scholarly journals Takotsubo Cardiomyopathy Due to Combined Use of Phentermine and Lisdexamfetamine

2020 ◽  
Author(s):  
Tara Burleigh ◽  
Khandalavala Birgit
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Report ◽  
Left Ventricular ◽  
Ventricular Wall ◽  
Takotsubo Syndrome ◽  
Coronary Syndrome ◽  
First Case ◽  
Combined Use ◽  
Menopausal Women ◽  
Post Menopausal

Objectives: This is the first case report of iatrogenic Takotsubo syndrome (TS) due to a combination of lisdexamfetamine and phentermine. Background: TS is characterized by transient acute ballooning of the left ventricular wall. Typically, it occurs in extremely stressed post-menopausal women, however a few iatrogenic causes have been described recently. Results: A 55-year old woman prescribed lisdexamfetamine and phentermine, presented with acute substernal chest pain. Acute coronary syndrome was excluded. The echocardiogram was diagnostic of TS, and she recovered spontaneously, with supportive care. Conclusion: Caution with the use of sympathomimetic medications in post-menopausal women appears warranted.

Takotsubo cardiomyopathy associated with adrenal insufficiency in the context of long-term steroid use mimicking acute coronary syndrome

2021 ◽  
Vol 14 (1) ◽  
pp. e234983
Author(s):  
Timothy Bagnall ◽  
Ying Ran Tow ◽  
Nicholas Bunce ◽  
Zoe Astroulakis
Keyword(s):  
Acute Coronary Syndrome ◽  
Adrenal Insufficiency ◽  
Takotsubo Cardiomyopathy ◽  
Left Ventricular ◽  
Lv Function ◽  
Rapid Improvement ◽  
Steroid Use ◽  
Coronary Syndrome ◽  
First Case

Takotsubo cardiomyopathy (TCMP) is an important, though under-recognised, syndrome which mimics acute coronary syndrome (ACS) presenting with similar clinical, biochemical and ECG features. A 68-year-old man was referred as ACS for emergency coronary angiography; however, a history of lethargy, weight loss and electrolyte abnormalities prompted further investigations. Angiography was postponed, adrenal insufficiency confirmed and steroid replacement commenced. Echocardiography demonstrated reduced left ventricular (LV) function (45%) with regional wall motion abnormalities, although angiography confirmed unobstructed arteries. Steroid replacement induced a rapid improvement in symptoms and LV function. Few cases of TCMP associated with adrenal insufficiency have been reported. This appears to be the first case describing TCMP precipitated by new-onset secondary adrenal insufficiency following long-term steroid use in a male patient, and highlights the importance of considering TCMP in patients presenting with suspected ACS. Here, prompt recognition and treatment of a serious underlying disorder prevented a potentially life-threatening Addisonian crisis.

scholarly journals Takotsubo Syndrome: A Review of Presentation, Diagnosis and Management

2022 ◽  
Vol 16 ◽  
pp. 117954682110657
Author(s):  
Joseph Assad ◽  
Giuseppe Femia ◽  
Patrick Pender ◽  
Tamer Badie ◽  
Rohan Rajaratnam
Keyword(s):  
Myocardial Stunning ◽  
Ventricular Dysfunction ◽  
Clinical Presentation ◽  
Treatment Options ◽  
Left Ventricular ◽  
Current Evidence ◽  
Takotsubo Syndrome ◽  
Diagnostic Strategies ◽  
Coronary Syndrome ◽  
Post Menopausal

Takotsubo Syndrome (TTS) is a condition of transient left ventricular dysfunction that is typically triggered by emotional or physical stress. Since first described in Japan in 1990, it has increasingly been recognised in clinical practice, accounting for up to 2% of Acute Coronary Syndrome (ACS) presentations. In fact, the clinical presentation can be indistinguishable from a myocardial infarction. Although current evidence suggests a catecholamine induced myocardial stunning, the pathophysiological mechanisms remain unknown. Interestingly, it is more common in woman, particularly those who are post-menopausal. This review aims to summarise the current research and provide an overview of the diagnostic strategies and treatment options.

scholarly journals Takotsubo syndrome in a young woman during puerperium: case report

2015 ◽  
Vol 76 (2) ◽  
Author(s):  
Mariantonietta D’Agostino ◽  
Francesco Giallauria ◽  
Caterina Montuori ◽  
Francesca Farina ◽  
Luigi Maresca ◽  
...  
Keyword(s):  
Case Report ◽  
Left Ventricle ◽  
Young Woman ◽  
Apical Segment ◽  
Takotsubo Syndrome ◽  
Thoracic Pain ◽  
Case Presentation ◽  
Menopausal Women ◽  
Post Menopausal

Introduction. Takotsubo syndrome is a reversibile cardiomyopathy that often occurs during an emotional stress and is more frequent in post-menopausal women. Case presentation. We describe a clinic case of a 42 years old woman, admitted to our emergency unit because of a thoracic pain. The ECG showed ST-T elevation in V1- V4, the echocardiography revealed akinesia of apical segment of left ventricle. Coronary arteries were free from significant stenosis and ventriculography showed akinesia of apical segment of left ventricle. In the following days, ECG evolved toward a normalization of ST-T segment with appearance of negative T wave in V2-V6, and also the echocardiography showed a normalized LV wall motion. The patient was discharged and ECG and echocardiography were normal at two months follow up. Conclusion. In this case report, a young woman during puerperium presented with a Takotsubo syndrome. We speculate that the high Prolactin level and her emotional state contributed to the clinical manifestation of the syndrome.

