scholarly journals Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e59075 ◽  
Author(s):  
Chang Yang ◽  
Jian-Feng Liu ◽  
Bai-Sheng Chai ◽  
Qin Fang ◽  
Ning Chai ◽  
...  
Keyword(s):  
Time Window ◽  
Long Term Memory ◽  
Term Memory

scholarly journals Critical Time-Window for NO–cGMP-Dependent Long-Term Memory Formation after One-Trial Appetitive Conditioning

2002 ◽  
Vol 22 (4) ◽  
pp. 1414-1425 ◽  
Author(s):  
Ildikó Kemenes ◽  
György Kemenes ◽  
Richard J. Andrew ◽  
Paul R. Benjamin ◽  
Michael O'Shea
Keyword(s):  
Time Window ◽  
Critical Time ◽  
Memory Formation ◽  
Long Term Memory ◽  
Appetitive Conditioning ◽  
Term Memory

scholarly journals Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Smitha Karunakaran
Keyword(s):  
Fear Conditioning ◽  
Time Window ◽  
Fear Memory ◽  
Long Term Memory ◽  
Term Memory ◽  
Contextual Fear ◽  
Adrenoceptor Agonist ◽  
Hippocampal Ca1 ◽  
Memory Persistence

AbstractIn this study we demonstrate that 2 month old APPswe/PS1dE9 mice, a transgenic model of Alzheimer’s disease, exhibited intact short-term memory in Pavlovian hippocampal—dependent contextual fear learning task. However, their long-term memory was impaired. Intra-CA1 infusion of isoproterenol hydrochloride, the β-adrenoceptor agonist, to the ventral hippocampus of APPswe/PS1dE9 mice immediately before fear conditioning restored long-term contextual fear memory. Infusion of the β-adrenoceptor agonist + 2.5 h after fear conditioning only partially rescued the fear memory, whereas infusion at + 12 h post conditioning did not interfere with long-term memory persistence in this mouse model. Furthermore, Intra-CA1 infusion of propranolol, the β-adrenoceptor antagonist, administered immediately before conditioning to their wildtype counterpart impaired long-term fear memory, while it was ineffective when administered + 4 h and + 12 h post conditioning. Our results indicate that, long-term fear memory persistence is determined by a unique β-adrenoceptor sensitive time window between 0 and + 2.5 h upon learning acquisition, in the ventral hippocampal CA1 of APPswe/PS1dE9 mice. On the contrary, β-adrenoceptor agonist delivery to ventral hippocampal CA1 per se did not enhance innate anxiety behaviour in open field test. Thus we conclude that, activation of learning dependent early β-adrenoceptor modulation underlies and is necessary to promote long-term fear memory persistence in APPswe/PS1dE9.

scholarly journals Semantic Congruence Drives Long-Term Memory and Similarly Affects Neural Retrieval Dynamics in Young and Older Adults

2021 ◽  
Vol 13 ◽  
Author(s):  
Ricardo J. Alejandro ◽  
Pau A. Packard ◽  
Tineke K. Steiger ◽  
Lluis Fuentemilla ◽  
Nico Bunzeck
Keyword(s):  
Recognition Memory ◽  
Healthy Aging ◽  
Time Window ◽  
Age Groups ◽  
Event Related Potentials ◽  
Long Term Memory ◽  
Term Memory ◽  
Related Potentials ◽  
Semantic Congruence

Learning novel information can be promoted if it is congruent with already stored knowledge. This so-called semantic congruence effect has been broadly studied in healthy young adults with a focus on neural encoding mechanisms. However, the impacts on retrieval, and possible impairments during healthy aging, which is typically associated with changes in declarative long-term memory, remain unclear. To investigate these issues, we used a previously established paradigm in healthy young and older humans with a focus on the neural activity at a final retrieval stage as measured with electroencephalography (EEG). In both age groups, semantic congruence at encoding enhanced subsequent long-term recognition memory of words. Compatible with this observation, semantic congruence led to differences in event-related potentials (ERPs) at retrieval, and this effect was not modulated by age. Specifically, congruence modulated old/new ERPs at a fronto-central (Fz) and left parietal (P3) electrode in a late (400–600 ms) time window, which has previously been associated with recognition memory processes. Importantly, ERPs to old items also correlated with the positive effect of semantic congruence on long-term memory independent of age. Together, our findings suggest that semantic congruence drives subsequent recognition memory across the lifespan through changes in neural retrieval processes.

scholarly journals Serotonin Signals Modulate Mushroom Body Output Neurons for Sustaining Water-Reward Long-Term Memory in Drosophila

2021 ◽  
Vol 9 ◽  
Author(s):  
Wang-Pao Lee ◽  
Meng-Hsuan Chiang ◽  
Li-Yun Chang ◽  
Wei-Huan Shyu ◽  
Tai-Hsiang Chiu ◽  
...  
Keyword(s):  
Mushroom Body ◽  
Molecular Mechanisms ◽  
Time Window ◽  
Time Windows ◽  
Long Term Memory ◽  
Specific Time ◽  
Water Reward ◽  
Term Memory ◽  
Output Neurons

