Healthy ageing across the life course

2018 ◽  
Author(s):  
Diana Kuh ◽  
Rebecca Hardy ◽  
Catharine Gale ◽  
Jane Elliott ◽  
Yoav Ben-Shlomo ◽  
...  
Keyword(s):  
Life Course ◽  
Qualitative Interviews ◽  
Later Life ◽  
Healthy Ageing ◽  
Individual Level ◽  
Optimal Functioning ◽  
Cognitive Capability ◽  
The Individual ◽  
Meta Analyses ◽  
The Life Course

This chapter describes the Healthy Ageing across the Life Course (HALCyon) NDA collaborative research project, the aim of which was to investigate biological and social factors from early life that influence healthy ageing in later life. Healthy ageing was studied as optimal functioning at the individual level, in terms of physical and cognitive capability and wellbeing. The roles of lifetime socioeconomic circumstances, cognitive development and education, body size and diet were investigated, as well as underlying biology (the hypothalamic-pituitary-adrenal (HPA) axis, telomeres and genes). The project undertook: systematic reviews and meta-analyses of all available studies; comparative analysis using harmomised data across nine British cohort studies; in depth analysis of single cohorts with unique data; and qualitative interviews with sub-samples of participants from three of these cohorts.

scholarly journals PRECARITY AND LATER LIFE: UNDERSTANDING NEW INEQUALITIES AND RISKS IN LATER LIFE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S588-S588
Author(s):  
Dale Dannefer ◽  
Christopher Phillipson ◽  
Dale Dannefer
Keyword(s):  
Older People ◽  
Life Course ◽  
Social Dynamics ◽  
Later Life ◽  
Academic Disciplines ◽  
Potential Contribution ◽  
Term Care ◽  
Economic Changes ◽  
Individual Level ◽  
The Life Course

Abstract This symposium addresses debates around the theme of precarity and its implications for understanding social and economic changes affecting the lives of older people. To date, the concept of precarity has been applied to several subpopulations by various academic disciplines but has yet to be systematically applied to later life. The symposium will give particular attention to the extent to which the lens provided by precarity can illuminate different types of inequalities experienced through the life course and reflected in public policies directed at older people. Chris Phillipson reviews theoretical perspectives relating to precarity, examining their potential contribution for the development of critical gerontology. His paper also considers the extent to which the concept of ‘precarious ageing’ offers a competing or complementary view to theories of ‘active’ and ‘successful ageing’. Larry Polivka examines the growing precarity of life for older Americans emanating from austerity budgets and privatization of public services. The paper suggests that policies such as health care and long term care are in jeopardy, creating a glide path toward the extension of precarious employment into a precarious retirement for millions of older people. Wenxuan Huang examines how the focus on agency and other individual-level foci obscure understanding of social dynamics. Finally, Amanda Grenier draws on a scoping review of precarity to outline conceptual distinctions between frailty, vulnerability, and precarity. She presents reflections on what these concepts offer in terms of understandings of late life the study of disadvantage across the life course.

scholarly journals AGENCY AS IDEOLOGY: PRECARITY AND DISEMBEDDEDNESS IN THE 21ST CENTURY LIFE COURSE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S589-S589
Author(s):  
wenxuan huang
Keyword(s):  
Life Course ◽  
Transition To Adulthood ◽  
Social Institutions ◽  
Historical Time ◽  
Cultural Traditions ◽  
Individual Level ◽  
Individual Agency ◽  
Transition Research ◽  
The Individual ◽  
The Life Course

Abstract The “individualization” thesis has gradually merged into the discussion of increasing heterogeneity of the life course as well as growing inequality over historical time. As individuals are “disembedded” from both cultural traditions and more recently social institutions, individual agency has drawn revived interest in outlining “choice biography” that is seen as paramount to personal outcomes and even containing overcoming force against structure. This practice mutes the consideration of the ongoing forces of social structure that by their very nature continue to constitute individual selves and possibilities. The uncritical treatment of individual agency makes it problematic for the study of precarity, mystifying and obscuring the analysis of inequality-generating mechanisms, reducing them to the individual-level. We analyze current uses of the concept of agency in the life course research, and particularly in the areas of transition research, e.g., transition to adulthood/retirement, where individual agency is assumed to be most active.

scholarly journals Factors associated with symptoms of anxiety and depression in five cohorts of community-based older people: the HALCyon (Healthy Ageing across the Life Course) Programme

