scholarly journals Hypertension Accelerates Diabetic Nephropathy in Wistar Fatty Rats, a Model of Type 2 Diabetes Mellitus, via Mitogen-Activated Protein Kinase Cascades and Transforming Growth Factor-.BETA.1

2003 ◽  
Vol 26 (4) ◽  
pp. 339-347 ◽  
Author(s):  
Goro IMAI ◽  
Takeo SATOH ◽  
Toshio KUMAI ◽  
Mei MURAO ◽  
Hiroki TSUCHIDA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Growth Factor Beta

scholarly journals The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Karina Braga Gomes ◽  
Kathryna Fontana Rodrigues ◽  
Ana Paula Fernandes
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Inflammatory Responses ◽  
Low Grade ◽  
Anti Inflammatory

Several studies have demonstrated that chronic and low-grade inflammation is closely linked to type 2 diabetes mellitus. The associated mechanisms are related to synthesis and release of proinflammatory and anti-inflammatory cytokines, mainly by the adipose tissue. Moreover, there are evidences that cytokines and adhesion molecules are important for development of diabetic nephropathy. Among the cytokines associated with inflammatory responses in type 2 diabetes mellitus, the transforming growth factor-β (TGF-β) has been recognized as a central player in the diabetic nephropathy being involved in the development of glomerulosclerosis and interstitial fibrosis, as observed in the course of end-stage renal disease. Although TGF-β1 is classically an anti-inflammatory immune mediator it has been shown that in the presence of IL-6, which increases before the onset of T2D, TGF-β1 favors the differentiation of T helper 17 (Th17) cells that are activated in many pro-inflammatory conditions. Since TGF-β1 mRNA and consequently serum TGF-β1 levels are under genetic control, this review aims to discuss the relationship of TGF-β1 levels and polymorphisms in the development of nephropathy in type 2 diabetes mellitus.

scholarly journals Changes of transforming growth factor beta 1 in patients with type 2 diabetes and diabetic nephropathy

Medicine ◽  
2017 ◽  
Vol 96 (15) ◽  
pp. e6583 ◽  
Author(s):  
Yong-Chao Qiao ◽  
Yin-Ling Chen ◽  
Yan-Hong Pan ◽  
Wei Ling ◽  
Fang Tian ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Growth Factor Beta
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