scholarly journals Simvastatin Impairs Growth Hormone-Activated Signal Transducer and Activator of Transcription (STAT) Signaling Pathway in UMR-106 Osteosarcoma Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e87769 ◽  
Author(s):  
María Claudia Sandoval-Usme ◽  
Adriana Umaña-Pérez ◽  
Borja Guerra ◽  
Orlando Hernández-Perera ◽  
José Manuel García-Castellano ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Signaling Pathway ◽  
Signal Transducer ◽  
Osteosarcoma Cells ◽  
Stat Signaling ◽  
Umr 106

Atomistic insight into the inhibition mechanisms of suppressors of cytokine signaling on Janus kinase

2019 ◽  
Vol 21 (24) ◽  
pp. 12905-12915 ◽  
Author(s):  
Yaru Wei ◽  
Zhiyang Zhang ◽  
Nai She ◽  
Xin Chen ◽  
Yuan Zhao ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Negative Feedback ◽  
Janus Kinase ◽  
Cytokine Signaling ◽  
Signal Transducer ◽  
Jak Kinase ◽  
Stat Signaling ◽  
Suppressors Of Cytokine Signaling ◽  
Insight Into

Suppressors of cytokine signaling (SOCS) act as negative feedback regulators of the Janus kinase/signal transducer (JAK–STAT) signaling pathway by inhibiting the activity of JAK kinase.

scholarly journals The JAK/STAT signaling pathway: from bench to clinic

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Xiaoyi Hu ◽  
Jing li ◽  
Maorong Fu ◽  
Xia Zhao ◽  
Wei Wang
Keyword(s):  
Signaling Pathway ◽  
Current Knowledge ◽  
Janus Kinase ◽  
Signal Transducer ◽  
Quarter Century ◽  
Cellular Processes ◽  
Stat Signaling ◽  
Cancer And Inflammation ◽  
Stat Pathway

AbstractThe Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.

Downregulation of the growth hormone-induced Janus kinase 2/signal transducer and activator of transcription 5 signaling pathway requires an intact actin cytoskeleton

2004 ◽  
Vol 294 (1) ◽  
pp. 269-280 ◽  
Author(s):  
Elizabeth Rico-Bautista ◽  
Ciro Negrı́n-Martı́nez ◽  
Javier Novoa-Mogollón ◽  
Leandro Fernández-Perez ◽  
Amilcar Flores-Morales
Keyword(s):  
Growth Hormone ◽  
Actin Cytoskeleton ◽  
Signaling Pathway ◽  
Janus Kinase ◽  
Signal Transducer ◽  
Janus Kinase 2

scholarly journals Desensitization of the Growth Hormone-Induced Janus Kinase 2 (Jak 2)/Signal Transducer and Activator of Transcription 5 (Stat5)-Signaling Pathway Requires Protein Synthesis and Phospholipase C*

Endocrinology ◽  
1998 ◽  
Vol 139 (4) ◽  
pp. 1815-1824 ◽  
Author(s):  
Leandro Fernández ◽  
Amilcar Flores-Morales ◽  
Olivier Lahuna ◽  
Daniel Sliva ◽  
Gunnar Norstedt ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Protein Synthesis ◽  
Phospholipase C ◽  
Signaling Pathway ◽  
Janus Kinase ◽  
Signal Transducer ◽  
Janus Kinase 2

scholarly journals Growth Hormone-Regulated Intracellular Signaling in UMR 106 Osteosarcoma Cells

2000 ◽  
Vol 15 (11) ◽  
pp. 2284-2290 ◽  
Author(s):  
Orlando Morales ◽  
Urban Lindgren ◽  
Lars-Arne Haldosén
Keyword(s):  
Growth Hormone ◽  
Intracellular Signaling ◽  
Osteosarcoma Cells ◽  
Umr 106
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