scholarly journals Everolimus for the treatment of epithelioid hemangioma: a case report

2021 ◽  
Author(s):  
Mururul Aisyi ◽  
Ayu Hutami Syarif ◽  
Dewi Aisyah Mukarramah ◽  
Rio Hermawan ◽  
Dewi Iriani
Keyword(s):  
Targeted Therapy ◽  
Therapeutic Strategy ◽  
Hand Function ◽  
Surgical Excision ◽  
Vascular Tumor ◽  
Lesion Size ◽  
Test Results ◽  
Epithelioid Hemangioma ◽  
Slow Growing

Epithelioid hemangioma is a rare benign vascular tumor manifested as slow-growing subcutaneous or dermal nodules. A previously therapeutic strategy involved surgical excision and sclerotherapy. However, no standard treatment has been established. Here, we reported an atypical case of epithelioid hemangioma that had a locally aggressive behavior and was successfully treated with everolimus, a rapamycin analog used for cancer therapy. A 1-year-old boy presented with an ulcerated lump in the left palmar region. The imaging test results, confirmed through histopathologic examination, suggested a diagnosis of epithelioid hemangioma. Targeted therapy with everolimus was administered orally because of a minimal response to initial transarterial sclerotherapy. The patient achieved a satisfactory response with a significantly reduced lesion size and improved hand function after a 2-year follow-up. This finding showed that patients with locally aggressive forms of epithelioid hemangioma may significantly benefit from everolimus as a potential targeted therapy.

scholarly journals Gingival Lipoma: A Rare Case Report

2017 ◽  
Vol 1 (1) ◽  
pp. 37-39
Author(s):  
Sweta Shrestha ◽  
Shaili Pradhan ◽  
Ranjita Shrestha Gorkhali
Keyword(s):  
Rare Case ◽  
Surgical Excision ◽  
Soft Tissue Tumors ◽  
Rare Case Report ◽  
Postsurgical Complication ◽  
Benign Tumours ◽  
One Year ◽  
Slow Growing ◽  
Oral Soft Tissue

Lipomas are benign tumours of mesenchymal origin (mature adipocytes) that are comparatively uncommon in the oral cavity corresponding to less than 4.4% of all benign oral soft tissue tumors. Clinically, they present as slow growing, soft, asymptomatic masses. Histopathologically, they appear as thinly encapsulated lesion composed of mature adipocytes with inconspicuous vascularity. The pathogenetic mechanisms of oral lipomas are still unclear. They are usually treated by surgical excision and bear excellent prognosis. Here we report a case of intraoral lipoma in 54 year old male patient in the left lower lingual alveolar mucosal region that was treated by surgical excision using electrocautery without any postsurgical complication. One-year follow-up showed no evidence of recurrence.

Follow-up results in tuberculous cervical lymphadenitis

2005 ◽  
Vol 120 (2) ◽  
pp. 129-132 ◽  
Author(s):  
Mehmet F Oktay ◽  
Ismail Topcu ◽  
Abdurrahman Senyigit ◽  
Aslan Bilici ◽  
Adem Arslan ◽  
...  
Keyword(s):  
Medical Treatment ◽  
Residual Disease ◽  
Surgical Excision ◽  
X Rays ◽  
Test Results ◽  
Cervical Lymphadenitis ◽  
Antituberculous Treatment ◽  
High Incidence ◽  
The Mean

Objective: To investigate the efficacy of medical antituberculous treatment in patients with tuberculous cervical lymphadenitis (TCL).Methods: In the period 1996–2002, 73 TCL patients were reviewed and the results of clinical and laboratory testing were documented. The efficacy of a four-drug chemotherapy regimen was investigated.Results: Purified protein derivatives (PPD) skin test results were positive in 58 (79 per cent) patients. Chest X-rays revealed changes consistent with tuberculosis in nine (12.3 per cent) patients. The mean duration of medical treatment was 10.04 months. In follow-up evaluation, 14 (20 per cent) patients were considered suspicious for resistant TCL and total excision of all nodes was performed. Histopathology confirmed TB in only 10 of these cases.Conclusion: The high incidence of residual disease in our study indicates that medical treatment (at least nine months of four combined antituberculous drugs) did not seem to be effective. If lymphadenopathy persists, total surgical excision of lymph nodes should be the treatment of choice.

