scholarly journals Blood Pressure Variability and Cardiovascular Risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52438 ◽  
Author(s):  
Rosalinde K. E. Poortvliet ◽  
Ian Ford ◽  
Suzanne M. Lloyd ◽  
Naveed Sattar ◽  
Simon P. Mooijaart ◽  
...  
Keyword(s):  
Blood Pressure ◽  
At Risk ◽  
Cardiovascular Risk ◽  
Prospective Study ◽  
Blood Pressure Variability ◽  
The Elderly

scholarly journals Plasma Lipoproteins and Apolipoproteins as Predictors of Cardiovascular Risk and Treatment Benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)

Circulation ◽  
2005 ◽  
Vol 112 (20) ◽  
pp. 3058-3065 ◽  
Author(s):  
Chris J. Packard ◽  
Ian Ford ◽  
Michele Robertson ◽  
James Shepherd ◽  
Gerard J. Blauw ◽  
...  
Keyword(s):  
At Risk ◽  
Cardiovascular Risk ◽  
Prospective Study ◽  
The Elderly ◽  
Plasma Lipoproteins ◽  
Treatment Benefit

scholarly journals Old hypertensive patient: a hard challenge

2013 ◽  
pp. 109-112
Author(s):  
Giuseppe Rossetti ◽  
Diana Solari ◽  
Maria Laura Rainoldi ◽  
Stefano Carugo
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Elderly People ◽  
Diastolic Pressure ◽  
Beta Blockers ◽  
The Elderly ◽  
Pressure Control ◽  
World Population ◽  
Continuous Increase ◽  
Hypertensive Therapy

BACKGROUND High blood pressure is one of the most important cardiovascular risk factor and its incidence is continuously increasing: on 2025 1/3 of adult world population will suffer of it. Moreover, the therapy of elderly hypertension sufferer patient is still growing up in importance for the continuous increase of world population average life. With ageing, the cardiovascular system suffers neurohormonal and haemodinamic modifications which determine the onset of isolate systolic hypertension, which is characteristic of the elderly. This pathology results linked to a higher cardiovascular risk. AIM OF THE STUDY This review aims to analyze and evaluate present and future therapeutic opportunities about anti-hypertensive therapy in elderly people. DISCUSSION AND CONCLUSIONS Also in elderly people systolic blood pressure values must be lower than 150 mmHg, but it’s also important to maintain diastolic pressure not under 70 mmHg, to avoid phenomenons of cerebral and coronary hypo-perfusion (J curve). The benefits of an effective anti-hypertensive therapy are achieved thanks to both blood pressure lowering “per se” and to the decrease of cardiovascular mortality and morbility. Blood pressure control in the elderly is a hard challenge for the low compliance to the therapy, for the importance of the comorbidity and for the supplementary risk factors. ESH-ESC 2007 guidelines recommend for elderly highblood pressure sufferer patient the use first of all of calcium-antagonists and thiazides diuretics, and for second line ACE-inhibitors, ARB and beta-blockers. In several patients combinations of two or more drugs are necessary to obtain pressure control.

A Comparative Study of Short-Term Blood Pressure Variability in Hemodialysis Patients with and without Intradialytic Hypertension

2018 ◽  
Vol 48 (4) ◽  
pp. 295-305 ◽  
Author(s):  
Athanasios Bikos ◽  
Elena Angeloudi ◽  
Evangelos Memmos ◽  
Charalampos Loutradis ◽  
Antonios Karpetas ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Blood Pressure Variability ◽  
Hemodialysis Patients ◽  
Adverse Outcomes ◽  
Short Term ◽  
Ambulatory Bp Monitoring ◽  
Average Real Variability ◽  
Regular Hemodialysis ◽  
Sustained Increase

