Cine MRI phase contrast measurements of entrance blood flow in the aorta

Phase-contrast cine MRI (PC-MRI) is the gold-standard noninvasive technique for measuring vessel blood flow and has previously been applied in the human fetal circulation. We aimed to assess the feasibility of using PC-MRI to define the distribution of the fetal circulation in sheep. Fetuses were catheterized at 119–120 days of gestation (term, 150 days) and underwent MRI at ∼123 days of gestation under isoflurane anesthesia, ventilated at a [Formula: see text] of 1.0. PC-MRI was performed using a fetal arterial blood pressure catheter signal for cardiac triggering. Blood flows were measured in the major fetal vessels, including the main pulmonary artery, ascending and descending aorta, superior vena cava, ductus arteriosus, left and right pulmonary arteries, umbilical vein, ductus venosus, and common carotid artery and were indexed to estimated fetal weight. The combined ventricular output, pulmonary blood flow, and flow across the foramen ovale were calculated from vessel flows. Intraobserver and interobserver agreement and reproducibility was assessed. Blood flow measurements were successfully obtained in 61 out of 74 vessels (82.4%) interrogated in 9 fetuses. There was good intraobserver [ R = 0.998, P < 0.0001; intraclass correlation (ICC) = 0.997] and interobserver agreement ( R = 0.996, P < 0.0001; ICC = 0.996). Repeated MRI measurements showed good reproducibility ( R = 0.989, P = 0.0002; ICC = 0.990). We conclude that PC-MRI using fetal catheters for gating triggers is feasible in the major vessels of late gestation fetal sheep. This approach may provide a useful new tool for assessing the circulatory characteristics of fetal sheep models of human disease, including fetal growth restriction and congenital heart disease.

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Fast Phase-Contrast Cine MRI for Assessing Intracranial Hemodynamics and Cerebrospinal Fluid Dynamics

Diagnostics ◽

10.3390/diagnostics10040241 ◽

2020 ◽

Vol 10 (4) ◽

pp. 241 ◽

Cited By ~ 1

Author(s):

Naoki Ohno ◽

Tosiaki Miyati ◽

Tomohiro Noda ◽

Noam Alperin ◽

Takashi Hamaguchi ◽

...

Keyword(s):

Blood Flow ◽

Cerebrospinal Fluid ◽

Phase Contrast ◽

Free Breathing ◽

Breath Holding ◽

Cine Mri ◽

Breath Hold ◽

Fast Phase ◽

Full Inspiration ◽

Conventional Methods

We propose fast phase-contrast cine magnetic resonance imaging (PC-cine MRI) to allow breath-hold acquisition, and we compared intracranial hemo- and hydrodynamic parameters obtained during breath holding between full inspiration and end expiration. On a 3.0 T MRI, using electrocardiogram (ECG)-synchronized fast PC-cine MRI with parallel imaging, rectangular field of view, and segmented k-space, we obtained velocity-mapped phase images at the mid-C2 level with different velocity encoding for transcranial blood flow and cerebrospinal-fluid (CSF) flow. Next, we calculated the peak-to-peak amplitudes of cerebral blood flow (ΔCBF), cerebral venous outflow, intracranial volume change, CSF pressure gradient (ΔPG), and intracranial compliance index. These parameters were compared between the proposed and conventional methods. Moreover, we compared these parameters between different utilized breath-hold maneuvers (inspiration, expiration, and free breathing). All parameters derived from the fast PC method agreed with those from the conventional method. The ΔPG was significantly higher during full inspiration breath holding than at the end of expiration and during free breathing. The proposed fast PC-cine MRI reduced scan time (within 30 s) with good agreement with conventional methods. The use of this method also makes it possible to assess the effects of respiration on intracranial hemo- and hydrodynamics.

