scholarly journals Characterization of a Novel Curcumin based Schiff base Ligand, Synthesized by Microwave Method

2021 ◽  
Vol 37 (6) ◽  
pp. 1488-1492
Author(s):  
Beena Kumari K. S ◽  
Sudha Devi R ◽  
Nayana Senan V
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Spectroscopic Method ◽  
Aromatic Proton ◽  
Molar Conductance ◽  
Azomethine Group ◽  
Nmr Spectrum ◽  
Hydroxyl Proton ◽  
Ft Ir

A new Schiff base ligand derived from curcumin and ethylenediamine has been synthesized by the microwave irradiation method. The synthesized ligand was characterized by using FT-IR, UV-VIS, Molar conductance, NMR, PL and DLS studies. The results confirmed that the successful formation of Curcumin Based Schiff Base ligand. The ligand synthesized was stable at room temperature, completely soluble in hot methanol/DMF, partially soluble in ethanol/DMSO/acetone and insoluble in water. The spectra studies of FTIR and UV-visible confirmed the formation of the azomethine group in the ligand. NMR spectrum confirmed the presence of aromatic proton, hydroxyl proton, amine proton etc in the ligand. The luminescent property of the ligand was confirmed by the photoluminescence spectroscopic method. The low molar conductance value showed the non-electrolytic nature of the ligand. The dynamic light scattering studies showed that the ligand synthesized was in nanometer scale. The structure of the ligand was also proposed based on the analysis reports.

scholarly journals Antitumor and Antimicrobial Potential of Manganese(II), Nickel(II) and Copper(II) Complexes of 4-Methoxy Benzohydrazide Derived Schiff Base Ligand

2021 ◽  
Vol 11 (1) ◽  
pp. 3249-3260
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Antimicrobial Activities ◽  
Molar Ratio ◽  
Gram Positive Bacteria ◽  
Ft Ir ◽  
Dose Dependent

Herein, we describe the synthesis and characterization of a Schiff base ligand (E)-N'-(2-hydroxybenzylidene)-4-methoxybenzohydrazide (HBMB) and its Mn(II), Ni(II), and Cu(II) metal complexes (C1-C3) respectively. The ligand HBMB was synthesized by reacting condensation of salicylaldehyde and 4-methoxy benzohydrazide in a 1:1 molar ratio. The structure of HBMB and its metal complexes (C1-C3) were evaluated by using UV-Vis, FT-IR, 1H-NMR, mass spectroscopy as well as on the basis of elemental analysis, conductivity measurements, and thermogravimetric techniques (TGA). The synthesized molecules' tumoricidal properties were performed against human breast cancer (MCF-7) and colon cancer (HT 29) cell lines. The biological results indicated that the ligand, HBMB, and metal complexes possess dose-dependent selective cytotoxicity against the tested carcinoma cells. The synthesized compounds were further evaluated for their in vitro antimicrobial activities against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli), and fungal strains (Aspergillus niger).

scholarly journals Synthesis, Characterization and Antibacterial Activity of Schiff Base, 4-Chloro-2-{(E)-[(4-Fluorophenyl)imino]methyl}phenol Metal (II) Complexes

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
F. K. Ommenya ◽  
E. A. Nyawade ◽  
D. M. Andala ◽  
J. Kinyua
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Condensation Reaction ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Elemental Analysis Data ◽  
Ft Ir

A new series of Mn (II), Co (II), Ni (II), Cu (II), and Zn (II) complexes of the Schiff base ligand, 4-chloro-2-{(E)-[(4-fluorophenyl)imino]methyl}phenol (C13H9ClFNO), was synthesized in a methanolic medium. The Schiff base was derived from the condensation reaction of 5-chlorosalicylaldehyde and 4-fluoroaniline at room temperature. Elemental analysis, FT-IR, UV-Vis, and NMR spectral data, molar conductance measurements, and melting points were used to characterize the Schiff base and the metal complexes. From the elemental analysis data, the metal complexes formed had the general formulae [M(L)2(H2O)2], where L = Schiff base ligand (C13H9ClFNO) and M = Mn, Co, Ni, Cu, and Zn. On the basis of FT-IR, electronic spectra, and NMR data, “O” and “N” donor atoms of the Schiff base ligand participated in coordination with the metal (II) ions, and thus, a six coordinated octahedral geometry for all these complexes was proposed. Molar conductance studies on the complexes indicated they were nonelectrolytic in nature. The Schiff base ligand and its metal (II) complexes were tested in vitro to evaluate their bactericidal activity against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Bacillus subtilis and Staphylococcus typhi) using the disc diffusion method. The antibacterial evaluation results revealed that the metal (II) complexes exhibited higher antibacterial activity than the free Schiff base ligand.

