scholarly journals COMPARISON OF POLYMORPHISM rs3813865 CYTOCHROME P450 FAMILY 2 SUBFAMILY E POLYPEPTIDE 1 (CYP2E1) GENE IN VARIOUS CLINICAL STAGE OF UNDIFFERENTIATED TYPE NASOPHARYNGEAL CARCINOMA

2019 ◽  
Vol 12 (04) ◽  
pp. 2055-2061
Author(s):  
I Ketut Suanda ◽  
I Gde Ardika Nuaba ◽  
Ni Made Alit Ardianti
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Clinical Stage ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Barr Virus ◽  
Cyp2e1 Gene ◽  
Undifferentiated Type ◽  
Epstein Barr

Nasopharyngeal carcinoma is caused by interaction of Epstein-Barr virus chronic infection, environtment, and genetic factors. Epstein-Barr virus (EBV) infect nasopharyngeal ephitelial cell in latent period. This infection will cause mutation and further causing malignancy. This is a cross-sectional study in undifferentiated type NPC patients after hystopatological examination and were examined in RSUP Sanglah Denpasar from January 2017 to December 2018. This study is using 62 subjects who meets inclusion criteria. Univariate analysis was done to show subject characteristics which include age, gender, occupation, clinical stage, gene allele and rs3813865 polymorphism CYP2E1 gene. Mean age of subject is 48.05 years with standard deviation of 10.86 years. The youngest is 17 years old and the oldest is 73 years old. The most are men as many as 47 subjects (75.8%), and the most occupation are government employee as many as 17 subjects (27.4%). The most clinical stage of undifferentiated type NPC are stage II as many as 7 subjects (11.3%). Based on TNM, the most are T4 as many as 32 subjects (51.6%), N3 as many as 21 subjects (33.9%), and M0 as many as 60 subjects (96.8%).

Epstein-Barr Virus Load in Whole Blood Correlates With HIV Surrogate Markers and Lymphoma: A French National Cross-Sectional Study

2009 ◽  
Vol 50 (4) ◽  
pp. 427-429 ◽  
Author(s):  
Corinne Amiel ◽  
Jérôme LeGoff ◽  
François Xavier Lescure ◽  
Marianne Coste-Burel ◽  
Claire Deback ◽  
...  
Keyword(s):  
Whole Blood ◽  
Epstein Barr Virus ◽  
Cross Sectional Study ◽  
Surrogate Markers ◽  
Sectional Study ◽  
Cross Sectional ◽  
Virus Load ◽  
Barr Virus ◽  
Epstein Barr

Simultaneous occurrence of Epstein-Barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study

2021 ◽  
Author(s):  
Humberto Jácome-Santos ◽  
Naira da Silva e Silva ◽  
Renata Gonçalves Resende ◽  
Helder Henrique Costa Pinheiro ◽  
Luiz Fernando Almeida Machado ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Epstein Barr Virus ◽  
Cross Sectional Study ◽  
Simultaneous Occurrence ◽  
Sectional Study ◽  
Cross Sectional ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Association Between Environmental Factors and Oral Epstein-Barr Virus DNA Loads: A Multicenter Cross-sectional Study in China

2018 ◽  
Vol 219 (3) ◽  
pp. 400-409 ◽  
Author(s):  
Yong-Qiao He ◽  
Xiao-Yu Liao ◽  
Wen-Qiong Xue ◽  
Ya-Fei Xu ◽  
Feng-Hua Xu ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Odds Ratio ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Barr Virus ◽  
Associated Diseases ◽  
Epstein Barr

Abstract Background Oral Epstein-Barr virus (EBV) status reflects host EBV activity and potentially links to EBV-associated diseases, however, factors influencing oral EBV loads or reactivation, such as environmental exposures or host factors, are not fully understood. Methods A 2-stage, multicenter, cross-sectional study of 6558 subjects from 21 administrative cities of southern China and 3 populations from representative geographical areas in China (referred to as the south, north, and northeastern populations) was performed. The relationships between demographical factors and environmental exposures to EBV loads were analyzed by logistic regression models. Results Current smoking, with a dose-response effect, was found to be strongly associated with higher oral EBV loads in the pooled data, with an odds ratio of 1.58 (95% confidence interval, 1.39–1.79), as well as in each of the separate populations. The odds ratio increased to 3.06 when current smokers in southern China were compared to never smokers in northern China. Additionally, higher oral EBV loads tended to be detected in older participants, male participants, and participants in southern China. Conclusions This study provided evidence linking the effect of host-environmental factors, particularly smoking, to oral EBV activity. It could strengthen our understanding of the possible causal roles of EBV-related diseases, which may help to prevent or mitigate EBV-associated diseases.

