The Differential Diagnosis of Foot Lumps: 101 Cases Treated Surgically in North Glasgow Over 4 Years

INTRODUCTION There are a wide variety of different lesions which present as lumps of the foot. There have been very few studies which look at the presenting characteristics or the differential diagnosis of such lesions. PATIENTS AND METHODS All patients who underwent excision or biopsy of a foot lump over a period of 4 years were studied in order to determine patient demographics, presenting characteristics, diagnoses encountered and to assess the diagnostic accuracy of the surgeon. RESULTS In total, 101 patients were identified. Average age was 47.3 years (range, 14–79 years); there was a marked female preponderance with 73 females and 28 males. Thirty different histological types were identified; ganglion cysts were the most commonly encountered lesions and there was only one malignant lesion encountered in this study. Only 58 out of the 101 lumps were correctly diagnosed prior to surgery. Certain lesions were more commonly encountered in specific zones of the foot. CONCLUSIONS We have shown that there are a wide variety of potential diagnoses which have to be considered when examining a patient with a foot lump. There is a low diagnostic accuracy for foot lumps and, therefore, surgical excision and histological diagnosis should be sought if there is any uncertainty.

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Leiomyoma on the shaft of penis

Open Medicine ◽

10.2478/s11536-010-1034-5 ◽

2010 ◽

Vol 5 (5) ◽

pp. 538-540

Author(s):

R Siddharth ◽

SN Mehra

Keyword(s):

Differential Diagnosis ◽

Soft Tissue ◽

English Literature ◽

Malignant Lesion ◽

Surgical Excision ◽

Effective Therapy ◽

Histological Diagnosis ◽

Pathologic Finding ◽

Soft Tissue Tumours ◽

Penile Neoplasm

AbstractPrimary soft tissue tumours of the penis, such as leiomyomas, are very rare. Most present as small and painless but gradually increasing swellings on the penis. To the best of our knowledge, only 9 cases have been reported in the literature so far. This rare pathologic finding, which usually mimics a malignant lesion, should be included in the differential diagnosis of penile neoplasm. Surgical excision of the lesion provides both the histological diagnosis and an effective therapy. We report a case of a large leiomyoma on the shaft of the penis measuring 8x5 cm, which possibly represents the largest reported leiomyoma of the penis in English literature till date.

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Clinical analysis on the differential diagnosis of gastrointestinal neoplasms by real-time endoscopic ultrasonography

Proceedings of Anticancer Research ◽

10.26689/par.v3i3.1102 ◽

2020 ◽

Vol 3 (3) ◽

Author(s):

Yumin Zhang

Keyword(s):

Differential Diagnosis ◽

Diagnostic Accuracy ◽

Real Time ◽

Endoscopic Ultrasonography ◽

Elastic Strain ◽

Digestive System ◽

Benign Lesion ◽

Malignant Lesion ◽

Lesion Group ◽

Tissue Elastography

Abstract: objective: to study and analyze the effect of real-time endoscopic ultrasonography in the differential diagnosis of gastrointestinal tumors.Selection methods: between January 2014 and January 2015 xinyang 53 cases of digestive system cancer patients admitted in hospital, a total of 79 substantial tumor of the digestive system lesions, all patients were diagnosed by endoscopic ultrasonography real-time tissue elastography, use elastic imaging score, for patients with lesions and their surrounding structures control the elastic strain rate ratio of measure and comparison analysis.Results: compared with the malignant lesion group, the difference between the benign lesion group and the benign lesion group was statistically significant (P<0.05).The ratio of elastic strain rate in benign lesion group was lower than that in malignant lesion group (P<0.05).The diagnostic accuracy, sensitivity and specificity were 91.14%, 94.74% and 81.82% respectively.Conclusion: endoscopic ultrasound real-time tissue elastography is effective in the differential diagnosis of digestive system tumors, and can effectively determine the benign and malignant tumors and improve the diagnostic accuracy.

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Etiological structure and diagnosis of abnormal uterine bleeding

GYNECOLOGY ◽

10.26442/2079-5696_2018.2.14-18 ◽

2018 ◽

Vol 20 (2) ◽

pp. 14-17

Author(s):

G E Chernukha ◽

I A Ivanov ◽

Z N Efendieva ◽

M R Dumanovskaya ◽

A V Asaturova

Keyword(s):

Diagnostic Accuracy ◽

Endometrial Hyperplasia ◽

Ultrasound Examination ◽

Abnormal Uterine Bleeding ◽

Uterine Bleeding ◽

Histological Diagnosis ◽

Reproductive Age ◽

Endometrial Polyps ◽

Chronic Endometritis ◽

Endometrial Pathology

Abnormal uterine bleeding (AUB) is one of the most common indications for hysteroscopy. Most of the AUB cases occur due to endometrial or myometrium pathology. Among it, endometrial polyps (EP) and chronic endometritis (CE) prevalent in reproductive age, while endometrial hyperplasia (EH) and EP dominate in perimenopause. It was determined that EP and CE are characterized with menorrhagia and metrorrhagia approximately equally, whereas EH reveals AUB with oligomenorrhoea. Verification of exact endometrial pathology by ultrasound examination is hindered, that results in deviations of ultrasound and histological diagnosis. The usage of ultrasound data and AUB’s characteristics may improve the diagnostic accuracy on preadmission period.

