Air Pollution and Biomarkers of Systemic Inflammation and Tissue Repair in COPD Patients

Aim. To evaluate the structural and functional changes in the lungs of ST elevation myocardial infarction (STEMI) patients with absence or presence of chronic obstructive lung disease (COPD), and the relation with myocardial dysfunction and systemic inflammation.Material and methods. Totally, 189 STEMI patients included: group 1 — STEMI with COPD of moderate and mild grade, 2 — STEMI with no lung pathology. Groups were comparable by clinical and anamnestic parameters. Assessment of lung function and blood collection were done at 1012 day of STEMI. For comparison of the parameters representing structural and functional changes in the lungs and comparison of Creactive protein (CRP), Nterminal probrain natriuretic peptide (NTproBNP) concentration, a control group was formed with no pulmonary pathology, comparable by age and sex with the STEMI patients.Results. In COPD patients, higher values revealed of the parameters representing the part of residual volumes in pulmonary structure. Higher residual volume (RV) was found also in STEMI and no COPD comparing to controls, however the relation RV/TLC (total lung capacity) was not higher than normal range. In both groups there were lower values of diffusion lung capacity (DLCO) comparing to controls. The lowest DLCO found in COPD patients. Concentration of NTproBNP (H=41,6; p<0,001) and CRP (H=38,6; p<0,001) in COPD was significantly higher in STEMI with no COPD patients than in controls. The negative correlations found for NTproBNP and CRP with forced expiratory volume 1 sec, FEV/FVC1, DLCO, and positive — with the values of thoracic volume, RV/TLC.Conclusion. In STEMI patients the increase revealed of residual lung volumes. Mostly the level of residual volumes is high in STEMI and COPD patients. There are associations of NTproBNP and CRP with structural and functional parameters of the lungs regardless of COPD.

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STUDY OF HS-CRP AND TNF-A LEVELS IN COPD PATIENTS ACCOMPANIED WITH CORONARY ARTERY DISEASE

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2014.4_5.6 ◽

2014 ◽

pp. 48-56

Author(s):

Van Thi Tran ◽

Van Bang Le ◽

Thị Thu Huong Hoang

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Systemic Inflammation ◽

Chronic Obstructive ◽

Low Grade ◽

Cross Sectional ◽

Copd Patients ◽

Coronary Artery Angiography ◽

Hs Crp ◽

Artery Disease

Aim: Some studies have linked the present of chronic obstructive oulmonary disease (COPD) to coronary artery disease (CAD). Low grade systemic inflammation occurs in patients with COPD as well as patients with CAD. This study was designed to find out the concentration differences of hs-CRP and TNF-a in patients having both chronic obstructive pulmonary and coronary artery diseases with those having either. Methods: A cross - sectional descriptive study was conducted in 200 patients undergoing a coronary artery angiography in the Heart Institute, Thong Nhat Hospital and 115 People Hospital. COPD was diagnosed using GOLD classification. Result: Our study had shown that the levels of hs-CRP and TNF-a were statistically increased in patients with COPD, CAD as well as in patients who had COPD with CAD (p<0,05). The levels of hs-CRP were higher in CAD than in COPD nad the levels of TNF-a were higher in COPD than in CAD. In patients with COPD and CAD, there were increased the levels of both hs-CRP and TNF-a in serum. Conclusion: Systemic inflammation presents in both COPD and CAD. Key words: hs-CRP, TNF-a, coronary artery disease (CAD).

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Systemic Inflammation (C-Reactive Protein) in Older Chinese Adults Is Associated with Long-Term Exposure to Ambient Air Pollution

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18063258 ◽

2021 ◽

Vol 18 (6) ◽

pp. 3258

Author(s):

Mona Elbarbary ◽

Artem Oganesyan ◽

Trenton Honda ◽

Geoffrey Morgan ◽

Yuming Guo ◽

...

Keyword(s):

