Morphological brain differences in healthy control subjects with and without family history of pain/psychiatric disorders

Personality traits are important candidate predictors of suicidal behavior. Several studies have reported an association between personality/temperament traits and suicidal behavior, suggesting personality traits as intermediary phenotypes related to suicidal behavior. Thus, it is possible that suicide attempts can be accounted for by increased familial rates of risk personality traits. The aim of this work was to evaluate personality traits in affective disorder patients with attempted suicide and to compare them with the personality trait scores of their parents. In addition, ITC scores in the two groups were compared with a healthy control sample. The patients evaluated met the DSM-IV criteria for major depression disorder or dysthymia and had a documented history of suicide attempts. Psychiatric diagnoses of patients and parents were done according to the SCID-I and the personality was assessed using the Temperament and Character Inventory. We analyzed 49 suicide attempt subjects and their parents (n=95) and 89 control subjects. We observed that temperament and character dimensions were similar between patients and their parents (P>0.05). In particular, we observed that high HA and low P, SD, and CO were shared among families. Our study is the first to report that the personality traits of affective disorder patients with a history of attempted suicide are shared between patients and their parents.

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Psychiatric family history and urinary MHPG in healthy control subjects

Biological Psychiatry ◽

10.1016/0006-3223(90)90636-g ◽

1990 ◽

Vol 28 (2) ◽

pp. 174-176 ◽

Cited By ~ 3

Author(s):

Michael Garvey ◽

Brian Cook ◽

Russell Noyes ◽

Nancee Blum

Keyword(s):

Family History ◽

Control Subjects ◽

Healthy Control

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Postpartal psychosis: Serbian experience

European Psychiatry ◽

10.1016/s0924-9338(11)72803-6 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 1098-1098

Author(s):

M. Jasovic-Gasic ◽

A. Damjanovic ◽

M. Ivkovic ◽

B. Dunjic-Kostic

Keyword(s):

Family History ◽

Psychiatric Disorders ◽

Positive Family History ◽

Clinical Manifestations ◽

Significant Risk ◽

Significant Risk Factor ◽

Psychiatric Disturbances ◽

Psychological Disturbances ◽

Clinical Center ◽

History Of

IntroductionChildbirth and the postpartal period present a form of specific maturational crisis and an extremely vulnerable period for every woman, especially for those who have potential for some psychological disturbances.AimWe explored sociodemographic and clinical manifestations of women in the postpartal period who were hospitalized at the Institute of Psychiatry, Clinical Center of Serbia.MethodThis retrospective study included 60 patients with psychiatric disorders developed within six months after childbirth. Inclusion criteria were: negative psychiatric hystory, negative history of puerperal episode, and postpartal disorder as a first manifestation of psychiatric disturbances. Patients were diagnosed according to RDC criteria (research diagnostic criteria).ResultsPatients with psychotic features were predominant, average age 23.6; married; mothers of male offspring and with positive family history of psychiatric disorders in 30%. Subacute development of clinical manifestations was noticed, 3.5 weeks after childbirth on average. No psychopathology was observed before third postpartal day. Obstetric manifestations did not influence psychopathology.ConclusionChildbirth is a significant risk factor for the expression of mental dysfunction in the puerperal period. The most vulnerable group is women with clinical expression of dysfunction, specific sociodemographic characteristics, and positive family history of psychiatric disorders.

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FAMILY HISTORY OF PSYCHIATRIC DISORDERS AND AUTISM SPECTRUM DISORDERS: A STUDY ABOUT 963 CASES

10.26226/morressier.5d1a035e57558b317a13f82e ◽

2019 ◽

Author(s):

Zeineb Azouz ◽

Takoua Brahim ◽

Asma Guedria ◽

Slama hela ◽

GADDOUR NAOUFEL ◽

...

