Linking Cellular Disorder Strength and Shear Stiffness using Quantitative Phase Imaging

2016 ◽  
Author(s):  
Will J. Eldridge ◽  
Brianna Loomis ◽  
Adam Wax
Keyword(s):  
Shear Stiffness ◽  
Phase Imaging ◽  
Disorder Strength ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase

scholarly journals Tissue disorder strength measured by quantitative phase imaging as intrinsic cancer marker

2017 ◽  
Author(s):  
Masanori Takabayashi ◽  
Hassaan Majeed ◽  
Andre Kajdacsy-Balla ◽  
Gabriel Popescu
Keyword(s):  
Refractive Index ◽  
Imaging System ◽  
Tissue Sample ◽  
Optical Path Length ◽  
Phase Imaging ◽  
Disorder Strength ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase ◽  
Path Length Difference ◽  
Malignant Breast

AbstractTissue refractive index provides important information about morphology at the nanoscale. Since the malignant transformation involves both intra- and inter-cellular changes in the refractive index map, the tissue disorder measurement can be used to extract important diagnosis information. Quantitative phase imaging (QPI) provides a practical means of extracting this information as it maps the optical path-length difference (OPD) across a tissue sample with sub-wavelength sensitivity. In this work, we employ QPI to compare the tissue disorder strength between benign and malignant breast tissue histology samples. Our results show that disease progression is marked by a significant increase in the disorder strength. Since our imaging system can be added as an upgrading module to an existing microscope, we anticipate that it can be integrated easily in the pathology work flow.

scholarly journals Disorder strength measured by quantitative phase imaging as intrinsic cancer marker in fixed tissue biopsies

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194320 ◽  
Author(s):  
Masanori Takabayashi ◽  
Hassaan Majeed ◽  
Andre Kajdacsy-Balla ◽  
Gabriel Popescu
Keyword(s):  
Phase Imaging ◽  
Disorder Strength ◽  
Quantitative Phase Imaging ◽  
Cancer Marker ◽  
Fixed Tissue ◽  
Quantitative Phase

scholarly journals Simultaneous measurement of neurite and neural body mass accumulation via quantitative phase imaging

The Analyst ◽  
2021 ◽  
Author(s):  
Soorya Pradeep ◽  
Tasmia Tasnim ◽  
Huanan Zhang ◽  
Thomas A. Zangle
Keyword(s):  
Body Mass ◽  
Biomass Production ◽  
Simultaneous Measurement ◽  
Neural Differentiation ◽  
Phase Imaging ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase ◽  
Mass Accumulation

Quantitative phase imaging (QPI) used to quantify the mass of soma (cell bodies) and neurites as well as the rates of biomass production due to neurite maturation and formation during neural differentiation.

scholarly journals High-speed line-field confocal holographic microscope for quantitative phase imaging

2016 ◽  
Vol 24 (9) ◽  
pp. 9251 ◽  
Author(s):  
Changgeng Liu ◽  
Sebastian Knitter ◽  
Zhilong Cong ◽  
Ikbal Sencan ◽  
Hui Cao ◽  
...  
Keyword(s):  
High Speed ◽  
Phase Imaging ◽  
Quantitative Phase Imaging ◽  
Line Field ◽  
Quantitative Phase

Analysis of edge effects in attenuating phase-shift masks using quantitative phase imaging

2013 ◽  
Author(s):  
Aamod Shanker ◽  
Martin Sczyrba ◽  
Brid Connolly ◽  
Andy Neureuther ◽  
Laura Waller
Keyword(s):  
Phase Shift ◽  
Edge Effects ◽  
Phase Imaging ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase
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