Air Pollution ◽

Systemic Inflammation ◽

Ambient Air ◽

Ambient Air Pollution ◽

Chinese Adults ◽

Reactive Protein ◽

Hs Crp ◽

Older Chinese ◽

Older Chinese Adults

There is an established association between air pollution and cardiovascular disease (CVD), which is likely to be mediated by systemic inflammation. The present study evaluated links between long-term exposure to ambient air pollution and high-sensitivity C reactive protein (hs-CRP) in an older Chinese adult cohort (n = 7915) enrolled in the World Health Organization (WHO) study on global aging and adult health (SAGE) China Wave 1 in 2008–2010. Multilevel linear and logistic regression models were used to assess the associations of particulate matter (PM) and nitrogen dioxide (NO2) on log-transformed hs-CRP levels and odds ratios of CVD risk derived from CRP levels adjusted for confounders. A satellite-based spatial statistical model was applied to estimate the average community exposure to outdoor air pollutants (PM with an aerodynamic diameter of 10 μm or less (PM10), 2.5 μm or less (PM2.5), and 1 μm or less (PM1) and NO2) for each participant of the study. hs-CRP levels were drawn from dried blood spots of each participant. Each 10 μg/m3 increment in PM10, PM2.5, PM1, and NO2 was associated with 12.8% (95% confidence interval; (CI): 9.1, 16.6), 15.7% (95% CI: 10.9, 20.8), 10.2% (95% CI: 7.3, 13.2), and 11.8% (95% CI: 7.9, 15.8) higher serum levels of hs-CRP, respectively. Our findings suggest that air pollution may be an important factor in increasing systemic inflammation in older Chinese adults.

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Prolonged systemic inflammation and damage to the vascular endothelium following intratracheal instillation of air pollution nanoparticles in rats

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-180377 ◽

2019 ◽

Vol 72 (1) ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Rachel A. Adams ◽

Stephen Potter ◽

Kelly Bérubé ◽

Timothy P. Higgins ◽

Timothy P. Jones ◽

...

Keyword(s):

Air Pollution ◽

Systemic Inflammation ◽

Vascular Endothelium ◽

Intratracheal Instillation

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P2517Influence of air pollution exposure on systemic inflammation and enzymatic infarct size in patients with STEMI successfully treated with primary PCI

European Heart Journal ◽

10.1093/eurheartj/ehy565.p2517 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Author(s):

L Diaz-Chiron ◽

L Negral ◽

A Suarez ◽

I Pascual ◽

B Suarez-Pena ◽

...

Keyword(s):

Air Pollution ◽

Infarct Size ◽

Systemic Inflammation ◽

Primary Pci ◽

Air Pollution Exposure ◽

Pollution Exposure

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Suppressor of Variegation 3-9 Homologue 1 Impairment and Neutrophil-skewed Systemic Inflammation Are Associated with Comorbidities in COPD

10.21203/rs.3.rs-45674/v2 ◽

2020 ◽

Author(s):

Tzu-Tao Chen ◽

Sheng-Ming Wu ◽

Kuan-Yuan Chen ◽

Chien-Hua Tseng ◽

Shu-Chuan Ho ◽

...

Keyword(s):

Blood Cell ◽

Clinical Outcomes ◽

Systemic Inflammation ◽

Mononuclear Cells ◽

Chronic Obstructive ◽

Th2 Response ◽

Neutrophilic Inflammation ◽

Cell Counts ◽

Blood Cell Counts ◽

Copd Patients

Abstract BACKGROUND: Systemic manifestations and comorbidities are characteristics of chronic obstructive pulmonary disease (COPD) and are probably due to systemic inflammation. The histone methyltransferase SUV39H1 controls the Th1/Th2 balance. We previously reported that reduced SUV39H1 expression contributed to abnormal inflammation in COPD.METHODS: To assess whether impaired SUV39H1 expression in COPD patients leads to neutrophilic inflammation, downstream responses to IL-8 and suppression of Th2 responses, the SUV39H1 levels in peripheral blood mononuclear cells (PBMCs) from 13 healthy subjects and 30 COPD patients were measured by immunoblotting. Clinical outcomes associated with SUV39H1-related inflammation were also studied. The relationships between SUV39H1 and neutrophil or eosinophil (Th2 response) counts and clinical outcomes were evaluated. In an extended COPD cohort (213 patients), association analyses of blood cell counts with comorbidities and exacerbations were performed.RESULTS: Low SUV39H1 expression was associated with high neutrophil counts and a trend towards low eosinophil counts. In the extended cohort, the high comorbidity group had higher neutrophil counts than the low comorbidity group but similar whole white blood cell counts. The eosinophil percentage and eosinophil/neutrophil ratio displayed contrasting results. The proportion of neutrophils was correlated with COPD comorbidities. Patients with 0-1 moderate to severe exacerbations in the past year had numbers of neutrophils and eosinophils similar to those of patients who experienced more than an exacerbation. Finally, patients with high comorbidities had lower SUV39H1 levels in their PBMCs than did those with low comorbidities.CONCLUSION: Blood neutrophil counts are associated with comorbidities in COPD patients. Impaired SUV39H1 expression in PBMCs from COPD patients are correlated with neutrophilic inflammation and comorbidities.

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