STUDY OF HS-CRP AND TNF-A LEVELS IN COPD PATIENTS ACCOMPANIED WITH CORONARY ARTERY DISEASE

2014 ◽  
pp. 48-56
Author(s):  
Van Thi Tran ◽  
Van Bang Le ◽  
Thị Thu Huong Hoang
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
Chronic Obstructive ◽  
Low Grade ◽  
Cross Sectional ◽  
Copd Patients ◽  
Coronary Artery Angiography ◽  
Hs Crp ◽  
Artery Disease

Aim: Some studies have linked the present of chronic obstructive oulmonary disease (COPD) to coronary artery disease (CAD). Low grade systemic inflammation occurs in patients with COPD as well as patients with CAD. This study was designed to find out the concentration differences of hs-CRP and TNF-a in patients having both chronic obstructive pulmonary and coronary artery diseases with those having either. Methods: A cross - sectional descriptive study was conducted in 200 patients undergoing a coronary artery angiography in the Heart Institute, Thong Nhat Hospital and 115 People Hospital. COPD was diagnosed using GOLD classification. Result: Our study had shown that the levels of hs-CRP and TNF-a were statistically increased in patients with COPD, CAD as well as in patients who had COPD with CAD (p<0,05). The levels of hs-CRP were higher in CAD than in COPD nad the levels of TNF-a were higher in COPD than in CAD. In patients with COPD and CAD, there were increased the levels of both hs-CRP and TNF-a in serum. Conclusion: Systemic inflammation presents in both COPD and CAD. Key words: hs-CRP, TNF-a, coronary artery disease (CAD).

scholarly journals Low-Density Lipoprotein Triglycerides Associated With Low-Grade Systemic Inflammation, Adhesion Molecules, and Angiographic Coronary Artery Disease

Circulation ◽  
2004 ◽  
Vol 110 (19) ◽  
pp. 3068-3074 ◽  
Author(s):  
Winfried März ◽  
Hubert Scharnagl ◽  
Karl Winkler ◽  
Andreas Tiran ◽  
Markus Nauck ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Adhesion Molecules ◽  
Systemic Inflammation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Grade ◽  
Low Density ◽  
Artery Disease

scholarly journals Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ertuğrul Kurtoğlu ◽  
Hasan Korkmaz ◽  
Erdal Aktürk ◽  
Mücahid Yılmaz ◽  
Yakup Altaş ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Artery Disease ◽  
The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

scholarly journals Current symptom-based risk scores for stable coronary artery disease evaluation are not applicable in COPD patients

2020 ◽  
Vol 6 (4) ◽  
pp. 00492-2020
Author(s):  
Christoph Beyer ◽  
Alex Pizzini ◽  
Anna Boehm ◽  
Judith Loeffler-Ragg ◽  
Guenter Weiss ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Chest Pain ◽  
Coronary Artery ◽  
Symptom Onset ◽  
Invasive Coronary Angiography ◽  
Risk Scores ◽  
Control Group ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Artery Disease

BackgroundCardiovascular diseases are arguably the most important comorbidity in patients with COPD. Despite an increased prevalence of coronary artery disease (CAD) in COPD patients, there are no dedicated diagnostic recommendations.ObjectivesWe investigated whether COPD patients receive adequate primary evaluation of CAD despite overlapping symptoms.MethodsIn total, 302 patients with COPD who underwent invasive coronary angiography (ICA) were retrospectively matched (for age, body mass index and cardiovascular risk factors) with 302 patients without functional lung diseases. Quality and onset of symptoms prior to ICA were documented, and individual patients’ pretest probabilities according to European Society of Cardiology (ESC) guidelines were calculated. Endpoints were delay of ICA referral after symptom onset and clinical outcome, defined as subsequent revascularisation.ResultsMean delay between symptom onset and ICA was 19.9±22.0 months in COPD patients compared to 8.3±12.7 months in the control group (p<0.0001). COPD patients had a lower rate of typical chest pain (25.2% versus 38.1%, p=0.0009), and dyspnoea only (18.2% versus 26.8%, p=0.015). Sub-analysis of Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades revealed an incremental delay with increasing COPD severity: GOLD 1: 16.1±17.3 months; GOLD 2: 17.6±22.1 months; GOLD 3: 20.1±21.3 months; and GOLD 4: 24.2±23.4 months. Overall significant CAD prevalence (>70% stenosis) was 35.3%; the revascularisation rate increased with higher pretest probability for the control group but decreased for patients with COPD GOLD 1–4.ConclusionPatients with COPD are insufficiently evaluated for CAD due to overlapping symptoms. Current CAD risk scores for stable chest pain appear inappropriate for patients with COPD.

Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease

2013 ◽  
Vol 109 (05) ◽  
pp. 920-929 ◽  
Author(s):  
Sanne Larsen ◽  
Erik Grove ◽  
Steen Kristensen ◽  
Anne-Mette Hvas
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Antiplatelet Therapy ◽  
Platelet Activation ◽  
Platelet Reactivity ◽  
Low Grade ◽  
Serum Thromboxane ◽  
Hs Crp ◽  
Artery Disease ◽  
Low Grade Inflammation

SummaryInflammation has been proposed to modify platelet function. This may lead to increased platelet reactivity and reduced antiplatelet drug efficacy in patients with coronary artery disease (CAD). However, this hypothesis has not been investigated in stable CAD patients receiving aspirin as mono antiplatelet therapy. It was the objective of this study to investigate the association between platelet reactivity, the inflammatory markers high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6), and platelet activation. We performed a cross-sectional study on 524 stable high-risk CAD patients. Among these, 91% had a history of myocardial infarction, 23% had type 2 diabetes, and 13% had both. All patients received 75 mg aspirin daily as mono antiplatelet therapy. Platelet reactivity was assessed by multiple electrode aggregometry (Multiplate®, MEA) and VerifyNow®. Inflammation was evaluated by hs-CRP and IL-6. Platelet activation was assessed by soluble P-selectin (sP-selectin), and cyclooxygenase-1 inhibition was evaluated by measurement of serum thromboxane B2. Hs-CRP levels were significantly higher in upper platelet reactivity tertile patients than in lower platelet reactivity tertile patients (p≤0.02). Similar results were obtained with IL-6, though not statististically significant (p≥0.15). Platelet activation evaluated by sP-selectin was significantly higher in patients with MEA reactivity levels in the upper tertile than in the lower tertile (p=0.0001). Optimal compliance was confirmed by low serum thromboxane B2 levels in all patients. In conclusion, increased levels of hs-CRP were associated with augmented platelet reactivity in stable high-risk CAD patients receiving aspirin as mono antiplatelet therapy. These findings may suggest that chronic low-grade inflammation reduce the antiplatelet effect of aspirin.

scholarly journals The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: A Review

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1864 ◽  
Author(s):  
Alex Pizzini ◽  
Lukas Lunger ◽  
Thomas Sonnweber ◽  
Guenter Weiss ◽  
Ivan Tancevski
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Acute Phase Proteins ◽  
Current Knowledge ◽  
Decisive Role ◽  
Chronic Obstructive ◽  
Low Grade ◽  
Omega 3 ◽  
Artery Disease

Chronic obstructive pulmonary disease (COPD) is a growing healthcare concern and will represent the third leading cause of death worldwide within the next decade. COPD is the result of a complex interaction between environmental factors, especially cigarette smoking, air pollution, and genetic preconditions, which result in persistent inflammation of the airways. There is growing evidence that the chronic inflammatory state, measurable by increased levels of circulating cytokines, chemokines, and acute phase proteins, may not be confined to the lungs. Cardiovascular disease (CVD) and especially coronary artery disease (CAD) are common comorbidities of COPD, and low-grade systemic inflammation plays a decisive role in its pathogenesis. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert multiple functions in humans and are crucially involved in limiting and resolving inflammatory processes. n-3 PUFAs have been intensively studied for their ability to improve morbidity and mortality in patients with CVD and CAD. This review aims to summarize the current knowledge on the effects of n-3 PUFA on inflammation and its impact on CAD in COPD from a clinical perspective.

scholarly journals High Sensitive C-Reactive Protein (hs-CRP) and Its Correlation with Angiographic Severity of Patient with Coronary Artery Disease (CAD)

1970 ◽  
Vol 19 (2) ◽  
pp. 91-97 ◽  
Author(s):  
MA Hasnat ◽  
AEMM Islam ◽  
AW Chowdhury ◽  
HILR Khan ◽  
MZ Hossain
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Extent Score ◽  
Hs Crp ◽  
Artery Disease ◽  
Vessel Score

Background: Association between the plasma hs-CRP levels and the severity of coronary stenosis in subjects remains controversial. This cross sectional study was performed in the Department of Cardiology, Dhaka Medical College during July 2008 to December 2009, to determine whether the concentrations of hs-CRP correlate with the coronary atherosclerotic disease assessed by coronary angiography. Methods: For this purpose, a total number of 90 consecutive patients having IHD admitted in the Dhaka Medical College Hospitals were enrolled in this study. Patients were divided into three groups according to their level of hs-CRP. Out of 90 cases, 22(24.4%) patients were in group I, in group II 33(36.7%) patients and rest 35(38.9%) were in group III according to their hs-CRP level. Severity of CAD was assessed by vessel score, stenosis score and extent score. Result: Significant positive correlation (r=0.7409; p<0.001 r=0.6648; p<0.001 and r=0.6386; p<0.001) was found between hs-CRP and vessel score, stenosis score and hs-CRP and extent score suggesting increasing level of hs-CRP strongly suggestive of extensive coronary artery disease. Conclusion: High level of hs-CRP strongly suggestive of extensive coronary artery disease Key words: hs-CRP; angiogram; coronary artery disease; vessel score; stenosis score and extent score. DOI: 10.3329/jdmc.v19i2.7076J Dhaka Med Coll. 2010; 19(2) : 91-97

scholarly journals A Cross-sectional Comparative Study of hs-CRP Levels between Non Diabetic and Diabetic Patients of Chronic Obstructive Pulmonary Disease