2011 ◽  
Vol 41 (10) ◽  
pp. 2057-2073 ◽  
Author(s):  
C. R. Gale ◽  
A. Aihie Sayer ◽  
C. Cooper ◽  
E. M. Dennison ◽  
J. M. Starr ◽  
...  
Keyword(s):  
Older People ◽  
Life Course ◽  
Physical Function ◽  
Birth Cohort ◽  
Depression Scale ◽  
Later Life ◽  
Healthy Ageing ◽  
Anxiety And Depression ◽  
Increased Risk ◽  
The Life Course

BackgroundSymptoms of anxiety and depression are common in older people, but the relative importance of factors operating in early and later life in influencing risk is unclear, particularly in the case of anxiety.MethodWe used data from five cohorts in the Healthy Ageing across the Life Course (HALCyon) collaborative research programme: the Aberdeen Birth Cohort 1936, the Caerphilly Prospective Study, the Hertfordshire Ageing Study, the Hertfordshire Cohort Study and the Lothian Birth Cohort 1921. We used logistic regression to examine the relationship between factors from early and later life and risk of anxiety or depression, defined as scores of 8 or more on the subscales of the Hospital Anxiety and Depression Scale, and meta-analysis to obtain an overall estimate of the effect of each.ResultsGreater neuroticism, poorer cognitive or physical function, greater disability and taking more medications were associated in cross-sectional analyses with an increased overall likelihood of anxiety or depression. Associations between lower social class, either in childhood or currently, history of heart disease, stroke or diabetes and increased risk of anxiety or depression were attenuated and no longer statistically significant after adjustment for potential confounding or mediating variables. There was no association between birth weight and anxiety or depression in later life.ConclusionsAnxiety and depression in later life are both strongly linked to personality, cognitive and physical function, disability and state of health, measured concurrently. Possible mechanisms that might underlie these associations are discussed.

scholarly journals Eurofound’s Reference Framework: Sustainable work over the life course in the EU

2021 ◽  
Vol 6 (1) ◽  
pp. 67-83
Author(s):  
Franz Eiffe
Keyword(s):  
Life Course ◽  
Working Life ◽  
Physical And Mental Health ◽  
Outcome Indicators ◽  
Individual Level ◽  
Reference Framework ◽  
Research Priority ◽  
Work Outcome ◽  
The Individual ◽  
The Life Course

Demographic change has triggered policy debates and responses across Europe. The need of keeping workers in employment longer is a consequence that requires rethinking new solutions for working conditions and career paths helping workers to retain their physical and mental health – as well as motivation and productivity – throughout an extended working life. Eurofound has titled the broad goal set out by this statement as ‘making work sustainable over the life course’. Identifying and analysing the factors and actions underpinning sustainable work throughout working life has been a research priority for Eurofound since 2013. In this article, the Eurofound reference framework of sustainable work is introduced and its components are discussed. In a first step, the rather expansive concept of sustainable work was illuminated by a framework that explains our approach and that has been used as reference point for a range of Eurofound research projects examining different aspects of sustainable work. Section 2 presents sustainable work outcome indicators on the societal and the individual level and provides some reflections of how those can be used jointly to map overall beneficial work environments for sustainable work. Section 3 investigates contextual factors such as infrastructures, workplace practices and job quality. The specific role of motivation is highlighted in section 4 based on empirical analysis. The paper closes with some conclusions and a policy outlook. 

Aging, sarcopenia and the life-course

2006 ◽  
Vol 16 (4) ◽  
pp. 265-274 ◽  
Author(s):  
Avan Aihie Sayer ◽  
Cyrus Cooper
Keyword(s):  
Life Course ◽  
Life Course Perspective ◽  
Human Aging ◽  
Maintenance And Repair ◽  
Individual Level ◽  
Disposable Soma Theory ◽  
Somatic Maintenance ◽  
Variable Capacity ◽  
The Individual ◽  
The Life Course

There is growing support for characterizing human aging from a life-course perspective, in terms of recognizing important influences operating from conception to death, and this approach provides a framework for understanding aging processes operating at the individual level. Kirkwood's disposable soma theory proposes that aging is a manifestation of imperfect somatic maintenance and repair processes. We can therefore predict that differing exposure to the determinants of somatic damage across the life-course, and variable capacity to respond in terms of repair are likely to underlie the wide variation in rates of aging between individuals.

scholarly journals New Perspectives on Loneliness: From Micro Qualitative to Macro Quantitative Cross-National Comparisons

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 609-609
Author(s):  
Marja Aartsen
Keyword(s):  
Life Course ◽  
Ecological Model ◽  
Longitudinal Research ◽  
Qualitative Interviews ◽  
Later Life ◽  
Life Course Perspective ◽  
Effective Prevention ◽  
The Life Course ◽  
The Impact

