Feasibility Study on an Upgraded Future Monju Core Concept with Extended Operation Cycle Length of One Year and Increased Fuel Burnup

This paper presents an analysis of TRU-fueled VHTR systems focusing on applications requiring an extended operation with minimized control and no refueling (single-batch mode). As an example of such applications, international deployment opportunities for grid-appropriate VHTR systems could be mentioned addressing demands for electricity, industrial heat and co-generation in those regions where minimized servicing is desirable for various reasons. The study is performed for the hexagonal block core concept within the framework of the ongoing U.S. DOE NERI Project on utilization of higher actinides (TRUs and partitioned MAs) as a fuel component for extended-life VHTRs. The up-to-date analysis has shown reasonable reactivity swings, core life limits with respect to fast fluences and criticality.

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Reconstruction of Pretibial Defect Using Bone-Anchored Advancement Flap

Journal of Wound Management and Research ◽

10.22467/jwmr.2021.01403 ◽

2021 ◽

Vol 17 (1) ◽

pp. 72-75

Author(s):

Suhwan Kim ◽

Kyeong-Tae Lee ◽

Jin-Woo Park

Keyword(s):

Skin Graft ◽

Free Flaps ◽

Advancement Flap ◽

Split Thickness Skin Graft ◽

Skin Defect ◽

Major Drawback ◽

Medial Side ◽

Thickness Skin ◽

Extended Operation ◽

One Year

While free flaps have been widely used for reconstruction of pretibial defects, the extended operation times are known to be a major drawback. This report presents a case of successful lower leg reconstruction for a large pretibial defect with a bone-anchored advancement flap and split-thickness skin graft. A 59-year-old female patient underwent wide excision of sarcoma on the pretibial area. The skin defect measured 14×6 cm with a 10×2 cm exposure of the tibia in the medial aspect of the defect. An advancement flap was elevated from the medial side of the tibia to cover the exposed bone. The bone defect was reconstructed by the advancement flap with the aid of an anchoring suture to the tibia. Remaining defect with exposed muscles was covered using split-thickness skin graft. No immediate postoperative complication developed. One year after the operation, well-contoured reconstruction was achieved without functional morbidities. In reconstruction of pretibial defects, bone-anchored advancement flap can be considered in patients who are reluctant to or have risk factors for free flap reconstruction.

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A prospective feasibility study of one-year administration of adjuvant S-1 therapy for resected biliary tract cancer in a multi-institutional trial (Tokyo Study Group for Biliary Cancer: TOSBIC01)

BMC Cancer ◽

10.1186/s12885-020-07185-6 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Osamu Itano ◽

Yusuke Takemura ◽

Norihiro Kishida ◽

Eiji Tamagawa ◽

Hiroharu Shinozaki ◽

...

Keyword(s):

Biliary Tract ◽

Feasibility Study ◽

Biliary Tract Cancer ◽

Study Group ◽

Biliary Cancer ◽

Tract Cancer ◽

One Year

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C. ANALISIS STUDI KELAYAKAN USAHA DI RESTO “I AM QUEEN”

Inovasi Manajemen dan Kebijakan Publik ◽

10.54980/imkp.v2i2.86 ◽

2020 ◽

Vol 2 (2) ◽

pp. 32

Author(s):

Rika Susanti ◽

Dwi Choirun Nisa ◽

Sundari . ◽

Hanik Aminatul Khurriyah ◽

Erli Nurida Bahtiar ◽

...

Keyword(s):

