scholarly journals Up Regulation of the Maternal Immune Response in the Placenta of Cattle Naturally Infected with Neospora caninum

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e15799 ◽  
Author(s):  
Anne Rosbottom ◽  
Helen Gibney ◽  
Peter Kaiser ◽  
Catherine Hartley ◽  
Robert F. Smith ◽  
...  
Keyword(s):  
Immune Response ◽  
Neospora Caninum ◽  
Maternal Immune Response

scholarly journals Maternal immune response in the placenta of sheep during recrudescence of natural congenital infection of Neospora caninum

2020 ◽  
Vol 285 ◽  
pp. 109204
Author(s):  
Daniel Gutiérrez-Expósito ◽  
Marta González-Warleta ◽  
Jose Espinosa ◽  
Raquel Vallejo-García ◽  
Jose Antonio Castro-Hermida ◽  
...  
Keyword(s):  
Immune Response ◽  
Neospora Caninum ◽  
Congenital Infection ◽  
Maternal Immune Response

scholarly journals NLRP7 Promotes Choriocarcinoma Growth and Progression through the Establishment of an Immunosuppressive Microenvironment

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2999
Author(s):  
Deborah Reynaud ◽  
Roland Abi Nahed ◽  
Nicolas Lemaitre ◽  
Pierre-Adrien Bolze ◽  
Wael Traboulsi ◽  
...  
Keyword(s):  
Immune Response ◽  
Tumor Cells ◽  
Major Gene ◽  
Critical Role ◽  
Orthotopic Model ◽  
Independent Manner ◽  
Maternal Immune Response ◽  
The Impact

The inflammatory gene NLRP7 is the major gene responsible for recurrent complete hydatidiform moles (CHM), an abnormal pregnancy that can develop into gestational choriocarcinoma (CC). However, the role of NLRP7 in the development and immune tolerance of CC has not been investigated. Three approaches were employed to define the role of NLRP7 in CC development: (i) a clinical study that analyzed human placenta and sera collected from women with normal pregnancies, CHM or CC; (ii) an in vitro study that investigated the impact of NLRP7 knockdown on tumor growth and organization; and (iii) an in vivo study that used two CC mouse models, including an orthotopic model. NLRP7 and circulating inflammatory cytokines were upregulated in tumor cells and in CHM and CC. In tumor cells, NLRP7 functions in an inflammasome-independent manner and promoted their proliferation and 3D organization. Gravid mice placentas injected with CC cells invalidated for NLRP7, exhibited higher maternal immune response, developed smaller tumors, and displayed less metastases. Our data characterized the critical role of NLRP7 in CC and provided evidence of its contribution to the development of an immunosuppressive maternal microenvironment that not only downregulates the maternal immune response but also fosters the growth and progression of CC.

scholarly journals Associations of maternal immune response with MeHg exposure at 28 weeks’ gestation in the Seychelles Child Development Study

2018 ◽  
Vol 80 (5) ◽  
pp. e13046 ◽  
Author(s):  
Emeir M. McSorley ◽  
Alison J. Yeates ◽  
Maria S. Mulhern ◽  
Edwin van Wijngaarden ◽  
Katherine Grzesik ◽  
...  
Keyword(s):  
Immune Response ◽  
Child Development ◽  
Mehg Exposure ◽  
Development Study ◽  
Maternal Immune Response

Oligomannose-coated liposome-entrapped dense granule protein 7 induces protective immune response to Neospora caninum in cattle

Vaccine ◽  
2013 ◽  
Vol 31 (35) ◽  
pp. 3528-3535 ◽  
Author(s):  
Maki Nishimura ◽  
Junko Kohara ◽  
Yasuhiro Kuroda ◽  
Jun Hiasa ◽  
Sachi Tanaka ◽  
...  
Keyword(s):  
Immune Response ◽  
Neospora Caninum ◽  
Dense Granule ◽  
Protective Immune Response ◽  
Granule Protein

scholarly journals Differential Gamma Interferon- and Tumor Necrosis Factor Alpha-Driven Cytokine Response Distinguishes Acute Infection of a Metatherian Host with Toxoplasma gondii and Neospora caninum

2017 ◽  
Vol 85 (6) ◽  
Author(s):  
Shannon L. Donahoe ◽  
David N. Phalen ◽  
Bronwyn M. McAllan ◽  
Denis O'Meally ◽  
Milton M. McAllister ◽  
...  
Keyword(s):  
Immune Response ◽  
Toxoplasma Gondii ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Neospora Caninum ◽  
Necrosis Factor Alpha ◽  
Content Type ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT Toxoplasma gondii and Neospora caninum (both Apicomplexa) are closely related cyst-forming coccidian parasites that differ significantly in their host ranges and ability to cause disease. Unlike eutherian mammals, Australian marsupials (metatherian mammals) have long been thought to be highly susceptible to toxoplasmosis and neosporosis because of their historical isolation from the parasites. In this study, the carnivorous fat-tailed dunnart (Sminthopsis crassicaudata) was used as a disease model to investigate the immune response and susceptibility to infection of an Australian marsupial to T. gondii and N. caninum. The disease outcome was more severe in N. caninum-infected dunnarts than in T. gondii-infected dunnarts, as shown by the severity of clinical and histopathological features of disease and higher tissue parasite burdens in the tissues evaluated. Transcriptome sequencing (RNA-seq) of spleens from infected dunnarts and mitogen-stimulated dunnart splenocytes was used to define the cytokine repertoires. Changes in mRNA expression during the time course of infection were measured using quantitative reverse transcription-PCR (qRT-PCR) for key Th1 (gamma interferon [IFN-γ] and tumor necrosis factor alpha [TNF-α]), Th2 (interleukin 4 [IL-4] and IL-6), and Th17 (IL-17A) cytokines. The results show qualitative differences in cytokine responses by the fat-tailed dunnart to infection with N. caninum and T. gondii. Dunnarts infected with T. gondii were capable of mounting a more effective Th1 immune response than those infected with N. caninum, indicating the role of the immune response in the outcome scenarios of parasite infection in this marsupial mammal.

