Solvent-free accelerated organic syntheses using microwaves

2001 ◽  
Vol 73 (1) ◽  
pp. 193-198 ◽  
Author(s):  
Rajender S. Varma
Keyword(s):  
Organic Synthesis ◽  
High Speed ◽  
Multicomponent Reactions ◽  
Solvent Free ◽  
Parallel Synthesis ◽  
One Pot ◽  
Reduction Reactions ◽  
Heterocyclic Molecules ◽  
Organic Syntheses

A solvent-free approach for organic synthesis is described which involves microwave (MW) exposure of neat reactants (undiluted) either in the presence of a catalyst or catalyzed by the surfaces of inexpensive and recyclable mineral supports such as alumina, silica, clay, or "doped" surfaces, namely, Fe(NO3)3-clay (clayfen), Cu(NO3)2-clay (claycop), NH2OH-clay, PhI(OAc)2-alumina, NaIO4-silica, MnO2-silica, and NaBH4-clay. A variety of deprotection, condensation, cyclization, oxidation, and reduction reactions are presented including the efficient one-pot assembly of heterocyclic molecules from in situ generated intermediates such as enamines and a-tosyloxyketones. The application of this solvent-free MW approach to multicomponent reactions is highlighted that can be adapted for high-speed parallel synthesis of the library of dihydropyrimidine-2(1H)-ones and imidazo [1,2-a]annulated pyridines, pyrazines, and pyrimidines.

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu
Keyword(s):  
Reaction Time ◽  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Propargyl Bromide ◽  
Important Goal ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Volatile Organic

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

scholarly journals One-pot synthesis of hollow hydrangea Au nanoparticles as a dual catalyst with SERS activity for in situ monitoring of a reduction reaction

RSC Advances ◽  
2019 ◽  
Vol 9 (18) ◽  
pp. 10314-10319 ◽  
Author(s):  
Yazhou Qin ◽  
Yuxiang Lu ◽  
Wufan Pan ◽  
Dongdong Yu ◽  
Jianguang Zhou
Keyword(s):  
Au Nanoparticles ◽  
Reduction Reaction ◽  
In Situ Monitoring ◽  
One Pot ◽  
Reduction Reactions ◽  
One Pot Synthesis

We prepared hollow flower-shaped Au nanoparticles as a bifunctional material by a one-pot method for in situ monitoring of reduction reactions.

Environmentally Friendly Organic Synthesis Using Bismuth Compounds. Bismuth Trifluoromethanesulfonate-Catalyzed Allylation of Dioxolanes

2008 ◽  
Vol 61 (6) ◽  
pp. 419 ◽  
Author(s):  
Matthew J. Spafford ◽  
James E. Christensen ◽  
Matthew G. Huddle ◽  
Joshua R. Lacey ◽  
Ram S. Mohan
Keyword(s):  
Organic Synthesis ◽  
Multicomponent Reaction ◽  
Scale Up ◽  
Environmentally Friendly ◽  
Solvent Free ◽  
Bismuth Compounds ◽  
Solvent Free Conditions ◽  
In Situ Derivatization

A bismuth trifluoromethanesulfonate (triflate)-catalyzed (2.0 mol-%) multicomponent reaction involving the allylation of dioxolanes followed by in situ derivatization with anhydrides to generate highly functionalized esters has been developed under solvent-free conditions. Most reagents used to date for allylation of dioxolanes are highly corrosive and are often required in stoichiometric amounts. In contrast, the use of a relatively non-toxic and non-corrosive bismuth(iii)-based catalyst makes this methodology especially attractive for scale-up.

Uncatalyzed Synthesis of Unsymmetrical Indole-substituted Methane Derivatives via One-pot Multicomponent Reactions under Solvent-free Conditions

2021 ◽  
Vol 18 ◽  
Author(s):  
Shiyin Li ◽  
Xinru Lin ◽  
Xiling Gao ◽  
Wangyu Zeng ◽  
Xiaoyi Wu ◽  
...  
Keyword(s):  
Multicomponent Reactions ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Experimental Results ◽  
Synthetic Method ◽  
One Pot ◽  
Solvent Free Conditions ◽  
First Time

For the first time, one-pot multi-component reactions containing indole, aromatic aldehydes, and dimedone have been achieved in the absence of any catalyst under solvent-free conditions. A class of unsymmetrical indole-substituted methane derivatives and symmetrical diindolylmethanes have been synthesized through this green organic synthetic method. Based on experimental results, a reasonable mechanism for this condensation is emphasized here.

