114 Effect of Collagen Matrix on Bone Strength Properties

2006 ◽  
Vol 2006.45 (0) ◽  
pp. 27-28
Author(s):  
Masahiro TODOH ◽  
Shigeru TADANO ◽  
Yusuke IMARI
Keyword(s):  
Bone Strength ◽  
Collagen Matrix ◽  
Strength Properties

scholarly journals Optimal bone mechanical and material properties require a functional glucagon-like peptide-1 receptor

2013 ◽  
Vol 219 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Guillaume Mabilleau ◽  
Aleksandra Mieczkowska ◽  
Nigel Irwin ◽  
Peter R Flatt ◽  
Daniel Chappard
Keyword(s):  
Bone Strength ◽  
Material Properties ◽  
Gastrointestinal Hormones ◽  
Gut Hormones ◽  
Collagen Matrix ◽  
Outer Diameter ◽  
Three Point Bending ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Positive Effect

Bone is permanently remodeled by a complex network of local, hormonal, and neuronal factors that affect osteoclast and osteoblast biology. Among these factors, a role for gastrointestinal hormones has been proposed based on the evidence that bone resorption dramatically falls after a meal. Glucagon-like peptide-1 (GLP1) is one of these gut hormones, and despite several reports suggesting an anabolic effect of GLP1, or its stable analogs, on bone mass, little is known about the effects of GLP1/GLP1 receptor on bone strength. In this study, we investigated by three-point bending, quantitative X-ray microradiography, microcomputed tomography, qBEI, and FTIRI bone strength and bone quality in male Glp1r knockout (Glp1r KO) mice when compared with control WT animals. Animals with a deletion of Glp1r presented with a significant reduction in ultimate load, yield load, stiffness, and total absorbed and post-yield energies when compared with WT animals. Furthermore, cortical thickness and bone outer diameter were significantly decreased in deficient animals. The mineral quantity and quality were not significantly different between Glp1r KO and WT animals. On the other hand, the maturity of the collagen matrix was significantly reduced in deficient animals and associated with lowered material properties. Taken together, these data support a positive effect of GLP1R on bone strength and quality.

scholarly journals Factors of radial bone strength after marginal defect formation

2021 ◽  
Vol 27 (2) ◽  
pp. 187-198
Author(s):  
N.M. Aleksandrov ◽  
◽  
V.D. Veshutkin ◽  
A.E. Zhukov ◽  
I.D. Veshaev ◽  
...  
Keyword(s):  
Bone Strength ◽  
Defect Formation ◽  
Strength Properties ◽  
Affecting Factors ◽  
The Finite Element Method ◽  
Calculation Methods ◽  
Strain Behaviour ◽  
Intact Bone ◽  
Normal Strength ◽  
Radial Bone

Purpose To determine the effect of biometrical parameters of the radial bone and due to edge defect formed on the radius strength properties using calculation methods. Materials and methods The study of bone strength affecting factors was conducted with the aid of experimental and calculation methods. Biometrical parameters were studied in 10 pairs of the human cadaveric radius as an intact bone initially and after the formation of rectangular or triangle-shaped edge cuts. To determine the stress-strain behaviour, mathematical calculations were performed based on the beam flexural theory for isotropic materials. Computation study were conducted using the finite element method with the NX Siemens software package. Based on assumed mathematical models, the actual areas of safe loads in the presence of cuts and values of destructive loads depending on the depth and shape of a cut taking into account the initial curvature of the bone as well as the criteria of a required residual strength in variation of influencing parameters were identified by means of calculations. Results It was established that an increase in bone curvature results in the reduction of longitudinal destructive loads and in increasing values of the normal strength. The 0.05 bone curvature combined with the 0.5 cut causes a decrease in the ultimate load by 20 times (up to 4.8 % for a rectangular cut and to 5.4 % for a triangular cut). A 0.5-deep cut in the bone which curvature is 0.05 enhances the normal stress by 6.9 times for a triangular cut and by 7.8 times for a rectangular one as compared to a bone without curvature. The critical values for the curvature and depth of the cut were established which permit to avoid additional bone reinforcement. Conclusion The strength of the radius with a maginal defect depends not only on the depth of a cut but on its location, shape and on the radius curvature.

