scholarly journals Paraneoplastic polymyositis presenting as a clinically occult breast cancer

2017 ◽  
Vol 99 (2) ◽  
pp. e40-e43 ◽  
Author(s):  
N Merali ◽  
M Yousuff ◽  
V Pronisceva ◽  
A Poddar
Keyword(s):  
Paraneoplastic Syndrome ◽  
Rare Case ◽  
Primary Tumour ◽  
Imaging Studies ◽  
Occult Breast Cancer ◽  
Symptom Stability ◽  
Underlying Malignancy ◽  
Neurological Presentation ◽  
Complete History ◽  
Metaplastic Breast Carcinoma

Paraneoplastic syndrome affects less than 1% of cancer patients. Diagnosis of paraneoplastic syndrome with neurological presentation requires screening for an underlying malignancy, including a complete history, physical examination and imaging studies. Treatment often results in symptom stability, rather than improvement. Paraneoplastic polymyositis can precede or instantaneously occur at diagnosis or treatment of a primary tumour, while neurological symptoms can persist even following cancer treatment. We report a rare case of metaplastic breast carcinoma with an unusual presentation of paraneoplastic polymyositis.

scholarly journals Paget’s Disease of the Breast in a Patient with Amyopathic Dermatomyositis

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Sirin Yasar ◽  
Gunay Gurleyik ◽  
Yesim Sabuncuoglu ◽  
Ali Aktekin ◽  
Bulent Yasar ◽  
...  
Keyword(s):  
Rare Case ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Lymph Node Biopsy ◽  
Amyopathic Dermatomyositis ◽  
Dermatology Department ◽  
Node Biopsy ◽  
Areola Complex ◽  
Underlying Malignancy ◽  
Recurrent Malignancy

Amyopathic dermatomyositis (AD) can be a part of paraneoplastic syndrome of an underlying malignancy. Paget’s disease is a rare form of breast cancer. We present a very rare case of Paget’s disease associated with AD. Paget’s disease has been diagnosed in a patient with AD who is under surveillance of dermatology department. The patient has undergone central lumpectomy with removal of the nipple-areola complex and sentinel lymph node biopsy. Surgical margins after lumpectomy and sentinel node biopsy were negative. The whole breast irradiation was performed after surgery. The patient receives medical treatment for AD of which lesions regressed in 1 year during the follow-up period. This is a very rare case of Paget’s disease diagnosed in a patient with AD. Female patients with dermatomyositis have been absolutely recommended to undergo screening for breast and gynaecological malignancies. AD may be an early finding of primary or recurrent malignancy of the breast.

scholarly journals Spinal intraosseous epidural arteriovenous fistula with perimedullary drainage obliterated with Onyx embolization: case report

2015 ◽  
Vol 23 (2) ◽  
pp. 250-253 ◽  
Author(s):  
Chang-Hsien Ou ◽  
Hao-Kuang Wang ◽  
Tzu-Hsien Yang ◽  
Cheng-Loong Liang ◽  
Ho-Fai Wong
Keyword(s):  
Case Report ◽  
Arteriovenous Fistula ◽  
Rare Case ◽  
Direct Evidence ◽  
Embolic Agent ◽  
Imaging Studies ◽  
Disease Evolution ◽  
Compressive Fracture ◽  
Rare Location ◽  
Vein Reflux

The authors report an extremely rare case of spinal intraosseous epidural arteriovenous fistula (AVF) with perimedullary vein reflux causing symptoms of myelopathy. The intraosseous fistula tracts were completely obliterated with Onyx embolic agent, resulting in a total resolution of symptoms. The unique features of this case include the rare location of the fistula in the vertebral body and the association of the fistula with a compressive fracture. Imaging studies confirmed these hemodynamic findings and provided clarity and direct evidence regarding the association of epidural AVF formation with the vertebral compressive fracture. The authors also propose a possible disease evolution based on the previously adduced reflux-impending mechanism.

