scholarly journals Cerebellar foliation via non-uniform cell accumulation caused by fiber-guided migration of granular cells

2021 ◽  
Author(s):  
Hironori TAKEDA ◽  
Yoshitaka KAMEO ◽  
Takahiro YAMAGUCHI ◽  
Kazunori NAKAJIMA ◽  
Taiji ADACHI
Keyword(s):  
Granular Cells ◽  
Cell Accumulation

The structure of the gills of the axolotl, Ambystoma mexicanum

1987 ◽  
Vol 45 ◽  
pp. 824-825
Author(s):  
Mohinder S. Jarial
Keyword(s):  
Leydig Cells ◽  
Secretory Granules ◽  
Light And Electron Microscopy ◽  
Cell Types ◽  
Ambystoma Mexicanum ◽  
Basal Cells ◽  
Granular Cells ◽  
Gill Filaments ◽  
Mitotic Figures ◽  
Apical Membranes

The axolotl is a strictly aquatic salamander in which the larval external gills are retained throughout life. The external gills of the adult axolotl have been studied by light and electron microscopy for ultrastructural evidence of ionic transport. The thin epidermis of the gill filaments and gill stems is composed of 3 cell types: granular cells, the basal cells and a sparce population of intervening Leydig cells. The gill epidermis is devoid of muscles, and no mitotic figures were observed in any of its cells.The granular cells cover the gill surface as a continuous layer (Fig. 1, G) and contain secretory granules of different forms, located apically (Figs.1, 2, SG). Some granules are found intimately associated with the apical membrane while others fuse with it and release their contents onto the external surface (Fig. 3). The apical membranes of the granular cells exhibit microvilli which are covered by a PAS+ fuzzy coat, termed “glycocalyx” (Fig. 2, MV).

Factors inducing mast cell accumulation in skeletal muscle

1996 ◽  
Vol 22 (3) ◽  
pp. 248-255 ◽  
Author(s):  
J.-P. Lefauch eur ◽  
B. Gjata ◽  
A. Sebille
Keyword(s):  
Skeletal Muscle ◽  
Mast Cell ◽  
Cell Accumulation

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation Through Direct Regulation of IL-21

2019 ◽  
Author(s):  
William J. Olson ◽  
Bojana Jakic ◽  
Verena Labi ◽  
Katia Schöler ◽  
Michaela Kind ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Helper Cell ◽  
Orphan Nuclear Receptor ◽  
Follicular Helper ◽  
Cell Accumulation ◽  
T Follicular Helper Cell ◽  
Direct Regulation

Adrenomedullin Stimulates Renin Release and Renin mRNA in Mouse Juxtaglomerular Granular Cells

Hypertension ◽  
1997 ◽  
Vol 29 (5) ◽  
pp. 1148-1155 ◽  
Author(s):  
Boye L. Jensen ◽  
Bernhard K. Krämer ◽  
Armin Kurtz
Keyword(s):  
Renin Release ◽  
Granular Cells ◽  
Renin Mrna

scholarly journals CXCL16 Stimulates Antigen-Induced MAIT Cell Accumulation but Trafficking During Lung Infection Is CXCR6-Independent

2020 ◽  
Vol 11 ◽  
Author(s):  
Huifeng Yu ◽  
Amy Yang ◽  
Ligong Liu ◽  
Jeffrey Y. W. Mak ◽  
David P. Fairlie ◽  
...  
Keyword(s):  
Lung Infection ◽  
Cell Accumulation ◽  
Mait Cell

scholarly journals sFasL—The Key to a Riddle: Immune Responses in Aging Lung and Disease

2021 ◽  
Vol 22 (4) ◽  
pp. 2177
Author(s):  
Shulamit B. Wallach-Dayan ◽  
Dmytro Petukhov ◽  
Ronit Ahdut-HaCohen ◽  
Mark Richter-Dayan ◽  
Raphael Breuer
Keyword(s):  
Cell Death ◽  
Lung Disease ◽  
Fas Ligand ◽  
Death Receptor ◽  
Mesenchymal Cells ◽  
Soluble Form ◽  
Cell Accumulation ◽  
Key Factor ◽  
Aged Subjects

By dint of the aging population and further deepened with the Covid-19 pandemic, lung disease has turned out to be a major cause of worldwide morbidity and mortality. The condition is exacerbated when the immune system further attacks the healthy, rather than the diseased, tissue within the lung. Governed by unremittingly proliferating mesenchymal cells and increased collagen deposition, if inflammation persists, as frequently occurs in aging lungs, the tissue develops tumors and/or turns into scars (fibrosis), with limited regenerative capacity and organ failure. Fas ligand (FasL, a ligand of the Fas cell death receptor) is a key factor in the regulation of these processes. FasL is primarily found in two forms: full length (membrane, or mFasL) and cleaved (soluble, or sFasL). We and others found that T-cells expressing the mFasL retain autoimmune surveillance that controls mesenchymal, as well as tumor cell accumulation following an inflammatory response. However, mesenchymal cells from fibrotic lungs, tumor cells, or cells from immune-privileged sites, resist FasL+ T-cell-induced cell death. The mechanisms involved are a counterattack of immune cells by FasL, by releasing a soluble form of FasL that competes with the membrane version, and inhibits their cell death, promoting cell survival. This review focuses on understanding the previously unrecognized role of FasL, and in particular its soluble form, sFasL, in the serum of aged subjects, and its association with the evolution of lung disease, paving the way to new methods of diagnosis and treatment.

Sign in / Sign up

Export Citation Format

Share Document