scholarly journals Molecular Structure and Spectral Characterization of Diamagnetic Co(III) Complex Incorporating Hexaadentate Schiff Base Ligand

2019 ◽  
Vol 31 (8) ◽  
pp. 1871-1876
Author(s):  
Eida S. Al-Farraj ◽  
Amani S. Alturiqi ◽  
Murefah M. Anazy ◽  
Reda A. Ammar
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Atomic Charge ◽  
Molar Ratio ◽  
Lumo Energy ◽  
Ft Ir ◽  
Uv Visible ◽  
Homo Lumo ◽  
Mulliken Atomic Charge

A novel Co(III) complex derived from hexaadentate Schiff base ligand, H3L was described. The ligand is prepared from the reaction of tris-2-aminoethyl amine and o-vanillin in 1:3 molar ratio. The structure of the ligand and its Co(III) complex was described by micro-analyses, FT-IR, NMR, ESI-MS and UV/visible and thermal stability. DFT study was carried out to get insights into the ligand and its Co(III) complex to compare the values of bond lengths and angles with each other. The electronic spectra, Mulliken atomic charge distribution, HOMO-LUMO energy and the thermodynamic parameters have been calculated.

scholarly journals Preparation and Characterization of the Schiff Base Ligand (E)- N-(3-nitrobenzylidene) isonicotinohydrazide and its Silver (I) Complex [Ag(NNBIH)2]+

2012 ◽  
Vol 9 (2) ◽  
pp. 191-195
Author(s):  
SHAHRIAR GHAMMAMY ◽  
SAJJAD SEDAGHAT
Keyword(s):  
Thermal Decomposition ◽  
Schiff Base ◽  
Schiff Base Ligand ◽  
Synthesis And Characterization ◽  
Nitrate Salt ◽  
Visible Spectroscopy ◽  
Multistage Processes ◽  
Ft Ir ◽  
Uv Visible

We describe the synthesis and characterization of a new silver (I) complex of the Schiff base ligand (E) - N-(3-nitrobenzylidene) is onicotinohydrazide that abbreviated as NNBIH was synthesized and characterized. Ag (I) Metal complex of this Schiff base ligand prepared by reaction of nitrate salt of Ag (I) with NNBIH. Characterization of the ligand was made by microanalyses, FT-IR, UV–Visible spectroscopy and its complex was made by microanalyses, FT-IR and UV–Visible spectroscopy. TG- DTA and other analytical methods have been applied to the investigation of the thermal behavior and Structure of the compound [Ag(NNBIH)2]+. Thermal decomposition of these compounds is multistage processes.

scholarly journals Synthesis, Spectral Characterization, Molecular Modeling, and Antimicrobial Studies of Cu(II), Ni(II), Co(II), Mn(II), and Zn(II) Complexes of ONO Schiff Base

2012 ◽  
Vol 9 (4) ◽  
pp. 2145-2154 ◽  
Author(s):  
Padmaja Mendu ◽  
J. Pragathi ◽  
B. Anupama ◽  
C. Gyana Kumari
Keyword(s):  
Schiff Base ◽  
Molecular Modeling ◽  
Oxygen Atom ◽  
Schiff Base Ligand ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Azomethine Group ◽  
Pyrone Ring ◽  
Antimicrobial Studies ◽  
Benzoyl Hydrazine