Feasibility Study ◽

Financial Analysis ◽

Production Capacity ◽

Payback Period ◽

Market Demand ◽

Product Demand ◽

Marketing Analysis ◽

One Year ◽

Management Functions ◽

Descriptive Method

ABSTRAK Usaha “I AM QUEEN” merupakan usaha baru yang didirikan pada tahun 2017 dengan modal sendiri. Produk yang dihasilkan berupa ayam crispy, ayam geprek, serta menu tambahan lainnya seperti burger, pizza, spaghetty, chicken steak, dan frenchfries. Penelitian ini bertujuan untuk mengetahui tingkat kelayakan investasi dalam pendirian usaha “I AM QUEEN” yang beralamat di Jalan Manukan Tama Blok 19/33-34 Kav. 198 A-B Surabaya. Metode penelitian yang digunakan yaitu metode deskriptif dengan menganalisis aspek pasar dan pemasaran, aspek teknis dan produksi, aspek organisasi dan manajemen, serta aspek finansial dengan perhitungan kelayakan investasi berupa Payback Period. Analisis pasar dan pemasaran menunjukan bahwa prospek usaha cukup baik, dilihat dari peningkatan jumlah permintaan produk. Analisis teknis dan produksi menunjukkan bahwa lokasi usaha “I AM QUEEN” dan peralatan usaha terjaga dengan baik dan dalam kondisi bersih untuk melakukan kegiatan produksi, serta dapat memenuhi kapasitas produksi untuk permintaan pasar. Analisis organisasi dan manajemen menunjukkan pemilik usaha yang telah menjalankan fungsi manajemen dengan baik dan sebagaimana mestinya. Analisis finansial dengan menggunakan modal sendiri didapatkan hasil Payback Period yaitu satu tahun dua bulan. Kata Kunci : Aspek – Aspek Studi Kelayakan Bisnis, Bisnis, Studi Kelayakan Bisnis, ABSTRACT ‘I AM QUEEN’ Resto is a new bussiness established by self funding in 2017. The products are crispy chicken, geprek chicken, and other additional menus such as burger, pizza, spaghetty, chicken steak, and frenchfries. This research aims to determine the feasibility of investment in the establishment of a “I AM QUEEN” bussiness where located at Manukan Tama Street, Block 19/33-34 Kav. 198 A-B Surabaya.The research method used is descriptive method by analyzing market and marketing aspect, technical and production aspects, organizational and management aspects, and financial aspects with the calculation of the feasibility of investment Payback Period. Market and marketing analysis indicates that the bussiness prospect is good enough, it is seen from the increasing number of product demand. Technical and production analysis showed that the location of “I AM QUEEN” and bussiness equipment is well maintained and in a clean condition to carry out production activities, and also can fulfill the production capacity for market demand. Organizational and management analysis shows that bussiness owner has been running the management functions well. And the result of financial analysis showed that Payback Period of that bussiness is one year two months. Keyword: Aspects of Feasibility Study, Bussiness, Feasibility Study

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An evidence‐based structured one‐year programme to sustain physical activity in patients with heart failure in primary care: A non‐randomized longitudinal feasibility study

Nursing Open ◽

10.1002/nop2.510 ◽

2020 ◽

Vol 7 (5) ◽

pp. 1388-1399

Author(s):

Lena Nordgren ◽

Anne Söderlund

Keyword(s):

Physical Activity ◽

Heart Failure ◽

Primary Care ◽

Feasibility Study ◽

Evidence Based ◽

Patients With Heart Failure ◽

One Year

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Succeeding with prolonged usage of consumer-based activity trackers in clinical studies: A mixed methods approach

10.21203/rs.3.rs-16826/v4 ◽

2020 ◽

Author(s):

André Henriksen ◽

Anne-Sofie Sand ◽

Trygve Deraas ◽

Sameline Grimsgaard ◽

Gunnar Hartvigsen ◽

...

Keyword(s):

Heart Rate ◽

Energy Expenditure ◽

Feasibility Study ◽

Success Factors ◽

Communicable Disease ◽

Qualitative Interviews ◽

Perceived Usefulness ◽

Clinical Trial Registry ◽

Wear Time ◽

One Year

Abstract Background: Lack of physical activity (PA) is a risk factor for death and non-communicable disease. Despite this, more than one fourth of adults worldwide do not follow PA guidelines. As part of a feasibility study to test a complex intervention for increasing PA, we included a consumer-based activity tracker (AT) as a tool to measure PA outcomes and to track heart rate during exercise sessions. The aim of the present study was to identify factors that increase wear time when using a consumer-based AT for monitoring of participants in clinical research. Methods: Sixteen participants aged 55-74 years, with obesity, sedentary lifestyle, and elevated cardiovascular risk were recruited to a 12-month feasibility study. Participants wore a Polar M430 AT to collect continuous PA data during a six-month intervention followed by six months of follow-up. We performed quantitative wear time analysis, tested the validity of the AT, and completed two rounds of qualitative interviews to investigate how individual wear-time was linked to participant responses. Results: From one year of tracking, mean number of valid wear days were 292 (SD=86), i.e. 80%. The Polar M430 provides acceptable measurements for total energy expenditure. Motivations for increased wear time were that participants were asked to wear it and the ability to track PA progress. Perceived usefulness included time keeping, heart rate- and sleep tracking, becoming more conscious about day-to-day activity, and improved understanding of which activity types were more effective for energy expenditure. Sources of AT annoyance were measurement inaccuracies and limited instruction for use. Suggestions for improvement were that the AT was big, unattractive, and complicated to use.Conclusions: Adherence to wearing a consumer-based AT was high. Results indicate that it is feasible to use a consumer-based AT to measure PA over a longer period. Potential success factors for increased wear time includes adequate instruction for AT use, allowing participants to choose different AT designs, and using trackers with accurate measurements. To identify accurate trackers, AT validation studies in the target cohort may be needed. Trial registration: U.S. National Library of Medicine, Clinical Trial registry: NCT03807323; Registered 16 September 2019 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03807323

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Protocol for Take home naloxone In Multicentre Emergency setting (TIME): Feasibility Study

10.21203/rs.2.20128/v2 ◽

2020 ◽

Author(s):

Matthew Jones ◽

Fiona Bell ◽

Jonathan Benger ◽

Sarah Black ◽

Penny Buykx ◽

...