Abstract Longitudinal research revealed a number of micro-level drivers of loneliness, such as widowhood, exclusion from the wider society, ill health and migrant status, but a number of questions are still unanswered. For example, the prevalence of loneliness varies substantially across countries, but we do not know precisely what causes these differences. It may be due to differences in the composition of the populations, it may also be caused by macro-level drivers, or by variations in the impact of risk factors between countries. For example, losing a spouse may be loneliness provoking in countries where living with a partner is the norm, but less so in countries where living alone is more valued. Also how early childhood and events over the life course affect the level of loneliness in later life is still under-researched. The aim of our symposium is to address this gap by presenting different perspectives on loneliness and social isolation. The first presenter interprets five-year follow-up information from qualitative interviews with a life course perspective. The second investigates the role of trust as factor producing social integration, which leads to variations in loneliness. The third compares and discusses loneliness in three different continents, based on an ecological model of contexts. The forth presenter critically discusses ways to measure loneliness in societies that are culturally distinct from western cultures. The last presenter discusses the dynamics between loneliness and material deprivation in Europe. The findings provide a new lens through which we can understand loneliness and inform about effective prevention.

scholarly journals Intrapair Comparison of Life-Course Appetite and Physical Activity in Elderly Danish Twins: Reliability and Association With Subsequent Survival

2016 ◽  
Vol 19 (5) ◽  
pp. 447-455 ◽  
Author(s):  
Laura E. Løkkegaard ◽  
Lisbeth A. Larsen ◽  
Kaare Christensen
Keyword(s):  
Physical Activity ◽  
Life Course ◽  
Healthy Aging ◽  
Positive Association ◽  
Late Life ◽  
Lifestyle Factors ◽  
Physically Active ◽  
Individual Level ◽  
The Individual ◽  
The Life Course

Avoiding overeating and being physically active is associated with healthy aging, but methodological issues challenge the quantification of the association. Intrapair comparison of twins is a study design that attempts to minimize social norm-driven biased self-reporting of lifestyle factors. We aimed to investigate the association between self-reported lifestyle factors and subsequent survival in 347 Danish twin pairs aged 70 years and older and, additionally, to investigate the reliability of these self-reports. The twins were interviewed in 2003 and followed for mortality until 2015. They were asked to compare their appetite and physical activity to that of their co-twins in different stages of life. On an individual level, we found a positive association between current self-reported physical activity and late-life survival for elderly twins. This was supported by the intrapair analyses, which revealed a positive association between midlife and current physical activity and late-life survival. A positive association between lower appetite and late-life survival was found generally over the life course in the individual level analyses but not in the intrapair analyses. Kappa values for the inter-twin agreement on who ate the most were 0.16 to 0.34 in different life stages, and for physical activity 0.19 to 0.26, corresponding to a slight-to-fair agreement. Approximately, 50% of the twin pairs were not in agreement regarding physical activity, and of these twins 75% (95% CI: 67–82%) considered themselves the most active twin. These findings indicate a still-existing tendency of answering according to social norms, even in a twin study designed to minimize this.

Old age and the fourth age paradigm

2016 ◽  
Author(s):  
Paul Higgs ◽  
Chris Gilleard
Keyword(s):  
Life Course ◽  
Old Age ◽  
Later Life ◽  
Healthy Ageing ◽  
Third Age ◽  
Active And Healthy Ageing ◽  
The Life Course

This chapter outlines the fourth age paradigm. It argues that later life is increasingly losing its coherence as a unitary stage in the life course. Diversity in the discourses and practices surrounding later life abound. The discourses of active and healthy ageing in particular promote an optimistic ‘third age’ culture. This framing of later life as a time for autonomy, self-expression and pleasure creates the conditions for the shadowy background of a fourth age imaginary. It is within this imaginary sphere that all the fears and failures of ageing and agedness are deposited.

Associations between life-course frailty and later-life heart size and function in the 1946 NSHD British birth cohort-an epidemiological study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C.C Topriceanu ◽  
J.C Moon ◽  
R Hardy ◽  
A.D Hughes ◽  
N Chaturvedi ◽  
...  
Keyword(s):  
Life Course ◽  
Birth Cohort ◽  
Frailty Index ◽  
Later Life ◽  
Left Ventricular ◽  
Step Change ◽  
Deficit Accumulation ◽  
Heart Size ◽  
And Function ◽  
The Life Course