scholarly journals Occult Breast Carcinoma Presenting as Scalp Metastasis

2017 ◽  
Vol 10 (3) ◽  
pp. 992-997 ◽  
Author(s):  
Ricardo L.B. Costa ◽  
Rubens B. Costa-Filho ◽  
Marilin Rosa ◽  
Brian J. Czerniecki
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Breast Tumor ◽  
Rare Case ◽  
De Novo ◽  
Metastatic Breast ◽  
Primary Breast Tumor ◽  
Occult Breast Cancer ◽  
Scalp Metastasis ◽  
Occult Breast Carcinoma

Breast cancer is the most common tumor among women, and approximately 6% of the patients have de novo metastatic breast cancer. Occult breast cancer accounts for only 0.1–0.8% of the cases and most commonly presents with axillary lymphadenopathy. Scalp metastases are rare and have been described as a sign of progression or widespread metastatic disease. Here, we describe a rare case of de novo metastatic breast cancer to the scalp as the single site of spread and without an identifiable primary breast tumor.

scholarly journals A rare clinical case: schwannoma of tongue

2019 ◽  
Vol 5 (3) ◽  
pp. 789
Author(s):  
Chandra Veer Singh ◽  
Sheetal Radia ◽  
Saalim Sheikh ◽  
Vijay Haribhakti
Keyword(s):  
Head And Neck ◽  
Rare Case ◽  
Neck Region ◽  
Surgical Excision ◽  
Imaging Studies ◽  
Head And Neck Tumours ◽  
Head And Neck Region ◽  
Complete Surgical Excision ◽  
Slow Growing ◽  
Rule Out

<p class="abstract">Schwannoma are slow growing tumours, which can arise from any peripheral nerve. 10% of schwannomas that occur in the head and neck region mostly originate from the vagus or sympathetic nervous system. Extracranial schwannomas in the head and neck region are rare neoplasm. Intraoral schwannoma are only 1% of the all head and neck tumours. Diagnosis is established by imaging studies such as magnetic resonance imaging or computed tomography, while FNAC is used to rule out other conditions. We report a rare case of lingual schwannomas generally present as a painless lump schwannoma of the tongue in a 27-year-old male complaining of asymptomatic swelling over a posterolateral surface of the tongue, treated by complete surgical excision. The diagnosis was established on the basis of clinical, histopathological, and immunohistochemical examination. We report a rare case of schwannoma over the posterolateral surface of tongue. Prognosis is good for the patient when this condition is correctly diagnosed as the condition rarely recurs after complete resection.</p>

scholarly journals A Rare Paraneoplastic Syndrome of Lung Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
R. Azzeddine ◽  
L. Herrak ◽  
A. Rhanim ◽  
A. Jniene ◽  
M. Elftouh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lower Esophageal Sphincter ◽  
Paraneoplastic Syndrome ◽  
Rare Case ◽  
Loss Of Function ◽  
Esophageal Sphincter

Achalasia is a neurodegenerative motor disease of the esophagus resulting mainly from a loss of function of the lower esophageal sphincter, the pathophysiology of which is still poorly understood. Its incidence is rare—it is 1.6 per 100,000—and its occurrence in the context of paraneoplastic syndrome has been rarely described in the literature. We report a rare case of paraneoplastic achalasia associated with lung cancer.

scholarly journals Whole-Body18FDG-PET in an Arthritis Paraneoplastic Syndrome Revealed an Underlying Hematological Neoplasm

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Serge Cammilleri ◽  
Marie Caroline Guzian ◽  
Jean-Pierre Mattei ◽  
Olivier Mundler ◽  
Sandrine Guis
Keyword(s):  
Paraneoplastic Syndrome ◽  
Fdg Pet ◽  
Clinical Symptoms ◽  
Solid Cancer ◽  
Underlying Malignancy ◽  
Hematological Neoplasm

We showed the first image of18FDG-PET, which leads to a diagnosis of lymphoma in an atypical polyarthritis. About 4% of patients with lymphoma or leukemia suffered from rheumatologic paraneoplastic symptoms like arthralgia and about 10% of the patients with rheumatologic or neurologic clinical symptoms develop a solid cancer or hematological neoplasm.18FDG-PET is an interesting exam to identify an underlying malignancy when a paraneoplastic syndrome is suspected; it can detect the primitive lesion and/or the metastasis lesions. The use of the18FDG-PET can help to detect earlier hematological neoplasm in cases of paraneoplastic syndrome without a determined cause and to treat more rapidly and specifically the patient.

