Carcinogenesis of asbestos switched on by inducing cross- linkage between DNA complementary pair bases

2002 ◽  
Vol 47 (13) ◽  
pp. 1086 ◽  
Author(s):  
Qianhuan DAI
Author(s):  
Masaatsu Koike ◽  
Koichi Nakashima ◽  
Kyoko Iida

Penicillin exerts the activity to inhibit the peptide cross linkage between each polysaccharide backbone at the final stage of wall-peptidoglycan biosynthesis of bacteria. Morphologically, alterations of the septal wall and mesosome in gram-positive bacteria, which were occurred in early time after treatment with penicillin, have been observed. In this experiment, these alterations were cytochemically investigated by means of silver-methenamine staining after periodate oxidation, which is applied for detection of localization of wall mucopolysaccharide.Staphylococcus aureus strain 209P treated with 100 u/ml of penicillin G was divided into two aliquotes. One was fixed by Kellenberger-Ryter's OSO4 fixative at 30, 60 and 120 min after addition of the antibiotic, dehydrated through alcohol series, and embedded in Epon 812 (Specimen A). The other was fixed by 21 glutaraldehyde, dehydrated through glycolmethacrylate series and embedded in glycolmethacrylate mixture, according to Bernhard's method (Specimen B).


2010 ◽  
Vol E93-B (11) ◽  
pp. 3189-3192 ◽  
Author(s):  
Lifeng HE ◽  
Fang YANG ◽  
Kewu PENG ◽  
Jian SONG

1987 ◽  
Vol 42 (11-12) ◽  
pp. 1165-1170 ◽  
Author(s):  
Uwe J. Jürgens ◽  
Baldur Rieth ◽  
Jürgen Weckesser ◽  
Crawford S. Dow ◽  
Wilfried A. König

The rigid layer and peptidoglycan fractions from two strains (ATCC 17100 and Rm 5) of the budding phototrophic Rhodomicrobium vannielii were isolated. Rigid layers of both strains contain protein in addition to peptidoglycan. They were free of polysaccharides and fatty acids. The respective peptidoglycan fractions contain glucosamine, muramic acid, ʟ-and ᴅ-alanine, ᴅ-glutamic and meso-diaminopimelic acid in approximately equimolar ratios except for a signifi­ cant lower relative ᴅ-alanine content. Analysis of partial acid hydrolysates revealed A 1 γ-type structure of Rhodomicrobium vannielii peptidoglycan (shown with strain ATCC 17100). An about 10-30% lack of N-acetylation of glucosamine was indicated. The degree of cross-linkage was found to be about 60% . No differences in peptidoglycan composition and degree of cross-linkage were found between swarmer-and chain-cells as examined with strain Rm 5.


1977 ◽  
Vol 131 ◽  
pp. 91-97 ◽  
Author(s):  
Anna Goździcka-Józefiak ◽  
Jacek Augustyniak
Keyword(s):  

1966 ◽  
Vol 100 (3) ◽  
pp. 593-600 ◽  
Author(s):  
M Wallis ◽  
HBF Dixon

1. A method is described for the chromatographic preparation of ox growth hormone. It involves chromatography of an extract of anterior pituitary lobes on DEAE-cellulose, followed by rechromatography on a dextran gel of low cross-linkage (Sephadex G-100). 2. The product is highly active in growth-hormone assays, and is obtained in good yield. It was homogeneous by several criteria, but showed some heterogeneity on starch-gel electrophoresis. 3. The molecular weight of the hormone was estimated from its behaviour on gel-filtration columns under various conditions. Evidence that the hormone may dissociate into sub-units under some conditions is presented.


2001 ◽  
Vol 18 (4) ◽  
pp. 658-684
Author(s):  
Simon P. Keefe

Given the chronological separation of Mozart's final piano concertos, K. 537 and K. 595, from his extraordinary sequence of 15 piano concertos of 1782-86 (K. 413-503), it is no surprise that critics have continually stressed stylistic and affective departures from the composer's norm. But the stylistic significance of these final concertos remains fundamentally misunderstood. In spite of sharply contrasting characteristics——ostentatious virtuosity in K. 537 and carefully measured writing in K. 595——these works are, in fact, kindred spirits. In both concertos Mozart experiments with the introduction of abrupt juxtapositions of harmonically contrasting material while avoiding the outright opposition of piano and orchestral forces evident in his earlier Viennese first movements; with piano figuration, omitting it when expected or reconstituting it at important formal junctures; and with unexpected thematic and harmonic disjunctions. While Mozart's harmonic experimentation in K. 537 and 595 can be partially explained in general stylistic terms, given similarities to passages in the last three symphonies, and considered representative of the "bizarre tonal sequences" and "striking modulations" often remarked upon by Mozart's contemporaries, it cannot be attributed to a fundamental shift in the composer's "world view." Rather, the complementary nature of radicalism and innovation in the two first movements in particular——K. 537 in the orchestral and solo expositions and recapitulation and K. 595 in the development——reveals these final concertos as thoroughly pragmatic and systematic essays in stylistic reinvention.


2017 ◽  
Vol 8 (11) ◽  
pp. 7324-7329 ◽  
Author(s):  
Tyler M. Porter ◽  
Gavin P. Heim ◽  
Clifford P. Kubiak

The measurement of the dimerization constants of hydrogen-bonded ruthenium complexes (12, 22, 32) linked by a self-complementary pair of 4-pyridylcarboxylic acid ligands in different redox states is reported.


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