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Intrascrotal lipoblastoma in adulthood

BMJ Case Reports ◽

10.1136/bcr-2019-231320 ◽

2019 ◽

Vol 12 (12) ◽

pp. e231320

Author(s):

Mário José Pereira-Lourenço ◽

Duarte Vieira-Brito ◽

João Pedro Peralta ◽

Noémia Castelo-Branco

Keyword(s):

Case Report ◽

Magnetic Resonance ◽

S100 Protein ◽

Surgical Excision ◽

Large Mass ◽

Histological Diagnosis ◽

Physical Exam ◽

Nodular Lesion ◽

Inferior Portion ◽

The Right

This case report describes the case of a 37-year-old man that noticed an intrascrotal right mass with 1 month of evolution. During physical exam presented with a large mass at the inferior portion of the right testicle, clearly separated from the testicle, with a tender consistency and mobile. An ultrasound was performed that showed a solid and subcutaneous nodular lesion, extra testicular, heterogeneous, measuring 7.2 cm. Pelvic magnetic resonance imageMRI showed a lesion compatible with a lipoma. The patient was subjected to surgical excision of the lesion by scrotal access, having histology revealed a lipoblastoma (LB) of the scrotum. Histological diagnosis was obtained by microscopic characteristics (well-circumscribed fatty neoplasm) and immunohistochemistry (stains for CD34, S100 protein and PLAG1 were positive; stains for MDM2 and CDK4 were negative). LB is extremely rare after adolescence in any location, being this first described case of intrascrotal LB described in adulthood.

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Validity of different copeptin assays in the differential diagnosis of the polyuria-polydipsia syndrome

Scientific Reports ◽

10.1038/s41598-021-89505-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Clara Odilia Sailer ◽

Julie Refardt ◽

Claudine Angela Blum ◽

Ingeborg Schnyder ◽

Jose Alberto Molina-Tijeras ◽

...

Keyword(s):

Differential Diagnosis ◽

Diagnostic Accuracy ◽

Healthy Volunteers ◽

Primary Outcome ◽

The Other ◽

Poor Correlation ◽

Elisa Assay ◽

Moderate Correlation ◽

High Diagnostic Accuracy ◽

Osmotic Stimulation

AbstractThe aim of this study was to correlate three commercially available copeptin assays and their diagnostic accuracy in the differential diagnosis of the polyuria-polydipsia syndrome. Analyzed data include repeated copeptin measures of 8 healthy volunteers and 40 patients with polyuria-polydipsia syndrome undergoing osmotic stimulation and of 40 patients hospitalized with pneumonia. Copeptin was measured using the automated Brahms KRYPTOR, the manual Brahms LIA and the manual Cloud Clone ELISA assay. Primary outcome was the interrater correlation coefficient (ICC) and diagnostic accuracy in the polyuria-polydipsia syndrome of the three assays. In healthy volunteers, there was a moderate correlation for the KRYPTOR and LIA (ICC 0.74; 95% CI 0.07 to 0.91), and a poor correlation for the KRYPTOR and ELISA (ICC 0.07; 95% CI − 0.06 to 0.29), as for the LIA and ELISA (ICC 0.04; 95% CI − 0.04 to 0.17). The KRYPTOR had the highest diagnostic accuracy (98% (95% CI 83 to100)), comparable to the LIA (88% (95% CI 74 to 100)), while the ELISA had a poor diagnostic accuracy (55% (95% CI 34 to 68)) in the differential diagnosis of the polyuria-polydipsia syndrome. The KRYPTOR and LIA yield comparable copeptin concentrations and high diagnostic accuracy, while the ELISA correlates poorly with the other two assays and shows a poor diagnostic accuracy for polyuria-polydipsia patients. The current copeptin cut-off is valid for the KRYPTOR and LIA assay. Our results indicate that interpretation with other assays should be performed with caution and separate validation studies are required before their use in differentiating patients with polyuria-polydipsia syndrome.Trial registration: NCT02647736 January 6, 2016/NCT01940614 September 12, 2013/NCT00973154 September 9, 2009.