scholarly journals Solvent-free preparation of amidoalkyl phenols catalyzed by trityl chloride under neutral media

2015 ◽  
Vol 93 (11) ◽  
pp. 1245-1248 ◽  
Author(s):  
Ahmad Reza Moosavi-Zare ◽  
Mohammad Ali Zolfigol ◽  
Fateme Derakhshan-Panah ◽  
Masoume Daraei
Keyword(s):  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Solvent Free ◽  
One Pot ◽  
Multicomponent Condensation ◽  
Solvent Free Condition ◽  
Neutral Media ◽  
In Situ Generation

A one-pot, multicomponent condensation reaction of phenols, aromatic aldehydes, and amides in the presence of catalytic amount of trityl chloride as a homogeneous organocatalyst under solvent-free condition to prepare amidoalkyl phenols has been reported. It is interesting that trityl chloride by in situ generation of trityl carbocation with inherent instability catalyzes the reaction.

scholarly journals Microwave-assisted Eco-Friendly Synthesis and Antimicrobial Evaluation of Aryl-Triazole-1,3,4-Thiadiazols

2017 ◽  
Vol 1 (3) ◽  
pp. 17-22 ◽  
Author(s):  
Shalini Jaiswal ◽  
Smriti Dwivedi
Keyword(s):  
Microwave Irradiation ◽  
Organic Synthesis ◽  
Research Programme ◽  
Biologically Active Compounds ◽  
Solvent Free ◽  
Biologically Active ◽  
Aromatic Acid ◽  
One Pot ◽  
Active Compounds ◽  
Solvent Free Condition

Due to the growing awareness about environmental pollution and environmental legislation, recent years have witnessed a phenomenal increase in the application of microwave irradiation (MW) in organic synthesis. Heterocyclic compounds are abundant in nature and are of great significance to life because their structural subunits exist in many natural products such as vitamins, hormones, and antibiotics; hence, they have attracted considerable attention in the design of biologically active molecules and advanced organic chemistry. The application of molecular diversity technique to drug discovery is a multidisciplinary effort in organic synthesis. Medicinal chemistry concerns with the discovery, development, interpretation and the identification of mechanism of action of biologically active compounds at the molecular level. Encouraged by above reports and as part of our research programme for development of eco-friendly synthetic protocol for biologically active compounds as well as in pursuing of our work on new solvent-free cyclisation here we report the synthesis of aryl-triazalo -1, 3, 4-thidiazoles. The one-pot reaction of mercapto-s-triazole with aromatic acid using AlCl3 as a catalyst under microwave irradiation (2-3 min) and in solvent-free condition gave aryl-triazalo -1, 3, 4-thidiazoles with improved yield is described here. Keywords: Aryl-triazalo-1, 3, 4-thiadiazoles, Aromatic acid, AlCl3, cyclisation, S. aureus, E. coli, B. subtilis.

An Outlook to Six- and Pseudo Six-component Reactions in Organic Synthesis with a Glance at Some Aspects of Green Chemistry

2020 ◽  
Vol 07 ◽  
Author(s):  
Fatemeh Molaei Yielzoleh ◽  
Kobra Nikoofar
Keyword(s):  
Green Chemistry ◽  
Ambient Temperature ◽  
Organic Synthesis ◽  
Thermal Energy ◽  
Total Yield ◽  
Atom Economy ◽  
Energy Usage ◽  
One Pot ◽  
Organic Syntheses ◽  
Reaction Media

Abstract:: In this review, we focused on the six- and pseudo six-component transformations in organic syntheses as a class of important and applicable MCRs. Although the MCRs usage in recent years is enhanced but the reports for more than five-component MCRs is still rare. In some cases this kinds of MCRs is the combination of some tandem named reactions which generated a union MCR. Preparation of multi-functionalized heterocycles, prevention of intermediate separation, reaction progressing in a one-pot continues manner, elevated total yield, high atom economy, and preparation of potent bioactive multi-cycles hetero-organics via construction of several new bonds are some highlighted features of MCRs. In this article we classified the mentioned six-component reactions based on reaction media. Another subdivision applied based on the thermal energy usage or ambient temperature. In fact two aspects of the green chemistry rules has been discussed.

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