A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies

Abstract BackgroundThis study has evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by constructing a meta-analysis.MethodsThe heterogeneity in the study was tested by the Q-test and I2, and then the random ratio or fixed effect was utilized to merge the odds ratios (OR) and 95% confidence interval (CI), to estimate the strength of the association between ACE polymorphisms and susceptibility to lung cancer. We have performed Sensitivity analysis. Using funnel plot and Begger’s regression test investigated the publication bias. All data Statistical analyses were performed using Stata 12.0 and Revman 5.3.ResultsA total of 4307 participants (2181 patients; 2126 controls) were included in twelve case-control studies selected. No significant association was found between the ACE I/D polymorphism and lung cancer risks (II vs ID + DD: OR = 1.22, 95% CI = 0.89–1.68; II + ID vs DD: OR = 1.21, 95% CI = 0.90–1.63; I vs D: OR =1.15, 95% CI = 0.95–1.39). In the subgroup analysis by ethnicity, no significant association between this polymorphism and lung cancer risks was also found among Asia and Caucasian populations for the comparison of II vs ID + DD, II + ID vs DD and I vs D genetic models.ConclusionOur study indicated that the ACE I/ D polymorphism was not associated with the risk of lung cancer.

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Dietary carbohydrate intake, glycaemic index, glycaemic load and digestive system cancers: an updated dose–response meta-analysis

British Journal Of Nutrition ◽

10.1017/s0007114519000424 ◽

2019 ◽

Vol 121 (10) ◽

pp. 1081-1096

Author(s):

Xianlei Cai ◽

Xueying Li ◽

Mengyao Tang ◽

Chao Liang ◽

Yuan Xu ◽

...

Keyword(s):

Cohort Studies ◽

Dose Response ◽

Digestive System ◽

Meta Analysis ◽

Glycaemic Index ◽

Case Control ◽

Carbohydrate Intake ◽

Dietary Carbohydrate ◽

Case Control Studies ◽

Glycaemic Load

Abstract Several studies analysed the associations between dietary carbohydrate intake, glycaemic index (GI) and glycaemic load (GL) and digestive system cancers; however, the results remain controversial. This study was to perform a meta-analysis evaluating the quantitative and dose–response associations between carbohydrate intake, GI and GL, and risk of digestive system cancers. We searched medical and biological databases up to June 2018 and identified twenty-six cohort studies and eighteen case–control studies. Meta-analytic fixed or random effects models were applied to process data. We also performed dose–response analysis, meta-regression and subgroup analyses. We found that high levels of GI were significantly associated with the risk of digestive system cancers at the highest compared with the lowest categories from cohort studies (summary relative risk (RR)=1·10, 95 % CI 1·05, 1·15). Similar effects were observed from case–control studies of the comparison between the extreme categories, but the difference did not reach statistical significance (summary OR=1·28, 95 % CI 0·97, 1·69). We also observed significant dose–response association between GI and digestive system cancers, with every 10-unit increase in GI (summary RR=1·003; 95 % CI 1·000, 1·012 for cohort studies; summary OR=1·09; 95 % CI 1·06, 1·11 for case–control studies). In addition, both cohort studies and case–control studies indicated that neither dietary carbohydrate intake nor GL bore any statistical relationship to digestive system cancers from the results of the highest compared with the lowest categories analyses and dose–response analyses. The results suggest a moderate association between high-GI diets and the risk of digestive system cancers.

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Associations Between I/ D polymorphism in the ACE gene and lung cancer: an updated systematic review and a meta-analysis

10.21203/rs.3.rs-60841/v2 ◽

2021 ◽

Author(s):

Junjian Chen ◽

Mao Sun ◽

Min Zhou ◽

Renfu Lu

Keyword(s):

Lung Cancer ◽

Lung Cancer Risk ◽

Meta Analysis ◽

Case Control ◽

Rank Test ◽

Case Control Studies ◽

Cancer Risks ◽

Funnel Plot ◽

Random Ratio ◽

Q Statistic

Abstract Background: This study has evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by constructing a meta-analysis.Methods: The heterogeneity in the study was tested by the Cochran c2-based Q statistic test and I2 test, and then the random ratio or fixed effect was utilized to merge the odds ratios (OR) and 95% confidence interval (CI), to estimate the strength of the association between ACE polymorphisms and susceptibility to lung cancer. We have performed Sensitivity analysis. Using funnel plot and Begg's rank test investigated the publication bias. All data Statistical analyses were performed using Stata 12.0 and Revman 5.3.Results: A total of 4307 participants (2181 patients; 2126 controls) were included in twelve case-control studies selected. No significant association was found between the ACE I/D polymorphism and lung cancer risks (II vs ID + DD: OR = 1.22, 95% CI = 0.89–1.68; II + ID vs DD: OR = 1.21, 95% CI = 0.90–1.63; I vs D: OR =1.15, 95% CI = 0.95–1.39). In the subgroup analysis by ethnicity, no significant association between this polymorphism and lung cancer risks was also found among Asia and Caucasian populations for the comparison of II vs ID + DD, II + ID vs DD and I vs D genetic models.Conclusion: Our study indicated that the ACE I/ D polymorphism was not associated with the risk of lung cancer.

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