High- and Low-Affinity Epidermal Growth Factor Receptor-Ligand Interactions Activate Distinct Signaling Pathways

Growth Factor ◽

Epidermal Growth Factor ◽

Signaling Pathways ◽

Growth Factor Receptor ◽

Receptor Ligand ◽

Ligand Interactions ◽

Faculty Opinions recommendation of Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717961086.793463969 ◽

2012 ◽

Author(s):

Darryl Knight

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Pulmonary Fibrosis ◽

Essential Role ◽

Transforming Growth Factor ◽

Growth Factor Receptor ◽

Transforming Growth Factor Β ◽

Receptor Ligand ◽

Endothelin-1 Stimulates Cyclooxygenase-2 Expression in Ovarian Cancer Cells Through Multiple Signaling Pathways: Evidence for Involvement of Transactivation of the Epidermal Growth Factor Receptor

Journal of Cardiovascular Pharmacology ◽

10.1097/01.fjc.0000166255.12229.0d ◽

2004 ◽

Vol 44 (Supplement 1) ◽

pp. S140-S143 ◽

Cited By ~ 18

Author(s):

Francesca Spinella ◽

Laura Rosan?? ◽

Giacomo Elia ◽

Valeriana Di Castro ◽

Pier Giorgio Natali ◽

...

Keyword(s):

Ovarian Cancer ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Cancer Cells ◽

Signaling Pathways ◽

Growth Factor Receptor ◽

Ovarian Cancer Cells ◽

Epidermal Growth ◽

Multiple Signaling

Identification of a Determinant of Epidermal Growth Factor Receptor Ligand-Binding Specificity Using a Truncated, High-Affinity Form of the Ectodomain

Biochemistry ◽

10.1021/bi010037b ◽

2001 ◽

Vol 40 (30) ◽

pp. 8930-8939 ◽

Cited By ~ 65

Author(s):

Thomas C. Elleman ◽

Teresa Domagala ◽

Neil M. McKern ◽

Maureen Nerrie ◽

Björn Lönnqvist ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Ligand Binding ◽

Growth Factor Receptor ◽

Binding Specificity ◽

Receptor Ligand ◽

High Affinity ◽

The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression

Journal of Hepatology ◽

10.1016/j.jhep.2009.06.030 ◽

2009 ◽

Vol 51 (6) ◽

pp. 1010-1020 ◽

Cited By ~ 14

Author(s):

Ana Pardo-Saganta ◽

Maria Ujue Latasa ◽

Josefa Castillo ◽

Laura Alvarez-Asiain ◽

María J. Perugorría ◽

...

Keyword(s):

Gene Expression ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Acute Phase ◽

Growth Factor Receptor ◽

Negative Regulator ◽

Receptor Ligand ◽

Proteinase-activated Receptor-2 Transactivation of Epidermal Growth Factor Receptor and Transforming Growth Factor-β Receptor Signaling Pathways Contributes to Renal Fibrosis

Journal of Biological Chemistry ◽

10.1074/jbc.m113.492793 ◽

2013 ◽

Vol 288 (52) ◽

pp. 37319-37331 ◽

Cited By ~ 52

Author(s):

Hyunjae Chung ◽

Rithwik Ramachandran ◽

Morley D. Hollenberg ◽

Daniel A. Muruve

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Signaling Pathways ◽

Renal Fibrosis ◽

Transforming Growth Factor ◽

Growth Factor Receptor ◽

Transforming Growth Factor Β ◽

Epidermal Growth ◽

Β Receptor

The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis

Hepatology ◽

10.1002/hep.22437 ◽

2008 ◽

Vol 48 (4) ◽

pp. 1251-1261 ◽

Cited By ~ 81

Author(s):

Maria J. Perugorria ◽

M. Ujue Latasa ◽

Alexandra Nicou ◽

Hugo Cartagena-Lirola ◽

Josefa Castillo ◽

...

Keyword(s):

Growth Factor ◽

Liver Fibrosis ◽

Epidermal Growth Factor ◽

Mouse Liver ◽

Growth Factor Receptor ◽

Receptor Ligand ◽

Sequential Changes in Epidermal Growth Factor Receptor/Ligand Function in Cultured Rat Liver Epithelial Cells Transformed Chemically in vitro

Pathobiology ◽

10.1159/000163560 ◽

1990 ◽

Vol 58 (1) ◽

pp. 3-14 ◽

Cited By ~ 11

Author(s):

Joe W. Grisham ◽

Ming-Sound Tsao ◽

David C. Lee ◽

Shelton Earp

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Epithelial Cells ◽

Rat Liver ◽

Growth Factor Receptor ◽

Receptor Ligand ◽

Epidermal Growth ◽

Rat Liver Epithelial Cells

Epidermal growth factor receptor levels increase but epidermal growth factor receptor ligand levels decrease in mouse mammary tumors during progression from hormone dependence to hormone independence

Breast Cancer Research and Treatment ◽

10.1007/bf00665807 ◽

1993 ◽

Vol 26 (3) ◽

pp. 289-295 ◽

Cited By ~ 5

Author(s):

Clemens B. M. Kienhuis ◽

Mels Sluyser ◽

Cees C. J. de Goeij ◽

Paul G. Koenders ◽

Theo J. Benraad

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Mammary Tumors ◽

Hormone Dependence ◽

Receptor Ligand ◽

Mouse Mammary Tumors ◽

Epidermal Growth ◽

Hormone Independence

Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-006-0219-4 ◽

2006 ◽

Vol 58 (5) ◽

pp. 577-584 ◽

Cited By ~ 31

Author(s):

Baoli Qin ◽

Hiroshi Ariyama ◽

Eishi Baba ◽

Risa Tanaka ◽

Hitoshi Kusaba ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Signaling Pathways ◽

Growth Factor Receptor ◽

Human Gallbladder ◽

Adenocarcinoma Cells ◽

Epidermal Growth ◽

Gallbladder Adenocarcinoma ◽

Gefitinib Resistance

Migfilin Protein Promotes Migration and Invasion in Human Glioma through Epidermal Growth Factor Receptor-mediated Phospholipase C-γ and STAT3 Protein Signaling Pathways

Journal of Biological Chemistry ◽

10.1074/jbc.m112.393900 ◽

2012 ◽

Vol 287 (39) ◽

pp. 32394-32405 ◽

Cited By ~ 22

Author(s):

Yunwei Ou ◽

Ling Ma ◽

Lijia Dong ◽

Liying Ma ◽

Zitong Zhao ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Signaling Pathways ◽

Phospholipase C ◽

Growth Factor Receptor ◽

Migration And Invasion ◽

Protein Signaling ◽

Human Glioma ◽