Immunogenicity of a DNA vaccine expressing the Neospora caninum surface protein NcSRS2 in mice

2009 ◽  
Vol 57 (1) ◽  
pp. 51-62 ◽  
Author(s):  
Zhanzhong Zhao ◽  
Jun Ding ◽  
Qun Liu ◽  
Ming Wang ◽  
Jinshu Yu ◽  
...  
Keyword(s):  
Immune Response ◽  
Dna Vaccine ◽  
Neospora Caninum ◽  
Serum Antibody ◽  
Pcr Amplification ◽  
Surface Protein ◽  
Cell Mediated Immunity ◽  
E Coli ◽  
Mammalian Expression ◽  
Antibody Titres

The immunogenicity of a DNA vaccine expressing the surface protein NcSRS2 of Neospora caninum was studied in BALB/c mice. The NcSRS2-encoding DNA was obtained by PCR amplification of the NcSRS2 ORF gene from the p43 plasmid encoding the N. caninum surface protein NcSRS2, ligated to the mammalian expression vector pcDNA3.1/Zeo(+) and propagated in E. coli DH5α to produce the N. caninum NcSRS2 DNA vaccine. BALB/c mice were immunised by two intramuscular injections of the DNA vaccine with or without complete Freund’s adjuvant (CFA). Serum antibody titres and nitric oxide (NO) concentrations, and splenocyte proliferation and cytokine expression were measured after immunisation. The DNA vaccine induced T-cell-mediated immunity as shown by significantly increased NO concentrations, cytokine gene (IL-2 and IFN-γ) expression, and NcSRS2 protein-stimulated lymphocyte proliferation in mice immunised with the DNA vaccine. The vaccine also induced weak humoral immunity. The immunogenicity of the DNA vaccine was slightly enhanced by CFA. The immune response was specific to NcSRS2. No immune response was observed in mice immunised with the pcDNA3.1/Zeo(+) vector alone.

Characterization of the Immune Response in the Placenta of Cattle Experimentally Infected with Neospora caninum in Early Gestation

2006 ◽  
Vol 135 (2-3) ◽  
pp. 130-141 ◽  
Author(s):  
S.W. Maley ◽  
D. Buxton ◽  
C.N. Macaldowie ◽  
I.E. Anderson ◽  
S.E. Wright ◽  
...  
Keyword(s):  
Immune Response ◽  
Neospora Caninum ◽  
Early Gestation

MATERNAL IMMUNE RESPONSE TO HIV-1 AND PERINATAL TRANSMISSION

1998 ◽  
Vol 18 (2) ◽  
pp. 355-369
Author(s):  
Alan L. Landay ◽  
Joan N. Siegel ◽  
Kenneth Rich
Keyword(s):  
Immune Response ◽  
Perinatal Transmission ◽  
Maternal Immune Response ◽  
Hiv 1

Endogenous and exogenous transplacental transmission of Neospora caninum – how the route of transmission impacts on epidemiology and control of disease

Parasitology ◽  
2009 ◽  
Vol 136 (14) ◽  
pp. 1895-1900 ◽  
Author(s):  
D. J. L. WILLIAMS ◽  
C. S. HARTLEY ◽  
C. BJÖRKMAN ◽  
A. J. TREES
Keyword(s):  
Immune Response ◽  
Vertical Transmission ◽  
Neospora Caninum ◽  
Protozoan Parasite ◽  
Transplacental Transmission ◽  
Highly Efficient ◽  
Route Of Transmission ◽  
And Control

SUMMARYVertical transmission of the protozoan parasite, Neospora caninum is highly efficient and can take two forms – endogenous transplacental transmission resulting from activation of the quiescent bradyzoite stage during pregnancy or exogenous transplacental transmission resulting from ingestion of oocysts during pregnancy. Calves born carrying infection derived from either endogenous or exogenous transplacental transmission are capable of infecting their offspring when they start to breed. This review considers firstly the frequency with which exogenous and endogenous transmission occur, secondly the role of the immune response in controlling N. caninum infection and thirdly how the parasite persists in an immune-competent host and is re-activated during pregnancy.

Sign in / Sign up

Export Citation Format

Share Document