Memory consolidation is a time-dependent process through which an unstable learned experience is transformed into a stable long-term memory; however, the circuit and molecular mechanisms underlying this process are poorly understood. The Drosophila mushroom body (MB) is a huge brain neuropil that plays a crucial role in olfactory memory. The MB neurons can be generally classified into three subsets: γ, αβ, and α′β′. Here, we report that water-reward long-term memory (wLTM) consolidation requires activity from α′β′-related mushroom body output neurons (MBONs) in a specific time window. wLTM consolidation requires neurotransmission in MBON-γ3β′1 during the 0–2 h period after training, and neurotransmission in MBON-α′2 is required during the 2–4 h period after training. Moreover, neurotransmission in MBON-α′1α′3 is required during the 0–4 h period after training. Intriguingly, blocking neurotransmission during consolidation or inhibiting serotonin biosynthesis in serotoninergic dorsal paired medial (DPM) neurons also disrupted the wLTM, suggesting that wLTM consolidation requires serotonin signals from DPM neurons. The GFP Reconstitution Across Synaptic Partners (GRASP) data showed the connectivity between DPM neurons and MBON-γ3β′1, MBON-α′2, and MBON-α′1α′3, and RNAi-mediated silencing of serotonin receptors in MBON-γ3β′1, MBON-α′2, or MBON-α′1α′3 disrupted wLTM. Taken together, our results suggest that serotonin released from DPM neurons modulates neuronal activity in MBON-γ3β′1, MBON-α′2, and MBON-α′1α′3 at specific time windows, which is critical for the consolidation of wLTM in Drosophila.

Abstract WP95: Delayed Progesterone Treatment Attenuates Infarct and Behavioral Deficits Induced by Permanent Middle Cerebral Artery Occlusion (pMCAO) in Middle-Aged Rats: Therapeutic Time Window Study

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Bushra Wali ◽  
Iqbal Sayeed ◽  
Tauheed Ishrat ◽  
Seema Yousuf ◽  
Soonmi Won ◽  
...  
Keyword(s):  
Grip Strength ◽  
Therapeutic Dose ◽  
Time Window ◽  
Memory Deficits ◽  
Long Term Memory ◽  
Term Memory ◽  
Sensory Motor ◽  
Therapeutic Time Window ◽  
Sensory Neglect

BACKGROUND: Previously we carried out a dose response study and reported 8 mg/kg PROG to be the optimal therapeutic dose following in pMCAO. A systematic preclinical progesterone (PROG) therapeutic time window study is lacking. In the present study we used a clinically relevant middle-aged rat and long-term sensory, motor, and cognitive outcome measures to determine the effects of delayed PROG treatment. METHODS: Male Sprague-Dawley rats (12 months old) underwent pMCAO by electrocoagulation or sham operation. Beginning 3, 6, or 24 h post-occlusion, rats were given IP injections of 8 mg/kg of PROG or vehicle, followed by SC injections at 5 h after the first IP injection and then every 24 h for 7 days. The dose was tapered over the final 2 treatments. Behavioral recovery was evaluated at repeated intervals on sensory, motor, and cognitive tasks. Rats were killed at 22 days post-stroke and brains perfused for infarct evaluation. RESULTS: Three weeks post-pMCAO, PROG treatment delayed by 3 h improved grip strength by 64.48%, rotarod stability by 94.29%, sensory neglect by 94.48%, and long-term memory deficits by 60.56%. PROG treatment delayed by 6 h improved grip strength by 82.62%, rotarod stability by 75.89%, sensory neglect by 60.14%, and long-term memory deficits by 60.16%. Automated, computer-assisted gait assessment showed that PROG treatments significantly improved motor deficits in the affected limb on parameters like stride length, paw print and swing speed. When PROG treatment was compared to non-treated group, a significant reduction of 49.59 and 58.06% in infarct size was observed with 3- ( F (1,14) = 8.25, p <0.01) and 6-h delay of treatment ( F (1,13) = 4.44, p <0.05), respectively. CONCLUSION: The therapeutic dose of 8 mg/kg PROG was found to be effective within a large therapeutic time window. After both 3- and 6-h delays, PROG was effective in improving motor, sensory and memory function deficit. A 24-h treatment delay did not produce significant improvement in most of the outcome measures. PROG shows pre-clinical promise and should be examined for safety and efficacy in a clinical trial for ischemic stroke.

scholarly journals Consolidation of Memory for Odor–Reward Association: β-Adrenergic Receptor Involvement in the Late Phase

1999 ◽  
Vol 6 (2) ◽  
pp. 88-96 ◽  
Author(s):  
Susan J. Sara ◽  
Pascal Roullet ◽  
Jean Przybyslawski
Keyword(s):  
Temporal Dynamics ◽  
Time Window ◽  
Food Reinforcement ◽  
Late Phase ◽  
Critical Time ◽  
Current View ◽  
Long Term Memory ◽  
Term Memory ◽  
Noradrenergic Receptors

Experimentally naive rats can learn rapidly to discriminate among three odors to obtain food reinforcement. After three massed trials, they show almost errorless performance. This task has proved to be useful in studying time-dependent postacquisition intracellular processes necessary for long-term memory. The present experiments evaluated the temporal dynamics of the role of β-noradrenergic receptors in long-term consolidation. Rats were implanted with intracerebroventricular cannulae and trained in a single session to find reinforcement in a hole in a sponge impregnated with a particular odor. Injections of the β-receptor antagonist timolol were made at 5 min, 1, 2, or 5 hr after training. Memory and relearning ability were evaluated 48 hr later. Rats treated with timolol 2 hr after training showed a memory deficit at the retention test, but were able to relearn the task normally. Injections at the earlier or later time points were ineffective. The results reinforce previous observations with systemic injections that β-noradrenergic receptors are involved in the late phase of memory consolidation and suggest a critical time window during which they are necessary. The time window is compatible with the current view that long-term memory depends on late involvement of the cAMP cascade leading to new protein synthesis necessary for synaptic reorganization.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

Sign in / Sign up

Export Citation Format

Share Document