scholarly journals Screening for Epstein–Barr virus (EBV) infection status in university freshmen: acceptability of a gingival swab method

2019 ◽  
Vol 147 ◽  
Author(s):  
J. M. Grimm-Geris ◽  
S. K. Dunmire ◽  
L. M. Duval ◽  
E. A. Filtz ◽  
H. J. Leuschen ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
College Freshmen ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Efficacy Trial ◽  
Cross Sectional ◽  
Freshman Year ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr

AbstractProphylactic vaccines against Epstein–Barr virus (EBV) are under development. EBV-naïve college freshmen are ideal candidates for an efficacy trial, because their incidence of infectious mononucleosis (mono) during freshman year is as high as 20%. To assess perceptions about mono and a mono vaccine, and to learn if EBV immune status could be determined using a gingival swab rather than phlebotomy, we performed a cross-sectional study of 235 healthy students at the beginning of their freshman year. Subjects completed questionnaires and donated oral washes, gingival swabs and venous blood. Overall, 90% of students found the swab easy to use and 80% preferred the swab over venepuncture. Of the 193 students with sufficient samples, 108 (56%) had EBV antibodies in bloodvs.87 (45.1%) in the gingival swab. The sensitivity and specificity of the swab compared with blood for detecting EBV antibodies was 75.9% and 94.1%, respectively, with an accuracy of 89.3%. EBV DNA was detected in the oral wash and swab of 39.2% and 30.4% of blood-antibody-positive individuals, respectively. In conclusion, 44% of our freshmen were EBV-naïve and thus vaccine candidates, the gingival swab was an acceptable alternative to phlebotomy for detecting EBV antibody but needs improved sensitivity, and the perceived value of EBV vaccine was high (72% believed they would benefit).

scholarly journals Deteksi Gen Litik BRLF1 Epstein-Barr Virus pada Penderita Karsinoma Nasofaring

Biosfera ◽  
2018 ◽  
Vol 35 (1) ◽  
pp. 29
Author(s):  
Tri Yulia Ningsih ◽  
Daniel Joko Wahyono ◽  
Nur Signa Aini Gumilas
Keyword(s):  
Molecular Markers ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Venous Blood ◽  
Lytic Cycle ◽  
Conventional Pcr ◽  
Cross Sectional ◽  
Barr Virus ◽  
Pcr Method ◽  
Epstein Barr

Rosenmuller fossa. Epithelial malignancy is often found in Chinese populations and Southeast Asia including Indonesia. Undifferentiated nasopharyngeal carcinoma (NPC WHO-3) type is 100% associated with Epstein-Barr virus (EBV) infection. Bam-HI R Leftward Reading Frame 1 (BRLF1) lytic gene has an important function as a transition mediator of latent phase to the lytic phase in EBV cycle. Detection of BRLF1 gene by PCR can be used for NPC diagnosis. The aim of this study is to identify BRLF1 lytic genes as molecular markers of Epstein-Barr virus in nasopharyngeal carcinoma patients with conventional PCR method and to determine the sensitivity of conventional PCR method to detect BRLF1 gene. The research design was cross sectional study. A total of 22 DNA samples were isolated from venous blood of NPC patients from RSUD Prof dr Margono Soekarjo, Purwokerto with informed consent. BRLF1 gene identification is done with conventional PCR technique. The results of this research showed that BRLF1 genes as molecular markers lytic cycle of Epstein-Barr virus in nasopharyngeal carcinoma patients can be identified conventional PCR technique that will produced DNA 157 bp. BRLF1 gene was detected in 16 samples (72.73%) of 22 samples of this study.

scholarly journals Epstein-Barr virus in the cerebrospinal fluid of HIV-positive patients. Observational cross-sectional study

2014 ◽  
Vol 14 (S4) ◽  
Author(s):  
Ruxandra V Moroti-Constantinescu ◽  
Ioana D Olaru ◽  
Adriana Hristea ◽  
Ana-Maria Petrescu ◽  
Victoria Aramă ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Epstein Barr Virus ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Sectional Study ◽  
Cross Sectional ◽  
Barr Virus ◽  
Epstein Barr
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