scholarly journals Malignant Chondroid Syringoma With Nose and Paranasal Sinus Extension: A Case Report

2019 ◽  
Vol 10 ◽  
pp. 215265671989336
Author(s):  
Raghul Sekar ◽  
Raja Kalaiarasi ◽  
Sivaraman Ganesan ◽  
Arun Alexander ◽  
Sunil K. Saxena
Keyword(s):  
Benign Tumor ◽  
Bone Destruction ◽  
Neck Region ◽  
Surgical Excision ◽  
Mixed Tumor ◽  
Head And Neck Region ◽  
Chondroid Syringoma ◽  
Slow Growing ◽  
Nose And Sinuses

Chondroid syringoma is a rare, skin appendageal tumor. It is also known as mixed tumor of skin, as it histologically resembles mixed tumor of salivary gland (pleomorphic adenoma). It is most commonly a benign tumor, but a few malignant counterparts have been described in history. It usually presents as a solid, slow-growing, solitary, and painless nodule in the head and neck region. Malignant counterpart is rare and commonly affects trunk and extremities. Early diagnosis and surgery by wide local excision are the most reliable treatments to date. Recurrences are common and hence close follow-up is advised. In this study, we present a case of malignant chondroid syringoma of face with extensive extension into nose and paranasal sinuses, which was recurrent and managed by surgical excision and radiotherapy. To the best of our knowledge, this is the first reported case with extension and bone destruction into nose and sinuses.

scholarly journals Chondroid Syringoma of Dorsum of the Nose

2018 ◽  
Vol 26 (3) ◽  
pp. 219-221
Author(s):  
Netra Aniruddha Pathak ◽  
Vidya Vasant Rokade ◽  
Kiran Jayawant Shinde
Keyword(s):  
Surgical Excision ◽  
Benign Tumors ◽  
Adult Males ◽  
Seborrheic Keratosis ◽  
Chondroid Syringoma ◽  
External Nose ◽  
Middle Aged Adult ◽  
Slow Growing ◽  
Mixed Tumors

IntroductionChondroid syrigomas are rare, usually benign tumors occurring predominantly in the head and neck area. These are also known as mixed tumors of skin. Preoperative diagnosis is difficult and generally histopathology examination confirms the diagnosis.  The usual presentation is that of a slowly growing mass.Case ReportA rare case of chondroid syringoma on dorsum of external nose in 30 year old female patient   is presented.DiscussionChondroid syringoma presents as slow‐growing, painless, subcutaneous or intracutaneous nodule in middle‐aged adult males. The tumor is often initially confused with more common dermatologic skin disorders such as sebaceous cysts, dermoid cysts, neurofibromas, dermatofibromas, basal cell carcinoma, histiocytoma and seborrheic keratosis. The treatment of choice is surgical excision with negative margins with follow-up to detect recurrences.

scholarly journals Osteoma of mastoid part of temporal bone - a rare clinical entity

1970 ◽  
Vol 16 (2) ◽  
pp. 136-138
Author(s):  
Naseem Yasmeen ◽  
M Alamgir Chowdhury ◽  
SM Golam Rabbani ◽  
Mousumi Malakar
Keyword(s):  
Temporal Bone ◽  
Postoperative Period ◽  
Surgical Excision ◽  
Rare Clinical Entity ◽  
Malignant Cells ◽  
X Ray ◽  
Slow Growing ◽  
Bony Erosion ◽  
Stony Hard