A series of Cu(II), Ni(II), Co(II), Mn(II), and Zn(II) complexes have been synthesized from the schiff base ligand L. The schiff base ligand [(4-oxo-4H-chromen-3-yl) methylene] benzohydrazide (L) has been synthesized by the reaction between chromone-3-carbaldehyde and benzoyl hydrazine. The nature of bonding and geometry of the transition metal complexes as well as schiff base ligand L have been deduced from elemental analysis, FT-IR, UV-Vis,1HNMR, ESR spectral studies, mass, thermal (TGA and DTA) analysis, magnetic susceptibility, and molar conductance measurements. Cu(II), Ni(II), Co(II), and Mn(II) metal ions are forming 1:2 (M:L) complexes, Zn(II) is forming 1:1 (M:L) complex. Based on elemental, conductance and spectral studies, six-coordinated geometry was assigned for Cu(II), Ni(II), Co(II), Mn(II), and Zn(II) complexes. The complexes are 1:2 electrolytes in DMSO except zinc complex, which is neutral in DMSO. The ligand L acts as tridentate and coordinates through nitrogen atom of azomethine group, oxygen atom of keto group ofγ-pyrone ring and oxygen atom of hydrazoic group of benzoyl hydrazine. The 3D molecular modeling and energies of all the compounds are furnished. The biological activity of the ligand and its complexes have been studied on the four bacteriaE. coli, Edwardella, Pseudomonas, andB. subtilisand two fungipencilliumandtricodermaby well disc and fusion method and found that the metal chelates are more active than the free schiff base ligand.

Synthesis and Characterization of Binuclear Indium(Ⅲ) Complexes with Bis-Schiff Bases Derived from Benzidine or its Derivatives

2011 ◽  
Vol 197-198 ◽  
pp. 627-630 ◽  
Author(s):  
Xu Dong Jin ◽  
Yue Hong Jin ◽  
Zhi Gang Cui ◽  
Yuan Yuan Li ◽  
Hai Bo Wang
Keyword(s):  
Schiff Base ◽  
Infrared Spectrum ◽  
Schiff Bases ◽  
Schiff Base Ligand ◽  
Molar Conductance ◽  
Synthesis And Characterization ◽  
Gravimetric Analysis ◽  
Thermal Gravimetric ◽  
Indium Chloride

By reactions of indium chloride tetrahydrate with three bis-Schiff bases ligands (N, N’-bis (3-methoxy-salicylidene)benzidine = L1; N, N’-bis (3-methoxysalicylidene)-2, 2’-dimethyl- benzidine =L2; N, N’-bis (3-methoxysalicylidene)-o- dianisidine = L3), respectively, three novel corresponding complexes 1~3 were obtained. The complexes were characterized by infrared spectrum, molar conductance, elemental analysis and thermal gravimetric analysis. The chemical formulae of the complexes 1~3 were determined as (InCl3)2Ln (1, n = 1; 2, n = 2; 3, n = 3). All the complexes are constructed with binuclear indium ions. Every complex consists of two central In (III) ions, one corresponding bis-Schiff base ligand and six Cl-.

scholarly journals Synthesis and characterization of N, N′-bis (isatin) diamino zirconium (IV) complexes

2019 ◽  
Vol 54 (4) ◽  
pp. 297-306
Author(s):  
A Sarker ◽  
T Hossain ◽  
MN Bashir ◽  
KJ Fatema ◽  
AKML Rahman
Keyword(s):  
Condensation Reaction ◽  
Analytical Data ◽  
Carbonyl Oxygen ◽  
Molar Conductance ◽  
Azomethine Group ◽  
Molar Ratios ◽  
Vibrational Bands ◽  
Ft Ir ◽  
1Hnmr Spectroscopy

N, N′-bis (isatin) diamine schiff base ligands were synthesized by the condensation reaction of Isatin with various diamine (ethane-1,2-diamine, propane-1,3-diamine and hexane-1,6-diamine) in 2:1 molar ratios. These ligands were used to prepare Zr (IV) complexes. Prepared ligands and complexes were characterized by using conductance measurement, FT-IR, UV-Visible and 1HNMR spectroscopy. The presence of FT-IR band for azomethine group supports the formation of ligand. Vibrational bands for Zr←N and Zr←O in complexes signify the coordination through O and N sites of ligands. 1HNMR peak for NH moiety in ligand gets almost disappeared in complex reveals tautomerism of NH with nearby carbonyl oxygen due to the effect of complexation. The absence of peak above 500 nm in the electronic spectra indicates d0 system of zirconium in complexes. The elemental analytical data was analogous to theoretical composition of ligands and complexes. The molar conductance values obtained for the complexes represent their non-electrolytic character. Bangladesh J. Sci. Ind. Res.54(4), 297-306, 2019

scholarly journals Synthesis and Characterization of Co (III) Complex of the New Chiral Schiff Base

2012 ◽  
Vol 9 (1) ◽  
pp. 55-59
Author(s):  
Shahriar Ghammamy ◽  
Sajjad Sedaghat
Keyword(s):  
Schiff Base ◽  
Metal Complex ◽  
Schiff Base Ligand ◽  
Synthesis And Characterization ◽  
Ft Ir ◽  
Chiral Schiff Base

