Comparison of risk profile in pre-menopausal and post-menopausal women with acute coronary syndrome

Background: The physiological changes associated with menopause are responsible for increase in cardiovascular disease after menopause. BMI, physical inactivity, metabolic syndrome, hypertension and diabetes mellitus increase in post-menopausal women which are all powerful predictors of cardiovascular events. The risk factor profile between pre-menopausal and post-menopausal women presenting with acute coronary syndrome was thus studied.Methods: This study was a prospective cross-sectional hospital based study and was conducted in the Department of Medicine and Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana wherein 50 pre-menopausal women and 50 post- menopausal women who presented with acute coronary syndrome were enrolled. The risk factor profile and angiography findings amongst the 2 groups were compared.Results: There was no difference in the incidence of Diabetes Mellitus and Hypertension among the pre & post-menopausal groups. The prevalence of family history of cardiovascular disease was higher in the pre-menopausal group. The post-menopausal women showed a significant decrease in physical activity due to sedentary lifestyle. Both the groups had high BMI and increased waist circumference. Lipid parameters did not show any significant difference between the two groups. However, pre-menopausal women had higher LDL-C and triglyceride levels and lower HDL-C levels. On analysis of the angiographic findings in diabetics and non-diabetics, of both the groups diabetes mellitus was much higher in subjects presenting with triple vessel disease suggesting extensive atherosclerosis.Conclusions: study showed physical inactivity as an important cardiovascular risk factor in post-menopausal women. Obesity is an important risk factor for coronary artery disease in both pre- and post-menopausal women.

Download Full-text

Takotsubo Cardiomyopathy Due to Combined Use of Phentermine and Lisdexamfetamine

European Journal of Case Reports in Internal Medicine ◽

10.12890/2020_001595 ◽

2020 ◽

Author(s):

Tara Burleigh ◽

Khandalavala Birgit

Keyword(s):

Acute Coronary Syndrome ◽

Case Report ◽

Left Ventricular ◽

Ventricular Wall ◽

Takotsubo Syndrome ◽

Coronary Syndrome ◽

First Case ◽

Combined Use ◽

Menopausal Women ◽

Post Menopausal

Objectives: This is the first case report of iatrogenic Takotsubo syndrome (TS) due to a combination of lisdexamfetamine and phentermine. Background: TS is characterized by transient acute ballooning of the left ventricular wall. Typically, it occurs in extremely stressed post-menopausal women, however a few iatrogenic causes have been described recently. Results: A 55-year old woman prescribed lisdexamfetamine and phentermine, presented with acute substernal chest pain. Acute coronary syndrome was excluded. The echocardiogram was diagnostic of TS, and she recovered spontaneously, with supportive care. Conclusion: Caution with the use of sympathomimetic medications in post-menopausal women appears warranted.

Download Full-text

TCTAP A-038 Is Diabetes Mellitus a Second High-risk Factor in Acute Coronary Syndrome Patients

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2017.03.064 ◽

2017 ◽

Vol 69 (16) ◽

pp. S19

Author(s):

Janaswamy Vibhav Sri Narayana ◽

Maddury Jyotsna

Keyword(s):

Diabetes Mellitus ◽

Acute Coronary Syndrome ◽

Risk Factor ◽

High Risk ◽

Coronary Syndrome ◽

High Risk Factor

Download Full-text

Impact of Age on Risk Factors and Clinical Manifestations of Acute Coronary Syndrome: Observations From the Coronary Care Unit of Sulaimani, Iraq

Hospital Practices and Research ◽

10.34172/hpr.2020.06 ◽

2020 ◽

Vol 5 (1) ◽

pp. 28-34

Author(s):

Amanj Abubakr Jalal Khaznadar ◽

Rebin Wahid Salh

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Acute Coronary Syndrome ◽

Physical Inactivity ◽

Coronary Care Unit ◽

St Segment Elevation ◽

Atypical Symptoms ◽

Coronary Syndrome ◽

St Segment ◽

Coronary Care

Background: ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI ) are common types of acute coronary syndrome which are associated with the risk factors of age, obesity, hypertension, and diabetes. Objective: The present study aimed to examine the effects of age on the risk factors and clinical symptoms of acute coronary syndrome. Methods: A cross-section prospective study was conducted on 125 patients with acute coronary syndrome chosen by non-probability convenience sampling method in the coronary care unit in Sulaimani, the Kurdistan region of Iraq. Acute coronary syndrome types were diagnosed through clinical presentations, electrocardiography (ECG), and troponin test. Data was collected using a researcherbased checklist through face-to-face interviews. Results: The results indicated that males were the dominant group. The age group 45-65 had the highest prevalence rate of acute coronary syndrome. The most frequent risk factors for acute coronary syndrome were hypertension (54.4%), dyslipidemia (52%), smoking (42.4%), and diabetes mellitus (38.4%). Typical chest pain was found to be the most frequent clinical presentation (88%). There was a significant difference between the age groups in terms of the effect of age on typical and atypical symptoms; however, neither age nor typical/atypical symptoms had a significant effect on type of acute coronary syndrome. Similarly, family history, hypertension, diabetes mellitus, obesity, smoking, physical inactivity, and dyslipidemia had no effect on type of acute coronary syndrome. Conclusion: Age is a predictive factor for acute coronary syndrome, but family history, hypertension, diabetes mellitus, obesity, smoking, physical inactivity, and dyslipidemia cannot predict acute coronary syndrome.

Download Full-text