Here a case of osteoma is described situated in right mastoid part of temporal bone (post auricular region) in a 35-year-old female. The swelling was slow-growing, oval in shape, stony hard in consistency, 3cm x 5cm in size with normal & free overlying skin but fixed to the bone & non-tender. FNAC revealed no malignant cells. X-ray Mastoids Towne's view showed right mastoiditis. CT scan findings were in favour of angular dermoid without bony erosion. Surgical excision was done under general anaesthesia. Histopathological report was osteoma. Postoperative period was uneventful and follow up after 10 days was fine. Key words: Osteoma; Temporal bone.DOI: 10.3329/bjo.v16i2.6851Bangladesh J Otorhinolaryngol 2010; 16(2): 136-138

Transnasal microscopic approach for juvenile nasopharyngeal angiofibroma

2018 ◽  
Vol 72 (5) ◽  
pp. 31-36 ◽  
Author(s):  
Wiesław Gołąbek ◽  
Anna Szymańska ◽  
Kamal Morshed
Keyword(s):  
Infratemporal Fossa ◽  
Surgical Excision ◽  
Vascular Tumor ◽  
Stage I ◽  
Juvenile Nasopharyngeal Angiofibroma ◽  
Preoperative Embolization ◽  
Stage Iiia ◽  
Nasopharyngeal Angiofibroma ◽  
Feeding Vessels

Introduction: Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign, vascular tumor originating in the nasopharynx. The treatment of choice for JNA is surgical excision. In recent years, surgical management has been greatly influenced by the use of the transnasal endoscopic technique. The aim: The aim of the study was to present our experience with the transnasal microscopic removal of JNA. Material and methods: Ten patients with JNA aged 12-17 underwent diagnostics imaging and transnasal microscopic tumor excision. Medical records of patients were retrospectively reviewed. The main outcome measures were complications and recurrences. Preoperative embolization of feeding vessels was performed in 7 patients. Results: According to Andrews’ classification, the group included 2 stage I patients, 6 stage II patients and 2 stage IIIA patients with the extensive occupation of the infratemporal fossa. 9 patients had no recurrence in 6-11 years follow up. One stage IIIA patient had a recurrence posteriorly to the pterygopalatine process and it was completely removed. No complications during or after surgery occurred. Conclusion: Transnasal microscopic excision is an effective approach to resect stage I-IIIA JNA

scholarly journals Biphenotypic Sinonasal Sarcoma: A Case Report and Review of Literature

2021 ◽  
pp. 014556132199919
Author(s):  
Evan Kominsky ◽  
Andre E. Boyke ◽  
Daniel Madani ◽  
Ameet Kamat ◽  
Bradley A. Schiff ◽  
...  
Keyword(s):  
Surgical Excision ◽  
Adjuvant Radiation ◽  
Low Grade ◽  
Recurrence Rates ◽  
Radiologic Evaluation ◽  
Standardized Treatment ◽  
Slow Growing ◽  
Biphenotypic Sinonasal Sarcoma

Objectives: Biphenotypic sinonasal sarcoma (BSNS), previously low-grade sinonasal sarcoma with neural and myogenic features, is a rare tumor of the sinonasal tract first described in 2012. Due to its rarity, limited literature is available in providing clinicians with a standardized treatment regimen, particularly in cases of positive surgical margins. This article aims to provide a clinical review of the currently available reported cases of BSNS, as well as presenting clinical, radiologic, and pathologic details of 2 novel cases. Methods: Online electronic databases include PubMed and Embase where queried for reports of biphenotypic sinonasal sarcoma or low-grade sinonasal sarcoma with neural and myogenic features. Two previously unpublished cases were included in the results. Data including clinical presentation, epidemiologic data, radiologic evaluation, intraoperative details, histopathology, treatment modality, and postoperative follow-up information were included. Results: A total of 100 previously published cases were identified in 12 prior articles. Mean age at presentation was 52.9 years. Extrasinonasal extension was observed in 27.4% of cases with most common site of extension being cribriform plate. Forty-seven cases included treatment details with surgical excision being the most common modality. Recurrence rates were identical for both surgical excision alone and surgical excision with adjuvant radiotherapy (33.3%). Conclusions: Biphenotypic sinonasal sarcoma is a slow-growing tumor that is amenable to surgical resection. Recurrence rates are similar between surgical excision and surgical excision with adjuvant radiation therapy, but limited data in reported cases preclude a determination of treatment superiority.