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Non-invasive quantification of pulmonary blood flow in pediatric patients using phase-contrast cine MRI

International Congress Series ◽

10.1016/j.ics.2005.03.035 ◽

2005 ◽

Vol 1281 ◽

pp. 1303

Author(s):

Masayuki Kumashiro ◽

Kenji Waki ◽

Kenya Murase ◽

Takashi Tabuchi ◽

Takashi Kiyono ◽

...

Keyword(s):

Blood Flow ◽

Pulmonary Blood Flow ◽

Phase Contrast ◽

Pediatric Patients ◽

Cine Mri ◽

Non Invasive

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Haemodynamic changes in cirrhosis following terlipressin and induction of sepsis—a preclinical study using caval subtraction phase-contrast and cardiac MRI

European Radiology ◽

10.1007/s00330-020-07259-w ◽

2020 ◽

Author(s):

Manil D. Chouhan ◽

Stuart A. Taylor ◽

Alan Bainbridge ◽

Simon Walker-Samuel ◽

Nathan Davies ◽

...

Keyword(s):

Heart Rate ◽

Blood Flow ◽

Cardiac Mri ◽

Phase Contrast ◽

Systolic Function ◽

Cine Mri ◽

Chronic Liver Failure ◽

Cardiac Cine ◽

Haemodynamic Changes ◽

Cardiac Systolic Function

Abstract Objectives Effects of liver disease on portal venous (PV), hepatic arterial (HA), total liver blood flow (TLBF), and cardiac function are poorly understood. Terlipressin modulates PV flow but effects on HA, TLBF, and sepsis/acute-on-chronic liver failure (ACLF)-induced haemodynamic changes are poorly characterised. In this study, we investigated the effects of terlipressin and sepsis/ACLF on hepatic haemodynamics and cardiac function in a rodent cirrhosis model using caval subtraction phase-contrast (PC) MRI and cardiac cine MRI. Methods Sprague-Dawley rats (n = 18 bile duct–ligated (BDL), n = 16 sham surgery controls) underwent caval subtraction PCMRI to estimate TLBF and HA flow and short-axis cardiac cine MRI for systolic function at baseline, following terlipressin and lipopolysaccharide (LPS) infusion, to model ACLF. Results All baseline hepatic haemodynamic/cardiac systolic function parameters (except heart rate and LV mass) were significantly different in BDL rats. Following terlipressin, baseline PV flow (sham 181.4 ± 12.1 ml/min/100 g; BDL 68.5 ± 10.1 ml/min/100 g) reduced (sham − 90.3 ± 11.1 ml/min/100 g, p < 0.0001; BDL − 31.0 ± 8.0 ml/min/100 g, p = 0.02), sham baseline HA flow (33.0 ± 11.3 ml/min/100 g) increased (+ 92.8 ± 21.3 ml/min/100 g, p = 0.0003), but BDL baseline HA flow (83.8 ml/min/100 g) decreased (− 34.4 ± 7.5 ml/min/100 g, p = 0.11). Sham baseline TLBF (214.3 ± 16.7 ml/min/100 g) was maintained (+ 2.5 ± 14.0 ml/min/100 g, p > 0.99) but BDL baseline TLBF (152.3 ± 18.7 ml/min/100 g) declined (− 65.5 ± 8.5 ml/min/100 g, p = 0.0004). Following LPS, there were significant differences between cohort and change in HA fraction (p = 0.03) and TLBF (p = 0.01) with BDL baseline HA fraction (46.2 ± 4.6%) reducing (− 20.9 ± 7.5%, p = 0.03) but sham baseline HA fraction (38.2 ± 2.0%) remaining unchanged (+ 2.9 ± 6.1%, p > 0.99). Animal cohort and change in systolic function interactions were significant only for heart rate (p = 0.01) and end-diastolic volume (p = 0.03). Conclusions Caval subtraction PCMRI and cardiac MRI in a rodent model of cirrhosis demonstrate significant baseline hepatic haemodynamic/cardiac differences, failure of the HA buffer response post-terlipressin and an altered HA fraction response in sepsis, informing potential translation to ACLF patients. Key Points Caval subtraction phase-contrast and cardiac MRI demonstrate: • Significant differences between cirrhotic/non-cirrhotic rodent hepatic blood flow and cardiac systolic function at baseline. • Failure of the hepatic arterial buffer response in cirrhotic rodents in response to terlipressin. • Reductions in hepatic arterial flow fraction in the setting of acute-on-chronic liver failure.