Abstract Background Cardiovascular diseases are an important component of the multi-morbidity syndrome which is associated with negative health outcomes resulting in a major societal economic burden. An objective way to assess multi-morbidity is to calculate a frailty index based on medical deficit accumulation. Late-life frailty has been validated to predict mortality, but little is known about the association between life-course frailty and cardiovascular health in later-life. Purpose To study the association between life-course frailty and later-life heart size and function using data from the world's longest running birth cohort with continuous follow-up. Methods A 45-deficit frailty index (FI) was calculated at 4 age-intervals across the life-course (0 to 16 years old, 19 to 44 years old, 45 to 54 years old and 60 to 64 years old) in participants from the UK 1946 Medical Research Council (MRC) National Survey of Heath and Development (NSHD) birth cohort. The life-course frailty indices (FI0_16, FI19_44, FI45_54 and FI60_64) reflect the cumulative medical deficits at the corresponding age-intervals. They were used to derive FImean and FIsum reflecting overall-life frailty. The step change in deficit accumulation between age-intervals was also calculated (FI2-1, FI3-1, FI4-1, FI3-2, FI4-2, FI4-3). Echocardiographic data at 60–64 years provided: E/e' ratio, ejection fraction (EF), myocardial contraction fraction index (MCFi) and left ventricular mass index (LVmassi). Generalized linear mixed models with gamma distribution and log link assessed the association between FIs and echo parameters after adjustment for sex, socio-economic position and body mass index. Results 1.805 NSHD participants were included (834 male). Accumulation of a single deficit had a significant impact (p<0.0001 to p<0.049) on LVmassi and MCFi in all the life-course FIs and overall FIs. LVmassi increased by 0.89% to 1.42% for the life-course FIs and by 0.36%/1.82% for FIsum and FImean respectively. MCFi decreased by 0.62% to 1.02% for the life-course FIs and by 0.33%/ 1.04%. for FIsum and FImean respectively. One accumulated deficit translated into higher multiplicative odds (13.2 for FI60-64, 2.1 for FI4-1, 75.4 for FI4-2 and 78.5 for FI4-3) of elevated filling pressure (defined as E/e' ratio >13, p<0.0.005 to p<0.02).A unit increase in frailty decreased LV EF (%) by 11%/12% for FI45-54 and FI60-64 respectively, by 10% to 12% for FI2-1, FI3-1, FI4-1 and FI4-2, and 4%/15% for FIsum and FImean respectively (p<0.0014 to p<0.044). Conclusion Frailty during the life-course, overall life-frailty and the step change in deficit accumulation is associated with later-life cardiac dysfunction. Frailty strain appears to have its greatest impact on pathological myocardial hypertrophy (high LVmassi and low MCFi) potentially paving the way to later-life systolic or diastolic dysfunction in susceptible individuals. Funding Acknowledgement Type of funding source: None

scholarly journals Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Saira Khan ◽  
K. Y. Wolin ◽  
R. Pakpahan ◽  
R. L. Grubb ◽  
G. A. Colditz ◽  
...  
Keyword(s):  
Body Size ◽  
Benign Prostatic Hyperplasia ◽  
Life Course ◽  
Early Life ◽  
Prostate Volume ◽  
Late Life ◽  
Later Life ◽  
Normal Weight ◽  
Prostatic Hyperplasia ◽  
The Life Course

Abstract Background Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes. Methods Our study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Associations for body size in early- (age 20), mid- (age 50) and late-life (age ≥ 55, mean age 60.7 years) and weight change with incident BPH-related outcomes (including self-reported nocturia and physician diagnosis of BPH, digital rectal examination-estimated prostate volume ≥ 30 cc, and prostate-specific antigen [PSA] concentration > 1.4 ng/mL) were examined using Poisson regression with robust variance estimation. Results Men who were obese in late-life were 25% more likely to report nocturia (Relative Risk (RR): 1.25, 95% Confidence Interval (CI): 1.11–1.40; p-trendfor continuous BMI < 0.0001) and men who were either overweight or obese in late-life were more likely to report a prostate volume ≥ 30 cc (RRoverweight: 1.13, 95% CI 1.07–1.21; RRobese: 1.10, 95% CI 1.02–1.19; p-trendfor continuous BMI = 0.017) as compared to normal weight men. Obesity at ages 20 and 50 was similarly associated with both nocturia and prostate volume ≥ 30 cc. Considering trajectories of body size, men who were normal weight at age 20 and became overweight or obese by later-life had increased risks of nocturia (RRnormal to overweight: 1.09, 95% CI 0.98–1.22; RRnormal to obese: 1.28, 95% CI 1.10–1.47) and a prostate volume ≥ 30 cc (RRnormal to overweight: 1.12, 95% CI 1.05–1.20). Too few men were obese early in life to examine the independent effect of early-life body size. Later-life body size modified the association between physical activity and nocturia. Conclusions We found that later-life body size, independent of early-life body size, was associated with adverse BPH outcomes, suggesting that interventions to reduce body size even late in life can potentially reduce the burden of BPH-related outcomes and nocturia.

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