Keyword(s):

Autism Spectrum Disorders ◽

Family History ◽

Psychiatric Disorders ◽

Autism Spectrum ◽

History Of ◽

Spectrum Disorders

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Delineating genetic and familial risk for psychopathology in the ABCD study

10.1101/2020.09.08.20186908 ◽

2020 ◽

Author(s):

Clare E Palmer ◽

Robert John Loughnan ◽

Carolina Makowski ◽

Wesley Thompson ◽

Deanna Barch ◽

...

Keyword(s):

Family History ◽

Psychiatric Disorders ◽

Genetic Risk ◽

Familial Risk ◽

Risk Scores ◽

Typically Developing ◽

Polygenic Risk ◽

Hyperactivity Disorder ◽

History Of ◽

Risk Predictors

Psychiatric disorders place a huge burden on those affected and their families, as well as society. Nearly all psychiatric disorders have a heritable component and lifetime prevalence rates of several disorders are higher among first degree biological relatives of individuals with a diagnosis. Given that many psychiatric disorders have their onset in adolescence, estimating genetic risk during childhood may identify at-risk individuals for early intervention that can reduce this burden. Here we measured genetic risk for psychopathology using both polygenic risk scores (PRS) and family history in a large typically developing sample of 9-10 year old children from the Adolescent Brain and Cognitive Development (ABCD) StudySM and determined associations with a large battery of behavioural phenotypes. By including all genetic risk predictors in the same model, we were able to delineate unique behavioral associations across these measures. Polygenic risk for Attention Deficit Hyperactivity Disorder (ADHD) and depression (DEP) was associated with unique patterns of both externalizing and internalizing behaviors. Family history of conduct problems, depression and anxiety/stress additionally predicted unique behavioral variance across similar measures. These findings provide important insight into the potential predictive utility of PRS and family history in early adolescence and suggest that they may be signaling differential, additive information that could be useful for quantifying risk during development.

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The Immediate Effect of COVID-19 Pandemic on Children and Adolescents with Obsessive Compulsive Disorder

10.21203/rs.3.rs-54132/v4 ◽

2020 ◽

Author(s):

Judith Becker Nissen ◽

David Højgaard ◽

Per Hove Thomsen

Keyword(s):

Depressive Symptoms ◽

Family History ◽

Psychiatric Disorders ◽

Obsessive Compulsive Disorder ◽

Age Of Onset ◽

Close Contact ◽

Clinical Group ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

History Of

Abstract Background Obsessive compulsive disorder (OCD) is a distressing psychiatric disorder. Traumas may trigger or aggravate OCD symptoms. COVID-19 pandemic has coursed a global crisis and has been associated with onset of psychiatric disorders in adults. Little is known about children/adolescents with OCD. The present study aimed to examine how children/adolescents with OCD react towards COVID-19 crisis. Methods A questionnaire was distributed to two separate groups of children/adolescents. One group was a clinical group newly diagnosed at a specialized OCD clinic. All the children/adolescents had a current close contact to a therapist or doctor. The other group was a survey group identified through the Danish OCD Association. Most of these children/adolescents were diagnosed years ago, and their primary treatment was completed. For the clinical group, data from patient files was available. Results In both groups, but most pronounced in the survey group, participants experienced a worsening of their OCD, anxiety, and depressive symptoms. The aggravation of OCD correlated with the worsening of anxiety, depressive symptoms, and the extent of avoidance behavior. For both groups, OCD aggressive symptoms predicted a significant worsening. Poor baseline insight showed a trend to predict a symptom worsening. The worsening was most pronounced in children with early age of onset and a family history of attention deficit hyperactivity disorder. Conclusions To our knowledge, this is one of the first studies examining the effect of COVID-19 in children/adolescents with OCD. The effect was examined in two separate populations strengthening the findings. The study points towards an influence of the OCD phenotype, baseline insight suggesting a continued vulnerability, and a family history of psychiatric disorders. Trial registration The study is approved by the Danish Data Protection Agency (1-16-02-147-20) registered 1 st of April 2020. Oral and written information was given to parents and patients and written consent from patients over 15 years and parents were received.

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