Layered double hydroxide nanomaterials as potential cellular drug delivery agents

2006 ◽  
Vol 78 (9) ◽  
pp. 1771-1779 ◽  
Author(s):  
Zhi Ping Xu ◽  
G. Q. (Max) Lu
Keyword(s):  
Drug Delivery ◽  
Layered Double Hydroxide ◽  
Recent Progress ◽  
Cellular Delivery ◽  
Paper Briefly ◽  
Efficient Delivery ◽  
Anionic Drugs ◽  
Double Hydroxide

This paper briefly reviews the recent progress in using layered double hydroxide (LDH) nanomaterials as cellular delivery agents. The advantages of LDHs as cellular delivery agents are summarized, and the processes of interaction/de-intercalation of anionic drugs (genes) into/from LDH nanoparticles are discussed. Then the cellular delivery of LDH-drug (gene) nanohybrids and subsequent intracellular processes are presumably proposed. At the end, some challenges and remarks for efficient delivery of drugs (genes) via LDH nanoparticles are provided to the best of our knowledge.

scholarly journals The Impact of Magnesium–Aluminum-Layered Double Hydroxide-Based Polyvinyl Alcohol Coated on Magnetite on the Preparation of Core-Shell Nanoparticles as a Drug Delivery Agent

2019 ◽  
Vol 20 (15) ◽  
pp. 3764 ◽  
Author(s):  
Mona Ebadi ◽  
Kalaivani Buskaran ◽  
Bullo Saifullah ◽  
Sharida Fakurazi ◽  
Mohd Zobir Hussein
Keyword(s):  
Drug Delivery ◽  
Polyvinyl Alcohol ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
The Body ◽  
Normal Fibroblast ◽  
Cellular Environment ◽  
Double Hydroxide ◽  
The Impact

One of the current developments in drug research is the controlled release formulation of drugs, which can be released in a controlled manner at a specific target in the body. Due to the diverse physical and chemical properties of various drugs, a smart drug delivery system is highly sought after. The present study aimed to develop a novel drug delivery system using magnetite nanoparticles as the core and coated with polyvinyl alcohol (PVA), a drug 5-fluorouracil (5FU) and Mg–Al-layered double hydroxide (MLDH) for the formation of FPVA-FU-MLDH nanoparticles. The existence of the coated nanoparticles was supported by various physico-chemical analyses. In addition, the drug content, kinetics, and mechanism of drug release also were studied. 5-fluorouracil (5FU) was found to be released in a controlled manner from the nanoparticles at pH = 4.8 (representing the cancerous cellular environment) and pH = 7.4 (representing the blood environment), governed by pseudo-second-order kinetics. The cytotoxicity study revealed that the anticancer delivery system of FPVA-FU-MLDH nanoparticles showed much better anticancer activity than the free drug, 5FU, against liver cancer and HepG2 cells, and at the same time, it was found to be less toxic to the normal fibroblast 3T3 cells.

CaAl-layered double hydroxide as a drug delivery system: effects on solubility and toxicity of the antiretroviral efavirenz

2016 ◽  
Vol 85 (3-4) ◽  
pp. 281-288 ◽  
Author(s):  
Danilo Augusto Ferreira Fontes ◽  
Magaly Andreza Marques de Lyra ◽  
Jeyce Kelle Ferreira de Andrade ◽  
Giovanna Christinne Rocha de Medeiros Schver ◽  
Larissa Araújo Rolim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Double Hydroxide

Self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system for bone repair materials

2017 ◽  
Vol 5 (12) ◽  
pp. 2245-2253 ◽  
Author(s):  
Yi-Xuan Chen ◽  
Rong Zhu ◽  
Zheng-liang Xu ◽  
Qin-Fei Ke ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Self Assembly ◽  
Bone Repair ◽  
Repair Materials ◽  
Double Hydroxide ◽  
First Time ◽  
Bone Repair Materials

The self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system was demonstrated for the first time to improve the cytocompatibility and enhance the osteoinductivity for the treatment of bone defects.

Methotrexate Intercalated CaAl Layered Double Hydroxide Nanohybrid for Drug Delivery

2016 ◽  
Vol 8 (6) ◽  
pp. 450-459 ◽  
Author(s):  
Manjusha Chakraborty ◽  
Sayantan Ray ◽  
Suman Saha ◽  
Jiten Ghosh ◽  
Swapankumar Ghosh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Layered Double Hydroxide ◽  
Double Hydroxide
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