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Accuracy of MRI in the Differential Diagnosis of Wilms Tumor

10.53350/pjmhs211582057 ◽

2021 ◽

Vol 15 (8) ◽

pp. 2057-2059

Author(s):

Maham Ashraf ◽

Aysha Anjum ◽

Eisha Tahir ◽

Amber Goraya ◽

Rabia Aqeel

Keyword(s):

Differential Diagnosis ◽

Diagnostic Accuracy ◽

Gold Standard ◽

Wilms Tumor ◽

Correct Diagnosis ◽

Renal Tumors ◽

Common Finding ◽

Predictive Values ◽

Female Ratio ◽

Male Predominance

Background & Objective: Renal tumors are a common finding in diagnostic imaging; these lesions usually are solid or cystic, benign or malignant, and the correct diagnosis may be difficult. The current study aims at to determine the diagnostic accuracy of magnetic resonance imaging for the diagnosis of Wilms tumor taking histopathology as gold standard. Methodology: This cross-sectional study was carried at the Department of Radiology, The Children’s Hospital & Institute of Child Health Lahore over 6 months from March 2019 to September 2019. The study involved 125 children of both genders aged between 2 years to 14 years presenting with a neoplastic mass in the retroperitoneum on ultrasound abdomen during initial workup. These children were assessed on MRI for the diagnosis of Wilms tumor. Later the diagnosis was confirmed on histopathology which was taken as gold standard and the diagnosis of MRI was judged accordingly as true/false and positive/negative. A written informed consent was obtained from every patient. Results: The mean age of the children was 5.8±3.9 years having a male predominance with male to female ratio of 1.8:1. Wilms tumor was suspected in 13 (10.4%) children on MRI. The diagnosis of Wilms tumor was confirmed in 13 (10.4%) children on histopathology. MRI was found to be 76.9% sensitive, 97.3% specific and 95.2% accurate with positive and negative predictive values of 76.9% and 97.3% respectively. Conclusion: In the present study, MRI was found to be 95.2% accurate in the differential diagnosis of Wilms tumor in children presenting with retroperitoneal mass which along with its non-invasive and radiation free nature advocates the preferred use of MRI in the diagnostic evaluation of such children in future oncologic practice. Keywords: Retroperitoneal Tumor, Wilms Tumor, MRI, Diagnostic Accuracy

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PAX2 in endometrial carcinogenesis and in differential diagnosis of endometrial hyperplasia: A systematic review and meta-analysis of diagnostic accuracy

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1111/aogs.13512 ◽

2019 ◽

Vol 98 (3) ◽

pp. 287-299 ◽

Cited By ~ 26

Author(s):

Antonio Raffone ◽

Antonio Travaglino ◽

Gabriele Saccone ◽

Massimo Mascolo ◽

Luigi Insabato ◽

...

Keyword(s):

Systematic Review ◽

Differential Diagnosis ◽

Diagnostic Accuracy ◽

Endometrial Hyperplasia ◽

Meta Analysis

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Differential Diagnosis of a Left Atrial Mass after Surgical Excision of Myxoma: a Remnant or a Thrombus?

Korean Circulation Journal ◽

10.4070/kcj.2016.46.6.875 ◽

2016 ◽

Vol 46 (6) ◽

pp. 875 ◽

Cited By ~ 4

Author(s):

Hanbit Park ◽

Seokjung Jo ◽

Yun Kyung Cho ◽

Jongkwan Kim ◽

Sangcheol Cho ◽

...

Keyword(s):

Differential Diagnosis ◽

Left Atrial ◽

Surgical Excision ◽

Atrial Mass

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Extensive parapharyngeal and skull base neuroglial ectopia; a challenge for differential diagnosis and treatment: case report

Sao Paulo Medical Journal ◽

10.1590/s1516-31802010000500011 ◽

2010 ◽

Vol 128 (5) ◽

pp. 302-305 ◽

Cited By ~ 4

Author(s):

Giulianno Molina de Melo ◽

Gabrielle do Nascimento Holanda Gonçalves ◽

Ricardo Antenor de Souza e Souza ◽

Danilo Anunciatto Sguillar

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Skull Base ◽

Infratemporal Fossa ◽

Newborn Infants ◽

Surgical Excision ◽

Neck Mass ◽

Oral Feeding ◽

Feeding Difficulties ◽

Complete Surgical Excision

CONTEXT: Neuroglial ectopia has been defined as a mass composed of differentiated neuroectodermal tissue isolated from the spinal canal or cranial cavity and remains rare. This lesion has to be considered in the differential diagnosis among newborn infants with classical symptoms of respiratory distress, neck mass and feeding difficulties. We present a rare case of extensive parapharyngeal and skull base neuroglial ectopia in 6-month-old girl who presented respiratory and feeding obstruction at birth. CASE REPORT: A six-month-old girl who presented upper respiratory and feeding obstruction at birth and was using tracheostomy and gastrostomy tubes was referred to our institution. Complete surgical excision of the mass consisted of a transcervical-transparotid approach with extension to the infratemporal fossa by means of a lateral transzygomatic incision, allowing preservation of all vital neurovascular structures. The anatomopathological examination showed a solid mass with nests of neural tissue, with some neurons embedded in poorly encapsulated fibrovascular stroma, without mitotic areas, and with presence of functioning choroid plexus in the immunohistochemistry assay. Neurovascular function was preserved, thus allowing postoperative decannulation and oral feeding. Despite the large size of the mass, the child has completed one year and six months of follow-up without complications or recurrence. Neuroglial ectopia needs to be considered in diagnosing airway obstruction among newborns. Surgical treatment is the best choice and should be performed on clinically stable patients. An algorithm to guide the differential diagnosis and improve the treatment was proposed.

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