Actinomycosis of the thyroid gland masquerading as a neoplasm

1997 ◽  
Vol 111 (2) ◽  
pp. 172-174 ◽  
Author(s):  
J. Yiotakis ◽  
P. Tzounakos ◽  
L. Manolopoulos ◽  
A. Tzagaroulakis ◽  
G. Adamopoulos
Keyword(s):  
Thyroid Gland ◽  
Head And Neck ◽  
Histological Examination ◽  
Rare Case ◽  
Clinical Laboratory ◽  
Thyroid Neoplasm ◽  
Diagnosis And Treatment ◽  
Imaging Studies ◽  
Thyroid Swelling

AbstractActinomycetal infections involving the head and neck often pose a diagnostic puzzle to the otolaryngologist. A rare case of unilateral thyroid swelling due to actinomycosis is described. Although the clinical, laboratory and imaging studies strongly suggested a thyroid neoplasm, the histological examination revealed the presence ofActinomycessp. in the excised lesion. The manifestations of actinomycosis of the head and neck, its pathogenesis and the difficulties encountered in the diagnosis and treatment of the disease are hereby reviewed.

scholarly journals Leucocytosis and Stroke in a Lung Cancer Patient

2020 ◽  
Author(s):  
Neha Akkad ◽  
Yang Jiang ◽  
Daniel Shin
Keyword(s):  
Paraneoplastic Syndrome ◽  
Underlying Mechanism ◽  
Tumour Resection ◽  
Bone Marrow Stimulation ◽  
Interleukin 5 ◽  
Gm Csf ◽  
Underlying Malignancy ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Significant leucocytosis in the setting of an underlying malignancy may be attributed to several causes and is not uncommon; however, extreme leucocytosis (>50×109 cells/l) and hypereosinophilia is less common and may represent a paraneoplastic syndrome. The underlying mechanism is thought to be bone marrow stimulation by tumour-produced cytokines, most notably interleukin-5 (IL-5) and granulocyte-macrophage colony-stimulating factor (GM-CSF). This paraneoplastic syndrome is likely reflective of extensive disease and dissemination, and options for treatment are limited but include tumour resection, corticosteroids and hydroxyurea. In this report, we discuss an unusual case of known stage III lung adenocarcinoma presenting with an ischaemic stroke and extreme leucocytosis and hypereosinophilia. 

scholarly journals Benign Cerebral Edema and Increased Intracranial Pressure (ICP) as Manifestations of COVID-19 Reinfection; A Case Report

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Heidary AH ◽  
Elahi R ◽  
Nazari M
Keyword(s):  
Intracranial Hypertension ◽  
Cerebral Edema ◽  
Rare Case ◽  
Vaccine Development ◽  
Gastrointestinal Symptoms ◽  
First Episode ◽  
Neurological Manifestations ◽  
Imaging Studies ◽  
Increased Intracranial Pressure ◽  
Blurred Vision

Reinfection with COVID-19 is of great importance since it can substantially affect the future of disease control and vaccine development. COVID-19 can present with diverse neurological, as well as respiratory and gastrointestinal symptoms. Here, we present a rare case of COVID-19 reinfection with neurological manifestations. The patient was a healthy 26-year-old male that had experienced first episode of COVID-19 infection with mild respiratory and gastrointestinal symptoms. In his second episode of infection, he presented to the emergency department with vertigo, vomiting, metamorphopsia, blurred vision, headache, and gate disturbance. Based on the clinical data and imaging studies, the patient was diagnosed with benign cerebral edema and intracranial hypertension. Then, he was treated using intravenous/intramuscular corticosteroids in addition to the supplementary therapies. His symptoms dramatically improved during the next 2 days. No important neurologic or systemic adverse events in response to the treatment were noted. This case reveals that infection with COVID-19, despite positive IgG, does not protect the patient from reinfection. Moreover, COVID-19 reinfection can present with benign cerebral edema and intracranial hypertension, in which case, inflammatory suppression therapy should be considered.

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