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Assessment of Coronary Artery Blood Flow Velocity Using Breath-hold Phase Contrast MR Angiography in Patients With Acute Myocardial Infarction

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)85194-7 ◽

1998 ◽

Vol 31 (2) ◽

pp. 340A ◽

Cited By ~ 2

Author(s):

A Furber

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Blood Flow ◽

Coronary Artery ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Phase Contrast ◽

Mr Angiography ◽

Breath Hold ◽

Artery Blood Flow

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Quantitative analysis of cerebrospinal fluid dynamics at phase contrast cine-MRI: predictivity of neurosurgical "Shunt" responsiveness in patients with idiopathic normal pressure hydrocephalus

Journal of Neurosurgical Sciences ◽

10.23736/s0390-5616.17.04092-9 ◽

2020 ◽

Vol 64 (5) ◽

Author(s):

Alessandro Stecco ◽

Alessia Cassarà ◽

Alberto Zuccalà ◽

Mihaela B. Anoaica ◽

Egidio Genovese ◽

...

Keyword(s):

Fluid Dynamics ◽

Cerebrospinal Fluid ◽

Quantitative Analysis ◽

Normal Pressure Hydrocephalus ◽

Phase Contrast ◽

Normal Pressure ◽

Idiopathic Normal Pressure Hydrocephalus ◽

Cine Mri ◽

Cerebrospinal Fluid Dynamics

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Evaluation of cerebrospinal fluid flow dynamic changes in patients with idiopathic intracranial hypertension using phase contrast cine MR imaging

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-020-00227-7 ◽

2020 ◽

Vol 56 (1) ◽

Author(s):

Tamer Belal ◽

Abd-Elhalim Al Tantawy ◽

Fatema Mohamed Sherif ◽

Alshaimaa Ramadan

Keyword(s):

Cerebrospinal Fluid ◽

Medical Treatment ◽

Intracranial Hypertension ◽

Idiopathic Intracranial Hypertension ◽

Phase Contrast ◽

Cine Mri ◽

Mean Flow ◽

Csf Flow ◽

Flow Dynamic ◽

Dynamic Changes

Abstract Background Idiopathic intracranial hypertension (IIH) mainly affects overweight women in the middle age period. The pathophysiology of IIH stays unclear, but suggested mechanisms include excess CSF production, reduced CSF absorption, increased brain water content, and increased cerebral venous pressure Objectives To assess the cerebrospinal fluid (CSF) flow dynamic changes in aqueduct of Sylvius in patients of idiopathic intracranial hypertension (IIH) with new MRI technique: phase contrast cine MRI (PCC-MRI). Methods Thirty patients diagnosed with idiopathic intracranial hypertension were divided into 3 groups according to treatment options (no treatment, medical treatment, and medical treatment with repeated lumbar tapping). CSF flow data were evaluated by phase contrast cine MRI. Results PCC-MRI parameters were significantly higher in group who was on medical treatment (group II) than other groups. The sensitivity of PCC MRI parameters ranged from 56.7 (stroke volume (SV) and mean flow (MF)) to 83.3% (peak systolic velocity (PSV)). A statistically significant difference was found for the mean flow value (p 0.039) between the control group and IIH patients. Conclusion The most specific CSF flowmetry parameter detected to help diagnosis of IIH is mean flow especially among early discovered patients. PCC MRI can be used as non-invasive technique for diagnosis of IIH and treatment follow-up.

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