2021 ◽  
Author(s):  
Rajesh Sahu ◽  
Ratan Kumar ◽  
Jusmita Dutta ◽  
Gayatri Yadav
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Systemic Inflammation ◽  
Diabetic Group ◽  
Airflow Limitation ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Hs Crp

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is characterised by persistent airflow limitation and is a global health issue with high social and economic burden. Type 2 Diabetes Mellitus (T2DM) is a major global metabolic disorder affecting approximately 300 million individuals worldwide. Accordingly, chronic low grade systemic inflammation is probably one of the common denominators between COPD and T2DM. Aim: To evaluate the status of systemic inflammation in COPD patient with/without T2DM, using quantitative serum high sensitivity C-Reactive Protein (hs-CRP) and Total Leucocyte Count (TLC). Materials and Methods: This cross-sectional study was conducted for a period of one year from May 2019 to April 2020 on 100 patients of COPD patients attending outpatient department. Either known patients of COPD or patients with complains of chronic cough was evaluated with chest x-ray and pulmonary function test (spirometry) after thorough history and physical examination. Global Initiative for Chronic Obstructive Lung Disease-GOLD guidelines a grading system for COPD was used for assessing severity. For assessing diabetes, criteria adopted from American Diabetes Association (ADA) i.e., symptoms of diabetes plus random plasma glucose >200 mg/dL (11.1 mMol/L). Venous blood samples were obtained to perform quantitative hs-CRP estimation by immune turbidimetry method as a marker of systemic inflammation. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) version 26.0 of International Business Machines (IBM) Corporation, California, United States of America (USA). Results: The T2DM was present in 40% COPD patients. The frequencies of T2DM in patients with GOLD stages I, II, III, and IV were 16%, 45%, 28%, and 11%, respectively. The mean hs-CRP levels for diabetic group was 5.45±1.07 mg/L, which was significantly higher (p<0.05) than 2.26±0.69 mg/L that of non diabetic group. Conclusion: Present study concluded that the inflammatory process is a definite pathophysiological factor that has a significant link between COPD and T2DM and can be evaluated using a marker like hs-CRP level and TLC.

Influence of Comorbidities on Hospital Mortality and Healthcare Utilization in Hospitalized Chronic Obstructive Pulmonary Disease Patients

2020 ◽  
Vol 103 (7) ◽  
Keyword(s):  
Atrial Fibrillation ◽  
Chronic Obstructive Pulmonary Disease ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Hospital Mortality ◽  
Healthcare Utilization ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Artery Disease

Background: Comorbidities of chronic obstructive pulmonary disease (COPD) are associated with both increased short-term and long-term mortality. However, information on regarding the influence of comorbidities on hospital mortality and healthcare utilization remain limited. Objective: To evaluate the influence of COPD and comorbidities associated with increased risk of hospital mortality and healthcare utilization. Materials and Methods: A retrospective cohort study was performed on COPD patients admitted to the Chiang Mai University Hospital between 2007 and 2013. Logistic regression was performed to identify independent comorbidities that increased the risk of hospital mortality and influenced healthcare utilization. Results: The present study involved 739 COPD patients with 1,099 visits. The hospital mortality rate was 12.3%. The comorbidities associated with increased hospital mortality were depression (odds ratio [OR] 8.61, 95% confidence interval [CI] 1.66 to 43.95, p=0.010), atrial fibrillation (OR 2.37, 95% CI 1.33 to 4.21, p=0.003), and coronary artery disease (OR 1.85, 95% CI 1.03 to 3.32, p=0.04). The comorbidities were also associated with increased hospital length of stay [7 (3 to 12) versus 5 (3 to 8) days, p=0.001], mechanical ventilation days [5 (2 to 13) versus 3 (2 to 6) days, p=0.029], and total hospital costs [915.1 (401.2 to 2,258.4) versus 562.1 (338.1 to 1,372.9) USD, p=0.010]. In addition, comorbidities were associated with increased hospital mortality (one and two comorbidities: OR 2.06, 95% CI 1.24 to 3.43, p=0.005 and OR 5.47, 95% CI 2.07 to 14.47, p=0.001, respectively). Conclusion: The COPD comorbidities, which are depression, atrial fibrillation, and coronary artery disease, were associated with increased hospital mortality and healthcare utilization. Keywords: COPD, Comorbidity, Mortality, Healthcare utilization

The Role of Epicardial Adipose Tissue Lymphocytes in Low-Grade Inflammation and Coronary Artery Disease

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 469-P
Author(s):  
MILOS MRAZ ◽  
ANNA CINKAJZLOVA ◽  
ZDENA LACINOVÁ ◽  
JANA KLOUCKOVA ◽  
HELENA KRATOCHVILOVA ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Epicardial Adipose Tissue ◽  
Low Grade ◽  
Artery Disease ◽  
Low Grade Inflammation
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