We describe the synthesis and characterization of a new Co(III) complex of the Schiff base ligand (N1 E, N2E) - N1-((1H- pyrrol-2-yl) methylene) - N2-(1- phenylethylidene) ethane- 1,2- diamineabbreviated as MPEAwas synthesized and characterized.Co (III) Metal complex of this Schiff base ligand prepared by reaction of CoCl2.6H2O with MPEA. Characterization of the ligand was made by microanalyses, FT-IR, 1HNMR and 13CNMR and its complex was made by FT-IR.

scholarly journals Spectral, Theoretical and Biological Studies of 3-((4-Mercaptophenyl)imino)- 1-phenylindolin-2-one Schiff Base and Its Organotellurium(IV) Complexes

2021 ◽  
Vol 33 (8) ◽  
pp. 1749-1756
Author(s):  
Manish Kumar ◽  
Poonam Jangra Darolia ◽  
Nidhi Antil ◽  
Mahak Dalal ◽  
Jitender Narwal ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Receptor Proteins ◽  
E Coli ◽  
Biological Studies ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Bacteria And Fungi

Schiff base ligand (3-((4-mercaptophenyl)imino)-1-phenylindolin-2-one) of 1-phenylindoline-2,3-dione and 4-aminothiophenol was synthesized by refluxing. Organotellurium(IV) complexes of type (RTeCl3.NPhIATP and R2TeCl2.NPhIATP, where R = 4-hydroxyphenyl, 4-methoxyphenyl and 3-methyl-4-hydroxyphenyl, NPhIATP = Schiff base ligand). The ligand and its organotellurium(IV) complexes (9a-f) were characterized by FT-IR, molar conductance, elemental analyses, UV-vis, mass, 1H & 13C NMR spectral studies. Geometry of all the compounds were optimized and octahedral geometry have been proposed for all the tellurium(IV) complexes. Molecular docking was studied to find the binding interactions between ligand (NPhIATP) and receptor proteins: E. coli (3t88) and S. aureus (3ty7). The antimicrobial activity of ligand and its tellurium(IV) complexes have been screened against bacteria and fungi. All the organotellurium(IV) complexes complexes showed good activity to ligand towards different studied microorganisms.

scholarly journals Synthesis, spectroscopic and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes derived from benzoic acid bidentate Schiff base ligand

2021 ◽  
Vol 25 (9) ◽  
pp. 1599-1603
Author(s):  
I. ADO ◽  
J. NA’ALIYA ◽  
S. SANI ◽  
M.M. HALEELU
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Magnetic Moment ◽  
Metal Ion ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Planar Geometry ◽  
Azomethine Group

The Schiff base was synthesized by condensation of 2-hydroxy-1-naphthaldehyde with 3- aminobenzoic acid in 1:1 molar ratio. The Schiff base ligand formed complexes with Co (II), Ni (II), Cu (II) and Zn (II) acetate via mechanochemical synthesis. The synthesized compounds were characterized by solubility test, thermal analysis, FT-IR, powder x-ray diffraction, molar conductance measurement, magnetic susceptibility and elemental analysis. The Schiff base has a melting point of 190 oC. The decomposition temperature of complexes was found to be in the range 289 – 302 oC. The Schiff base and its metal (II) complexes were soluble in DMF, DMSO and sparingly soluble in acetonitrile, chloroform, diethyl ether and insoluble in n-hexane which indicate the polar nature of the synthesized compounds. The IR spectral analysis of the free Schiff base shows a band at 1622 cm-1, assigned to v(C=N) stretching vibrations. This band was shifted in the spectra of complexes (1607 – 1633 cm-1), indicating coordination of the Schiff base to the metal ion through the azomethine group. The molar conductance of complexes determined are in the range 9.51 – 14.87 Ohm-1cm2mol-1 which indicate the non-electrolytic nature in DMF. Magnetic susceptibility measurements of Co (II), Ni (II) and Cu (II) complexes exhibit a magnetic moment in the range 1.25 – 3.08 BM. The values correspond to square-planar geometry. The magnetic moment value of Zn (II) complex indicates a diamagnetic behaviour. The elemental analysis of the complexes for C, H and N determined showed that the observed and the calculated percentages of the elements are in good agreement.

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