scholarly journals On-chip label-free biosensing based on active whispering gallery mode resonators pumped by a light-emitting diode

2019 ◽  
Vol 27 (23) ◽  
pp. 34405 ◽  
Author(s):  
Yeseul Kim ◽  
Hansuek Lee
Keyword(s):  
Light Emitting Diode ◽  
Whispering Gallery Mode ◽  
Label Free ◽  
Light Emitting ◽  
Whispering Gallery ◽  
On Chip

scholarly journals On-Chip Glass Microspherical Shell Whispering Gallery Mode Resonators

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chenchen Zhang ◽  
Alexander Cocking ◽  
Eugene Freeman ◽  
Zhiwen Liu ◽  
Srinivas Tadigadapa
Keyword(s):  
Whispering Gallery Mode ◽  
Whispering Gallery ◽  
On Chip

On-chip cavity-enhanced absorption spectroscopy using a white light-emitting diode and polymer mirrors

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 711-717 ◽  
Author(s):  
Cathy M. Rushworth ◽  
Gareth Jones ◽  
Martin Fischlechner ◽  
Emma Walton ◽  
Hywel Morgan
Keyword(s):  
Absorption Spectroscopy ◽  
White Light ◽  
Microfluidic Chip ◽  
Path Length ◽  
Light Emitting Diode ◽  
Absorption Path Length ◽  
Light Emitting ◽  
Enhanced Absorption ◽  
Cavity Enhanced Absorption Spectroscopy ◽  
On Chip

We have integrated disposable polymer mirrors within a microfluidic chip to form a multi-pass cell, which increases the absorption path length by a maximum of 28 times, providing micromolar detection limits in a probed volume of 10 nL.

scholarly journals Pinhole microLED Array as Point Source Illumination for Miniaturized Lensless Cell Monitoring Systems

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 866 ◽  
Author(s):  
Shinta Mariana ◽  
Gregor Scholz ◽  
Feng Yu ◽  
Agus Budi Dharmawan ◽  
Iqbal Syamsu ◽  
...  
Keyword(s):  
Image Quality ◽  
Light Emitting Diode ◽  
Free Cell ◽  
Monitoring Systems ◽  
Label Free ◽  
Light Emitting ◽  
Non Invasive ◽  
Cell Monitoring ◽  
Blue Spectral Region ◽  
Led Arrays

Pinhole‐shaped light‐emitting diode (LED) arrays with dimension ranging from 100 μm down to 5 μm have been developed as point illumination sources. The proposed microLED arrays, which are based on gallium nitride (GaN) technology and emitting in the blue spectral region (λ = 465 nm), are integrated into a compact lensless holographic microscope for a non‐invasive, label‐free cell sensing and imaging. From the experimental results using single pinhole LEDs having a diameter of 90 μm, the reconstructed images display better resolution and enhanced image quality compared to those captured using a commercial surface‐mount device (SMD)‐based LED.

Label-Free Pb(II) Whispering Gallery Mode Sensing Using Self-Assembled Glutathione-Modified Gold Nanoparticles on an Optical Microcavity

2014 ◽  
Vol 86 (13) ◽  
pp. 6299-6306 ◽  
Author(s):  
Sirirat Panich ◽  
Kerry A. Wilson ◽  
Philippa Nuttall ◽  
Christopher K. Wood ◽  
Tim Albrecht ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Whispering Gallery Mode ◽  
Label Free ◽  
Optical Microcavity ◽  
Whispering Gallery ◽  
Self Assembled

scholarly journals Trapped whispering-gallery optical modes in white light-emitting diode lamps with remote phosphor

2006 ◽  
Vol 89 (4) ◽  
pp. 041125 ◽  
Author(s):  
Hong Luo ◽  
Jong Kyu Kim ◽  
Yangang Andrew Xi ◽  
E. Fred Schubert ◽  
Jaehee Cho ◽  
...  
Keyword(s):  
White Light ◽  
Light Emitting Diode ◽  
Light Emitting ◽  
Whispering Gallery ◽  
Remote Phosphor ◽  
Optical Modes

Towards next-generation label-free biosensors: recent advances in whispering gallery mode sensors

Lab on a Chip ◽  
2017 ◽  
Vol 17 (7) ◽  
pp. 1190-1205 ◽  
Author(s):  
Eugene Kim ◽  
Martin D. Baaske ◽  
Frank Vollmer
Keyword(s):  
Real World ◽  
Whispering Gallery Mode ◽  
Label Free ◽  
Next Generation ◽  
Whispering Gallery ◽  
Recent Advances ◽  
Real World Applications

We review recent advances achieved in the field of optical whispering gallery mode biosensors. We discuss major challenges that these label-free sensors are faced with on their way towards future real-world applications and introduce different approaches suggested to overcome these issues. We furthermore highlight their potential future applications.

Development of a multispectral microscopy platform using laser diode illumination for effective and automatic label-free Plasmodium falciparum detection

2020 ◽  
Author(s):  
Yao Alvarez Kossonou ◽  
Jérémie Zoueu
Keyword(s):  
Light Emitting Diode ◽  
Malaria Diagnosis ◽  
Cell Detection ◽  
Light Sources ◽  
Label Free ◽  
Fluorescence Excitation ◽  
Light Emitting ◽  
Spectral Bands ◽  
Illumination System ◽  
Set Up

In this paper, we present the progress made in developing multimodal and multispectral light microscopy for label-free malaria diagnosis. Our previously developed light emitting diode (LED) illumination system was replaced by laser diodes as light sources in order to narrow the spectral bands and improve the effectiveness of the contrast function for infected blood cell detection. The acquisition system is now equipped with an algorithm for automatic field scanning and best in-focus determination. We demonstrate the potential of this platform to provide multiple investigation modalities like transmission, reflection, scattering, fluorescence, excitation, emission and polarisation. The application of this platform on malaria-infected samples has shown the effectiveness of such a system in label-free and all-optical malaria detection by allowing the possibility of using a different type of imaging set-up for the samples analysed. Also, fewer illumination sources are used to characterise malaria-infected red blood cells compared to our previous works on malaria detection using LEDs illumination sources.

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