Cord Blood Methylmercury and Fetal Growth Outcomes in Baltimore Newborns: Potential Confounding and Effect Modification by Omega-3 Fatty Acids, Selenium, and Sex

Background: Maternal nutrition plays a crucial role on influencing fetal growth and birth outcome. Any nutritional insult during critical periods of gestation is known to influence fetal development and increases the risk for development of diseases in later life. Omega 3 and omega 6 fatty acids have been studied to effect fetal growth and development. The balance between these two fatty acids have a definite effect on fetal growth and duration of gestation. Dietary intake of omega 3 fatty acids is less as compared to omega 6 fatty acids due to varied dietary sources.Methods: A study was conducted at a tertiary care hospital to study the pregnancy outcome in terms of neonatal birth weight and duration of gestation. A total of 200 patients were recruited into the study and divided into two groups by randomised alternative method. One group of 100 patients were supplemented with Omega 3 fatty acids and the other group was not supplemented. Both groups were followed till delivery and their duration of gestation and neonatal birth weight were studied and analysed.Results: The study showed that 78.8% patients supplemented with omega 3 fatty acids achieved neonatal birth weight more than 2.5Kg compared to 50% of patients who were not supplemented. No significant difference on duration of gestation was found in both the groups.Conclusions: Supplementation of Omega 3 fatty acids to patients in our study has shown to increase neonatal birth weight compared to patients who have not been supplemented, and did not show any significance in prolonging duration of gestation.

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Prevention of fetal growth restriction in pregnancy

Medical Council ◽

10.21518/2079-701x-2018-13-86-89 ◽

2018 ◽

pp. 86-89

Author(s):

N. A. Lomova ◽

Z. V. Khachatryan ◽

D. A. Mantrova ◽

A. A. Khachaturyan ◽

N. E. Kan ◽

...

Keyword(s):

Fatty Acids ◽

Fetal Growth ◽

Fetal Growth Restriction ◽

Growth Restriction ◽

Premature Delivery ◽

Daily Routine ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Smoking During Pregnancy ◽

Large Cities

Living in large cities, environmentally unfriendly background, smoking during pregnancy are associated with increasing number of complications, such as premature birth, intrauterine growth restriction, stillbirth and low birth weight. Pathogenetic mechanisms of these complications include oxidative stress, which can be combated by adding vitamin supplements with antioxidant activity to the daily routine of a pregnant woman. Smokers have a lower serum level of such important antioxidants as vitamins E, C and omega-3 fatty acids. The additional intake of vitamin complexes containing omega-3 fatty acids by pregnant women living in large megacities, adverse ecological regions and/or abusing smoking, has a preventive effect and can reduce the risk of premature delivery and fetal growth restriction among this cohort of patients.

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Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults

Yearbook of Anesthesiology and Pain Management ◽

10.1016/s1073-5437(08)71001-5 ◽

2008 ◽

Vol 2008 ◽

pp. 273-274

Author(s):

M.F. Roizen

Keyword(s):

Older Adults ◽

Fatty Acids ◽

Depressive Symptoms ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Omega 6

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Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000604 ◽

2019 ◽

pp. 1-7

Author(s):

Hadeer Zakaria ◽

Tarek M. Mostafa ◽

Gamal A. El-Azab ◽

Nagy AH Sayed-Ahmed

Keyword(s):

Fatty Acids ◽

Vitamin E ◽

Fish Oil ◽

Wheat Germ ◽

Hemodialysis Patients ◽

Nutritional Indices ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Wheat Germ Oil ◽

Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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