STABILITY EVALUATION OF CAFFEINE-8-THIOGLICOLIC ACID AMIDES, WITH DETERMINED ANTIHYPOXIC EFFECTS
Keyword(s):
This study evaluates a series of caffeine-8-thioglycolic acid amides that were synthesized in the study, for signs of possible degradation. The chemical stability of the test compounds was examined under different conditions of pH and temperature over time. A modified reversed phase-high-performance liquid chromatography method was applied to determine stability and identify possible degradation products. The study identified a new product from oxidative destruction of the test compound through controlled synthesis.
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