Left ventricular apical ballooning—A novel cardiac disease mimicking acute coronary syndrome: A case report in a Caucasian patient

2006 ◽  
Vol 106 (3) ◽  
pp. 398-400 ◽  
Author(s):  
Johann Auer ◽  
Michael Porodko ◽  
Robert Berent ◽  
Christian Punzengruber ◽  
Thomas Weber ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Report ◽  
Cardiac Disease ◽  
Apical Ballooning ◽  
Left Ventricular ◽  
Caucasian Patient ◽  
Coronary Syndrome

scholarly journals Comparison of risk profile in pre-menopausal and post-menopausal women with acute coronary syndrome

2020 ◽  
Vol 8 (5) ◽  
pp. 1612
Author(s):  
Sandeep Chhabra ◽  
Harmeet Pal S. Dhooria ◽  
Avantika Garg ◽  
Gurdeep S. Dhooria
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Acute Coronary Syndrome ◽  
Risk Factor ◽  
Physical Inactivity ◽  
Risk Factor Profile ◽  
Coronary Syndrome ◽  
Menopausal Women ◽  
Significant Difference ◽  
Post Menopausal

Background: The physiological changes associated with menopause are responsible for increase in cardiovascular disease after menopause. BMI, physical inactivity, metabolic syndrome, hypertension and diabetes mellitus increase in post-menopausal women which are all powerful predictors of cardiovascular events. The risk factor profile between pre-menopausal and post-menopausal women presenting with acute coronary syndrome was thus studied.Methods: This study was a prospective cross-sectional hospital based study and was conducted in the Department of Medicine and Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana wherein 50 pre-menopausal women and 50 post- menopausal women who presented with acute coronary syndrome were enrolled. The risk factor profile and angiography findings amongst the 2 groups were compared.Results: There was no difference in the incidence of Diabetes Mellitus and Hypertension among the pre & post-menopausal groups. The prevalence of family history of cardiovascular disease was higher in the pre-menopausal group. The post-menopausal women showed a significant decrease in physical activity due to sedentary lifestyle. Both the groups had high BMI and increased waist circumference. Lipid parameters did not show any significant difference between the two groups. However, pre-menopausal women had higher LDL-C and triglyceride levels and lower HDL-C levels. On analysis of the angiographic findings in diabetics and non-diabetics, of both the groups diabetes mellitus was much higher in subjects presenting with triple vessel disease suggesting extensive atherosclerosis.Conclusions: study showed physical inactivity as an important cardiovascular risk factor in post-menopausal women. Obesity is an important risk factor for coronary artery disease in both pre- and post-menopausal women.

Takotsubo syndrome and acute coronary syndrome: case report and literature review

2014 ◽  
Author(s):  
Serpil Yaylaci ◽  
Tuba Cimilli Ozturk ◽  
Mustafa Serinken ◽  
Cenker Eken ◽  
Ozgur Karcioglu
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Report ◽  
Literature Review ◽  
Takotsubo Syndrome ◽  
Coronary Syndrome

scholarly journals Tako-Tsubo Cardiomyopathy in a Patient with Advanced Colorectal Adenocarcinoma

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Yusuf Kasirye ◽  
Ihab B. Abdalrahman
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Report ◽  
Colorectal Adenocarcinoma ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Advanced Malignancy ◽  
Coronary Syndrome ◽  
Triggering Factors ◽  
Tako Tsubo Cardiomyopathy ◽  
Postmenopausal Female

Transient left ventricular dysfunction syndrome (TLVDS), or Tako-Tsubo cardiomyopathy (TC), is a clinical entity in which patients present with features of acute coronary syndrome, electrocardiogram abnormalities, and transient left ventricular (apical or mid-ventricular) dysfunction. Patients usually recover from this condition four to six weeks after the event. The etiology or triggering factors of TC remains unknown. Various triggering factors have been associated with this syndrome, with one of the most recent being malignancies. In this case report we present a postmenopausal female with underlying advanced malignancy who presented with TC. This is consistent with a recent hypothesis that in addition to currently known triggering factors, malignancies might well trigger TC in the context of a stressor or paraneoplastic phenomenon.

scholarly journals Complete Heart Block Complicating Takotsubo Syndrome: Case Report and Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Michael J. McGee ◽  
William Yu ◽  
Joshua McCarthy ◽  
Malcolm Barlow ◽  
Rosemary Hackworthy
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Report ◽  
Heart Block ◽  
Complete Heart Block ◽  
Final Diagnosis ◽  
Takotsubo Syndrome ◽  
Shortness Of Breath ◽  
Coronary Angiogram ◽  
Coronary Syndrome ◽  
Pacemaker Insertion

An 81-year-old woman presents with shortness of breath resulting in a diagnosis of picornavirus and complete heart block. Troponin was elevated and there was concern about acute coronary syndrome. The final diagnosis after echocardiogram and coronary angiogram was Takotsubo syndrome in addition to the heart block which required pacemaker insertion.

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