scholarly journals Neuropsychological assessment for detecting adverse effects of volatile organic compounds on the central nervous system.

1991 ◽  
Vol 95 ◽  
pp. 93-98 ◽  
Author(s):  
K I Bolla
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Volatile Organic Compounds ◽  
Adverse Effects ◽  
Organic Compounds ◽  
Neuropsychological Assessment ◽  
Volatile Organic ◽  
The Central Nervous System

Volatile Organic Compounds to Identify Infectious (Bacteria/Viruses) Diseases of the Central Nervous System - A Pilot Study

2019 ◽  
Author(s):  
Lei Guo ◽  
Zhongzhi Qiu ◽  
Yue Wang ◽  
Kaili Yu ◽  
Xiaoya Zheng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Volatile Organic Compounds ◽  
Ethylene Oxide ◽  
Organic Compounds ◽  
Solid Phase ◽  
Viral Meningitis ◽  
Gas Chromatography Mass Spectrometry ◽  
Volatile Organic ◽  
Potential Biomarkers

Abstract Background Central nervous system (CNS) infectious diseases are common diseases in emergency rooms and neurology departments. CNS pathogen identification methods are time-consuming and expensive and have low sensitivity and poor specificity. Some studies have shown that bacteria and viruses can produce specific volatile organic compounds (VOCs). The aim of this study is to find potential biomarkers by VOC analysis of cerebrospinal fluid (CSF) in patients with bacterial and viral meningitis/encephalitis (ME). Methods CSF samples from 16 patients with bacterial ME and 42 patients with viral ME were collected, and solid-phase microextraction (SPME) combined with gas chromatography-mass spectrometry (GC-MS) was used to analyze the metabolites in the CSF. Results There are two substances (Ethylene oxide and Phenol) that were found to be different between the two groups. Ethylene oxide was significantly greater in the group of bacterial ME patients than in the viral ME group of patients (P < 0.05). In addition, phenol was remarkably increased in the group of ME patients compared with the bacterial ME patients (P < 0.05). Conclusions Ethylene oxide and phenol may be potential biomarkers to distinguish bacterial ME and viral ME. VOC analysis of CSF may be used as a supporting tool for clinical diagnosis.

scholarly journals Volatile Organic Compounds to Identify Infectious (Bacteria/Viruses) Diseases of the Central Nervous System: A Pilot Study

2021 ◽  
pp. 1-8
Author(s):  
Lei Guo ◽  
Zhongzhi Qiu ◽  
Yue Wang ◽  
Kaili Yu ◽  
Xiaoya Zheng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Volatile Organic Compounds ◽  
Ethylene Oxide ◽  
Organic Compounds ◽  
Solid Phase ◽  
Viral Meningitis ◽  
Gas Chromatography Mass Spectrometry ◽  
Volatile Organic ◽  
Potential Biomarkers

<b><i>Background:</i></b> Central nervous system (CNS) infectious diseases are common diseases in emergency rooms and neurology departments. CNS pathogen identification methods are time consuming and expensive and have low sensitivity and poor specificity. Some studies have shown that bacteria and viruses can produce specific volatile organic compounds (VOCs). The aim of this study is to find potential biomarkers by VOC analysis of cerebrospinal fluid (CSF) in patients with bacterial and viral meningitis/encephalitis (ME). <b><i>Methods:</i></b> CSF samples from 16 patients with bacterial ME and 42 patients with viral ME were collected, and solid-phase microextraction combined with gas chromatography-mass spectrometry was used to analyze the metabolites in the CSF. <b><i>Results:</i></b> There are 2 substances (ethylene oxide and phenol) that were found to be different between the 2 groups. Ethylene oxide was significantly greater in the group of bacterial ME patients than in the viral ME group of patients (<i>p</i> &#x3c; 0.05). In addition, phenol was remarkably increased in the group of ME patients compared with the bacterial ME patients (<i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> Ethylene oxide and phenol may be potential biomarkers to distinguish bacterial ME and viral ME. VOC analysis of CSF may be used as a supporting tool for clinical diagnosis.

scholarly journals Anti-programmed cell death-1 (PD-1) monoclonal antibodies involve reversible cranial dura matter

2021 ◽  
Vol 2021 (9) ◽  
Author(s):  
Hiroshi Kataoka ◽  
Daisuke Shimada ◽  
Hitoki Nanaura ◽  
Kazuma Sugie
Keyword(s):  
Central Nervous System ◽  
Cell Death ◽  
Nervous System ◽  
Monoclonal Antibodies ◽  
Programmed Cell Death ◽  
Adverse Effects ◽  
Neuromuscular Disorders ◽  
Neurological Complications ◽  
Programmed Cell Death 1 ◽  
The Central Nervous System

ABSTRACT This case is the first document to describe a patient receiving anti-programmed cell death 1 (PD-1) antibodies which showed cranial dura matter involvement. According to the increasing use of anti-PD-1 monoclonal antibodies, adverse effects can occur in several organs since its ligand PD-L1 and PD-L2 are expressed in a wide variety of tissues. The estimated rate of neurological complications is 1–4.2% of patients, and neuromuscular disorders are the most common. Adverse effects on the central nervous system including encephalitis are less frequent. Here, a patient receiving anti-PD-1 antibodies showed cranial dura matter involvement, and the dura enhancement on MRI was resolved by withdrawal of the treatment with anti-PD-1 antibodies only.

Lanthanum chloride induces neuron damage by activating the nuclear factor-kappa B signaling pathway in activated microglia

Metallomics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1277-1287 ◽  
Author(s):  
Licheng Yan ◽  
Jinghua Yang ◽  
Miao Yu ◽  
Yanxin Lu ◽  
Liling Huang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rare Earth ◽  
Adverse Effects ◽  
Signaling Pathway ◽  
Earth Element ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Neuron Damage ◽  
The Central Nervous System

Lanthanum is a rare earth element which can have adverse effects on the central nervous system (CNS).

Ifosfamide-induced encephalopathy in a patient with metastatic fibrosarcoma

Oncoreview ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 0-0 ◽  
Author(s):  
Łukasz Galus
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adverse Effects ◽  
Toxic Effects ◽  
Cytostatic Drug ◽  
The Central Nervous System ◽  
The Common

Ifosfamide is a cytostatic drug commonly used in chemotherapy. One of the common adverse effects resulting from the treatment with ifosfamide is encephalopathy. This paper describes a case study of a 64-year-old patient who suffered from a full-blown encephalopathy as a result of chemotherapy administered during the treatment of fibrosarcoma of the femur. It provides a hypothesis of the mechanism behind toxic effects of ifosfamide on the central nervous system and elaborates on a number of documented ways of preventing aforementioned complications.

Transient Blindness following Hysteroscopy

2003 ◽  
Vol 31 (2) ◽  
pp. 152-155 ◽  
Author(s):  
A Karci ◽  
Y Erkin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adverse Effects ◽  
Inhibitory Effect ◽  
Retinal Cells ◽  
Hysteroscopic Myomectomy ◽  
Endoscopic Procedures ◽  
The Central Nervous System ◽  
Irrigation Solution

The potential adverse effects resulting from absorption of irrigation fluids during endoscopic procedures are well documented. Glycine, which is commonly used as an irrigation solution, has an inhibitory effect both on the central nervous system and on the retinal cells. We report the case of a woman who developed transient blindness following hysteroscopic myomectomy in which glycine was used as the irrigation solution.

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