Modern hospital practices with galloping growth in medical technology facilitate increase human life span, decrease mortality rate and increase natality rate. Life supporting health services generates potentially hazardous and infectious hospital wastes like pharmaceuticals, cottons, food, paper, plastics, radionuclide, sharps, and anatomical parts etc. These wastes are complex in nature with maximum part of municipal solid waste and small part of biomedical waste (anatomical parts, body parts etc.). Improper conduct and management of hospital waste create several problems and nosocomial diseases to human beings and harms environment. Traditional practices included for management are open burning, mixing waste, liquid discharge and waste disposal without treatment normally. Hence, this issue comes in lime light and several guidelines come to sort out this problem. Thus, challenges associated with traditional hospital waste management techniques and modern techniques for management are assessed in general and association with human society in particular in this chapter.