Keyword(s):

At Risk ◽

Feasibility Study ◽

Adverse Event Rate ◽

Opioid Overdose ◽

Emergency Setting ◽

Risk Of Death ◽

Emergency Ambulance ◽

Patients At Risk ◽

One Year

Abstract Background Opioids, such as heroin, kill more people worldwide by overdose than any other type of drug, and death rates associated with opioid poisoning in the UK are at record levels (1, 2). Naloxone is an opioid antagonist which can be distributed in ‘kits’ for administration by witnesses in an overdose emergency. This intervention is known as Take Home Naloxone (THN). We know that THN can save lives on an individual level, but there is currently limited evidence about the effectiveness of THN distribution on an aggregate level, in specialist drug service settings or in emergency service settings. Notably, we do not know whether THN kits reduce deaths from opioid overdose in at-risk populations, if there are unforeseen harms associated with THN distribution or if THN is cost-effective. In order to address this research gap, we aim to determine the feasibility of a fully-powered cluster Randomised Controlled Trial (RCT) of THN distribution in emergency settings. Methods We will carry out a feasibility study for a RCT of THN distributed in emergency settings at four sites, clustered by Emergency Department (ED) and catchment area within its associated ambulance service. THN is a peer-administered intervention. At two intervention sites, emergency ambulance paramedics and ED clinical staff will distribute THN to adult patients who are at risk of opioid overdose. At two control sites, practice will carry on as usual. We will develop a method of identifying a population to include in an evaluation, comprising people at risk of fatal opioid overdose, who may potentially receive naloxone included in a THN kit. We will gather anonymised outcomes up to one year following a 12 month ‘live’ trial period for patients at risk of death from opioid poisoning. We expect approximately 100 patients at risk of opioid overdose to be in contact with each service during the one year recruitment period. Our outcomes will include: deaths; emergency admissions; intensive care admissions; and ED attendances. We will collect numbers of eligible patients attended by participating emergency ambulance paramedics and attending ED; THN kits issued; and NHS resource usage. We will determine whether to progress to a fully-powered trial based on pre-specified progression criteria: sign-up of sites (n = 4); staff trained (>= 50%); eligible participants identified (>= 50%); THN provided to eligible participants (>= 50%); people at risk of death from opioid overdose identified for inclusion in follow up (>= 75% of overdose deaths); outcomes retrieved for high risk individuals (>= 75%); and adverse event rate (<10% difference between study arms).Discussion This feasibility study is the first randomised, methodologically robust investigation of THN distribution in emergency settings. The study addresses an evidence gap related to the effectiveness of THN distribution in emergency settings. As this study is being carried out in emergency settings, obtaining informed consent on behalf of participants is not feasible. We therefore employ novel methods for identifying participants and capturing follow up data, with effectiveness dependent on the quality of the available routine data.Trial registration ISRCTN13232859 (Registered 16/02/2018)

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Seasonal effects on behavioral estrus signs and estrus detection efficiency in Holstein heifers

Indian Journal of Animal Research ◽

10.18805/ijar.8594 ◽

2016 ◽

Author(s):

Adnan Unalan

Keyword(s):

Cycle Length ◽

Detection Efficiency ◽

The Other ◽

Seasonal Effects ◽

Estrus Cycle ◽

Estrus Detection ◽

The Mean ◽

One Year

In the study, 234 Holstein heifers were observed visually during a one-year period and 1622 estrus records were used to determine seasonal effects on behavioral estrus signs and estrus detection efficiency. Estrus records were classified as standing, mounting, vaginal mucus discharging, and the other estrus signs. The rates of these estrus signs were found to be 50.6%, 22.7%, 20.7% and 6.0%, respectively and the differences were significant (P<0.01). These results showed that standing behavior was the most observable estrus sign in Holstein heifers. In addition, the rates of standing behavior in each season (66.2%, 59.7%, 50.4% and 38.0% in summer, fall, spring and winter, respectively) showed that it was also more observable sign than the other signs. The rates of estrus records according to seasons were found to be 34.4%, 32.9%, 23.6% and 9.1% in winter, fall, spring and summer, respectively and the differences were also significant (P<0.01). In the study, the mean overall estrus cycle length was found to be 21.15±1.85 days. The mean overall estrus detection efficiency was calculated as 57.8%. The mean detection efficiencies according to seasons were found to be 79.5%, 75.9%, 54.6% and 21.1% in winter, fall, spring and summer respectively. These results could be interpreted that estrus detection efficiency was decreased significantly with increase of temperature.

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