Background: Short-term blood pressure (BP) variability (BPV) is associated with increased cardiovascular risk in hemodialysis. Patients with intradialytic hypertension have high risk of adverse outcomes. Whether BPV is increased in these patients is not clear. The purpose of this study was to compare short-term BPV in patients with and without intradialytic hypertension. Methods: Forty-one patients with and 82 patients without intradialytic hypertension (intradialytic SBP rise ≥10 mm Hg to > 150 mm Hg) matched in a 1: 2 ratio for age, sex, and hemodialysis vintage were included. All subjects underwent 48-h ambulatory BP monitoring during a regular hemodialysis and the subsequent interdialytic interval. Brachial and aortic BPV were calculated with validated formulas and compared between the 2 groups during the 48-h and the 44-h periods and during the 2 daytime and nighttime periods respectively. Results: During 48-h or 44-h periods and daytime or nighttime, brachial SBP/DBP and aortic SBP/DBP were significantly higher in cases than in controls. All brachial SBP/DBP BPV indexes [SD, weighted SD (wSD), coefficient-of-variation (CV) and average-real-variability (ARV)] were not significantly different between groups during the 48- or 44-h periods (48-h: SBP-ARV 11.59 ± 3.05 vs. 11.70 ± 2.68, p = 0.844, DBP-ARV: 8.60 ± 1.90 vs. 8.90 ± 1.63, p = 0.357). Analysis stratified by day or night between days 1 and 2 revealed, in general, similar results. No significant differences in dipping pattern were observed between groups. Analysis of aortic BPV had similar findings. Conclusions: BPV is similar between those with and without intradialytic hypertension. However, those with intradialytic hypertension have a sustained increase in systolic and diastolic BP during the entire interdialytic interval.

Blood pressure variability, cardiovascular risk and antihypertensive treatment

1995 ◽  
Vol 13 (supplement4) ◽  
pp. S27-A34 ◽  
Author(s):  
Gianfranco Parati ◽  
Luisa Ulian ◽  
Cinzia Santucciu ◽  
Stefano Omboni ◽  
Giuseppe Mancia
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Blood Pressure Variability ◽  
Antihypertensive Treatment

Physical Fitness and Long-term Blood Pressure Variability in Young Male Military Personnel

2020 ◽  
Vol 16 (2) ◽  
pp. 156-160 ◽  
Author(s):  
Gen-Min Lin ◽  
Kun-Zhe Tsai ◽  
Chin-Sheng Lin ◽  
Chih-Lu Han
Keyword(s):  
Blood Pressure ◽  
Physical Fitness ◽  
Military Personnel ◽  
Blood Pressure Variability ◽  
Young Male ◽  
The Elderly ◽  
Average Real Variability ◽  
The Right ◽  
Run Test

Aims: The aim of this study is to investigate the association of physical fitness with longterm Blood Pressure Variability (BPV) in young male adults. Methods: 1,112 healthy military males, aged 18-40 years (mean age, 32 years), in Taiwan were included for the current analysis. Resting blood pressures were measured over the right upper arm in a sitting position every two years from 2012 to 2018 (2012-14, 2014-15, 2015-16, 2016-18). Long-term BPV by Standard Deviation (SDSBP and SDDBP) and Average Real Variability (ARVSBP and ARVDBP) were assessed across 4 visits during the study period. Aerobic fitness was evaluated by the time taken for a 3000-meter run test, and anaerobic fitness was evaluated by the number of 2-minute sit-ups and 2-minute push-ups. Results: After adjusting the systolic and diastolic blood pressure, the time for a 3000-meter run was associated with ARVSBP, SDSBP, and SDDBP (β [SE]: 0.007 [0.002], 0.004 [0.002], and 0.005 [0.002], respectively, all p <0.05) but not with ARVDBP. In addition, the number of 2-minute sit-ups was inversely associated with ARVSBP (β [SE]: -0.041 [0.017], p =0.01) but not with ARVDBP, SDSBP, and SDDBP. There was no association of the number of 2-minute push-ups with the BPV indexes. After additionally adjusting the age, body mass index, and other covariates, all the associations were found to be not significant. Conclusion: It was found that there was no association of physical fitness with long-term BPV in young male military personnel. Previous studies have shown no association with cardiorespiratory fitness in the elderly. This study further increased the knowledge of a null association between anaerobic fitness and long-term BPV.

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