Bone mass, bone strength, and their relationship in developing CD-1 mice

2007 ◽  
Vol 85 (2) ◽  
pp. 274-279 ◽  
Author(s):  
Wendy E. Ward ◽  
Ana V. Piekarz ◽  
Debbie Fonseca
Keyword(s):  
Bone Mass ◽  
Bone Strength ◽  
Bone Mineral ◽  
Peak Load ◽  
Later Life ◽  
Strength Properties ◽  
Mineral Density ◽  
Effective Prevention ◽  
Nutritional Interventions ◽  
Skeletal Site

Optimizing nutrition during development may provide effective prevention strategies to protect against osteoporosis during later life. Because the mouse model is commonly used to test nutritional interventions on bone health, the overall objective of this study was to determine how bone develops during the first 4 months of life by assessing bone mass (bone mineral content (BMC) and bone mineral density (BMD)) and biomechanical strength properties such as peak load in male and female CD-1 mice. Bone outcomes were assessed at 1 month intervals from 1 to 4 months of age. Femur and spine BMC and BMD at 3 months were similar to 4 months, indicating that the accumulation of bone mass occurs primarily during the first 3 months of life. In contrast, the timing of changes in peak load, a measure of bone strength, varied by skeletal site. Regression analyses demonstrated that femur BMC is a significant predictor of femur peak load at the femur midpoint and neck. The study findings suggest that nutritional interventions aimed at optimizing peak bone mass to prevent osteoporosis may be most effective during pubertal growth.

744 Effect of Heat Degeneration of Collagen Matrix on Bone Strength

2008 ◽  
Vol 2008.5 (0) ◽  
pp. 3-4
Author(s):  
Yusuke IMARI ◽  
Masahiro TODOH ◽  
Shigeru TADANO
Keyword(s):  
Bone Strength ◽  
Collagen Matrix

Forearm muscle size, strength, force, and power in relation to pQCT-derived bone strength at the radius in adults

2011 ◽  
Vol 36 (5) ◽  
pp. 618-625 ◽  
Author(s):  
Amanda L. Lorbergs ◽  
Jonathan P. Farthing ◽  
Adam D.G. Baxter-Jones ◽  
Saija A. Kontulainen
Keyword(s):  
Bone Strength ◽  
Muscle Force ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Strength Properties ◽  
Muscle Size ◽  
Wrist Flexion ◽  
Cross Sectional ◽  
Muscle Cross Sectional Area ◽  
Forearm Muscle

We aimed to examine the relationship between forearm muscle cross-sectional area (MCSA), muscle force, or rate of torque development (RTD) and 2 estimated radius bone strength indices — compressive bone strength index (BSI) at the wrist and strength strain index in torsion (SSIp) at the shaft — in healthy middle-aged males and females. Distal (4%) and shaft (65%) sites of nondominant forearms were scanned using peripheral quantitative computed tomography (pQCT) in a sample of 48 adults (mean age ± SD, 49.4 ± 2.4 y) to obtain estimated bone strength indices and MCSA. Muscle force, measured by grip dynamometry and wrist flexion RTD, was obtained using an isokinetic dynamometer. Hierarchical linear regressions, adjusted for weight, explained 27% and 36% of the BSI variance at the 4% site in males and premenopausal females, respectively (p < 0.05). At the radius shaft, weight explained 26% (p < 0.05) and 83% (p < 0.01) of SSIp variance. The unique variance of BSI explained by MCSA was 16% in males (p < 0.05) and 31% in females (p < 0.01). Grip force predicted variance in SSIp in males (p < 0.01) and BSI in females (p < 0.05). RTD did not explain any variance in BSI or SSIp. Body weight was the only significant predictor (p < 0.05) of SSIp in females. Although forearm muscle size and grip strength are associated with estimates of radius bone strength at midlife, this relationship appears to be sex dependent. The differences observed between muscle size and strength properties and bone strength at distal and shaft sites of the radius suggest a property-, sex-, and site-specific relationship between muscle and bone in the forearm.

SEM Study of Tension Wood Fiber Morphology and its Effect on Paper Properties

1977 ◽  
Vol 35 ◽  
pp. 308-309
Author(s):  
K. W. Robinson
Keyword(s):  
Tension Wood ◽  
Wood Fiber ◽  
Strength Properties ◽  
Fiber Morphology ◽  
Paper Properties ◽  
Pure Cellulose ◽  
Short Rotation ◽  
Hardwood Trees ◽  
Sem Study

Tension wood (TW) is an abnormal tissue of hardwood trees; although it has been isolated from most parts of the tree, it is frequently found on the upper side of branches and leaning stems. TW has been classically associated with geotropic alignment, but more recently it has been associated with fast growth. Paper made from TW is generally lower in strength properties. Consequently, the paper industries' growing dependence on fast growing, short- rotation trees will result in higher amounts of TW in the final product and a corresponding reduction in strength.Relatively few studies have dealt with the role of TW in the structure of paper. It was suggested that the lower strength properties of TW were due to a combination of factors, namely, its unique morphology, compression failures in the cell wall, and lower hemicellulose content. Central to the unique morphology of the TW fiber is the thick gelatinous layer (G-layer) composed almost entirely of pure cellulose.

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