daily proteinuria, the dynamics of tacrolimus C0 blood concentration. To study the mechanism of photopheresis action in the late postoperative period, we evaluated the immunological parameters: subpopulation of naive T-cells (CD3+CD4+CD45RO–CD28+), the level of CD28 molecule expression (MFI) on these cells and also – subpopulation of T-regulatory cells (CD3+CD4+CD25 (Hi)CD127–).Results.The use of photopheresis leads to the graft function improvement in the late postoperative period: the creatinine concentration (p = 0.017) in the blood and daily proteinuria (p = 0.011) were lower in patients of the main group, the glomerular fi ltration rate was higher (p = 0.027). The incidence rate ratio (IRR) of rejection in the main group was signifi cantly lower than in the comparison group: 0.2509 (95% CI 0.05386, 0.9167), p = 0.0358. The risk of graft loss was also lower in the main group: IRR 0.2782 (95% CI 0.07562, 0.8657), p = 0.026, as well as the risk of infectious complications: IRR 0.3888 (95% CI 0.2754; 0, 5445), p < 0.0001. Survival rate of transplants was higher in the main group (Log Rank p = 0.009; Breslow p = 0.005). The use of photopheresis made it possible to reduce the concentration of tacrolimus in the late postoperative period (p = 0.0017) without increasing the risk of graft rejection. The photopheresis tolerogenic effect in the late postoperative period may be due to an increase in the population of T-regulatory cells with the CD3+CD4+CD25(Hi)+CD127– phenotype compared to the patients which received only standard immunosuppressive therapy (p = 0.024).Conclusion.The preventive use of photopheresis contributes to improvement of the kidney transplantation long-term outcomes. Further studies are needed to study the mechanisms of photopheresis action and markers of partial immunological tolerance to the allograft.


2001 ◽  
Vol 10 (4) ◽  
pp. 266-270 ◽  
Author(s):  
Jeffrey D. Henderer ◽  
Michael C. Heeg ◽  
George L. Spaeth ◽  
Marlene R. Moster ◽  
Jonathan S. Myers ◽  
...  

2017 ◽  
pp. 59-60
Author(s):  
A.A. Dovgan ◽  

The objective: to improve tactics of pregravidare training of women with hysteromyoma. Patients and methods. Under observation there were 100 patients of active and late genesial age (from 22 to 44 years), with the main diagnosis hysteromyoma established on the basis of complex inspection. To all patients the conservative myomectomy by laparotomny that laparoscopic accesses out of pregnancy was made, a course of complex rehabilitational therapy in the early and late postoperative period is conducted, the next and remote results are tracked. Results. Efficiency of pregravidarny training of patients with a hysteromyoma made 67.0%, thus authentically larger frequency of offensive of pregnancy is noted in group of the patients receiving in the postoperative period therapy by agonists of GNRG (73.0%), including at women with genesial problems (52.0%). Besides, purpose of agonists of GNRG after operation allows to reduce number of recurrence of a disease in the remote period. Conclusions. The advanced technique of pregravidarny preparation allows to improve the genesial forecast of women with hysteromyoma. Key words: hysteromyoma, pregravidarny preparation, optimization.


2011 ◽  
Vol 26 (6) ◽  
pp. 508-513 ◽  
Author(s):  
Patrícia Gomes da Silva ◽  
Daniele Cristina Cataneo ◽  
Fernanda Leite ◽  
Erica Nishida Hasimoto ◽  
Guilherme Antonio Moreira de Barros

PURPOSE: To compare analgesia traditionally used for thoracic sympathectomy to intrapleural ropivacaine injection in two different doses. METHODS: Twenty-four patients were divided into three similar groups, and all of them received intravenous dipyrone. Group A received intravenous tramadol and intrapleural injection of saline solution. Group B received intrapleural injection of 0.33% ropivacaine, and Group C 0.5% ropivacaine. The following aspects were analyzed: inspiratory capacity, respiratory rate and pain. Pain was evaluated in the immediate postoperative period by means of the visual analog scale and over a one-week period. RESULTS: In Groups A and B, reduced inspiratory capacity was observed in the postoperative period. In the first postoperative 12 hours, only 12.5% of the patients in Groups B and C showed intense pain as compared to 25% in Group A. In the subsequent week, only one patient in Group A showed mild pain while the remainder reported intense pain. In Group B, half of the patients showed intense pain, and in Group C, only one presented intense pain. CONCLUSION: Intrapleural analgesia with ropivacaine resulted in less pain in the late postoperative period with better analgesic outcomes in higher doses, providing a better ventilatory pattern.


2011 ◽  
Vol 2 (1) ◽  
pp. 54-56
Author(s):  
O P Sukhanova ◽  
T S Borondzhiyan ◽  
E V Minasyan

The purpose of the research was to determine morphological and urodynamic changes of supravesical urinary tract in patients after cystileoplastics. Methods. CT studies in the late postoperative period in 19 patients after radical cystectomy, combined with vesiculoprostatectomy and cystoileoplastics and malignant lesions of the bladder were performed. Results. None of cases revealed signs of continued growth. In 57% of the cases it was evidence of lymphadenopathy in the absence of negative dynamics of the underlying disease. No dependence of the state of anastomoses of the volume formed by the reservoir and the degree of shortening of the ureter was found. In assessing the state of supravesical urinary tract 11 from 19 (57,8%) patients were registered varying degrees of severity gidroureteronephrosis, and in 4 patients, pelvic ureteric reflux. All patients with urodynamic disorders identified "new bladder" had less volume than patients who did not have these disorders. Conclusion. CT study is the method of choice in the evaluation of supravesical urinary tract after cystoileoplastics for timely prevention of complications of an inflammatory process. It was revealed that the degree of changes in the urinary tract depending of the volume of the reservoir formed, requires further analysis.


2020 ◽  
Vol 34 (1) ◽  
pp. S91-S91
Author(s):  
Kyungho Park ◽  
Mee Yeon Park ◽  
Hyun Suk Lee ◽  
Junseok Jeon ◽  
Kyo Won Lee ◽  
...  

2003 ◽  
Vol 6 (3) ◽  
pp. 179-182 ◽  
Author(s):  
Yukio Kuniyoshi ◽  
Kageharu Koja ◽  
Kazufumi Miyagi ◽  
Mituyoshi Shimoji ◽  
Tooru Uezu ◽  
...  

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
O. G. Dudko

The paper presents the methodology of estimation of early and late outcome of polymeric osteosynthesis; basic criteria’s of estimation were determined and the score system was introduced. The experience of use of fixation devices made of polyamide-12 for osteosynthesis of limbs fractures in different location was analyzed. The peculiarities of clinical and X-ray picture were discribed. Appropriateness of CAT and MRI investigation in late postoperative period was substantiated. The suggested methodology may be used for estimation of osteosynthesis results with devices made of various metal alloys and other constructive materials.


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