scholarly journals Pleomorphic adenoma of the palate

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Naourez Kolsi ◽  
◽  
Emna Bergaoui ◽  
Rachida Bouatay ◽  
Jamel Koubaa ◽  
...  
Keyword(s):  
Ct Scan ◽  
General Anesthesia ◽  
Pleomorphic Adenoma ◽  
Soft Palate ◽  
Smooth Surface ◽  
Surgical Excision ◽  
Radiographic Evidence ◽  
History Of ◽  
Slow Growing

A woman 43 years, presented with 9 years history of a painless swelling in the palatal region, slow-growing. Her medical history was not significant. On intraoral examination, a median ovoid mass measuring 4 cm diameter was found at the junction of hard and soft palate. The mass was firm, with smooth surface. No radiographic evidence of bone involvement was seen on the CT scan (Figure A). Surgical excision under general anesthesia: excision of the mass was carried out, the overlying mucosa was healthy, so conserved (Figure B,C&D). Histopathologic report confirmed the lesion to be “pleomorphic adenoma”. The lesion has not recurred after four years follow-up.

scholarly journals EPIDERMOID CYST OF THE FOURTH VENTRICLE: AN UNUSUAL LOCATION

2020 ◽  
Vol 8 (12) ◽  
pp. 786-788
Author(s):  
S. Amalik ◽  
◽  
C. Ayadi ◽  
H. Essaber ◽  
J. El Fenni ◽  
...  
Keyword(s):  
Visual Impairment ◽  
Epidermoid Cyst ◽  
Fourth Ventricle ◽  
Cerebellopontine Angle ◽  
Clinical Signs ◽  
Surgical Excision ◽  
Basal Cistern ◽  
Chronic Daily Headaches ◽  
Slow Growing

Epidermoid cysts are slow-growing congenital tumors developed from ectodermal inclusions. They usually sit at the cerebellopontine angle or basal cistern, their location in the fourth ventricle are exceptional.We report the case of a 44-year-old patient admitted to the Neurosurgery department for chronic daily headaches with visual impairment recently aggravated by cerebellar stato-kinetic syndrome.The diagnosis of epidermoid cyst of the fourth ventricle was suspected on MRI especially in diffusion sequence and then confirmed by the anatomopatological studies. Subtotal surgical excision was performed. The evolution was marked by the disappearance of clinical signs. Radiological and clinical follow up were indicated.

scholarly journals Low grade fibromyxoid sarcoma of the perineum: a surgical challenge

2016 ◽  
Vol 4 (1) ◽  
pp. 429
Author(s):  
Afzal Anees ◽  
Kaushal D. Singh ◽  
Shehtaj Khan
Keyword(s):  
Local Recurrence ◽  
Surgical Management ◽  
Surgical Excision ◽  
Low Grade ◽  
Rare Presentation ◽  
Desmoid Fibromatosis ◽  
Fibromyxoid Sarcoma ◽  
Slow Growing ◽  
Late Metastasis

Low-grade fibromyxoid sarcoma is a rare, slow growing and deceptively benign-appearing neoplasm. It is presently diagnosed on the basis of histopathology (typical fibro-myxoid appearance), immunohistochemistry (vimentin staining) and cytogenetics [chimeric FUS/CREB3L2 gene produced by t (7;16), (q33;p11)]. This tumour should be differentiated from other resembling tumours like myxofibrosarcoma, sclerosing epitheloid fibrosarcoma, desmoid fibromatosis and others. It has the potential for local recurrence and late metastasis, if not treated adequately. Although surgical excision is the only hope for treatment, reporting of details of surgical management have often been neglected for this primarily pathological entity. We report a case of a 30-year female who had a perineal mass which was managed by wide surgical excision. It was diagnosed as low-grade fibromyxoid sarcoma on the basis of histopathology and immunohistochemistry. This extremely rare presentation is, thus, discussed in context of challenging nature of its surgical excision. Patient is in follow-up and has no recurrence even after 5 years.

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